194,618 research outputs found

    Multimodal Analgesia for Spine Surgery: Does the Intraoperative Opioid Dose Matter?

    No full text
    Author Contributions: Patrice Forget: This author wrote the first draft of the manuscript, contributed to the writing of the manuscript, approved the final version of this article and has read, and confirmed meeting the ICMJE criteria for authorship. Juan P. Cata: This author contributed to the writing of the manuscript, approved the final version of this article and has read, and confirmed meeting the ICMJE criteria for authorship. Funding: The authors received no specific funding for this work.Peer reviewe

    Forget Jacqueline P. — Population and Family Planning Classification

    No full text
    P. D. Forget Jacqueline P. — Population and Family Planning Classification. In: Population, 31ᵉ année, n°3, 1976. p. 744

    Forget Jacqueline P. — Population and Family Planning Classification

    No full text
    P. D. Forget Jacqueline P. — Population and Family Planning Classification. In: Population, 31ᵉ année, n°3, 1976. p. 744

    Serum diamine oxidase in the neonate

    No full text
    Serum diamine oxidase (DAO) activities were measured in 9 pregnant women and in 33 neonates during the 1st week of life. The radiometric method was used. Very high values were found in the mothers (mean +/- SE: 720 +/- 143 pmol ml-1 h-1). Neonates showed significantly elevated values (mean +/- SE: 178 +/- 54 pmol ml-1 h-1) on the 1st postnatal day when compared to the 7th day values (mean +/- SE: 27 +/- 5.7 pmol ml-1 h-1). Serial determinations showed a progressive decline from day 1 to day 7 after birth. We suggest the high serum DAO levels in neonates during the first days of life are due to leakage of placental enzyme into the circulation either at birth or during fetal life. Consequently, serum DAO cannot be used as a marker of small bowel functional integrity in the 1st postnatal week

    Scots should forget devo max – it’s not possible and wasn’t offered

    No full text
    First paragraph: One of the unfortunate things about the independence referendum debate is that it did not help us clarify the most likely outcome: the offer of more powers commonly known as devo max. For some, this refers to the idea of devolving everything except foreign and defence policy. Access this article on The Conversation website: https://theconversation.com/scots-should-forget-devo-max-its-not-possible-and-wasnt-offered-3211

    Forget Lance Armstrong, the next big cycling doper could be your dad

    No full text
    First paragraph: The Gran Fondo New York bicycle race is the biggest mass-participation event of its kind in the state, a 100-mile run between Manhattan and Bear Mountain. In May 2012 the organisers introduced drug testing. With thousands of entrants, this expensive process was limited to a handful of riders. Of those, two came back positive for EPO (erythropoietin), a blood-boosting hormone largely associated with the most elite professional end of the sport. Both riders were banned for two years.  Access this article on The Conversation website: https://theconversation.com/forget-lance-armstrong-the-next-big-cycling-doper-could-be-your-dad-3673

    On the Sherlocks, Jane Coleman and County Kildare in the Eighteen Forties

    No full text
    In the late 1980s and early 1990s the author acquired about 30,000 letters written mainly in the 1840s. These pertained to estates throughout Ireland managed by the firm of James Robert Stewart and Joseph Kincaid, hereafter denoted SK. Until the letters – called the SK correspondence in what follows – became the author’s property, they had not seen light of day since the 1840s. Addressed mainly to the firm’s office in Dublin, they were written by landlords, tenants, the partners in SK, local agents, etc. After about 200 years in operation as a land agency, the firm in which members of the Stewart family were the principal partners – Messrs J. R. Stewart & Son(s) from the mid- 1880s onwards – ceased operations in the mid-1980s. Since 1994 the author has been researching the SK correspondence of the 1840s. It gives many new insights into economic and social conditions in Ireland during the decade of the great famine, and into the operation of Ireland’s most important land agency during those years. It is intended ultimately to publish details on several of the estates managed by SK in a study more comprehensive than the present article, in book form. The proposed title is Landlords, tenants, famine: business of an Irish land agency in the 1840s, a draft of which has now been completed. A majority of the letters in that study are on themes some of which one might expect - rents, distraint (seizure of assets in lieu of rent); ‘voluntary’ surrender of land in return for ‘compensation’ upon quitting quietly; formal ejectment (a matter of last resort on estates managed by SK); landlordassisted emigration (on a scale much more extensive than most historians of Ireland in the 1840s appear to believe); petitions from tenants; complaints by tenants, both about other tenants and about local agents; landlord-financed and other relief of distress both before and during the great famine; major works of improvement (on almost all of the estates managed by SK which have been investigated in detail in the draft book); applications by SK, on behalf of landlords, for government loans to finance improvements; recommendations of agricultural advisers hired by SK, etc. Thus, most of the SK correspondence is about aspects of estate management. But the firm of SK was not only a manager of land. The correspondence reveals only two estates in Kildare, each of them relatively small, managed by SK in the 1840s. These were the lands of the Sherlocks near Naas and of Jane Coleman in the Kilcullen district. The correspondence on these properties differs substantively from most of those discussed in detail in the draft of Landlords, tenants, famine: first, it is relatively small in quantity, and secondly, it contains relatively little on the core aspects of estate management indicated above. Much of that on the Sherlocks focuses on misfortunes among family members, while the correspondence on Jane Coleman highlights the benevolence of that proprietor.

    Going Beyond Counting First Authors in Author Co-citation Analysis

    No full text
    The present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed

    Pharmacokinetics and efficacy of an ivermectin implant for long-term prevention of Dirofilaria immitis infection in dogs

    No full text
    An exploratory study was carried out to assess the in vivo efficacy of different prototypes of subcutaneous implants containing ivermectin (IVM) for the prevention of canine Dirofilaria immitis infection. The implants consisted of an ethylcellulose matrix containing IVM (3.0, 4.5, and 6.0 mg/implant; from 0.29 to 0.63 mg/kg bw) as active ingredient designed to release approximately 0.1 ng of IVM/mL in the plasma for at least 12 months. Six dogs were implanted on day -365. On day -12, three heartworm-free dogs were included in the study as a control group. All nine dogs were examined on day -7 and day 0 for circulating D. immitis microfilariae and by an antigen ELISA kit to confirm that the dogs were heartworm-free. The dogs were artificially infected with 75 D. immitis infective larvae (L3) each on day 0. Dogs in the control group were humanely euthanized on day 153 to verify the infectivity of the larvae, while implanted dogs were further examined for circulating D. immitis microfilariae and antigen on days 153, 195, and 246. The treated dogs were not necropsied. The pharmacokinetic profile of the IVM implant was assessed in plasma samples taken on day -364, then at different times until the infection day, and again on days, 15, 30, 60, 90, 120, and 153. Throughout the study, body weights were measured during clinical examination on days 0, 30, 60, 90, 120, and 153. At necropsy, all control dogs were found infected, each with 10-11 adult heartworms. Implanted dogs were negative at both microfilaria and D. immitis antigen examinations until day 246 (8 months from the infection). IVM plasma levels ranged 0.06-0.16 ng/mL on day 0 and remained stable until day 60, afterward they gradually decreased under the limit of quantification of the method. Throughout the study, no side effect was observed. On the basis of these results, it was possible to conclude that the different prototypes of implants were able to protect the dogs from D. immitis artificial infection for at least 12 months
    corecore