10,842 research outputs found
Interview of author Walter Satterthwait
No full textWalter Satterthwait, author of a series of contemporary crime novels, talks about his protagonists Joshua Croft and Rita Mondragon, and his novels set in Santa Fe, New Mexico. Satterthwait describes how he came to writing crime stories and why he chose to use a Latina as a main character. He describes his exposure to different cultures, his childhood of frequent moves, how he came to writing, and how he developed his characters. Satterthwait is interviewed by Diana Rivera at the 2005 Left Coast Crime Conference held in El Paso, Texas
Cardiovascular Pharmacogenomics
No full textBackground: Variability in response to pharmacological treatment is one of the most important issues in the clinical practice at first exclusively attributed to clinical and demographic factors such as age, sex, nutritional status, alcohol abuse, smoking, presence of comorbidities and polypharmacy. Nowadays, it is well known that also genetic factors can modify the outcomes of pharmacological treatments. Polymorphisms in genes encoding molecules involved in both pharmacodynamics and pharmacokinetics may influence efficacy, tolerability, and safety of medications; thus, the knowledge of these genetic variants may help physicians to individualize and optimize the therapies. Objective: The main aim of this review is to summarize the current scientific evidence about cardiovascular pharmacogenomics. Conclusion: Cardiovascular pharmacogenomics is recommended only for some antiplatelet, anticoagulant and antihypercholesterolemic drugs thanks to standardized pharmacogenetic tests that are helpful in preventing thromboembolic and hemorrhagic events. Despite many studies have demonstrated that the application of pharmacogenetics may be useful also to individualize the therapy with other cardiovascular drugs, the paucity of large clinical trials and of cost-effectiveness studies limits the translation of such knowledge into clinical practice
Anuson Walter Vella
No full textCremation volume for Vella, Walter F. (Walter Francis), 1924-1980, American author on Thailand; comprises condolences and papers on Thailand by both crematee and others
Letter from Walter M. Weglyn to Frank Chin, May 30, 1989
No full textA letter from Walter M. Weglyn to Frank Chin praising him for his writings about Japanese Americans draft resisters during World War II.These materials are from box 73 and 74 of the Frank Chin Papers. The Frank Chin Papers contain personal and professional correspondence between Frank Chin and Michi Weglyn relating to particular projects on which either author was working as well as files related to the Day of Remembrance Tribute to Michi Weglyn
Aerobic training workload affects human endothelial cells redox homeostasis
No full textPURPOSE: Moderate aerobic exercise reduces oxidative stress, whereas intense physical activity may produce the opposite result. At present, the effects of different exercise loads on oxidative stress markers and the response of human cells to different exercise volumes have not been fully elucidated.
METHODS: Human (Eahy-926) endothelial cells (EC), exposed or not exposed to oxidative stress, were conditioned with sera from two groups of triathletes practicing at different workloads.
RESULTS: Although no differences in functional and hemodynamic variables were observed between the two groups of triathletes, significant changes in some markers for oxidative stress were found in their sera. Thiobarbituric acid reactive substances and superoxide dismutase activity were similar, but triathletes practicing the sport at lower volume (T1) had higher serum nitric oxide and lower catalase activity than triathletes performing the training at greater load (T2). The EC conditioned with serum from T1 (T1-EC) showed higher survival and proliferation rates and lower senescence levels than the EC supplemented with T2 (T2-EC) serum both before and after oxidative stress induction. These effects depended on catalase as demonstrated via enzyme activity inhibition using 3-amino-1,2,4-triazole. After oxidative stress induction, Sirt1 activity, a regulator of the oxidative stress response, was significantly increased in the T1-EC but not in the T2-EC. Moreover, the T1-EC required less catalase activity than the T2-EC to counteract an equal amount of oxidative stress after H2O2 administration.
CONCLUSION: This study demonstrates that the beneficial effects of aerobic exercise are eliminated when the training is performed at a greater workload. Moreover, we suggest an oxidative stress marker, serum catalase activity, as a valid tool to use in the supervision of changes to exercise volume
Letter from Michi and Walter Weglyn to Frank Chin, July 25, 1993
No full textA personal letter from Michi and Walter Weglyn to Frank Chin.These materials are from box 73 and 74 of the Frank Chin Papers. The Frank Chin Papers contain personal and professional correspondence between Frank Chin and Michi Weglyn relating to particular projects on which either author was working as well as files related to the Day of Remembrance Tribute to Michi Weglyn
Letter from Carl Hayden to Bishop Walter Mitchell
No full textLetter from Carl Hayden to Walter Mitchell on building a Union Chapel in the Grand Canyon
Families in residence at Fresno Assembly Center and their community origin: names, family size, origin, center address of all evacuee family at Fresno Assembly Center
No full textPollock lists every family that is in residence at the Fresno Assembly Center. Includes "Fresno Assembly Center directory 1942."Walter E. Pollock was the head of the service division at the Fresno Assembly Center. He was deeply affected by his time working at the center and was working on a memoir of his experiences there, but unfortunately passed away before it could be completed. The collection contains his research and draft chapters
[Data], [incarcerees in Fresno Assembly Center]
No full textData is collected by Walter Pollock, numbers and statistics about the Fresno Assembly Center.Walter E. Pollock was the head of the service division at the Fresno Assembly Center. He was deeply affected by his time working at the center and was working on a memoir of his experiences there, but unfortunately passed away before it could be completed. The collection contains his research and draft chapters
[Prewriting ideas and titles]
No full textIn short and random snippets, Pollock tosses around "Title Thoughts," alongside potential paragraphs to insert into his piece "Fresno Assembly Center and a Time Beyond Tomorrow."Walter E. Pollock was the head of the service division at the Fresno Assembly Center. He was deeply affected by his time working at the center and was working on a memoir of his experiences there, but unfortunately passed away before it could be completed. The collection contains his research and draft chapters
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