4,003 research outputs found
Effet de l’atorvastatine sur la dysfonction endothéliale des artères coronaires épicardiques associée à l’hypertrophie ventriculaire gauche dans un modèle porcin
No full textEffet de l’atorvastatine sur la dysfonction endothéliale des artères coronaires épicardiques associée à l’hypertrophie ventriculaire gauche dans un modèle porcin
Forcillo J, Aubin MC, Horn A, Shi YF, Carrier M, Tardif JC, Perrault LP
Introduction: L’atorvastatine par ses effets pléiotropiques pourrait limiter la dysfonction endothéliale associée au développement de l’HVG.
Méthodologie : Un cerclage de l’aorte ascendante pendant 2 mois entraîne le développement d’HVG et les groupes ont été traités avec atorvastatine 40 ou 80 mg de 60 à 90 jours. L’HVG est confirmée par échographie. La réactivité vasculaire est évaluée en chambres d’organe, la fonction endothéliale par la quantification de la GMPc et des nitrites/nitrates plasmatiques. Le stress oxydant est mesuré par les niveaux d’ANG II et de la carbonylation des protéines.
Résultats : Après 60 et 90 j de cerclage, l’HVG est observée chez tous ces groupes. Les courbes concentrations-réponse des anneaux des artères coronaires épicardiques des groupes traités avec l’atorvastatine 40 et 80 mg pour 30 et 60 jours n’ont démontré aucune amélioration des relaxations dépendantes de l’endothélium. Une exacerbation significative de la dysfonction endothéliale a été observée. Les niveaux vasculaires de GMPc sont significativement diminués dans le groupe sans cerclage traité 60 d et ceux d’ANG II sont fortement augmentés chez ce dernier groupe ainsi que le groupe traité avec 80 mg pour 30 jours par rapport aux contrôles. L’expression de la carbonylation des protéines est augmentée dans le groupe témoin traité avec atorvastatine 80 mg, reflétant une augmentation du stress oxydant.
Conclusion : L’administration d’atorvastatine ne prévient pas le développement de l’HVG ni la dysfonction endothéliale dans notre modèle. Au contraire l’atorvastatine à haute dose a un effet toxique sur les artères coronaires épicardiques en augmentant la dysfonction endothéliale.Effect of atorvastatin on endothelial dysfunction of epicardial coronary arteries associated with left ventricular hypertrophy in a porcine model.
Forcillo J, Aubin MC, Horn A, Shi YF, Carrier M, Tardif JC, Perrault LP
Background: Atorvastatin, through pleiotropic effects, may prevent or reverse the endothelial dysfunction associated with LVH. Methods: After performing a banding of the ascending aorta for 2 months leading to the development of LVH, groups have been treated with atorvastatin 40 or 80 mg for 60 and 90 day periods. LVH was evaluated by echocardiographic studies. Vascular reactivity studies were performed in organ chambers. In vitro endothelial function was evaluated by plasmatic nitrites/nitrates, the degradations products of nitric oxide, and cGMP quantification. To quantify and qualify oxidative stress, protein carbonyl and angiotensin II levels were assessed.
Results: Following 60 and 90 days of aortic banding, the development of LVH was observed in these groups. Concentration-response curves from rings of epicardial coronary arteries of groups treated with atorvastatin 40 and 80 mg for 30 and 60 days showed a significant decrease of endothelium-dependent relaxations with worsening of the endothelial dysfunction. Levels of cGMP were significantly decreased in the 60 days treated sham group and levels of ANG II were increased in the latter and also in the 90 days banded groups treated with 80 mg for 30 days compared to controls. The expression of protein carbonyl increased in the sham group treated with atorvastatin 80 mg compatible with an increase in oxidative stress.
Conclusion: The administration of atorvastatin does not limit the development of LVH nor the endothelial dysfunction in our model. On the opposite, atorvastatin at a high dose has a toxic effect on epicardial coronary arteries by exacerbating the endothelial dysfunction
A Conversation with Jessica B. Harris
No full textA conversation with culinary historian and award-winning author Jessica B. Harris, moderated by Gabrielle Fulton Ponder
Effet de l’atorvastatine sur la dysfonction endothéliale des artères coronaires épicardiques associée à l’hypertrophie ventriculaire gauche dans un modèle porcin
No full textEffet de l’atorvastatine sur la dysfonction endothéliale des artères coronaires épicardiques associée à l’hypertrophie ventriculaire gauche dans un modèle porcin
Forcillo J, Aubin MC, Horn A, Shi YF, Carrier M, Tardif JC, Perrault LP
Introduction: L’atorvastatine par ses effets pléiotropiques pourrait limiter la dysfonction endothéliale associée au développement de l’HVG.
Méthodologie : Un cerclage de l’aorte ascendante pendant 2 mois entraîne le développement d’HVG et les groupes ont été traités avec atorvastatine 40 ou 80 mg de 60 à 90 jours. L’HVG est confirmée par échographie. La réactivité vasculaire est évaluée en chambres d’organe, la fonction endothéliale par la quantification de la GMPc et des nitrites/nitrates plasmatiques. Le stress oxydant est mesuré par les niveaux d’ANG II et de la carbonylation des protéines.
Résultats : Après 60 et 90 j de cerclage, l’HVG est observée chez tous ces groupes. Les courbes concentrations-réponse des anneaux des artères coronaires épicardiques des groupes traités avec l’atorvastatine 40 et 80 mg pour 30 et 60 jours n’ont démontré aucune amélioration des relaxations dépendantes de l’endothélium. Une exacerbation significative de la dysfonction endothéliale a été observée. Les niveaux vasculaires de GMPc sont significativement diminués dans le groupe sans cerclage traité 60 d et ceux d’ANG II sont fortement augmentés chez ce dernier groupe ainsi que le groupe traité avec 80 mg pour 30 jours par rapport aux contrôles. L’expression de la carbonylation des protéines est augmentée dans le groupe témoin traité avec atorvastatine 80 mg, reflétant une augmentation du stress oxydant.
Conclusion : L’administration d’atorvastatine ne prévient pas le développement de l’HVG ni la dysfonction endothéliale dans notre modèle. Au contraire l’atorvastatine à haute dose a un effet toxique sur les artères coronaires épicardiques en augmentant la dysfonction endothéliale.Effect of atorvastatin on endothelial dysfunction of epicardial coronary arteries associated with left ventricular hypertrophy in a porcine model.
Forcillo J, Aubin MC, Horn A, Shi YF, Carrier M, Tardif JC, Perrault LP
Background: Atorvastatin, through pleiotropic effects, may prevent or reverse the endothelial dysfunction associated with LVH. Methods: After performing a banding of the ascending aorta for 2 months leading to the development of LVH, groups have been treated with atorvastatin 40 or 80 mg for 60 and 90 day periods. LVH was evaluated by echocardiographic studies. Vascular reactivity studies were performed in organ chambers. In vitro endothelial function was evaluated by plasmatic nitrites/nitrates, the degradations products of nitric oxide, and cGMP quantification. To quantify and qualify oxidative stress, protein carbonyl and angiotensin II levels were assessed.
Results: Following 60 and 90 days of aortic banding, the development of LVH was observed in these groups. Concentration-response curves from rings of epicardial coronary arteries of groups treated with atorvastatin 40 and 80 mg for 30 and 60 days showed a significant decrease of endothelium-dependent relaxations with worsening of the endothelial dysfunction. Levels of cGMP were significantly decreased in the 60 days treated sham group and levels of ANG II were increased in the latter and also in the 90 days banded groups treated with 80 mg for 30 days compared to controls. The expression of protein carbonyl increased in the sham group treated with atorvastatin 80 mg compatible with an increase in oxidative stress.
Conclusion: The administration of atorvastatin does not limit the development of LVH nor the endothelial dysfunction in our model. On the opposite, atorvastatin at a high dose has a toxic effect on epicardial coronary arteries by exacerbating the endothelial dysfunction
Jessica Stremer: Cook Prize 2024, Silver Medal Acceptance Speech
No full textAuthor Jessica Stremer gives an acceptance speech for Great Carrier Reef (Holiday House)https://educate.bankstreet.edu/cook/1013/thumbnail.jp
Jessica Pierce: The Last Walk: Caring for Our Animal Companions
No full textBioethicist and author Jessica Pierce will discuss end-of-life care, dying, and euthanasia in the lives of our companion animals.https://thekeep.eiu.edu/humanitiescenter_authenticity1314/1003/thumbnail.jp
Providence College Faculty Author Series 2014-2015: Dr. Jessica Mulligan
No full textIn this installment of the Faculty Authors Series, Dr. Jessica Mulligan of the Health Policy & Management department discusses her book Unmanageable Care: An Ethnography of Health Care Privatization in Puerto Rico - elucidating the history and contemporary state of the Puerto Rican healthcare system
Providence College Faculty Author Series 2014-2015: Dr. Jessica Mulligan
No full textIn this installment of the Faculty Authors Series, Dr. Jessica Mulligan of the Health Policy & Management department discusses her book Unmanageable Care: An Ethnography of Health Care Privatization in Puerto Rico - elucidating the history and contemporary state of the Puerto Rican healthcare system
Jessica Hagedorn, 19th Annual ODU Literary Festival
No full textJessica Hagedorn Born and raised in the Philippines, Jessica Hagedorn is well-known as a performance artist, poet, and playwright. She is the author of the novel Dogeaters (Penguin), which was nominated for the National Book Award. Hagedorn wrote the screenplay for Fresh Kill, an independent first feature film directed and produced by Shu Lea Cheang and has collaborated on film projects, Color Schemes and Those Fluttering Objects of Desire. Her multimedia theater pieces include Teenytown, The Art of War: Nine situations, and Holy Food. Hagedorn is the recipient of a 1994 Lila Wallace Reader’s Digest Writers Award, and a 1995 NEA Creative Writing Fellowship. Her new novel, The Gangster of Love has been recently released by Houghton Mifflin
Reading: Jessica Bruder
No full textIn this audiovisual recording from Thursday, March 24, 2022, as part of the 53rd Annual UND Writers Conference: “Communities and the Individual,” Jessica Bruder reads excerpts from Nomadland. Bruder discusses what it means to be an immersion journalist and what brought her to write Nomadland. Bruder also responds to audience questions about the dynamic between author and those who share their stories for a novel like Nomadland, the connection between immersive journalism and the new journalism literary movement, the process of collecting, organizing, and transforming material into a novel, how faithful the film version of Nomadland was to the book, and if Linda ever got to build her Earthship.
Introduced by Dr. Lori Robison, Chair of the Department of English
Sequential Derivatization of Polar Organic Compounds in Cloud Water Using O-(2,3,4,5,6-Pentafluorobenzyl)hydroxylamine Hydrochloride, N, O-Bis(trimethylsilyl)trifluoroacetamide, and Gas-Chromatography/Mass Spectrometry Analysis
No full textCloud water samples from Whiteface Mountain, NY were used to develop a combined sampling and gas chromatography-mass spectrometric (GCMS) protocol for evaluating the complex mixture of highly polar organic compounds (HPOC) present in this atmospheric medium. Specific HPOC of interest were mono- and di keto-acids which are thought to originate from photochemical reactions of volatile unsaturated hydrocarbons from biogenic and manmade emissions and be a major fraction of atmospheric carbon. To measure HPOC mixtures and the individual keto-acids in cloud water, samples first must be derivatized for clean elution and measurement, and second, have low overall background of the target species as validated by GCMS analysis of field and laboratory blanks. Here, we discuss a dual derivatization method with PFBHA and BSTFA which targets only organic compounds that contain functional groups reacting with both reagents. The method also reduced potential contamination by minimizing the amount of sample processing from the field through the GCMS analysis steps. Once derivatized only gas chromatographic separation and selected ion monitoring (SIM) are needed to identify and quantify the polar organic compounds of interest. Concentrations of the detected total keto-acids in individual cloud water samples ranged from 27.8 to 329.3 ng mL-1 (ppb). Method detection limits for the individual HPOC ranged from 0.17 to 4.99 ng mL-1 and the quantification limits for the compounds ranged from 0.57 to 16.64 ng mL-1. The keto-acids were compared to the total organic carbon (TOC) results for the cloud water samples with concentrations of 0.607 to 3.350 mg L-1 (ppm). GCMS analysis of all samples and blanks indicated good control of the entire collection and analysis steps. Selected ion monitoring by GCMS of target keto-acids was essential for screening the complex organic carbon mixtures present at low ppb levels in cloud water. It was critical for ensuring high levels of quality assurance and quality control and for the correct identification and quantification of key marker compounds.Corrected proof of accepted manuscrip
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