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    Crustal structure of the Ischia-Phlegrean geothermal fields, near Naples, Italy, from gravity and aeromagnetic data

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    The crustal structure and thermal regime of the Ischia-Phlegrean Fields volcanic area (Naples, Italy) have been intensively studied using gravity and aeromagnetic data. Analysis and interpretation of the data indicate that there often exists a complicated relation between density, magnetization and temperature. In particular, thermal effects, such as thermal demagnetization and thermal mineral alteration, may play an important role locally and could be the possible sources of the observed magnetic anomalies. Two interpretations are proposed. In the first the anomalies are related to compositional discontinuities in the intermediate-deep crust; in the second they are related to deep thermal sources, such as partially melted trachybasalts (gravity field) and a local rise of the Curie point surface (magnetic field). -from Author

    Trafficking to the plasma membrane of the seven-transmembrane protein encoded by human herpesvirus 6 U51 gene involves a cell-specific function present in T lymphocytes

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    The sequence of human herpesvirus 6 (HHV-6) U51 open reading frame predicts a protein of 301 amino acid residues with seven transmembrane domains. To identify and characterize U51, we derived antipeptide polyclonal antibodies and developed a transient expression assay. We ascertained that U51 was synthesized in cord blood mononuclear cells infected with either variant A- or variant B-HHV-6 and was transported to the surface of productively infected cells. When synthesized in transient expression systems, U51 intracellular trafficking was regulated in a cell-type-dependent fashion. In human monolayer HEK-293 and 143tk- cells, U51 accumulated predominantly in the endoplasmic reticulum and failed to be transported to the cell surface. In contrast, in T-lymphocytic cell lines J-Jhan, Molt-3, and Jurkat, U51 was successfully transported to the plasma membrane. We infer that transport of U51 to the cell surface requires a cell-specific function present in activated T lymphocytes and T-cell lines
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