1,094 research outputs found
Variations on the Author
No full text“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Letter From Anne Byron to Mrs Isabella Hall
No full textabstract: Concerning Byron's orders concerning her personal finances and bank operations.Seller's Description: Note in upper right corner reads WDV 50.00.Curator's Note: Writing on verso reads "Wife of the Poet." The author is the wife of the poet Lord Byron.Postage Details: Stamped three times.
Address reads: Post & Paid
Mrs Isabella Hall
Harrington Lane Area
Co. Durham.Paper Details: Originally folded. Left side has small tears. Stamp in bled through on the verso
L'Egitto prima dei faraoni
No full textGeografia, storia degli studi, bibliografia, cronologia dei periodi di formazione dello Stato in Egitto * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * *
Telomerase as a potential anticancer target: growth inhibition and genomic instability
No full textStabilization of telomere length in chromosomes by an RNA-dependent DNA polymerase (telomerase) appears to be responsible for the replicative immortality of cancer cells. These findings provide the rational basis for generating experimental models to develop anti-telomerase drugs. However, there is conflicting evidence in the literature about the outcome of telomerase inhibition. While tumor cytostatic and cytotoxic effects associated with telomerase inhibition have been described, absence of telomerase has been associated with genetic instability and tumor development. Therefore, a therapeutic strategy based on telomerase inhibition will likely have to cope with problems related to innate or acquired mechanisms of drug resistance and possibly to therapy-related tumors. Copyright 2000 Harcourt Publishers Ltd
L'altro Nilo. Il Sudan dalla Preistoria ai Faraoni
No full textBreve sintesi di anni di ricerche archeologiche nella provincia del Sudan centrale, con riferimento alla dinamica del popolamento della valle del Nilo e all'emergenza delle società complesse e dello Stato in Egitto
Introduzione
No full textSaggio introduttivo all'edizione italiana del romanzo di Miguel de Unamuno, Amor y pedagogía, di cui l'autrice è anche traduttrice. L'introduzione ha un taglio storico-letterario e linguistico-traduttologico.Introductory essay to the Italian edition of Miguel de Unamuno's novel, Amor y pedagogía, of which the author is also a translator. The introduction offers an historical-literary and linguistic-traductological sketch
High-Dose Vitamin C: Preclinical Evidence for Tailoring Treatment in Cancer Patients
No full textHigh-dose vitamin C has been proposed as a potential therapeutic approach for patients with advanced tumors who failed previous treatment with chemotherapy. Due to vitamin C complex pharmacokinetics, only intravenous administration allows reaching sufficiently high plasma concentrations required for most of the antitumor effects observed in preclinical studies (>0.250 mM). Moreover, vitamin C entry into cells is tightly regulated by SVCT and GLUT transporters, and is cell type-dependent. Importantly, besides its well-recognized pro-oxidant effects, vitamin C modulates TET enzymes promoting DNA demethylation and acts as cofactor of HIF hydroxylases, whose activity is required for HIF-1α proteasomal degradation. Furthermore, at pharmacological concentrations lower than those required for its pro-oxidant activity (<1 mM), vitamin C in specific genetic contexts may alter the DNA damage response by increasing 5-hydroxymethylcytosine levels. These more recently described vitamin C mechanisms offer new treatment opportunities for tumors with specific molecular defects (e.g., HIF-1α over-expression or TET2, IDH1/2, and WT1 alterations). Moreover, vitamin C action at DNA levels may provide the rationale basis for combination therapies with PARP inhibitors and hypomethylating agents. This review outlines the pharmacokinetic and pharmacodynamic properties of vitamin C to be taken into account in designing clinical studies that evaluate its potential use as anticancer agent
High school success
No full textauthor: Isabella Jacoby.This archived document is maintained by the State Library of Oregon as part of the Oregon Documents Depository Program. It is for informational purposes and may not be suitable for legal purposes.Includes bibliographical references.Mode of access: Internet from the Oregon Government Publications Collection.Text in English
MiR-424 and miR-155 deregulated expression in cytogenetically normal acute myeloid leukaemia: correlation with NPM1 and FLT3 mutation status
No full textAbstract Background MicroRNA have a central role in normal haematopoiesis and are deregulated in acute myeloid leukaemia (AML). The purpose of the study was to investigate by qRT-PCR the expression of miRNAs involved in myeloid differentiation (miR-424, miR-155, miR-223, miR-17-5p) in 48 patients with cytogenetically normal AML well characterized for NPM1 and/or FLT3 mutations. Three types of normalization were used for the data validation. Findings We found that miR-424 was down-modulated in AMLs with NPM1mutA regardless of FLT3 status. On the contrary, miR-155 showed up-regulation in patients with FLT3 internal tandem duplications (ITD) with or without NPM1 mutations. No significant associations were found by analyzing miR-223 and miR-17-5p in relation to FLT3 and NPM1 status. Conclusions This study supports the view that major genetic subsets of CN-AML are associated with distinct miRNA signatures and suggests that miR-424 and miR-155 deregulation is involved in the pathogenesis of CN-AML with NPM1 and FLT3-ITD mutations, respectively.</p
Dampak Psikologis Tokoh Isabella Dalam Novel Isabella Karya Maulana Muhammad Saeed Dehlvi
No full textThe purpose of this research is to describe the role and impact of converting psychological character Isabella in the novel Isabella works of Maulana Muhammad Saeed Dehlvi by: (1) aspects of the Id, (2) aspects of the Ego, (3) aspects of the Super Ego. The data of this research are the word, phrase, phrases, and sentences that lead to the converting by Isabella that author expressed in the story. The data resources is founded in the novel itself. The data is collected by using descriptive methode that priorityzing the interaction interconcepts that studied empirically. The result of this research is thebpsychological impact that experienced by Isabella in the novel Isabella caused by id impulse that dominating herself
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