5 research outputs found
Pregio naturalistico del settore costiero antistante l’ex Ospedale al Mare (isola di Lido – Venezia)
No full textIn this paper we present the results of the analysis of plant communities/habitats, flora, fauna and
macromycetes present in a small but very significant sector of the Lido di Venezia coast. The almost
total reduction human pressures during about forty years, drives the area to the recovery of habitats
of the High Adriatic coast. Among the most significant habitats there are: 1210 - Annual vegetation
of drift lines, 2110 - Embryonic shifting dunes, 2130 * - Fixed coastal dunes with herbaceous
vegetation (gray dunes), 7210 * - Calcareous fens with Cladium mariscus and species of the Caricion
davallianae, 6420 - Mediterranean tall humid herb grasslands of the Molinio-Holoschoenion. All
the multidisciplinary assessments show the strengths of the recover paths. The floristic survey led to
the discovery of rare species of Veneto, among other Centaurium littorale and Cutandia maritima.
The observations on birds recorded the presence of species such as Charadrius alexandrinus and
Sternula albifrons in the near the sea sector, and the nesting of Caprimulgus europaeus and Lanius
collurio. Even the mycological surveys confirm the ecosystem recover, increasing the consistency
between existing and potential conditions.
The paper also shows the advantages and the limits of some coastal management approaches
Using neural networks for the recognition of specific motion symptoms of the parkinson’s disease
No full text
Exploring the mechanisms involved in prion degradation and spreading from cell-to-cell in neuronal cell models
No full textTransmissible spongiform encephalopathies (TSE), also known as prion diseases, are fatal neurodegenerative disorders present both in human and animals with different aetiology as they can occur genetically, spontaneously or by infection (Prusiner 1998). TSE are caused by the presence of proteinacious aggregates, called ‘prions’, in brains of afflicted individuals. According to the ‘protein-only’ hypothesis, the central event of prion pathogenesis is the conformational change of the cellular protein, PrPC, into its pathological counterpart, PrPSc in a process in which PrPSc acts as a template (Prusiner 1998). Differently from PrPC, mainly constitutes of α-helices, PrPSc is enriched in β-sheets, aggregation-prone and resistant to treatment with proteinase K. Despite the intense research, many questions in prion biology are still open related to both the physiological functions of PrPC and mechanism of the disease caused by the misfolded form PrPSc. Thus, exploring some of these aspects at the molecular and cellular level is of fundamental importance for a better understanding of these fatal disorders and for developing potential therapeutical approaches. However, due to the lack of PrPSc-specific antibodies, PrPSc cellular trafficking, production and degradation are poorly defined.
In the first part of my thesis I investigated the role of autophagy in prion disease. I demonstrated that although autophagic pathway is stimulated by prion infection, it is not involved in prion degradation. Furthermore, I showed that tamoxifen and its metabolite 4-hydroxil-tamoxifen (OHT) (previously shown to be autophagy inducers) reduce scrapie burden by redistributing cholesterol and PrP to lysosomes in an autophagy-independent manner. These data confirm the role of the lysosomal pathway in prion degradation and of cholesterol in prion formation. Furthermore, since tamoxifen is a wide-available pharmaceutical tool it might have potential application in therapy for prion disease.
Another important question in prion biology is related to the spreading of PrPSc. At the different stages of its lethal journey to the central nervous system, PrPSc is transferred from one cell to another and this passage can involve several mechanisms. Recently our laboratory has shown that PrPSc hijacks intercellular membranous channels, called tunneling nanotubes (TNT), for intercellular spread (Gousset et al., 2009; Langevin et al 2009). Therefore, in the second part of my PhD work I have better characterized TNT-mediated trafficking of PrPSc between neuronal cells, as model of prion infection. I also identified factors that could be involved in TNT formation and in the resulting transfer of PrPSc between cells. These results will contribute to the characterization of both TNT formation and prion spreading and open the way to further investigations
[WFAA News Clips and B-roll, ca. October 27-28, 1971]
No full text0:00 - (October 27, 1971) Everett Clinton Harris of Quinlan, Texas has been arrested as a suspect in the murders of Mesquite residents Susan Darlene Shaw, Forrest Covey, and Jena Covey; Harris was identified by several witnesses who placed him at each crime scene; various shots of Harris being escorted by police into the Dallas courtroom of Judge James Zimmermann (Harris was later released and charges were dropped – the 3 Mesquite murders were eventually tied to the McCrary family of serial killers known for the ''donut shop murders''); Dean Angel reporting (Silent). 0:47, 15:48 - Carl Junior Hackathorn is found guilty once again for the March 1963 murder of Bobbie Smith by a jury in the Dallas courtroom of Judge R. T. Scales (Hackathorn's previous conviction was overturned by the 5th Circuit Court of Appeals on a technicality); various shots of Hackathorn and council, including attorney Phil Burleson, who is seen standing to address Judge Scales (Silent). 1:09 - (October 27, 1971) Jim Hammond, director of the Dallas Legal Services Project (DLSP), talks about the conditions in the Dallas County Jail and the need for improvements. 2:24, 14:22 - (October 27, 1971) Lord Caradon (Hugh Mackintosh Foot, Baron Caradon), former Permanent Representative of the United Kingdom to the United Nations (UN), is in Dallas to speak at Southern Methodist University (SMU) as part of United Nations Week; at a press conference, Caradon talks about the benefits of China being admitted into the UN (amidst the controversy of Taiwan being excluded); he says that this is the beginning of a new era for the UN; Jim Mitchell reporting. 3:46 - (October 27, 1971) Dr. Nolan Estes, Dallas Independent School District (DISD) superintendent, discusses the Dallas School Board's desegregation progress report prepared for U.S. Dist. Judge William M. Taylor Jr.; Estes says that the report is submitted per court order and that they have done their best to implement and comply with Taylor's instructions; additional silent footage of the press conference; Cecile Burandt reporting. 4:22 - Julius Truelson, Fort Worth Independent School District (FWISD) superintendent, talks about ""white flight"" from Fort Worth (as a response to forced school busing) and says that he feels the district has complied with the court's desegregation order; he says that the district's plan is working to dismantle the ''dual system'' of segregated schools, but that the NAACP is trying to dismantle the city; Jerry Park reporting. 5:27 - A report on the ongoing picketing by members of Fort Worth Local 819 of the International Union of Operating Engineers at the Dallas-Fort Worth Regional Airport construction site, despite claims that the strike is unfounded and illegal; the union claims that B & J Excavation Company does not have an agreement with the Fort Worth local, but B & J argues that they are a subcontractor of Manhattan Construction of Dallas, which does have an agreement with them; Jim Green reporting. 7:00 - Carl L. Swanson, newly appointed regional director for the Federal Trade Commission (FTC), is in Dallas as part of an inspection tour; in an interview, he says that the FTC is learning more about deception in the marketplace and explains how they are playing a major role to tackle these problems. 8:01, 13:25 - A report on Orbis III, an electronic traffic monitoring system developed by Vought Missiles and Space Co. (a division of the LTV Aerospace Corp.), which is in use in Arlington and is being considered for use along the Dallas-Fort Worth Turnpike; Orbis takes a picture of a speeding car, its license plate, and its driver, then issues electronically generated speeding tickets; one of the concerns of installing the Orbis system on the turnpike is public acceptance of the ''Big Brother''-like device; additional silent footage of a meeting of the Texas Turnpike Authority (TTA), wherein Dick Myers, director of traffic systems for Vought, makes a presentation about the system; Jay Lewis reporting from Spur 303 in Arlington. 10:34 - (October 24, 1971) The Dallas Cowboys defeat the New England Patriots, 44-21, in the team's first game at Texas Stadium, before 65,708 fans; various highlights of the matchup (Silent). 11:23 - (October 23, 1971) The University of Texas Longhorns defeat the Rice University Owls, 39-10, in Austin; various highlights from the game (Silent). 13:23 - Brief shot of a statue in a field with several newly planted trees (Silent). 15:53, 21:18 - (October 28, 1971) Dr. Benjamin Spock – pediatrician, author, and peace activist – is in DFW to speak to local colleges about the progressive ''New Party,'' a fourth-party political coalition; Spock addresses a crowd from a podium (Silent); he says that his New Party is seeking a presidential candidate along the lines of Ralph Nader and explains why he refers to President Richard Nixon and Atty. Gen. John Mitchell as ''thugs''; he also says that Nixon is interfering with the federally mandated school-busing initiative. 16:06, 22:35 - (October 28, 1971) Former officers of the National Bankers Life Insurance Co. (NBL) are in federal court in Dallas to be arraigned on charges of criminal embezzlement (part of the larger Sharpstown Scandal stock-fraud case); brief, out-of-focus shot of Donald Akins, former NBL executive vice president, standing with a taller man in the Dallas Federal Court building; additional footage of former NBL president John Osorio walking out of the building (Akins and Osorio both pleaded innocent this day) (Silent). 16:09, 23:03 - (October 28, 1971) The National Association of Manufacturers (NAM) is holding a 26-city closed-circuit teleconference to announce Phase 2 of the Nixon administration's economic recovery program; various shots from the Dallas teleconference at the Adolphus Hotel; President Richard Nixon is seen on a large screen delivering a pre-recorded message praising the success of his wage-price freeze; Donald Rumsfeld, director of the Cost of Living Council, is also seen; additional silent footage of B. V. Thompson Jr. being interviewed; Thompson, president of Texas Steel Co., goes on to explain the purpose of the teleconference; Jim Mitchell reporting. 17:09, 23:42 - (October 28, 1971) Preston Parks, Dallas Police Association (DPA) president, holds a press conference to criticize the department's new policy on entrance testing (Silent); he goes on to explain their criticisms; Jim Mitchell reporting. 17:24, 25:52 - Ed Polk, former Dallas Legal Services Project (DLSP) director, is given a 6-month probated sentence in his driving-while-intoxicated (DWI) trial; various shots of Polk, his wife (Carol Polk), his father (Marion G. ''Doc'' Polk, in cowboy hat), and his attorney (Mike Buckley) in a courthouse hallway and in the Dallas courtroom of Judge John Orvis (Silent). 17:48 - (October 27, 1971) Lord Caradon is interviewed; Jim Mitchell reporting. 18:08 - (October 27, 1971) The Dallas School Board meets to present a progress report on DISD desegregation (Silent); Supt. Nolan Estes is interviewed; Dean Angel reporting. 19:03 - Fort Worth School Supt. Julius Truelson is interviewed; Jerry Park reporting (Silent). 19:40, 33:24, 39:00 - Various shots of construction at Dallas-Fort Worth Regional Airport; additional silent footage of a Fort Worth Local 819 picketer (Silent). 20:36 - (October 28, 1971) William D. Harvey was killed during a robbery at his home (9807 Lansdowne) in Pleasant Grove; 17-year-old Michael Arlan Higgins was arrested in East Texas and charged with the murder (Silent). 25:09 - (October 27, 1971) O'Byrne Cox of the Dallas County Sheriff's Office says that the department has been instructed by the District Attorney to make no statement on the arrest of Everett Clinton Harris (who was later released) for the murders of Susan Darlene Shaw, Forrest Covey, and Jena Covey (murders eventually tied to the ''donut shop murders'' committed by the McCrary family of serial killers). 26:20, 32:17 - (October 28, 1971) W. Kenneth Pope, regional bishop for the Methodist Church (seated with his wife, Kate Pope), holds a press conference after returning from a 32-day tour of Asia with the United Methodist Council of Bishops; he talks about the response in Taipei to the controversial decision by the United Nations (UN) to admit China but to expel Taiwan; Phil Reynolds reporting. 27:32 - Walt Garrison, Dallas Cowboys fullback, talks about the upcoming game against the Chicago Bears and his thoughts about Dick Butkus; Verne Lundquist reporting. 28:47, 32:39 - Jean-Paul LeBlanc of the Dallas Black Hawks interviews teammates Michel Archambault and J. P. Bordeleau in French; reporter Jerry Haynes goes on to interview LeBlanc about the upcoming game against the Fort Worth Wings; additional footage of a Hawks practice and of several women auditioning to be Hawkettes – usherettes at hockey games – who are seen listening to Hawks' publicist (and longtime Dallas sportscaster) Frank Filesi. 30:30, 33:16, 36:52 - (October 28, 1971) Dallas County Judge W. L. ''Lew'' Sterrett calls for the Dallas Bar Association to help fight a federal lawsuit filed by the Dallas Legal Services Project (DLSP), which is looking into conditions in the county jail; Sterrett says that DLSP has gotten out of hand and that the bar needs to help the county; Gene McIntyre reporting. 31:21 - Steve ''Snapper'' Jones of the Dallas Chaparrals talks about the improvements in the league this year and with the Chaps themselves; Verne Lundquist reporting. 33:30 - Brief shot of a Boy Scouts of America ''Silver Antelope'' certificate for R. W. Liston of Harlingen (Silent). 33:40, 36:32 - John R. Bunting Jr., president of the First Pennsylvania Corp. of Philadelphia, says that eliminating windfall profits would take the ''fun'' out of investing and would have a negative impact on the stock market; Bunting is in Dallas to speak to a group of securities analysts at the City Club; Phil Reynolds reporting. 34:51 - (October 28, 1971) Ralph Nader, consumer advocate, says at a press conference that he's not interested in any political office but is, instead, interested in community citizenship; Nader is in Dallas to speak to the Texas Society of Architects (TSA) about society's ills, including pollution (behind him is a poster for ''Texas Handle with Care,'' a TSA campaign promoting environmental education); Judi Hanna reporting. 36:02, 37:33 - (October 28, 1971) Three local Black organizations hold a press conference at the Community Christian Church in Fort Worth to issue a list of demands which, if not met, will result in a boycott of white-owned businesses – the representatives on the stage are (l to r) Jomo Tarik (né James Stein, leader of Black Methodists for Church Renewal), Akida Chagina (né Madison Hogan III, leader of the United Front), and El-Asa (né James Gaskin, leader of Committee on Police Brutality and Harassment) (Silent); in an interview, Tarik says that if their demands aren't met, they'll take action but does not specify what that is; several business owners respond to the press conference; Jerry Taff reporting
