1,721,099 research outputs found
Effetti del Nonilfenolo su linee cellulari di prostata unmana: Pathway molecolari coinvolti.
No full text
New Insights Into the Role of GSK-3 in the Regulation of Human Cardiac Electrophysiology
Full text link[Figure: see text
Boosting circadian autophagy by means of intermittent time-restricted feeding: a novel anti-ageing strategy?
Full text linkBoosting circadian autophagy by means of intermittent time-restricted feeding: a novel anti-ageing strategy
Mitochondrial complex I deficiency and cardiovascular diseases. current evidence and future directions
No full textCompelling evidence demonstrates the emerging role of mitochondrial complex I deficiency in the onset and development of cardiovascular diseases (CVDs). In particular, defects in single subunits of mitochondrial complex I have been associated with cardiac hypertrophy, ischemia/reperfusion injury, as well as diabetic complications and stroke in pre-clinical studies. Moreover, data obtained in humans revealed that genes coding for complex I proteins were associated with different CVDs. In this review, we discuss recent experimental studies that underline the contributory role of mitochondrial complex I deficiency in the etiopathogenesis of several CVDs, with a particular focus on those involving loss of function models of mitochondrial complex I. We also discuss human studies and potential therapeutic strategies able to rescue mitochondrial function in CVDs
The Virtual Museum of the Western Han Dynasty: 3D Documentation and Interpretation
No full textThis project, aimed to the digital documentation of archaeological sites, artifacts and cultural relics of the Western Han Dynasty, started in 2008. The anticipated outcome will be the creation of a virtual museum, based on collaborative environments, dedicated to the Western Han Dynasty and able to integrate new archaeological datasets coming from fieldwork activities (most part of them unpublished), monuments, and famous collections of artifacts of the Xi’an archaeological museums. All the archaeological datasets will be virtually reconstructed in a very accurate way, keeping all the spatial information even in the cyber space: GIS, remote sensing and laser scanning data, DGPS surveys, 3D reconstructions (landscapes, sites, monuments, artifacts). The Virtual Museum of the Western Han Dynasty will be the first archaeological example of international collaboration between Chinese institutions and Western countries based on virtual heritage methodologies and real time outputs. The archaeological fieldwork, mainly encompassing 3D documentation of new tombs in the center and in the surroundings of Xi’an, is managed integrating different technologies and methods: laser scanning, digital photogrammetry, photomodeling, remote sensing, and GIS. The final plan is to create at least two installations, one in Xi’an and one in California. At UCM, the Virtual Heritage Lab is working on the set up of two different virtual reality systems based on participatory learning: a stereo collaborative environment (virtual heritage room) and a simulation environment (Powerwall). The primary purpose is to visualize and display very high-resolution data from large scientific simulations performed via high-resolution imaging applications. This paper will give an overview on the principal technologies and methods used in the field for the documentation of monumental wall paintings’ tombs, archaeological sites, landscapes and museum artifacts
Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
New insights into the role of mTOR signaling in the cardiovascular system
No full textThe mTOR (mechanistic target of rapamycin) is a master regulator of several crucial cellular processes, including protein synthesis, cellular growth, proliferation, autophagy, lysosomal function, and cell metabolism. mTOR interacts with specific adaptor proteins to form 2 multiprotein complexes, called mTORC1 (mTOR complex 1) and mTORC2 (mTOR complex 2). In the cardiovascular system, the mTOR pathway regulates both physiological and pathological processes in the heart. It is needed for embryonic cardiovascular development and for maintaining cardiac homeostasis in postnatal life. Studies involving mTOR loss-of-function models revealed that mTORC1 activation is indispensable for the development of adaptive cardiac hypertrophy in response to mechanical overload. mTORC2 is also required for normal cardiac physiology and ensures cardiomyocyte survival in response to pressure overload. However, partial genetic or pharmacological inhibition of mTORC1 reduces cardiac remodeling and heart failure in response to pressure overload and chronic myocardial infarction. In addition, mTORC1 blockade reduces cardiac derangements induced by genetic and metabolic disorders and has been reported to extend life span in mice. These studies suggest that pharmacological targeting of mTOR may represent a therapeutic strategy to confer cardioprotection, although clinical evidence in support of this notion is still scarce. This review summarizes and discusses the new evidence on the pathophysiological role of mTOR signaling in the cardiovascular system
- …
