978 research outputs found
Alien Registration- Farrell, Grace F. (Danforth, Washington County)
No full texthttps://digitalmaine.com/alien_docs/2099/thumbnail.jp
Grace Aguilar’s historical romances
No full textPhDMy dissertation looks critically at Grace Aguilar’s historical romance novels and short
stories, and investigates English writers’ uses of history in early- to mid-nineteenth century
fiction. Shifting the current critical emphasis on Aguilar’s Jewish texts, I
have analyzed the ways in which Aguilar revises the genres of the national tale, the
gothic romance, and the medieval romance in order to demonstrate her participation
in the construction of nineteenth-century domestic values.
In Chapter One, I introduce to critical debate Aguilar’s juvenilia, relying on
unpublished manuscripts and novels published only in the twentieth century to
establish the origins of Aguilar’s interest in history and historical writing. Locating
Aguilar’s narrative style in the early nineteenth-century national tale, I show that as a
child Aguilar envisioned the English and Scottish nations as a family, making
domesticity both a private and a public—a female and a male—value.
Chapter Two focuses on Aguilar’s use of history to express nineteenth-century
domestic ideals in her version of the gothic romance. Deploying the setting of the
Catholic Inquisition in Spain and Portugal, Aguilar writes gothic tales that unite
Jewish and Protestant gender values. She makes heroic the Jewish female martyr to
suggest not only that nineteenth-century Protestants and Jews share similar domestic
principles, but also that Jewish women could be seen as ideal models for Protestant
women.
Finally, in Chapter Three I explore Aguilar’s participation in the nineteenth-century
medievalist tradition by reflecting on her revision of nineteenth-century literary
idealizations of the Middle Ages. In these short stories, Aguilar fictionalizes the
sixteenth-century European chivalric ethos, looking critically at the role of women in
court society at the end of the Middle Ages. Deploying the tropes prevalent in
popular nineteenth-century anti-medievalist fiction, Aguilar debunks celebrations of
the Middle Ages by showing how chivalry is antagonistic to nineteenth-century
domesticity
Cutting'aesthetic teeth' : Flannery O'Connor's habit of art
No full textDissertação (mestrado) - Universidade Federal de Santa Catarina, Centro de Comunicação e ExpressãoEste trabalho foi sugerido pela afirmação de Flannery O'Connor que sua "dedicação estética" nasceu através do contato com Art and Scholasticism de Jacques Maritain. O propósito foi chegar a uma interpretação do sentido da frase. Uma investigação detalhada foi feita do conteúdo de Art and Scholasticism, posteriormente contrastada com os resultados de uma pesquisa feita em seus ensaios e suas cartas, o que revelou numerosos ecos de diversos trechos constando no texto de Maritain. Três pontos principais foram escolhidos como critérios na análise do hábito artístico de O'Connor: 1) a prática de arte implica uma luta; 2) a arte somente pode ser percebida pelos sentidos; e 3) a prática de arte exige do artista a dedicação indivisa à obra nascente. O estudo conclui que, para O'Connor, o brotar da dentição estética, através da leitura de Art and Scholasticism, significou que, ao perceber na análise da natureza da arte algo com que podia concordar, ela reconheceu tanto sua própria capacidade de tornar-se uma artista literária, quanto sua vontade de assumir a tarefa de desenvolver em sua pessoa o hábito de arte
Jews and gender in British literature 1815-1865.
No full textPhDThis thesis examines the variety of relationships between Jews and gender in early
to mid-nineteenth century British literature, focussing particularly on representations
of and by Jewish women. It reconstructs the social, political and literary context in
which writers produced images and narratives about Jews, and considers to what
extent stereotypes were reproduced, appropriated, or challenged. In particular it
examines the ways in which questions of gender were linked to ideas about religious
or racial difference in the Victorian period.
The study situates literary representations of Jews within the context of
contemporary debates about the participation of the Jews in the life of the modern
state. It also investigates the ways in which these political debates were gendered,
looking in particular at the relationship between the cultural construction of
femininity and English national identity.
It first considers Victorian culture's obsession with Rebecca, the Jewess created in
Walter Scott's influential novel Ivanhoe (1819). It examines Rebecca's refusal to
convert to Christianity in the context of Scott's discussion of racial separatism and
modern national unity.
Evangelical writers like Annie Webb, Amelia Bristow and Mrs Brendlah were
prolific literary producers, and preoccupied with converting Jewish women.
Particularly during the 18'40s and 1850s, evangelical writing provided an important
forum for the construction and consolidation of women's national identity.
Grace Aguilar's writing was an attempt to understand Jewish identity within the
terms of Victorian domestic ideology. In contrast, Celia and Marion Moss, in their
historical romances, offered narratives of female heroism and national liberation,
drawing on the contemporary debate about slavery.
Benjamin Disraeli's construction of a "tough version of Jewish identity was a
response both to the contemporary stereotype of the feminised Jew and to the debate
about Jewish emancipation. It also drew on the virile ideology of the Young England
movement of the 1840s
Global GRACE Data Assimilation for Groundwater and Drought Monitoring: Advances and Challenges
No full textThe scarcity of groundwater storage change data at the global scale hinders our ability to monitor groundwater resources effectively. In this study, we assimilate a state-of-the-art terrestrial water storage product derived from Gravity Recovery and Climate Experiment (GRACE) satellite observations into NASA's Catchment land surface model (CLSM) at the global scale, with the goal of generating groundwater storage time series that are useful for drought monitoring and other applications. Evaluation using in situ data from nearly 4,000 wells shows that GRACE data assimilation improves the simulation of groundwater, with estimation errors reduced by 36% and 10% and correlation improved by 16% and 22% at the regional and point scales, respectively. The biggest improvements are observed in regions with large interannual variability in precipitation, where simulated groundwater responds too strongly to changes in atmospheric forcing. The positive impacts of GRACE data assimilation are further demonstrated using observed low-flow data. CLSM and GRACE data assimilation performance is also examined across different permeability categories. The evaluation reveals that GRACE data assimilation fails to compensate for the lack of a groundwater withdrawal scheme in CLSM when it comes to simulating realistic groundwater variations in regions with intensive groundwater abstraction. CLSM-simulated groundwater correlates strongly with 12-month precipitation anomalies in low-latitude and midlatitude areas. A groundwater drought indicator based on GRACE data assimilation generally agrees with other regional-scale drought indicators, with discrepancies mainly in their estimated drought severity.Water Resource
Farrell, Grace Evelyn (Birth, 1907-08-05)
No full textAddress: City Hospital4018/Pg.147/1907/F W/Pa./Pa./Interne, City HospitalOriginal record filed in drawer labeled 'EWRY-FARRICK'
Supplementary materials in support of the thesis "Methods to identify novel disease genes and uplift diagnosis rates in rare diseases"
No full textThis dataset supports the thesis entitled "Methods to identify novel disease genes and uplift diagnosis rates in rare diseases"
AWARDED BY: Univeristy of Southampton
DATE OF AWARD: 2023
This dataset contains:
1. Folder called 'Appendix papers'
This contains 15 published articles in peer review journals or preprint archives which represent work from my thesis.
Appendix Paper 1 | Strategies to Uplift Novel Mendelian Gene Discovery for Improved Clinical Outcomes
Appendix Paper 2 | Challenges in the diagnosis and discovery of rare genetic disorders using contemporary sequencing technologies
Appendix Paper 3 | The mutational constraint spectrum quantified from variation in 141,456 humans
Appendix Paper 4 | Transcript expression-aware annotation improves rare variant interpretation
Appendix Paper 5 | Addendum: The mutational constraint spectrum quantified from variation in 141,456 humans
Appendix Paper 6 | Advanced variant classification framework reduces the false positive rate of predicted loss of function (pLoF) variants in population sequencing data
Appendix Paper 7 | A gene-to-patient approach uplifts novel disease gene discovery and identifies 18 putative novel disease genes
Appendix Paper 8 | Response to Ramos et al.
Appendix Paper 9 | 100,000 Genomes Pilot on Rare-Disease Diagnosis in Health Care — Preliminary Report
Appendix Paper 10 | Loss-of-function variants in TAF4 are associated with a neurodevelopmental disorder. Human Mutation
Appendix Paper 11 | Monogenic de novo variants in DDX17 cause a novel neurodevelopmental disorder
Appendix Paper 12 | Targeting de novo loss of function variants in constrained disease genes improves diagnostic rates in the 100,000 Genomes Project
Appendix Paper 13 | A gene pathogenicity tool ‘GenePy’ identifies missed biallelic diagnoses in the 100,000 Genomes Project
Appendix Paper 14 | A panel-agnostic strategy ‘HiPPo’ improves diagnostic efficiency in the UK 2 Genome Medicine Service
Appendix Paper 15 | A novel variant in GATM causes idiopathic renal Fanconi syndrome and predicts progression to end-stage kidney disease
2. Folder called 'Supplementary Datasets'
All data can be opened using Microsoft Excel.
Supplementary Dataset SD1 | Enriched biological processes in DDX17 RNA-seq data [Co-author Cyril F. Bourgeois; University of Lyon]
Supplementary Dataset SD2 | Curation of pLoF variants in haploinsufficient genes
Supplementary Dataset SD3 | Curation of 3362 homozygous pLoF variants [Co-authors Moriel Singer-Berk, Eleina England; Broad Institute of MIT and Harvard]
Supplementary Dataset SD4 | Detailed phenotype table of patients with DDX17 variants
Supplementary Dataset SD5 | Differentially expressed genes in DDX17-KD cells compared to control cells [Co-author Cyril F. Bourgeois; University of Lyon]
Supplementary Dataset SD6 | Detailed phenotype table of patients with HDLBP variants
Supplementary Dataset SD7 | Manual curation of 45 remaining variants [Co-author N. Simon Thomas, University of Southampton]
Supplementary Dataset SD8 | Re-analysis of DeNovoLOEUF on 100,000 Genomes Project data
Supplementary Dataset SD9 | 36 possible missed diagnoses in patients with a cardiomyopathy phenotype
Supplementary Dataset SD10 | Genes associated with cardiomyopathies
Supplementary Dataset SD11 | Autosomal recessive disease genes
Supplementary Dataset SD12 | 682 participants with a potential missed diagnosis
Supplementary Dataset SD13 | Variants identified using the HiPPo protocol
3. Folder called 'Supplementary Tables'
All data can be opened using Microsoft Excel.
Supplementary Table S1 | Environmental tools in GEL
Supplementary Table S2 | List of 1,815 genes tolerant of homozygous loss-of-function variation [Co-author Moriel Singer-Berk; Broad Institute of MIT and Harvard]
Supplementary Table S3 | Genes tolerant of homozygous loss-of-function variation with an OMIM dominant association
Supplementary Table S4 | 27 genes with more than one Genomics England kindred affected
Supplementary Table S5 | 99 Class 2 and Class 3 genes
Supplementary Table S6 | Sequences of siRNAs against DDX17 [Co-author Cyril F. Bourgeois; University of Lyon]
Supplementary Table S7 | A summary of high-level phenotypes of the 100,000 Genomes Project patient population
Supplementary Table S8 | All human genes curated with a LOEUF score
Supplementary Table S9 | 182 participants without a listed cardiomyopathy phenotype that had a pathogenic variant returned by 100KGP in a cardiomyopathy-related gene
Supplementary Table S10 | Quality control of 24 samples from 8 families undergoing parallel research exome and clinical genome [Co-author Nichola Grahame; University of Southampton]
4. Folder called 'Supplementary Figures'
Contains a single word document will the following figures:
Supplementary Figure S1 | Crispr/Cas9 microinjection into X. tropicalis eggs produces mosaic homozygous crispant tadpoles encoding truncated Ddx17 which is inherited in the F1 generation [Co-authors Annie Godwin, Matt Guille; University of Portsmouth]
Supplementary Figure S2 | The amino acid alignment between the H. sapiens and X. tropicalis Ddx17 proteins [Co-authors Annie Godwin, Matt Guille; University of Portsmouth]
Supplementary Figure S3 | F0 mosaic homozygous X. tropicalis display reduced axon outgrowth, and working memory like F1 models, but also gastrulation defects and short term microcephaly [Co-authors Annie Godwin, Matt Guille]
Supplementary Figure S4 | Results of dark-light transitions assay and neuronal outgrowth [Co-authors Annie Godwin, Matt Guille; University of Portsmouth]
Supplementary Figure S5 | Compound heterozygous ddx17-/- tadpoles are morphologically normal but show working memory deficits [Co-authors Annie Godwin, Matt Guille; University of Portsmouth]
Supplementary Figure S6 | Network representation of the top 40 enriched biological processes [Co-author Cyril F. Bourgeois; University of Lyon]
Supplementary Figure S7 | Enriched biological processes for down-regulated and up-regulated genes [Co-author Cyril F. Bourgeois; University of Lyon]
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Enhancing spatial resolution of GRACE-derived groundwater storage anomalies in Urmia catchment using machine learning downscaling methods
No full textThe Urmia lake in north-west Iran has dried up to perilously low levels in the past two decades. In this study, we investigate the drivers behind the decline in lake water level with the help of in-situ and remote sensing data. We use total water storage (TWS) changes from the gravity recovery and climate experiment (GRACE) satellite mission. TWS from GRACE includes all the water storage compartments in a column and is the only remote sensing product that can help in estimating groundwater storage (GWS) changes. The coarse spatial (approx. 300 km) resolution of GRACE does not allow us to identify local changes that may have led to the Urmia lake disaster. In this study, we tackle the poor resolution of the GRACE data by employing three machine learning (ML) methods including random forest (RF), support vector regression (SVR) and multi-layer perceptron (MLP). The methods predict the groundwater storage anomaly (GWSA), derived from GRACE, as a function of hydro-climatic variables such as precipitation, evapotranspiration, land surface temperature (LST) and normalized difference vegetation index (NDVI) on a finer scale of 0.25° × 0.25°. We found that i) The RF model exhibited highest R (0.98), highest NSE (0.96) and lowest RMSE (18.36 mm) values. ii) The RF downscaled data indicated that the exploitation of groundwater resources in the aquifers is the main driver of groundwater storage and changes in the regional ecosystem, which has been corroborated by few other studies as well. The impact of precipitation and evapotranspiration on the GWSA was found to be rather weak, indicating that the anthropogenic derivers had the most significant impact on the GWSA changes. iii) We generally observed a significant negative trend in GWSA, having also significant positive correlations with the well data. However, over regions with dam construction significant negative correlations were found.</p
Open destinies : modern American women and the short story cycle
No full textThis thesis examines the juncture between the short story cycle form and gender politics. It explores how twentieth-century women from the United States have been using the form to represent and question gender identity. The introduction outlines commentaries on the story cycle and considers definitions of the form. It includes case studies of earlier twentieth-century cycles by American women: cycles such as Mary McCarthy's The Company She Keeps that have been passed over by critics of the form.
Chapter One presents Eudora Welty's The Golden Apples as a cycle paradigm, examining conventions such as the form's metafictional dimension and its preoccupation with communal identity. Chapter Two argues that Grace Paley's scattered Faith narratives set a standard for more dispersed versions of the form. Chapter Three considers how Joyce Carol Oates uses the sequential cycle to represent gender identity as a social construct. Chapters Four and Five examine the macrocosmic cycles of Gloria Naylor and Louise Erdrich and consider changes in their form and gender politics. The final 'composite' chapters explore postmodern versions of the form such as Susan Minot's Monkeys. The prose works of Sandra Cisneros stretch across the story cycle continuum, whilst Toni Morrison's Paradise is universally regarded as a novel. Readings of contemporary cycles by Melissa Bank, Elissa Schappell and Emily Carter demonstrate that American women are re-invigorating the form to facilitate the plural identity of the postmodern heroine
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