1,721,136 research outputs found
INVECCHIAMENTO E SISTEMA ENDOCRINO.LA SOMATOPAUSA, LA ADRENOPAUSA, LE MALATTIE DELLA TIROIDE
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Recreational boating in the Portofino Marine Protected Area (MPA), Italy: Characterization and analysis in the last decade (2006–2016) and some considerations on management
No full textRecreational boating is a significant nature-based activity, which is especially popular in the Mediterranean region. This study analyses this activity in the last decade in the Portofino MPA, a popular recreational boating area in the Ligurian Region (northwest of the Italian peninsula) in order to evaluate the maximum turnout and to provide management considerations to better achieve conservation and environmental management of a MPA. Monitoring activities were carried out during the summer from 2006 to 2016 and allowed locating the most critical sectors of MPA in consideration of different factors and kinds of boats. From the results of this long-term monitoring, the first conducted in Italy, it is evident that only some anchoring sectors of the Portofino MPA may suffer impacts from recreational boating and that the boats have different spatial and temporal distribution depending on the different summer months, on the public holidays and on weather conditions which mainly affect the boats units < 10 m (73% of the monitored boats). Due to direct impact of the anchorage on the seafloor, which hosts peculiar natural habitats, and the fairly constant presence of the recreational boaters over the years, different solutions for better protect the seabed without excessively prejudicing the enjoyment of recreational boating are discussed. Since the San Fruttuoso seagrass-friendly mooring area is one of the most visited sectors in the MPA, an increase in the number of seagrass-friendly moorings combined with a higher delimitation of the areas with special habitats may represent an optimal strategy
Association of Helicobacter pylori Infection with Autoimmune Thyroid Disease in the Female Sex
No full textBackground. Helicobacter pylori infection has been associated with an increased risk of thyroid diseases (TDs), although scientific evidence is conflicting. In the present study the relationship between TDs, including both autoimmune (AI) and non-autoimmune TD, and H. pylori infection was investigated. Methods: Data from records of patients undergoing upper endoscopy and histologically evaluated for H. pylori infection were retrieved. In addition to demographic information, the features of gastritis based on non-targeted biopsies collected from the antrum, angulus, and corpus were analyzed. The presence of H. pylori infection and atrophy and/or metaplasia and/or dysplasia in at least one gastric specimen was defined as a long-lasting H. pylori infection and the presence of a chronic-active gastritis as a current infection. Hashimoto's and Graves' diseases were included in the AITD group, and thyroid nodules, goiter, iatrogenic thyroid hypo/hyper function, and thyroidectomy in the non-autoimmune TD group. Results: A total of 8322 records from adult patients from Northern Sardinia, characterized by a similar genetic background, was analyzed. Participants were aged 18-93 years (females 5339, 64.1%), and more specifically, 562 (6.7%) had a diagnosis of AITD and 448 (5.4%) of non-autoimmune TD. A significant association between long-lasting H. pylori and AITD (OR 1.34; 95%CI 1.13-1.60) was found, irrespective of age, sex, body mass index, and smoking status, while it was not associated with non-autoimmune TD. Current H. pylori infection did not show significant ORs for AITD (OR 0.99; 95%CI 0.64-1.57) and non-autoimmune TD (OR 0.86; 95%CI 0.66-1.15). The association with long-lasting H. pylori infection was confirmed to be significant for both Hashimoto's thyroiditis and Graves' disease by multivariable regression analysis. Stratification according to sex revealed a significant association only for females (OR 1.39; 95%CI 1.12-1.72). Conclusions. Our results indicate that long-lasting H. pylori infection is associated with AITD in the female adult population of Northern Sardinia
Hepatitis A and B virus infection in children in northern Sardinia: preliminary results of a seroepidemiological survey
No full textThyroid function in elderly people: The role of subclinical thyroid disorders in cognitive function and mood alterations
No full textArtificial Intelligence for Prognosis of Gastro-Entero-Pancreatic Neuroendocrine Neoplasms
No full textGastro-entero-pancreatic neuroendocrine neoplasms (GEP-NENs) represent a challenging disease. Their large heterogeneity limits the possibility of providing accurate risk assessments or standardizing the most effective therapies for these patients. In recent years, artificial intelligence (AI), and in particular machine learning approaches, have shown real promise in addressing these complexities. By analyzing large volumes of clinical, imaging, and pathological data, AI-based tools can significantly improve the accuracy of survival predictions and guide more tailored treatment strategies. In this narrative review, we examine the potential applications of AI to develop effective prognostic models in GEP-NENs, and how these models may help clinicians in predicting survival and optimizing patient management. While early results are encouraging, important limitations remain, since available data stem from small, retrospective datasets, sometimes lacking external validation, and concerns around transparency and ethics still represent an open issue. Addressing these gaps will be key to moving from research applications to practical tools that can support everyday clinical decision-making
Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Tra repressione e tolleranza: diritto di associazione e dissenso politico tra Otto e Novecento
No full textIl saggio ricostruisce le strategie di contrasto dello Stato liberale nei confronti del nascente movimento sindacal
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