3 research outputs found
PENGARUH PEMBERIAN INJEKSI KETOROLAC INTRAPERITONEAL TERHADAP PENYEMBUHAN FRAKTUR KRURIS TIKUS WISTAR DEWASA
No full textBackground: Non-steroidal anti inflamatory drugs (NSAID) have been proven effective for pain management in fracture cases. However, studies had shown that long term usage of NSAID could retard bone healing. Ketorolac, a non-specific NSAID, is one of the most used for analgesic in fracture cases. The recommended maximum duration of its use is 5 days, since usage beyond that is associated with detrimental side effects. It is not yet known whether ketorolac usage for 5 days could impede fracture healing. Objective: To investigate the effects of ketorolac intraperitoneal injection on fracture healing in adult wistar rats Methods: This experiment used post-test only control group design. A sample of 20 adult wistar rats are randomly divided into 2 groups, control and intervention. The subjecs had their right cruris fractured using closed fracturisation technique and given gypsum spalk for external fixation. The control group were fed ad libitum food and water for 21 days. The intervention group were given 5mg/kgBB ketorolac intraperitoneal injection daily for the first 5 days, and fed ad libitum food and water for 21 days. On the 22nd day subjects were terminated with ether-choloform overdose, and the right tibias were harvested for histological assessment, using a modified Allen fracture healing scoring system. Results: The intervention group showed a significant delay in fracture healing with mean callus score of 3.67±0.274, as compared to the control group with mean callus score of 4.38±0.302. Independent t-test showed a significant difference between the 2 groups with p=0.0001. Conclusion: Ketorolac intraperitoneal injection for 5 days could delay fracture healing in adult wistar rats. Keywords: Fracture healing, ketorolac, callu
GIANT NON-FUNCTIONING ADRENOCORTICAL CARCINOMA
No full textObjective: This study aims to report a case of a 51 year old male who was referred to our Department of Urology and was diagnosed with a nonfunctioning giant ACC. Case(s) Presentation: The case report describes a 51-year-old Indonesian man who presented to our department with complaints of persistent upper left abdomen discomfort, previously misdiagnosed as dyspepsia. He was diagnosed as having non-functioning adrenocortical carcinoma and underwent open adrenalectomy. Discussion: Although the patient is 51 years old and the tumor has grown to a signify cant size, no lymph node involvement or metastases was found and resection margins were found to be negative. In our patient, functional adrenal work-up results were normal. This has led us to suspect a non-functioning adrenal tumor. Metastatic work-up with CT cranial, chest, and bone survey were performed, with negative result. The biopsy result after resection confirmed the diagnosis of ACC. Conclusion: ACC is a rare aggressive tumor, malignant with poor prognosis. In our case, the non-secretory mass was diagnosed late by manifestation of mass effect symptoms in the upper left quadrant of the abdomen and was previously misdiagnosed as symptoms of dyspepsia. The functional work-up of adrenal masses helped in the determination of its non-functional status. Early diagnosis of ACC and early surgical excision helps in improving the overall survival rate of the patient.
Keywords: Non-functioning, adrenocortical carcinoma (ACC), adrenalectomy, case report
SUPPLEMENTAL DATA: Genomic phylogeography of the White-crowned Manakin Pseudopipra pipra (Aves: Pipridae) illuminates a continental-scale radiation out of the Andes
No full textSUPPLEMENTAL DATA FOR
Genomic phylogeography of the White-crowned Manakin Pseudopipra pipra (Aves: Pipridae)
illuminates a continental-scale radiation out of the Andes
Author Affiliations:
Jacob S. Berv (1,2,3), Leonardo Campagna (1,2), Teresa J. Feo (4), Ivandy Castro-Astor (5),
Camila C. Ribas (6), Richard O. Prum (7), Irby J. Lovette (1,2)
1. Fuller Evolutionary Biology Program, Cornell Lab of Ornithology, 159
Sapsucker Woods Road, Ithaca, NY 14850, USA.
2. Department of Ecology and Evolutionary Biology, Cornell University,
215 Tower Road, Ithaca, NY 14853, USA.
3. Department of Ecology and Evolutionary Biology, and University of Michigan
Museum of Paleontology, 1105 North University Avenue, Biological Sciences
Building, Ann Arbor, MI 48109-1085, USA.
4. Department of Vertebrate Zoology, MRC-116, National Museum of Natural
History, Smithsonian Institution, Washington, DC 20013, USA.
5. Department of Biology, City College of New York and CUNY Graduate Center,
City University of New York, New York, NY 10031, USA
6. Coordenacão de Biodiversidade, Instituto Nacional de Pesquisas da Amazônia,
Manaus, AM, Brazil
7. Department of Ecology and Evolutionary Biology, and Peabody Museum of
Natural History, Yale University, New Haven, Connecticut, 06520, USA.
Correspondence to Jacob S. Berv ([email protected])
LAST UPDATED 28 APRIL 2021
CODE WILL ALSO BE MADE AVAILABLE AT
https://github.com/jakeberv
The parent directory contains many data files related to the analyses presented in
this manuscript. The top level file 'Pseudopipra_code.R' contains function definitions
and code used for most of the analyses in this article. This code is annotated with
descriptions throughout. Note that all files referenced within various subdirectories
must be unzipped for the R code to work. Download "Supplemental Data.zip" to
download the entire archive, or browse individual files for download.
SEE README.TXT for additional informatio
