1,720,967 research outputs found
Formulation And Evaluation Of Channa Striatus Extract And Fusidic Acid Aerosol For Treatment Of Wounds And Burn
Full text linkAerosol is a new drug delivery system for wound dressing and wound treatment. Aerosol has several benefits when compared with other delivery systems such as plasters or bandages for wound dressing and cream or gel for wound treatment. When applied to the body aerosol reduces pain that may result from the mechanical rubbing of gel and creams onto the skin. Aerosol could cover any size of wound which could not be covered by films due to films have a fixed size. Channa striatus has been used since a long time ago traditionally to accelerate the wound healing
Pengaruh Pemberian Ekstrak Belut (Monopterus albus) pada Penyembuhan Luka Bakar Tikus Putih Jantan Sprague-Dawley
No full textThe aim of this investigation was a clinical evaluation of the accelerating effect of Monopterus albus extract on the burn wound healing in male Sprague-Dawley rats weighted 200-300. The sample then extracted using wet rendering method using aqua-dest as extractor. This was experimental research with posttest only control group design. The subjects were ten male Sprague-Dawley rats devided into two group (control group 1 and experimental group 2). Every group consist of five rats. Heated metal plat (2cm x 2cm) used to get full thickness burn wound on dorsal rat part. Then, Monopterus albus extract was given to group 2 for 20 days. The results showed that Monopterus albus extract have significant effect (p < 0,05) to wound healing of rat models. Penelitian ini bertujuan untuk melihat percepatan penyembuhan luka bakar pada tikus putih jantan Sprague-Dawley (200-300 gram) dengan penggunaan ekstrak belut (Monopterus albus). Sampel diekstrak dengan air menggunakan metoda rendering basah. Penelitian menggunakan 10 hewan uji yang dibagi menjadi dua kelompok ( grup satu sebagai kontrol dan grup dua perlakuan). Tiap grup terdiri dari lima ekor hewan. Plat logam panas (2cm x 2cm) digunakan untuk membuat luka bakar pada punggung tikus. Kemudian ekstrak Monopterus albus dioleskan pada luka bakar grup 2 selama 20 hari. Hasil penelitian menunjukan bahwa ekstrak Monopterus albus mempunyai efek mempercepat penyembuhan luka bakar pada tikus percobaan secara signifikan
Efektivitas Sistem Penghantaran Liposom pada Katekin Sebagai Antioksidan
No full textA study on the effectiveness of liposome delivery system of catechin as an antioxidant has been done. Liposome was derived from phosphatidylcholine of egg and cholesterol. The method used to prepared liposome in this research was thin layer hydration method by using rotary evaporator. Liposome was made in 3 formulas with different comparison between phosphatidylcholine and cholesterol. The first formula with ratio of 1:1; second formula with ratio of 1:2 and third formula with a ratio of 2:1. The result found that the observation with SEM seen sperical liposome and some oval liposomes. The level of entrapment efficiency (%EP) obtained on Formula I, II, and III were 24.49%, 24.67%, and 20.06%, respectively. We can conclude that the increase of cholesterol will increase the efficiency of drug entrapment. Test of the effectiveness of antioxidant found formula II was better than formula I and formula III. It can be concluded that the increase of cholesterol was able to improve the formulation and stability of liposome.Telah dilakukan penelitian efektivitas sistem penghantaran liposom pada katekin sebagai antioksidan. Liposom dibuat dari fosfatidilkolin yang berasal dari telur dan kolesterol. Metoda liposom yang digunakan pada penelitian ini adalah metoda hidrasi lapis tipis menggunakan rotary evaporator. Liposom dibuat dalam 3 formula yang memiliki perbandingan berbeda antara fosfatidilkolin dan kolesterol. Formula 1 dengan perbandingan 1:1; formula 2 dengan perbandingan 1:2 dan formula 3 dengan perbandingan 2:1. Dari hasil pengamatan dengan SEM terlihat globul-globul liposom berbentuk bola sferis dan ada juga yang lonjong. Efisiensi penjerapan (% EP) didapatkan formula I sebesar 24,49%, Formula II sebesar 24,67% dan formula III sebesar 20,06%. Disini terlihat bahwa semakin meningkatnya kolesterol yang digunakan akan semakin meningkat pula efisiensi penjerapan obat. Pada uji daya antioksidan pada supernatan didapatkan formula II lebih baik dibandingkan formula I dan formula III, sehingga dapat disimpulkan bahwa semakin besar kolesterol maka formulasi liposom akan lebih bagus dan stabil
Formulation of Eel (Monopterus albus) extract membranes for wound dressing using plasticizers
Full text linkThe types of wound dressing will affect wound healing processes. The membrane is one of the potential wound
dressing that can maintain the moisture of the wound surface. The eel extract as an active ingredient could be added to the membrane formula to accelerate wound healing. This study aimed to formulate eel (Monopterus albus) extract membranes for wound dressing using some plasticizers. Polyvinyl alcohol (PVA) 146,000 was used as the polymer, while glycerol, propylene glycol, and polyethylene glycol (PEG) 400 were used as the plasticizers. Methylparaben and propylparaben were added as preservatives. Evaluations included thickness, water vapor permeability, and mechanical properties of the membranes that consisted of tensile strength, elongation at break, and Young's modulus were performed. The result showed that the use of different types of plasticizers affected the mechanical properties of the eel extract membrane. The formula that used glycerol as the plasticizer produced membranes with the best water vapor permeability and mechanical propertie
Formulation and evaluation of patchouli oil gel for burn wound
Full text linkEssential oils of the patchouli leaves (Pogostemon cablin, Benth) was known has the antibacterial effect and could be used to treat the burn. Aim of this study is to formulate patchouli oil into gel dosage form. Patchouli oil was used at three concentrations i.e. 2% (F1), 4% (F2) and 6% (F3). Evaluation of the resulting formulas includes examining its general appearance, homogeneity, skin irritation test, pH and spreadability test. Based on the evaluation data, it was found that gel with 2% patchouli oil was transparent. The greater the concentration of patchouli oil, the more opaque the gel is produced. The other parameters give results that are not different for the three formulas
Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Variations on the Author
Full text link“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Appropriate Similarity Measures for Author Cocitation Analysis
Full text linkWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
Dispelling the Myths Behind First-author Citation Counts
Full text linkWe conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued
use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation
counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more
sophisticated methods
- …
