17 research outputs found
Non cellular wireless communication systems
No full textElectrical Engineering, Mathematics and Computer Scienc
Een verkenning ten aanzien van de waterkwaliteit van het toekomstige Markiezaatsmeer
No full textIn 1983 is het in het kader van het WABASIM-project ontwikkelde eutrofiëringsmodel BLOOM II/CHARON overgedragen aan DDMI. Om nu ervaring met de werking. van het model op te doen, is besloten enige berekeningen voor een zoetwaterbekken uit te voeren. Om de hierboven vermelde reden is het nog niet bestaande nieuw te vormen Markiezaatsmeer gekozen. In de jaren 1977 - 1979 zijn er t.a.v. het Markiezaatsmeer reeds een aantal waterkwaliteitsvoorspellingen gedaan, die mede bepalend zijn geweest voor de inrichting van het gebied. Door de overdracht van het model BLOOM II/CHARON is er een nieuwe methodiek beschikbaar die alsnog toegepast wordt om de kwaliteit van het Markiezaatsmeer te voorspellen. Bovendien zijn ook twee andere voorspellingsmethodieken (Vollenweider en CUWVO) uitgewerkt.Wabasi
Veerse Meer aan de Oosterschelde: Toestand ecosysteem Veerse Meer vóór ingebruikname doorlaatmiddel
No full textAls het water vanaf mei 2004 wordt ververst, zal er een grote verandering optreden in met name het watersysteem. De waterkwaliteit zal naar verwachting merkbaar verbeteren en die verbetering zal effect hebben op het ecologisch functioneren van het hele gebied. Door de ontwikkelingen in het watersysteem goed in de gaten te houden (te monitoren) kan worden getoetst of het verversen met Oosterscheldewater voldoende is, of dat er nog aanvullende maatregelen nodig zijn om het gewenste streefbeeld te bereiken. De opgetreden verbetering is alleen te kwantificeren als de monitoringsresultaten afgezet kunnen worden tegen de uitgangssituatie (ook wel T0-situatie genoemd) van vóór het doorlaatmiddel. De uitgangssituatie wordt in dit rapport beschreven aan de hand van water- en bodemparameters en aspecten van planten en dieren die al geruime tijd gemeten (gemonitord) worden. Ook over aspecten die heel direct op de waterkwaliteit en het waterpeil reageren of daarvan afhangen, wordt de uitgangssituatie beschreven. Een en ander blijft beperkt tot het waterlichaam van het Veerse Meer, en de oeverdelen die onder directe invloed van het water staan. De verwachte effecten van het doorlaatmiddel op de visserij, recreatie, bewoning en beleving komen in dit rapport niet aan de orde. Aan de functie-eisen van het RBPN (Regionaal Beheerplan Nat) moet nu of op termijn worden voldaan (Anonymus 2002). Het beschrijven van de uitgangssituatie, op basis van onder andere de resultaten van het huidige monitoringsprogramma, was een goede gelegenheid om te toetsen of aan de functie-eisen wordt voldaan en een hypothese op te stellen voor de haalbaarheid in de toekomst. In het water van het Veerse Meer komen de voedingsstoffen stikstof (N) en fosfor (P) en ook enige verontreinigingen nu nog in concentraties voor die hoger zijn dan de MTR (Maximaal Toelaatbaar Risiconiveau) of de GW (Grenswaarde), gesteld in de Vierde Nota Waterhuishouding (NW4). Uit de toetsing volgde bovendien dat diverse funstie-eisen aangepast moeten worden aan de nieuwe situatie. Het verversen van water als nieuwe beheersmaatregel zal grote veranderingen van de waterkwaliteit, en daarmee het ecosysteem, tot gevolg hebben. Het monitoringsprogramma dient afgestemd te zijn op de toekomstige ontwikkelingen en veranderende functie-eisen. In dit rapport wordt de uitgangssituatie beschreven en een voorstel gedaan voor de monitoring van de effecten van het doorlaatmiddel op het waterlichaam. In de tabel op de volgende pagina is samengevat op grond van welke kenmerken de ontwikkelingen kunnen worden getoetst, aan welk streefbeeld dit is gerelateerd en in welk monitoringskader dit kan worden ondergebracht
Measurements in an incompressible three-dimensional turbulent boundary layer, under infinite swept-wing conditions, and comparison with theory
No full textFirst a three-dimensional turbulent boundary-layer experiment is described. This has been carried out with the specific aim of providing a test-case for calculation methods. Much attention has been paid to the design of the test set-up. An infinite swept-wing flow has been simulated with good accuracy. The initially two-dimensional boundary layer on the test plate was subjected to an adverse pressure gradient, which led to three-dimensional separation near the trailing edge of the plate. Next, a calculation method for three-dimensional turbulent boundary layers is discussed. This solves the boundary-layer equations numerically by finite differences. The turbulent shear stress is obtained from a generalized version of Bradshaw's two-dimensional turbulent shear stress equation. The results of the calculations are compared with those of the experiment. Agreement is good over a considerable distance; but large discrepancies are apparent near the separation line
Epiretinal Membrane Formation Associated With Idiopathic Macular Telangiectasia: Case Report
No full textA 46-year-old woman complained of blurred and distorted vision in both eyes. Ophthalmic examination showed that visual acuity was 20/200 for the right eye and counting fingers left eye. Fundoscopy revealed perimacular hemorrhages, aneurismal dilatation of the vessels in the posterior pole, and a white and elevated lesion adjacent to vascular changes. We report a case of idiopathic macular telangiectasia and epiretinal membrane that occurs concomitantly. To our knowledge, this is the first report that describes an association between idiopathic macular telangiectasia and epiretinal membrane formation.774264266Gass, J.D., Oyakawa, R.T., Idiopathic juxtafoveal retinal telangiectasis (1982) Arch Ophthalmol, 100 (5), pp. 769-780Abujamra, S., Telangiectasias perimaculares idiopáticas (2012) Rev Bras Oftalmol, 71 (4), pp. 213-216Bonanomi, M.T., Cresta, F.B., Abujamra, S., Telangiectasia retiniana justafoveolar idiopática do grupo 2A: hiperpigmentação macular incomum em dois pacientes (2001) Arq Bras Oftalmol, 64 (6), pp. 569-572Rentsch, F.J., The ultrastructure of preretinal macular fibrosis (1977) Albrecht Von Graefes Arch Clin Exp Ophthalmol, 203 (3-4), pp. 321-337Beach, J.M., Schwenzer, K.J., Srinivas, S., Kim, D., Tiedeman, J.S., Oximetry of retinal vessels by dual-wavelength imaging: calibration and influence of pigmentation (1999) J Appl Physiol (1985), 86 (2), pp. 748-758Yannuzzi, L.A., Bardal, A.M., Freund, K.B., Chen, K.J., Eandi, C.M., Blodi, B.C., Idiopathic macular telangiectasia (2006) Arch Ophthalmol, 124 (4), pp. 450-460. , Comment in: Arch Ophthalmol. 2006;124(4):573-4Charbel Issa, P., van der Veen, R.L., Stijfs, A., Holz, F.G., Scholl, H.P., Berendschot, T.T., Quantification of reduced macular pigment optical density in the central retina in macular telangiectasia type 2 (2009) Exp Eye Res, 89 (1), pp. 25-31Bringmann, A., Pannicke, T., Grosche, J., Francke, M., Wiedemann, P., Skatchkov, S.N., Muller cells in the healthy and diseased retina (2006) Prog Retin Eye Res, 25 (4), pp. 397-424Paunescu, L.A., Ko, T.H., Duker, J.S., Chan, A., Drexler, W., Schuman, J.S., Idiopathic juxtafoveal retinal telangiectasis: new findings by ultrahigh-resolution optical coherence tomography (2006) Ophthalmology, 113 (1), pp. 48-57Olson, J.L., Mandava, N., Macular hole formation associated with idiopathic parafoveal telangiectasia (2006) Graefe's Arch Clin Exp Ophthalmol, 244 (3), pp. 411-41
Determination of the mathematical model for the new dutch government civil aviation flying school flight simulator
No full textAerospace Engineerin
Clinical Trials In Brazilian Journals Of Ophthalmology: Where We Are
No full textPurpose: To compare clinical trials published in Brazilian journals of ophthalmology and in foreign journals of ophthalmology with respect to the number of citationsand the quality of reporting [by applying the Consolidated Standards for ReportingTrials (CONSORT) statement writing standards]. Methods: The sample of this systematic review comprised the two Brazilianjournals of ophthalmology indexed at Science Citation Index Expanded and sixof the foreign journals of ophthalmology with highest Impact Factor® accordingISI. All clinical trials (CTs) published from January 2009 to December 2010 at theBrazilians journals and a 1:1 randomized sample of the foreign journals wereincluded. The primary outcome was the number of citations through the end of2011. Subgroup analysis included language. The secondary outcome includedlikelihood of citation (cited at least once versus no citation), and presence orabsence of CONSORT statement indicators. Results: The citation counts were statistically significantly higher (P < 0.001) in theForeign Group (10.50) compared with the Brazilian Group (0.45). The likelihoodcitationwas statistically significantly higher (P < 0.001) in the Foreign Group (20/20-100%) compared with the Brazilian Group (8/20-40%). The subgroup analysis ofthe language influence in Brazilian articles showed that the citation counts werestatistically significantly higher in the papers published in English (P <0.04). Of 37possible CONSORT items, the mean for the Foreign Group was 20.55 and for theBrazilian Group was 13.65 (P < 0.003).Conclusion: The number of citations and the quality of reporting of clinical trialsin Brazilian journals of ophthalmology still are low when compared with the foreignjournals of ophthalmology with highest Impact Factor®.7612125Chamon, W., Melo Jr, L.A., Impact factor and insertion of the ABO in the world scientific literature (2011) Arq Bras Oftalmol Internet, 74 (4), pp. 243-244. , http://www.scielo.br/pdf/abo/v74n4/v74n4a01.pdf, [cited 2012 May 21]Juãdie;ni, P., Altman, D.G., Egger, M., Systematic reviews in health care: assessing the quality of controlled clinical trials. (2001) BMJ Internet, 323 (7303), pp. 42-6. , http://www.bmj.com/content/323/7303/42?view=longA&pmid=11440947, [cited 2011 Jan 21]Moher, D., Hopewell, S., Schulz, K.F., Montori, V., Gotzsche, P.C., Devereaux, P.J., Elbourne, D., Altman, D.G., CONSORT 2010 explanation and elaboration: updated guidelines for reporting parallel group randomised trials (2010) J Clin Epidemiol [Internet], 63 (8). , http://www.sciencedirect.com/science/article/pii/S0895435610001034, Consolidated Standards of Reporting Trials Group cited 2012 Jan 21, e1-37. Erratum in: J Clin Epidemiol. 2012;65(3):351Reuters, T., (2012), http://apps.webofknowledge.com, Web of Knowledge [Internet]. Philadelphia:. [cited Jun 30]Fonseca Jr, N.L., Luci, L.M., Badessa, M.P., Rehder, J.R., [Comparison of two modified lidocaine solutions for local anesthesia in blepharoplasty] (2009) Arq Bras Oftalmol [Internet], 72 (2), pp. 211-214. , http://www.scielo.br/pdf/abo/v72n2/15.pdf, [citado 2012 Jun 21] Portuguese. Dispon:Barreiro, T.P., Forseto, A.S., Pinto, L.F., Francesconi, C.M., Nosé, W., [Wavefront-guided Lasik for low to moderate myopia: CustomCornea versus Zyoptix] (2009) Arq Bras Oftalmol [Internet], 72 (4), pp. 519-525. , http://www.scielo.br/pdf/abo/v72n4/a16v72n4.pdf, [cited 2010 Out 21], Portuguese. Disponível em:Frantz, K.A., Moura Filho, E.R., Abud, M.B., Avila, M.P., Magacho, L., [Comparison of the analgesic effect between 0-MG etoricoxib and dipyrone after exeresis of primary pterygium with conjunctival autograft] (2009) Arq Bras Oftalmol [Internet], 72 (5), pp. 661-664. , http://www.scielo.br/pdf/abo/v72n5/12.pdf, [citado 2010 Jun 21], Portuguese. DisponiÁvel emGoncãcedil;alves, R.D., Cruz, A.A., [Oral sedation with midazolam in blepharoplasty] (2009) Arq Bras Oftalmol [Internet], 72 (5), pp. 665-668. , http://www.scielo.br/pdf/abo/v72n5/13.pdf, [citado 2010 Jul 21], PortugueseDisponiÁvel em:Hida, W.T., Motta, A.F., Kara-José Jr, N., Alves, E., Tadeu, M., Cordeiro, L.N., Comparison between OPD-Scan results and visual outcomes of monofocal and multifocal intraocular lenses (2009) Arq Bras Oftalmol [Internet], 72 (4), pp. 526-532. , http://www.scielo.br/pdf/abo/v72n4/a17v72n4.pdf, [citado 2010 Mar 21];. DisponiÁvel em:Kara-José Jr, N., Santhiago, M.R., Parede, T.R., Espindola, R.F., Mazurek, M.G., Germano, R., [Influence of cataract surgical correction on working perception] (2010) Arq Bras Oftalmol ,Internet, 73 (6), pp. 491-493. , http://www.scielo.br/pdf/abo/v73n6/v73n6a03.pdf, citado 2011 Fev 21Raskin, E., Paula, J.S., Cruz, A.A., Coelho, R.P., Effect of bevel position on the corneal endothelium after phacoemulsification (2010) Arq Bras Oftalmol ,Internet, 73 (6), pp. 508-510. , http://www.scielo.br/pdf/abo/v73n6/v73n6a08.pdf, [citado 2012 Dez 21]DisponiÁvel em:xRezende, M.P., Dias, A.F., Oshima, A., Andrade, E.P., Serracarbassa, P.D., [Study of visual acuity and intraocular pressure in the treatment of macular diabetic edema with intravitreous triamcinolone] (2010) Arq Bras Oftalmol [Internet], 73 (2), pp. 129-134. , http://www.scielo.br/pdf/abo/v73n2/v73n2a06.pdf, [citado 2012 Set 21];. DisponiÁvel em:Urbano, A.P., Nosé, W., [Correction of ocular aberrations in custom and standard LASIK retreatments] (2009) Arq Bras Oftalmol [Internet]., 72 (5), pp. 687-693. , http://www.scielo.br/pdf/abo/v72n5/18.pdf, [citado 2010 Jul 27]Portuguese. DisponiÁvel em:Nakano, C.T., Hida, W.T., Kara-Jose Junior, N., Motta, A.F., Reis, A., Pamplona, M., Comparison of central corneal edema and visual recovery between liquefaction and conventional phacoemulsification in soft cataracts (2009) Rev Bras Oftalmol [Internet], 68 (1), pp. 7-12. , http://www.scielo.br/pdf/rbof/v68n1/02.pdf, [citado 2011 Jun 21];.DisponiÁvel em:Barreto, R.D., Biancardi, A.L., Nascimento, E.M., Pereira, B.D., De Moraes, H.V., Uso de ciclosporina 0,05% tópica no tratamento de olho seco de pacientes portadores do vírus HIV (2009) Rev Bras Oftalmol [Internet], 68 (2), pp. 283-9. , http://www.scielo.br/pdf/rbof/v68n2/a04v68n2.pdf, [citado 2010 Mar 19];x. DisponiÁvel em:Martins, F.C., Miyaji, M.E., Lima, V.L., Rehder, J.R., Biometria ultrassônica no cálculo do poder dióptrico de lentes intraoculares: estudo comparativo dos métodos de contato e de imersaÃtild;o (2009) Rev Bras Oftalmol [Internet], 68 (4), pp. 212-215. , http://www.scielo.br/pdf/rbof/v68n4/a05v68n4.pdf, cited 2010 Aug 21Damasceno, E.D., Damasceno, N.A., Costa Filho, A.D., Ensino de oftalmologia na graduação médica (2009), 68 (4), pp. 231-236. , http://www.scielo.br/pdf/rbof/v68n4/a08v68n4.pdf, Estudo comparativo de aprendizado na oftalmoscopia direta com oftalmoscópico convencional e de campo amplo (Panoptic), Rev Bras Oftalmol [Internet].cited 2010 Jan 21Nakano, C.T., Hida, W.T., Kara-Jose Junior, N., Motta, A.F., Fante, D., Masson, V.F., Comparison between OPD-scan results and contrast sensitivity of three intraocular lenses: (2009) spheric AcrySof SN60AT, aspheric AcrySof SN60WF and multifocal AcrySof Restor lens. Rev Bras Oftalmol [Internet], 68 (4), pp. 216-222. , http://www.scielo.br/pdf/rbof/v68n4/a06v68n4.pdf, [citado 2010 Nov 21];.DisponiÁvel em:Mendes, M.H., Betinjane, A.J., Cavalcante, A.F., Castanheira, V.R., Cheng, C.T., Carani, J.C., Estudo comparativo entre imagens ultra-sonográficas obtidas com sondas de 10MHz e 20 MHz na avaliação de anormalidades do segmento posterior do globo ocular (2009) Rev Bras Oftalmol [Internet], 68 (5), pp. 291-295. , http://www.scielo.br/pdf/rbof/v68n5/a07v68n5.pdf, [citado 2010 Jan 21];.DisponiÁvel em:Portes, A.J., Gomes, L.P., Amaral, B.L., Massa, L., PercepcA¸aÃo da administracA̧aÃo toÁpica ocular de drogas: (2009), 68 (6), pp. 327-331. , http://www.scielo.br/pdf/rbof/v68n6/rbofv68n06a02.pdf, vaporizacÃcedil;aÃo x gotas. Rev Bras Oftalmol [Internet].[citado 2011 Jan 21];.DisponiÁvel emCorpa, J.H., Martinelli, E.J., Tarcha, F.A., Vitiello Neto, V., Ribeiro, L.G., Rede, J.R., Estudo comparativo entre desepitelização mecânica e química na ceratectomia fotorrefrativa - sintomatologia e re-epitelização pós operatória (2010) Rev Bras Oftalmol [Internet], 69 (1), pp. 123-6. , http://www.scielo.br/pdf/rbof/v69n1/05.pdf, [citado 2012 Jun 21];.DisponiÁvel em:Almodin, E.M., Almodin, J.M., Almodin, F.M., AvaliacA̧aÃo corneana apoÁs A"crosslinkA"utilizando dois tipos diferentes equipamentos (2010) Rev BrasOftalmol [Internet], 69 (3), pp. 159-164. , http://www.scielo.br/pdf/rbof/v69n3/a04v69n3.pdf, [citdo 2011 Fev 21];.DisponiÁvel em:Pinto, V.C., Martini da Costa, T., Grottone, G.T., Schor, P., Pisa, I.T., AvaliacA̧aÃo de um programa para computador de maÃo no auxiA´lio ao ensino de oftalmologia para estudantes de medicina (2010) Rev Bras Oftalmol [Internet], 69 (6), pp. 352-360. , http://www.scielo.br/pdf/rbof/v69n6/a02v69n6.pdf, [citado 2011 Jan 23];. DisponiÁvel em:Germano, J.E., Hida, W.T., Brasil, A.A., Germano, R.A., Yamane, I.S., Reis, A., Lente intraocular multifocal refrativa: a performance visual e qualidade de vida em implantes bilaterais versus unilaterais (2010) Rev Bras Oftalmol [Internet], 69 (6), pp. 372-377. , http://www.scielo.br/pdf/rbof/v69n6/a05v69n6.pdf, [citado 2011 Ago 25];. DisponiÁvel em:Bressler, N.M., Chang, T.S., Suñer, I.J., Fine, J.T., Dolan, C.M., Ward, J., Ianchulev, T., Vision-related function after ranibizumab treatment by better- or worse-seeing eye: clinical trial results from MARINA and ANCHOR (2010) Ophthalmology, 117 (4), pp. 747-756. , MARINA ANCHOR Research GroupsVogel, R., Crockett, R.S., Oden, N., Laliberte, T.W., Molina, L., Sodium Hyaluronate Ophthalmic Solution Study Group. Demonstration of efficacy in the treatment of dry eye disease with 0.18% sodium hyaluronate ophthalmic solution (vismed, rejena) (2010) Am J Ophthalmol, 149 (4), pp. 594-601. , Comment in: Am J Ophthalmol. 2010;150(5):757author reply 757Pavesio, C., Zierhut, M., Bairi, K., Comstock, T.L., Usner, D.W., Fluocinolone Acetonide Study Group. Evaluation of an intravitreal fluocinolone acetonide implant versus standard systemic therapy in noninfectious posterior uveitis (2010) Ophthalmology, 117 (3), pp. 567-75. , 575.e1Domalpally, A., Blodi, B.A., Scott, I.U., Ip, M.S., Oden, N.L., Lauer, A.K., Van Veldhuisen, P.C., The Standard Care vs Corticosteroid for Retinal Vein Occlusion (SCORE) study system for evaluation of optical coherence tomograms: SCORE study report 4 (2009) Arch Ophthalmol [Internet], 127 (11), pp. 1461-7. , http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2788490/, cited 2012 Nov 21, SCORE Study Investigator GroupScott, I.U., Oden, N.L., Van Veldhuisen, P.C., Ip, M.S., Blodi, B.A., Antoszyk, A.N., SCORE Study Report 7: incidence of intravitreal silicone oil droplets associated with staked-on vs luer cone syringe design (2009) Am J Ophthalmol [Internet], 148 (5). , http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2780008/, SCORE Study Investigator Group cited 2012 Jan 24, 725-32.e7Boyer, D.S., Heier, J.S., Brown, D.M., Francom, S.F., Ianchulev, T., Rubio, R.G., A Phase IIIb study to evaluate the safety of ranibizumab in subjects with neovascular age-related macular degeneration (2009) Ophthalmology, 116 (9), pp. 1731-1739. , http://ac.els-cdn.com/S0161642009005430/1-s2.0-S0161642009005430-main.pdf?_tid=c08a3786-8d8a-11e2-b888-00000aab0f26A&acdnat=1363363965_5a760f5706a3fa6af5ba0a61121bdb68, Comment in: Ophthalmology. 2010;117(9):1860author reply 1860-1.AKorenfeld, M.S., Silverstein, S.M., Cooke, D.L., Vogel, R., Crockett, R.S., Difluprednate Ophthalmic Emulsion 0.05% (Durezol) Study Group. Difluprednate ophthalmic emulsion 0.05% for postoperative inflammation and pain (2009) J Cataract Refract Surg, 35 (1), pp. 26-34. , http://online.liebertpub.com/doi/pdf/10.1089/jop.2010.0059Ip, M.S., Oden, N.L., Scott, I.U., Van Veldhuisen, P.C., Blodi, B.A., Figueroa, M., Antoszyk, A., Elman, M., SCORE Study report 3: study design and baseline characteristics (2009) Ophthalmology [Internet], 116 (9). , http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2785028/, cited 2011 Jun 21, 1770-7.e1.SCORE Study Investigators GroupSuner, I.J., Kokame, G.T., Yu, E., Ward, J., Dolan, C., Bressler, N.M., Responsiveness of NEI VFQ-25 to changes in visual acuity in neovascular AMD: validation studies from two phase 3 clinical trials (2009) Invest Ophthalmol Vis Sci [Internet], 50 (8). , http://www.iovs.org/content/50/8/3629.long, cited 2010 Jun 21, 3629-35Kohnen, T., Knorz, M.C., Cochener, B., Gerl, R.H., Arné, J.L., Colin, J., AcrySof phakic angle-supported intraocular lens for the correction of moderate- to-high myopia: one-year results of a multicenter European study (2009) Ophthalmology, 116 (7), pp. 1314-1321. , http://ac.els-cdn.com/S0161642009001031/1-s2.0-S0161642009001031-main.pdf?_tid=308438c0-8d8b-11e2-b5d0-00000aacb362Aacdnat=1363364152_64051f1sa592253031533dd5c497333d1Friberg, T.R., Tolentino, M., Weber, P., Patel, S., Campbell, S., Goldbaum, M., Pegaptanib sodium as maintenance therapy in neovascular age-related macular degeneration: the LEVEL study (2010) Br J Ophthalmol [Internet]., 94, pp. 1611-167. , http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2991041/, LEVEL Study Group [cited 2012 Apr 12];Ehrlich, J.S., Manche, E.E., Regression of effect over long-term follow-up of conductive keratoplasty to correct mild to moderate hyperopia (2009) J Cataract Refract Surg, 35 (9), pp. 1591-1596. , http://www.sciencedirect.com/science/article/pii/S0886335009005616Scott, I.U., Van Veldhuisen, P.C., Oden, N.L., Ip, M.S., Blodi, B.A., Jumper, J.M., Figueroa, M., SCORE Study Investigator Group. SCORE Study report 1: baseline associations between central retinal thickness and visual acuity in patients with retinal vein occlusion (2009) Ophthalmology [Internet], 116 (3), pp. 504-512. , http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2851408/, [cited 2010 Aug 4];Bressler, N.M., Chang, T.S., Fine, J.T., Dolan, C.M., Ward, J., Improved vision-related function after ranibizumab vs photodynamic therapy: a randomized clinical trial (2009) Arch Ophthalmol [Internet], 127 (1). , http://archopht.jamanetwork.com/article.aspx?articleid=420982, cited 2011 May 24, 13-21, Anti-VEGF Antibody for the Treatment of Predominantly Classic Choroidal Neovascularization in Age-Related Macular Degeneration (ANCHOR) Research GroupKeane, P.A., Patel, P.J., Ouyang, Y., Chen, F.K., Ikeji, F., Walsh, A.C., Effects of retinal morphology on contrast sensitivity and reading ability in neovascular age-related macular degeneration (2010) Invest Ophthalmol Vis Sci [Internet], 51 (11). , http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3061494/, cited 2012 Oct 21, 5431-7Repka, M.X., Kraker, R.T., Beck, R.W., Atkinson, C.S., Bacal, D.A., Bremer, D.L., Davis, P.L., Wheeler, M.B., Pediatric Eye Disease Investigator Group. 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Scaling of shoot and root respiration ofwoody and herbaceous plants
No full text10 Pags.- 5 Figs.- 2 Tabls. Data accessibility: Our data and code are available in the Dryad Digital Repository. © 2025 The Author(s). Published by the Royal Society under the terms of a Creative Commons Attribution License By .Woody and herbaceous plants are the main components of global terrestrial ecosystems, and their growth, adaptation and survival depend largely on the metabolism of shoots and roots. Therefore, understanding size-scaling of metabolic rates in woody and herbaceous plants, and in shoots and roots, is a fundamental issue in ecology. However, few empirical studies have examined metabolic scaling exponents across a wide range of plant sizes. Using whole-plant chamber systems, we measured respiration rates of entire root systems and shoots of 96 woody species (n = 1243) and 33 herbaceous species (n = 463) from various terrestrial biomes, with plant masses spanning nine orders of magnitude. Scaling exponents for relationships between respiration rates and fresh mass were greater in shoots than in roots, and both were greater in herbaceous plants than in woody plants. Furthermore, scaling of whole-plant respiration, including various species, converged separately for woody and herbaceous plants. These findings suggest some general physico-chemical constraints on energy use by shoots and roots of individual plants in various terrestrial biomes, including forests and grasslands. These data will advance our understanding of terrestrial ecosystem structure and function.This work was supported by the JSPS KAKENHI [19H02987, 19H01161, 24K01792, and 24KJ0457]. J.P.F. was supported by a JSPS long-term invitation fellowship [L-14560] and Reference Group (Gobierno de Aragón, Spain) [S74_23R].Peer reviewe
Mineralocorticoid Receptors Guide Spatial and Stimulus-Response Learning in Mice
No full textMineralocorticoid receptors guide spatial and stimulus-response learning in mice Arp, J.M.; ter Horst, J.P.F.; Kanatsou, S.; Fernández, G.; Joëls, M.; Krugers, H.J.; Oitzl, M.S. Published in: PLoS ONE DOI: 10.1371/journal.pone.0086236 Link to publication Citation for published version (APA): Arp, J. M., ter Horst, J. P., Kanatsou, S., Fernández, G., Joëls, M., Krugers, H. J., & Oitzl, M. S. (2014). Mineralocorticoid receptors guide spatial and stimulus-response learning in mice. PLoS ONE, 9(1), e86236. https://doi.org/10.1371/journal.pone.0086236 General rights It is not permitted to download or to forward/distribute the text or part of it without the consent of the author(s) and/or copyright holder(s), other than for strictly personal, individual use, unless the work is under an open content license (like Creative Commons). Disclaimer/Complaints regulations If you believe that digital publication of certain material infringes any of your rights or (privacy) interests, please let the Library know, stating your reasons. In case of a legitimate complaint, the Library will make the material inaccessible and/or remove it from the website. Please Ask the Library: https://uba.uva.nl/en/contact, or a letter to: Library of the University of Amsterdam, Secretariat, Singel 425, 1012 WP Amsterdam, The Netherlands. You will be contacted as soon as possible. Abstract Adrenal corticosteroid hormones act via mineralocorticoid (MR) and glucocorticoid receptors (GR) in the brain, influencing learning and memory. MRs have been implicated in the initial behavioral response in novel situations, which includes behavioral strategies in learning tasks. Different strategies can be used to solve navigational tasks, for example hippocampus-dependent spatial or striatum-dependent stimulus-response strategies. Previous studies suggested that MRs are involved in spatial learning and induce a shift between learning strategies when animals are allowed a choice between both strategies. In the present study, we further explored the role of MRs in spatial and stimulus-response learning in two separate circular holeboard tasks using female mice with forebrain-specific MR deficiency and MR overexpression and their wildtype control littermates. In addition, we studied sex-specific effects using male and female MR-deficient mice. First, we found that MR-deficient compared to control littermates and MR-overexpressing mice display altered exploratory and searching behavior indicative of impaired acquisition of novel information. Second, female (but not male) MR-deficient mice were impaired in the spatial task, while MR-overexpressing female mice showed improved performance in the spatial task. Third, MR-deficient mice were also impaired in the stimulus-response task compared to controls and (in the case of females) MR-overexpressing mice. We conclude that MRs are important for coordinating the processing of information relevant for spatial as well as stimulus-response learning
Produção de biomassa do fungo Agaricus subrufescens por processos fermentativos sólido e submerso para obtenção de polissacarídeos bioativos
No full textTese (doutorado) - Universidade Federal de Santa Catarina, Centro de Ciências Biológicas, Programa de Pós-graduação em Biotecnologia, Florianópolis, 2010Agaricus subrufescens (=A. brasiliensis) é um fungo comestível amplamente comercializado no Brasil e em outros países, devido as suas propriedades nutricionais e medicinais relacionadas principalmente aos polissacarídeos presentes em sua parede celular, tais como glucanas e glucomananas. Certos processos biotecnológicos têm sido utilizados para aumentar a escala produtiva do micélio e, consequentemente, aumentar a obtenção dos polissacarídeos. Previamente ao desenvolvimento desses processos de produção é importante estabelecer métodos de preservação do fungo in vitro e a recuperação do micélio após estocagem. Para a produção de biomassa foi utilizada a fermentação no estado sólido (FES) em grãos de trigo pré-tratados e a fermentação submersa (FSm) em hidrolisados de resíduos agroindustriais, como farelo de trigo (FT) e resíduo de cervejaria (RC). Polissacarídeos extraídos da frutificação (controle), do micélio em FES e do micélio isolado da FSm foram separados de acordo com suas massas molares por meio de diferentes membranas. Essas frações de polissacarídeos foram testadas na ativação de macrófagos in vitro. Entre os métodos de preservação, melhores resultados foram obtidos quando o meio de cultura foi suplementado com carvão ativo, tanto para a preservação quanto para a recuperação de A. subrufescens, sem alterações significativas na morfologia e genética do fungo durante um período de até 12 meses de estocagem. Para a FES, 21 min de cozimento dos grãos de trigo seguido de 24 min de molho após o cozimento demonstrou ser mais adequado para a produção de polissacarídeos (glucomananas) pelo fungo, inclusive quando o substrato não foi suplementado com cálcio, ou com adição máxima de 0,25 % CaCO3 (pH 6,6). A quantidade inicial de inoculante para a melhor produção de glucomananas (6,89 mg.mL-1) foi aproximadamente 10,3 %, numa temperatura ótima de incubação de 27,2 °C. As maiores biomassas de A. subrufescens para a FSm em hidrolisados de RC e FT foram obtidas na concentração de HCl 0,45 % e 20 min de hidrólise, apresentando 9,65 g.L-1 e 22,1 g.L-1, respectivamente. Porém, melhores resultados de bioconversão foram obtidos em hidrolisados utilizando até 0,3 % de HCl e 30 min de hidrólise, com adição de 2 g.L-1 de carvão ativo durante a hidrólise. Também foram obtidas altas taxas de biomassa de A. subrufescens no cultivo em hidrolisado com pH 5,3 e temperatura de incubação de 30,2 ºC. Na separação com membranas houve aumento da retenção dos polissacarídeos de todos os extratos à medida que o tamanho dos poros da membrana diminuiu. Os polissacarídeos separados pelas membranas de microfiltração (MF) e ultrafiltração (UF1) favoreceram a retenção de polissacarídeos de maior massa molar da frutificação (627 g.mol-1) e do micélio (310 g.mol-1), obtido tanto em FES quanto em FSm. Todos os polissacarídeos extraídos e retentados pelas membranas ativaram macrófagos através da expressão do Fator de Necrose Tumoral-a (TNF-a). Porém, somente os extratos brutos da frutificação e do micélio isolado da FSm, e seus polissacarídeos de maior massa molar retidos pela membrana MF ativaram macrófagos através da expressão de Óxido Nítrico Sintase Induzível (iNOS). Resultados importantes também foram obtidos para os polissacarídeos das frutificações de A. subrufescens, apresentando efeito antigenotóxico e atividade antiherpética quando esses foram sulfatados. Baseado nesses resultados, pesquisas complementares estão sendo desenvolvidas para a obtenção de produtos biotecnológicos com finalidade nutricêutica e/ou farmacêutica.Agaricus subrufescens (=A. brasiliensis) is an edible fungus widely commercialized in Brazil and other countries, mainly due to its nutritional and medicinal properties related principally to the polysaccharides present in the fungus cell wall, such as glucans and glucomannans. Biotechnological processes may in turn be used to scale up the production of mycelium and consequently the polysaccharides. Previous to the development of the production process it is important to establish techniques for the in vitro preservation and recovery of the mycelium after storage. Solid state fermentation (SSF) on pre-treated wheat grains and submerse fermentation (SmF) on hydrolyzed residues from the agro industries, such as wheat bran (FT) and brewery residues (RC) were used for biomass production. Polysaccharides extracted from fruiting bodies (control), mycelium on SSF and isolated mycelium from SmF were separated by molecular weight through different membranes. These polysaccharide fractions were tested on macrophage activity in vitro. Among the preservation techniques, better results were obtained when the media was supplemented with activated charcoal both for preservation and further recovery of A. subrufescens, without significant morphological and genetic changes within the 12 month storage period. For SSF, 21 min of wheat grain cooking followed by a 24 min resting time has shown to be the optimal condition for the production of polysaccharides (glucomannans) by the fungus, either with no supplement added, or when up to 0.25 % CaCO3 (pH 6.6) has been added to the substrate. The initial inoculum amount for the best polysaccharide production levels (6.89 %) was around 10.3 % with an optimal temperature of 27.2 °C. The highest biomass of A. subrufescens for the SmF in hydrolyzed RC and FT using HCL 0.45% and 20 min hydrolysis was 9.65 g.L-1 and 22.1 g.L-1, respectively. On the other hand, better results of bioconversion were obtained in hydrolyzed residues using up to 0.30 % HCl and 30 min hydrolysis, with the addition of 2 g.L-1 of activated charcoal throughout the process. High biomass levels were also obtained when the cultivation was carried out at a pH of 5.3 and with incubation temperature of 30.2 ºC. The results showed an increase in retention of all polysaccharide extracts as the membro ane porosity decreased. Microfiltration (MF) and ultrafiltration (UF1) membranes retained the highest polysaccharides from fruiting body (627 g.mol-1) and mycelium (310 g.mol-1) obtained on both SSF and SFm. All polysaccharide extracts and fractions separated by the membranes showed biological activity for TNF-a cytokines. On the other hand, only extracts obtained from fruiting bodies and isolated mycelium of FSm, and its high molecular weight polysaccharides retained by the MF membrane activated the iNOS. Important results were also obtained for the polysaccharides extracted from the fruiting bodies, showing antigenotoxic and antiherpetic activities after sulphatation. Based on these findings, additional research is currently in progress to purpose biotechnological products that can be used in both the nutraceutical and/or pharmaceutical areas
