193 research outputs found
De Angelis difusor de Vico: examen de un paradigma indiciario
No full textEl autor trata de determinar si la recepción de G. Vico en el contexto de la cultura rioplatense decimonónica se debió directamente a De Angelis o Michelet, aparentemente influido a su vez por De Angelis. Si la primera idea es plausible, dada la estancia del mismo italiano en la Argentina, entonces la conclusión parece clara: el verdadero papel de De Angelis en la difusión decimonónica de Vico no es un hecho, sino algo desconocido. Sin embargo, el hecho de que algo no se encuentre mostrado por la evidencia documental no impide su existencia ficcional.The author tries to determinate if the reception of G. Vico in the context of the River Plate Culture of the nineteenth century was due directly to De Angelis, or to Michelet, apparently influenced in turn by De Angelis. If the first idea is plausible, through the stay of the Italian himself in the Argentine, then the conclusion seems clear: the true rôle of De Angelis in the spread of Vico in the nineteenth century is an unknown, and not a fact. However, the fact that something is not shown by documentary evidence does not prevent it being fictionally suppoused
Erratum to: A Regenerative Approach with Dermal Micrografts in the Treatment of Chronic Ulcers (Stem Cell Rev and Rep, 10.1007/s12015-016-9692-2)
No full textThe original version of this article unfortunately contained a mistake. The name of the seventh author was incorrectly listed as Gabriella Maria Casella De Angelis, when it is actually Gabriella Maria Cusella De Angelis. The correct information is as shown above. The original article was corrected
Corrigendum to ‘Eribulin in combination with bevacizumab as second-line treatment for HER2-negative metastatic breast cancer progressing after first-line therapy with paclitaxel and bevacizumab: a multicenter, phase II, single arm trial (GIM11-BERGI)’: (ESMO Open (2021) 6(2), (S2059702921000089), (10.1016/j.esmoop.2021.100054))
No full textThe authors regret that at the time the article was published the following two authors were missing from the author list: R. Caputo and D. Cianniello. Both authors affiliation is the Breast Oncology Department, Istituto Nazionale Tumori Fondazione G. Pascale, Naples, Italy. The updated author list is as follows: C. De Angelis, D. Bruzzese, A. Bernardo, E. Baldini, L. Leo, A. Fabi, T. Gamucci, P. De Placido, F. Poggio, S. Russo, V. Forestieri, R. Lauria, I. De Santo, R. Caputo, D. Cianniello, A. Michelotti, L. Del Mastro, M. De Laurentiis, M. Giuliano, S. De Placido, G. Arpino. The authors would like to apologise for any inconvenience caused
The Egyptian Dialect for a Democratic Form of Literature: Considerations for a Modern Language Policy
No full textThis paper compares two different ways of approaching literature and language in Egypt. In particular, I concentrate on the use of colloquial Egyptian in literature, and more specifically in prose. I look at the ideas of Ṭaha Ḥusayn on Egyptian dialect and juxtaposes them with those of intellectuals and writers contemporary to Ḥusayn such as Salama Musa and Muṣṭafa Mušarrafatu, the first Egyptian author to write a novel entirely in patois. In a radio interview, Nagib Maḥfuẓ described dialect as a disease affecting his fellow countrymen and preventing them from attaining social as well as technical progress. In Ṭaha Ḥusayn’s opinion, dialect is unworthy of being called a language and unfit to fulfil the aims of intellectual life. On the other hand, intellectuals like Salama Musa maintain that the use of dialect, even as an official language, and a linguistic reform are the most important prerequisites for the progress of Egypt. Extremely interesting, moreover, is Musa’s idea that the use of colloquial language in literature would give birth to a literature for everybody, that is a popular or democratic literature
Un diploma imperiale e tre carte vescovili. Le origini e i primi sviluppi dei possedimenti della cattedrale bobbiese: una rilettura
No full textThree mills along the Bobbio torrent and as many mansi; a small vineyard and a few similarly small lands, among which were nine sortes. But above all, a curtis with a chapel and a number (of unspecified) dependencies of men and immovables. This was the original endowment of Bobbio’s episcopal mensa, roughly ten years after the foundation of the diocese. The setting is illustrated by a significant document: a diploma granted on 23 October 1027 by emperor
Conrad II, who was also the founder of the new bishopric’s documentary tradition. In fact, the two previous documents, with which it is said that the second and third bishop of Bobbio had donated those same properties which the emperor would merely confirm, have not survived. These possessions had been detached from the mensa of the monastery of Saint Columbanus, an institution with which the newly-established diocese of Bobbio entertained a symbiotic yet ambiguous relationship for a few years. But the transfer of the aforementioned res must have been far from painless, and certainly not devoid of opposing claims, at least for what concerns the most copious part of the patrimony; nor was its possession on a long-term basis. Through a reappraisal of the most ancient documents and an examination of unedited archival material, this paper intends to furnish a reconstruction of these conflicting dynamics and of their impact on the definition of the patrimonial framework of the bishopric and of Bobbio’s cathedral chapter. These two organisms were respectively the author and beneficiary of a carefully-planned (and successful) documentary strategy founded on an underhanded falsification activity
A nucleolar localizing Rev binding element inhibits HIV replication
No full textAbstract The Rev protein of the human immunodeficiency virus (HIV) facilitates the nuclear export of intron containing viral mRNAs allowing formation of infectious virions. Rev traffics through the nucleolus and shuttles between the nucleus and cytoplasm. Rev multimerization and interaction with the export protein CRM1 takes place in the nucleolus. To test the importance of Rev nucleolar trafficking in the HIV-1 replication cycle, we created a nucleolar localizing Rev Response Element (RRE) decoy and tested this for its anti-HIV activity. The RRE decoy provided marked inhibition of HIV-1 replication in both the CEM T-cell line and in primary CD34+ derived monocytes. These results demonstrate that titration of Rev in the nucleolus impairs HIV-1 replication and supports a functional role for Rev trafficking in this sub-cellular compartment.</p
Chimeric snRNA molecules carrying antisense sequences against the splice junctions of exon 51 of the dystrophin pre-mRNA induce exon skipping and restoration of a corrected phenotype in D48-50 DMD cells.
No full textDeletions and point mutations in the dystrophin gene cause either the severe progressive myopathy Duchenne muscular dystrophy (DMD) or the milder Becker muscular dystrophy, depending on whether the translational reading frame is lost or maintained. Because internal in-frame deletions in the protein produce only mild myopathic symptoms, it should be possible, by preventing the inclusion of specific mutated exon(s) in the mature dystrophin mRNA, to restore a partially corrected phenotype. Such control has been previously accomplished by the use of synthetic oligonucleotides; nevertheless, a significant drawback to this approach is caused by the fact that oligonucleotides would require periodic administrations. To circumvent this problem, we have produced several constructs able to express in vivo, in a stable fashion, large amounts of chimeric RNAs containing antisense sequences. In this paper we show that antisense molecules against exon 51 splice junctions are able to direct skipping of this exon in the human DMD deletion 48–50 and to rescue dystrophin synthesis. We also show that the highest skipping activity was found when antisense constructs against the 5′ and 3′ splice sites are coexpressed in the same cell
Treatment of skin and soft tissue infections due to community-associated methicillin-resistant Staphylococcus aureus in Europe: the role of trimethoprim-sulfamethoxazole0010
No full textNo abstract availabl
Correction to: Management of hepatitis B virus prophylaxis in patients treated with disease-modifying therapies for multiple sclerosis: a multicentric Italian retrospective study (Journal of Neurology, (2022), 269, 6, (3301-3307), 10.1007/s00415-022-11009-x)
No full textThe original version of this article unfortunately contained a mistake. The given and family names of authors were Interchanged and Dr. Spiezia has two given names (Antonio Luca). The author names should be Antonio Riccardo Buonomo, Giulio Viceconte, Massimiliano Calabrese, Giovanna De Luca, Valentina Tomassini, Paola Cavalla, Giorgia Teresa Maniscalco, Diana Ferraro, Viviana Nociti, Marta Radaelli, Maria Chiara Buscarinu, Damiano Paolicelli, Alberto Gajofatto, Pietro Annovazzi, Federica Pinardi, Massimiliano Di Filippo, Cinzia Cordioli, Emanuela Zappulo, Riccardo Scotto, Ivan Gentile, Antonio Luca Spiezia, Martina Petruzzo, Marcello De Angelis, Vincenzo Brescia Morra, Claudio Solaro, Claudio Gasperini, Eleonora Cocco, Marcello Moccia, Roberta Lanzillo The original article has been corrected
Amor, conocimiento y método. Propuesta de una relación de propiciamiento entre el amor y el método en la ética de Spinoza.
No full textEn este trabajo abordaremos la pregunta ¿es posible plantear una relación entre el método geométrico y el amor? Esta pregunta es relevante porque es menester ampliar el debate y el conocimiento teórico que se tiene sobre obras clásicas de la filosofía, más aún si este debate intenta profundizar en cuestiones que no han quedado del todo claras en dichas obras y, precisamente la obra de Spinoza genera preguntas que han hecho carrera a través de los años entre quienes se dedican a estudiarla, una de estas preguntas gira sobre la implementación del método geométrico dentro de la Ética pues, pese a ser el método geométrico un elemento tan característico en su obra podemos darnos cuenta que él “no nos ha explicado jamás qué cosa lo indujo a demostrar de aquel modo su Ética” (Angelis, 1968). Precisamente por esto la pregunta de esta investigación es relevante pues, de ser posible identificar una relación entre el amor y el método geométrico estaríamos realizando un aporte en torno esta cuestión, en tanto que uno de los elementos empleados por Spinoza dentro de su filosofía justificaría esta elección.Licenciado en FilosofíaTesis de pregrad
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