117,343 research outputs found
Apprendere trasformando: costruire e abitare le proprie pratiche lavorative
No full textCome utilizzare le competenze della comunità di pratiche per l’innovazione organizzativa? Usando come riferimento la teoria dell’attività (Engeström, 2006; Vygotskij, 1978) il cambiamento è il risultato della co-costruzione collettiva da parte degli attori organizzativi di nuove forme di ‘espansione’ organizzativa (Zucchermaglio, 2002). Tale quadro teorico ha guidato un percorso rivolto ai coordinatori pedagogici della Federazione Provinciale delle Scuole Materne di Trento. Anche mediante l’analisi di estratti di interazioni discorsive tra i partecipanti vengono evidenziati i punti di forza, nonché di criticità, di tale Laboratorio per il Cambiamento Organizzativo, che può essere considerato un caso di ‘successo’ di costruzione, condivisione e innovazione delle pratiche lavorative in una comunità lavorativa
Perspectives of stack and environmental monitoring in the surroundings of a waste-to-energy plant
No full textWaste-to-Energy (WtE) processes respond both to the emerging need for reducing the flow of waste into the environment and, at the same time, to the increasing demand for energy. Despite, these evident advantages, WtE plants still present some critical issues regarding the emissions of heavy metals into the atmosphere, which are regulated by the environmental legislations but, concerning the European Union, are regarded as groups of metals with no consideration of the different carcinogenic potential of each metal. In addition, there are uncertainties on the estimation of the balance of carbon dioxide, which depends on several factors like transportation, type of incoming waste, processes in use and secondary emissions. Despite great improvements in air pollution control from this sector, persistent organic pollutants are still emitted by WtE plants. Therefore, the implementation of adequate environmental
monitoring (EM) plans is essential to monitor the impact of WtE plants in their surroundings, especially in the presence of the population, fields and pastures. In view of these considerations, this paper aims to provide guidance on basic and novel approaches that are necessary for a comprehensive monitoring of the impacts of a new WtE plant in terms of air quality and public health. A case study regarding the EM plan proposed for a new WtE plant will also be reported as an example
Down syndrome fibroblasts and mouse Prep1-overexpressing cells display increased sensitivity to genotoxic stress.
No full textPREP1 (PKNOX1) maps in the Down syndrome (DS) critical region of chromosome 21, is overexpressed in some DS tissues and might be involved in the DS phenotype. By using fibroblasts from DS patients and by overexpressing Prep1 in F9 teratocarcinoma and Prep1(i/i) MEF to single out the role of the protein, we report that excess Prep1 increases the sensitivity of cells to genotoxic stress and the extent of the apoptosis directly correlates with the level of Prep1. The apoptotic response of Prep1-overexpressing cells is mediated by the pro-apoptotic p53 protein that we show is a direct target of Prep1, as its depletion reverts the apoptotic phenotype. The induction of p53 overcomes the anti-apoptotic role of Bcl-X(L), previously shown to be also a Prep1 target, the levels of which are increased in Prep1-overexpressing cells as well. Our results provide a rationale for the involvement of PREP1 in the apoptotic phenotype of DS tissues and indicate that differences in Prep1 level can have drastic effects
Going Beyond Counting First Authors in Author Co-citation Analysis
No full textThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
TERAPIA CON FARMACI ANTI TNF ALFA: EVENTI AVVERSI
No full textIl trattamento precoce con farmaci antiTNF migliora segni e sintomi dell'AR e previene il danno strutturale.
Abbiamo esaminato gli eventi avversi in 54 pazienti affetti da AR attiva trattati con farmaci biologici anti TNF alfa. 7/54 pazienti hanno interrotto il trattamento per la comparsa di eventi avversi di grado severo. 17/54 hanno mostrato eventi avversi lievi senza interruzione di trattamento.
I pazienti con una maggior durata di malattia e con più elevati indici di disabilità sono candidati a mostrare con maggior frequenza eventi avversi di una certa entità
A transcription-dependent micrococcal nuclease-resistant fragment of the urokinase-type plasminogen activator promoter interacts with the enhancer
No full textSquare Dancing with the Stars to Enhance Dynamic Hirschman Linkages?
No full textIn this Presidential Address, the author takes the reader on a reconnaissance of his life and time as a regional scientist. He points out scenery he found scintillating along the way, hoping that some may pick up the banner and chew on a few of the ideas for a while. He suggests a revisit to Albert O. Hirschman’s notion of key sectors and more empirical analysis related to Marcus Berliant’s and Masahisa Fujita’s notion of knowledge creation and transfer.Presidential Address, San Antonio, Texas, March 29, 2014 (53rd Meetings of the Southern Regional Science Association
Gonartrosi: valutazione ecografica di un trattamento intraarticolare con miscela di aminoacidi ed acido jaluronico
No full textLa gonartrosi e' la variante di atrosi che più frequentemente causa disabilità. Scopo dello studio è stato valutare l'efficacia della somministrazione intrarticolare di una miscela di acido jaluronico ed aminoacidi (Jalupro) mediante misurazione dello spessode della cartilagine articolare.
Abbiamo esaminato 16 pazienti affetti da gonartrosi di grado II (Kellgren e Lawrence). Su tutti i pazienti, a livello basale e dopo 3 e 6 mesi dalla terapia e' stao valutato lo spessore della cartilagine nel compartimento centrale, mediale e laterale mediante ecografia. I risultati hanno mostrato un miglioramento della sintomatologia clinica ed incrementi dello spessore della cartilagine già a 3 mesi
Appropriate Similarity Measures for Author Cocitation Analysis
No full textWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
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