196,563 research outputs found
Bone-marrow derived CXCR4-positive tissue-committed stem cell recruitment in human right ventricular remodeling
No full textHum Pathol. 2010 Nov;41(11):1566-76.
Bone-marrow-derived CXCR4-positive tissue-committed stem cell recruitment in human right ventricular remodeling.
Castellani C, Padalino M, China P, Fedrigo M, Frescura C, Milanesi O, Stellin G, Thiene G, Angelini A.
Source
Department of Medical-Diagnostic Sciences and Special Therapies, University of Padua, Medical School, 35121 Padua, Italy.
Abstract
The epicardium contributes to cardiac formation, particularly during embryogenesis. It remains to be seen if it is also involved in postnatal myocardial homeostasis. This study evaluates the topographic distribution of stem cells (c-Kit) and extracardiac progenitor cells (CXCR4+) and their contribution to ventricular remodeling in a model of pressure volume overload leading to right ventricle hypertrophy. Eleven specimens with hypoplastic left heart syndrome were evaluated and compared with 6 normal hearts from subjects matched for age and weight. All underwent Norwood procedure with the right ventricle becoming a systemic one, with pressure and volume overload leading to right ventricle remodeling. Transmural cardiac tissue samples from the right ventricle were analyzed by immunohistochemistry and morphometry. This is the first study to demonstrate that c-Kit-positive progenitor cells and tissue-committed stem cells (CXCR4+/CD45-) are higher in children with systemic right ventricle remodeling. We also show that the localization of cardiac progenitor and recruited CXCR4+ stem cells in the myocardium is site specific in hearts with right ventricle hypertrophy. These cells are mainly scattered in the interstitium of the epicardial layer. In contrast, myocyte proliferation is not a key process in right ventricular hypertrophy. Induced by the overexpression of SDF-1α by the myocardium, CXCR4 cell mobilization resembles SDF-1 homing factor distribution, showing transmural enhanced expression from the endocardium toward the epicardium. The study provides evidences of the site-specific epicardial localization of stem cells in a model of pressure/volume overload and suggests that the epicardium acts as a permissive niche in normal and pathologic conditions.
Copyright © 2010 Elsevier Inc. All rights reserved.
PMID:
20621330
[PubMed - indexed for MEDLINE
A field method for rapidly assessing deer density and impacts in forested ecosystems
No full textOn this page we provide the data and code used for the paper: Bennett A, Fedrigo M and Greet J (2021) A field method for rapidly assessing deer density
and impacts in forested ecosystems. Ecological Management and Restoration.
We also provide a field manual for the proposed new field method.
Any questions, don't hesitate to get in touch with us
Gazing left, gazing right: exploring a spatial bias in social attention
No full textFaces oriented rightwards are sometimes perceived as more dominant than faces oriented leftwards. In this study, we explored whether faces oriented rightwards can also elicit increased attentional orienting. Participants completed a discrimination task in which they were asked to discriminate, by means of a keypress, a peripheral target. At the same time, a task-irrelevant face oriented leftwards or rightwards appeared at the centre of the screen. The results showed that, while for faces oriented rightwards targets appearing on the right were responded to faster as compared to targets appearing on the left, for faces oriented leftwards no differences emerged between left and right targets. Furthermore, we also found a negative correlation between the magnitude of the orienting response elicited by the faces oriented leftwards and the level of conservatism of the participants. Overall, these findings provide evidence for the existence of a spatial bias reflected in social orienting
Compensating Nonlinear Effects in AO Control Loops
No full textIn this paper we propose an architecture to deal with non-linear effects like saturation that can severly limit the performance of an AO system while preserving good performance in both PSF output and piston management
Effect of Dynamic Stall, Finite Aspect Ratio and Streamtube Expansion on VAWT Performance Prediction using the BE-M Model
No full textA multiple-option analytical model for the evaluation of the energy performance and distribution of aerodynamic forces acting on a vertical-axis Darrieus wind turbine depending on both rotor architecture and operating conditions is presented. For this purpose, a numerical algorithm, capable of generating the desired rotor conformation depending on design geometric parameters, is coupled to a Single/Double-Disk Multiple-Streamtube Blade Element – Momentum code. Both single and double-disk configurations are analyzed and model predictions are compared to literature experimental data in order to test the capability of the code for predicting rotor performance. Effective airfoil characteristics based on local blade Reynolds number are obtained through interpolation of literature low-Reynolds airfoil databases. Some corrections are introduced inside the original model with the aim of simulating also the effects of blade dynamic stall, rotor streamtube expansion and blade finite aspect ratio, for which a new empirical relationship to better fit the experimental data is proposed. In order to predict also open field rotor operation, a freestream wind shear profile is implemented, reproducing the effect of atmospheric boundary layer
A large deviation principle for the free energy of random Gibbs measures with application to the REM
No full textA Large Deviation Principle (LDP) for the free energy of random Gibbs measures is proved in the form of a general LDP for random log-Laplace integrals. The principle is then applied to an extended version of the Random Energy Model (REM). The rate of exponential decay for the classical REM is stronger than the known concentration exponent, and probabilities of negative deviations are super-exponentially small
A field method for rapidly assessing deer density and impacts in forested ecosystems
No full textOn this page we provide the data and code used for the paper: Bennett A, Fedrigo M and Greet J (2021) A field method for rapidly assessing deer density
and impacts in forested ecosystems. Ecological Management and Restoration.
We also provide a field manual for the proposed new field method.
Any questions, don't hesitate to get in touch with us
A field method for rapidly assessing deer density and impacts in forested ecosystems
No full textOn this page we provide the data and code used for the paper: Bennett A, Fedrigo M and Greet J (2021) A field method for rapidly assessing deer density
and impacts in forested ecosystems. Ecological Management and Restoration.
We also provide a field manual for the proposed new field method.
Any questions, don't hesitate to get in touch with us
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