1,014 research outputs found
Author correction: A consensus-based transparency checklist
No full textContains fulltext :
214974.pdf (Publisher’s version ) (Open Access)In the version of this article initially published, the surname of author Marcus Munafò was misspelled. The error has been corrected in the HTML and PDF versions of the article.1 p
Interpreting clinical trials in acute coronary syndromes proceedings of an international conference held in Madrid, Spain, 30 January 1999
No full textVery early invasive angiography versus standard of care in higher-risk non-ST elevation myocardial infarction: study protocol for the prospective multicentre randomised controlled RAPID N-STEMI trial
No full textBackground: There are a paucity of randomised data on the optimal timing of invasive coronary angiography (ICA) in higher-risk patients with non-ST elevation myocardial infarction (N-STEMI). International guideline recommendations for early ICA are primarily based on retrospective subgroup analyses of neutral trials. Aims: The RAPID N-STEMI trial aims to determine whether very early percutaneous revascularisation improves clinical outcomes as compared with a standard of care strategy in higher-risk N-STEMI patients. Methods and analysis: RAPID N-STEMI is a prospective, multicentre, open-label, randomised-controlled, pragmatic strategy trial. Higher-risk N-STEMI patients, as defined by Global Registry of Acute Coronary Events 2.0 score ≥118, or >90 with at least one additional high-risk feature, were randomised to either: very early ICA±revascularisation or standard of care timing of ICA±revascularisation. The primary outcome is the proportion of participants with at least one of the following events (all-cause mortality, non-fatal myocardial infarction and hospital admission for heart failure) at 12 months. Key secondary outcomes include major bleeding and stroke. A hypothesis generating cardiac magnetic resonance (CMR) substudy will provide mechanistic data on infarct size, myocardial salvage and residual ischaemia post percutaneous coronary intervention. On 7 April 2021, the sponsor discontinued enrolment due to the impact of the COVID-19 pandemic and lower than expected event rates. 425 patients were enrolled, and 61 patients underwent CMR. Ethics and dissemination: The trial has been reviewed and approved by the East of England Cambridge East Research Ethics Committee (18/EE/0222). The study results will be submitted for publication within 6 months of completion. Trial registration number: NCT03707314; Pre-results
Author response
No full textMany insect species are host-obligate specialists. The evolutionary mechanism driving the adaptation of a species to a toxic host is, however, intriguing. We analyzed the tight association of Drosophila sechellia to its sole host, the fruit of Morinda citrifolia, which is toxic to other members of the melanogaster species group. Molecular polymorphisms in the dopamine regulatory protein Catsup cause infertility in D. sechellia due to maternal arrest of oogenesis. In its natural host, the fruit compensates for the impaired maternal dopamine metabolism with the precursor l-DOPA, resuming oogenesis and stimulating egg production. l-DOPA present in morinda additionally increases the size of D. sechellia eggs, what in turn enhances early fitness. We argue that the need of l-DOPA for successful reproduction has driven D. sechellia to become an M. citrifolia obligate specialist. This study illustrates how an insect's dopaminergic system can sustain ecological adaptations by modulating ontogenesis and development
Women responded to an early invasive strategy as well as men in the acute coronary syndrome
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Notocomplana palta (Marcus 1954) Faubel 1983
No full textNotocomplana palta (Marcus 1954) Faubel 1983 Synonym: Notoplana palta Marcus 1954 Material examined. Specimens of Notocomplana palta were provided by the Swedish Museum of Natural History, Stockholm, Sweden (SMNH). We designate as lectotype the specimen SMNH 110097- 110101 from the series of animals studied by Marcus (1954). New specimens were collected in 2006–2009 at different localities along the Patagonian coast; these are housed in the Invertebrate Zoology collection at the MLP (Table 1, Figure 1). Description. Live specimens are light to dark orange-colored (Figure 5 B). Central zone where pharynx is placed is darker. Body ovate and with ruffled edges. Studied specimens measure 10–20 mm long and 5–9 mm wide. Tentacles absent. Eyes placed in medial region, associated to brain zone. Brain eyes rounded, small, numbering 35 to 40 on each side. Tentacular eyes posterior to brain eyes, larger, and approximately ten on each side. Very small eyes in parenchyma ventrally and anteriorly to brain (Figure 5 A). Ventral and dorsal epidermis ciliated. Ventral cilia longer. Rhabdites on both surfaces, more abundant on ventral epidermis. Basal membrane thick, the ventral one being thinner than the height of the epithelium; dorsal basal membrane thickness equal to the epithelium height, folded in some of the thin sections. Body-wall musculature on dorsal surface consisting of an external thin circular layer, a diagonal middle layer (the thickest) and a longitudinal internal layer; a second internal circular layer is crossed by dorso-ventral muscles. On the ventral surface of the body, musculature is longitudinal, followed internally by a thin circular layer; the latter is packed inwards. Pharynx ruffled (approximately nine folds), placed in front of mid-length of body. Epithelium lining the pharynx cavity is ciliated. Mouth slightly behind mid-length of pharynx (Figure 5 C). Testicles ventral and ovaries dorsal, distributed throughout body length, including the region in front of the brain. Deferent ducts (one pair) thickenning and twisting before joining seminal vesicle. Seminal vesicle strongly muscular, rounded to oval. Ejaculatory duct long, thin and muscular. A short portion of ejaculatory duct projects into prostatic vesicle, which shows a tall and folded epithelium. Lumen of prostatic vesicle continuous with the lumen of penis papilla (Figure 4). Penis papilla conical, located in a male atrium and opening into a male pore (Figure 5 E, H–I). Female gonopore posterior to male pore (Figure 4). Muscular vagina inlaid with ciliate epithelium; shape sigmoidal, and lying perpendicular to surface in its first part, then running anteriorly, and later turning posteriorly. In female specimens, the portion reaching anteriorly carries abundant cement glands that open into that part of the vagina (Figures 4, 5 D, F). Uteri loaded with ovocites and continuing into two uterine ducts that join to form a single ciliate duct. The latter joins the proximal part of vagina at its ventral surface. Lang´s vesicle channel present after junction of uterus and vagina. This channel shows constrictions that give it a beaded appearance; it opens into Lang’s vesicle. At the junction of vesicle and duct there is a sphincter. Vesicle rounded to ovate, lined with a tall vacuolar epithelium, with scarce muscular fibres. Sperms were observed within it (Figures 4, 5 D, G). Remarks. This species was originally described by Marcus (1954) from the fjord region in southern Chile. The Patagonian specimens clearly agree with the original description of the species (Marcus, 1954) and with the material he had available for study (SMNH 110097- 110101). Bulnes (2009) recently mentioned Notocomplana palta in an area close to the type locality but the description given by this author does not agree with the original desciption (Marcus, 1954). Bulnes (2009) described small tentacles, a thin and short penis papilla, and a four-chambered seminal vesicle. These structures were not mentioned in the original description of this species (Marcus, 1954) nor are they present in the material studied by him and housed in the SMNH. Therefore, they can not be considered part of this taxon. The material housed in the SMNH was not designated originally as type material. To avoid future misidentifications of Notocomplana palta, the specimen described and illustrated by Marcus in the original work (Marcus 1954; 65; figs. 99, 101) and from the type locality (as recorded on the original label St. M 21) is designated as the lectotype under Article 74 of the fourth edition of ICZN (1999). The presence of this species along the Patagonian coast and southern Chile suggests a Magellanic distribution similar to that of other species of invertebrates (e.g. Boschi 2000, Balech & Ehrlich 2008).Published as part of Brusa, Francisco & Damborenea, Cristina, 2011, Polycladida Acotylea from Patagonia. Redescription of Crassiplana albatrossi (Pseudostylochidae), lectotype designation and first record of Notocomplana palta (Notoplanidae), pp. 29-38 in Zootaxa 2903 on pages 34-36, DOI: 10.5281/zenodo.20113
VIBRATIONAL SFECTRA FROM SEMI-CLASSICAL MECHANICS
No full textD.W. Noid, M.L. Koszykowski and R. A Marcus, J. Chem phys. 67, 404 (1977). M.L. Koszykowski, D.W. Noid and R.A Marcus, J. Chem Phys. 86, 2113 (1982).Author Institution: Arthur Amos Noyes Laboratory of Chemical Physics, California Institute of Technology Pasadena; Arthur Amos Noyes Laboratory of Chemical Physics, Oak Ridge National LaboratoryA spectral analysis, method for c1assical trajectories, presented in Ref. I, has been used fairly extensively to examine the dynamical properties of molecular and model systems. Result with this technique were shown to be in excellent agreement with quantum mechanical result for the vibrational transition frequencies and dipole matrix element of a Morse In the present lecture, transition intensities for non-resonant and resonant Hamiltonian systems are discussed. Current work is aimed at applying the technique to the vibrational degrees of freedom of triatomic molecules. Advantages and limitations of this spectral analysis are considered
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