805 research outputs found
Differences in the lesion formation process between focused ultrasound and microwave ablations
No full textA preliminary study of the distributions of Cd in the South China Sea
No full textThe water column distributions of dissolved cadmium & supporting parameters were determined during a cruise in the South China Sea in October, 2002. The investigation was focused on waters of the shelf & the central basin which have depths of o200m & 42000 m, respectively. In the surface waters, concentrations of Cd were 0.07–0.95 & 0.05–0.15nM for the shelf & central basin, respectively. The spatial distributions in the surface waters show that concentrations of Cd were relatively high in the Pearl River Estuary. In contrast, Cd was totally depleted in surface waters of the deep water basin. This is attributed to the riverine inputs from the East Asian continent in the shelf regions. The influence of riverine input is reduced by dilution process with waters containing low concentrations of Cd waters. In the central basin, vertical profiles of Cd show a nutrient-like distribution which is depleted in the surface, increases with depth to about 1000 m, & that is finally maintained within a narrow concentration range of 0.94–0.99nM in the deep water. Here, the Cd/PO4 ratio was 0.36970.011nM Cd/mM PO4, indicating that the biogeochemical processes of Cd & PO4 are similar to that in marginal seas of the western Pacific Ocean. However, the concentration gradients in surface waters show a southward increase. The results indicate that the relative enrichment of nutrients & the nutricline uplifted sharply in surface waters of the southern SCS
WHY HAS THE PAPER ENTITLED "GREATWALL-PHOSPHORYLATED Α-ENDOSULFINE IS BOTH AN INHIBITOR AND A SUBSTRATE OF PP2A-B55 HETEROTRIMERS" BY WILLIAMS, M.C. ET AL. THAT WAS PUBLISHED IN ELIFE [WILLIAMS, B.C., FILTER, J.J., BLAKE-HODEK, K.A., FUDA, N.J., SHALLOWAY, D. AND GOLDBERG, M.L. (2014) ELIFE, DOI: 10.7554/ELIFE.01695 ] NOT BEEN RETRACTED?
No full textThe paper entitled "Greatwall-phosphorylated α-Endosulfine is both an inhibitor and a substrate of PP2A-B55 heterotrimers" authored by Williams, B.C. et al. [Williams, B.C., Filter, J.J., Blake-Hodek, K.A., Fuda, N.J., Shalloway, D. and Goldberg, M.L. and Published in the Journal eLife [eLife (2014) e01695, doi: 10.7554/elife.01695] was the subject of an investigative critique [Tung, H.Y.L. (2020) J. Invest. Cri. Pub. Sci. Articles, Vol. 1, pp193-200, DOI: 10.5281/zenodo.5115188]. It was previously reported that the paper by Williams, et al. was riddled with Dishonest Scientific Reported, Data Falsification and possibly Data Fabrication. After, contacting the Editor in Chief of eLife, Drs Michael B. Eisen, the author of this report was referred to the Managing Editor of eLife, Dr Wei Mun Chan who is not an expert in Enzymology by any stretch of imagination. The Managing Editor of eLife apparently obtained some response from Williams, et al. which was not only unsatisfactory scientifically but aggravated the seriousness of this case as it was revealed that Williams et al. obtained conclusions of their paper based on some experiments in which they were counting ~3 cpm of radioactivity above background. When the author of this report pointed the fantastical results that Williams et al. claimed they were able to obtain, the author of this Report received no sign of life from the Managing editor and the Editor in Chief of eLife. This Report provides further evidence that Williams, B.C. et al. committed Dishonest Scientific Reporting, Data Falsification and Data Fabrication in their paper
Government information disclosure and citizen coproduction during COVID-19 in China
No full textWe provide five replication data sets and the do file for the publication in Governance Journal: Wu Y.P., Xiao H.Y. and Yang F. (2021) Government information disclosure and citizen coproduction during COVID-19 in China. DOI: 10.1111/gove.12645. https://onlinelibrary.wiley.com/doi/full/10.1111/gove.12645. The paper and the data sets provided here contain all necessary information for replication
WHAT IS THE PURPOSE OF SUBMITTING A PREPRINT ARTICLE TO BIORXIV AND CHEMRXIV: ARE BIORXIV AND CHEMRXIV ACTING AS MOB PEER REVIEW CENSORSHIP BOARD?
No full textAccording to their websites of bioRxiv and chemRxiv do not perform peer reviews of preprint articles that are submitted to them and that they only screen submitted preprint articles for . The experience of this author is that bioRxiv and chemRxiv not only perform extensive reviews of submitted preprint articles, they also act a Mob Peer Review Censorship Board. The qualifications of the Mob Peer Reviewers of bioRxiv and chemRxiv are questionable. It is impossible to contact the persons who run bioRxiv and chemRxiv. It is quite disturbing and disgusting that the flow of scientific information in the "freest country of the world" is controlled by two outfits that acts as Mob Peer Review Censorship Board. The actions of bioRxiv and chemRxiv which operate with tax paper's largesse are selective, opaque, arbitrary and a violations of Fundamental Right of the United States citizens to write and publish
Distinct contributions of metabolic dysfunction and genetic risk factors in the pathogenesis of non-alcoholic fatty liver disease
Full text linkFunding Information: This study was supported by Academy of Finland Grant 309263 (H.Y.-J.) and Grant 138006 (J.P.), EU H2020 project ?Elucidating Pathways of Steatohepatitis? EPoS Grant 634413 (H.Y.-J.), H2020-JTI-IMI2 EU project 777377-2 Liver Investigation: Testing Marker Utility in Steatohepatitis (LITMUS) (H.Y.-J.), Government Funding (H.Y.-J.), Novo Nordisk Foundation (H.Y.-J., P.K.L., M.A.-K.), Ralph Gr?sbeck Scholarship of the Minerva Foundation (P.K.L.), Novo Nordisk Foundation (P.K.L.), Juho Vainio Foundation (J.P.), Finnish Medical Foundation (V.M.), British Heart Foundation Senior Research Fellowship in Basic Science (FS/15/56/31645) (L.H.) and Kuopio University Hospital Project grant (J.P., EVO/VTR grants 2005-2019). Funding Information: This study was supported by Academy of Finland Grant 309263 (H.Y.-J.) and Grant 138006 (J.P.), EU H2020 project ‘Elucidating Pathways of Steatohepatitis’ EPoS Grant 634413 (H.Y.-J.), H2020-JTI-IMI2 EU project 777377-2 Liver Investigation: Testing Marker Utility in Steatohepatitis (LITMUS) (H.Y.-J.), Government Funding (H.Y.-J.), Novo Nordisk Foundation (H.Y.-J., P.K.L., M.A.-K.), Ralph Gräsbeck Scholarship of the Minerva Foundation (P.K.L.), Novo Nordisk Foundation (P.K.L.), Juho Vainio Foundation (J.P.), Finnish Medical Foundation (V.M.), British Heart Foundation Senior Research Fellowship in Basic Science (FS/15/56/31645) (L.H.) and Kuopio University Hospital Project grant (J.P., EVO/VTR grants 2005-2019). Publisher Copyright: © 2021 The Author(s)Background & Aims: There is substantial inter-individual variability in the risk of non-alcoholic fatty liver disease (NAFLD). Part of which is explained by insulin resistance (IR) (‘MetComp’) and part by common modifiers of genetic risk (‘GenComp’). We examined how IR on the one hand and genetic risk on the other contribute to the pathogenesis of NAFLD. Methods: We studied 846 individuals: 492 were obese patients with liver histology and 354 were individuals who underwent intrahepatic triglyceride measurement by proton magnetic resonance spectroscopy. A genetic risk score was calculated using the number of risk alleles in PNPLA3, TM6SF2, MBOAT7, HSD17B13 and MARC1. Substrate concentrations were assessed by serum NMR metabolomics. In subsets of participants, non-esterified fatty acids (NEFAs) and their flux were assessed by D5-glycerol and hyperinsulinemic-euglycemic clamp (n = 41), and hepatic de novo lipogenesis (DNL) was measured by D2O (n = 61). Results: We found that substrate surplus (increased concentrations of 28 serum metabolites including glucose, glycolytic intermediates, and amino acids; increased NEFAs and their flux; increased DNL) characterized the ‘MetComp’. In contrast, the ‘GenComp’ was not accompanied by any substrate excess but was characterized by an increased hepatic mitochondrial redox state, as determined by serum β-hydroxybutyrate/acetoacetate ratio, and inhibition of hepatic pathways dependent on tricarboxylic acid cycle activity, such as DNL. Serum β-hydroxybutyrate/acetoacetate ratio correlated strongly with all histological features of NAFLD. IR and hepatic mitochondrial redox state conferred additive increases in histological features of NAFLD. Conclusions: These data show that the mechanisms underlying ‘Metabolic’ and ‘Genetic’ components of NAFLD are fundamentally different. These findings may have implications with respect to the diagnosis and treatment of NAFLD. Lay summary: The pathogenesis of non-alcoholic fatty liver disease can be explained in part by a metabolic component, including obesity, and in part by a genetic component. Herein, we demonstrate that the mechanisms underlying these components are fundamentally different: the metabolic component is characterized by hepatic oversupply of substrates, such as sugars, lipids and amino acids. In contrast, the genetic component is characterized by impaired hepatic mitochondrial function, making the liver less able to metabolize these substrates.Peer reviewe
Transplantablity and Therapeutic Effects of Allogenic Bone Marrow-derived Mesenchymal Stem Cells in Mice with Osteoporosis
No full textSeismic soil-structure interaction for pile supported systems
No full textCivil engineering structures involve structural elements with direct contact with ground. When the external actions, such as earthquakes, act on these systems, neither the structural displacements nor the ground displacements, are independent of each other. The process in which the response of the soil influences the motion of the structure and the motion of the structure influences the response of the soil is termed as soil-structure interaction (SSI). Damage occurred in recent earthquakes, have highlighted that the seismic behaviour of a structure is highly influenced not only by the response of the superstructure (considered as fixed based), but also by the response of the foundation and the ground as well. Hence, some modern seismic design codes impose that the effect of SSI must be taken into account, even if only in particular situations (depending on the particular Code). The complex 3-component interaction (soil-foundation-structure) may be analysed (in the hypothesis of linear elasticity) with reference to two separate interaction, reflecting distinct physic phenomena. The first one is the modification of the input motion at the base of the structure due to the different stiffness of the foundation with respect to the soil, referred to as kinematic interaction; the structure vibrates (because of its inertia) in dependence also of the soil-foundation system, and the latter experiences additional deformations (inertial interaction). The thesis deal with seismic SSI problems for pile supported structures with particular reference to the design aspects in the light of the recent Italian Codes and Eurocodes. In fact, despite the state of the art in SSI analyses has evolved steadily over the last decades, the state of practice for engineering characterization of SSI effects for routine structures has not undergone recent similar advancement. For this reason, aim of the thesis is: - to better understand the mathematical and physical meaning of kinematic interaction; - to provide simplified formulas for evaluating its effects in terms of bending moments (interface and pile head);to find simply rules to estimate the importance of “filtering effect” exerted by piles on foundation input motion; - to investigate the relative importance of kinematic vs. inertial interaction; - to provide a criterion to combine inertial and kinematic maximum effects
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