9 research outputs found
Bulk Acoustic Wave Gyroscope With Spoked Structure
No full textA Coriolis-based bulk acoustic wave gyroscope includes a center-supported resonating element with capacitively-coupled drive, sense, and control electrodes. The resonating element has a first substantially solid or perforated region which is connected to the center-support by a second region characterized by a plurality of spokes or beams. When operating in a resonance state, the first region undergoes a bulk acoustic mode of vibration while the second region undergoes a flexural mode of vibration. Energy losses associated with the flexural mode of vibration reduce the overall quality factor (Q) at high resonance frequencies creating a large bandwidth and a fast response time without needing vacuum.Georgia Tech Research CorporationAyazi, FarrokhSung, Wang-KyungZaman, Mohammad Faisa
Synthesis, Identification, and Characterization of a Novel 1,2,5-Selenadiazole Derivative as a Microtubule Targeting Agent That Overcomes Multidrug Resistance
No full textABSTRACTMicrotubules are crucial for various cellular processes, including cell division, where they form highly dynamic spindle fibers for chromosomal alignment and segregation. Interference with microtubule dynamics through microtubule targeting agents (MTAs) blocks progression through mitosis, ultimately resulting in apoptosis. Although MTAs have been effectively used as a frontline treatment for various cancers, multidrug resistance (MDR) often limits their effectiveness. This study focuses on selenadiazoles, a group of organic selenium compounds with anticancer activities. Eighteen novel 1,2,5-selenadiazole derivatives were synthesized, three of which (9d, 9f, and 9i) showed potent antiproliferative activity in HCT116 colorectal cancer cells. Treatment of cells with 9f (SSE1706), one of the most potent compounds (GI50 value of 1.89 ± 0.99 µM), disrupted mitotic spindle formation, leading to G2/M arrest. 9f inhibited microtubule polymerization in cell-based assays, and long-term treatment with 9f stabilized p53 and induced apoptosis. Moreover, 9f effectively inhibited the growth of mouse and human colon cancer-derived organoids. Finally, 9f exhibited potent antiproliferative activity against MDR-1 overexpressing KB-V1 cells, highlighting its potential to overcome MDR. These findings suggest 9f as a lead compound for further optimization studies, particularly targeting MDR.This study received support from two Faculty Initiatives Fund grants (FIF-842) and (FIF-406) awarded by the Lahore University of ManagementSciences (LUMS) to Rahman Shah Zaib Saleem and Amir Faisal, respectively. Further support came from the Pakistan Science Foundation grant PSF/Res/P-LUMS/Chem (617) which was also awarded to Rahman Shah Zaib Saleem and Amir Faisal.This study received support from two Faculty Initiatives Fund grants(FIF-842) and (FIF-406) awarded by the Lahore University of Management Sciences (LUMS) to Rahman Shah Zaib Saleem and AmirFaisal, respectively. Further support came from the Pakistan ScienceFoundation grant PSF/Res/P-LUMS/Chem (617) which was alsoawarded to Rahman Shah Zaib Saleem and Amir Faisa
TREN PENELITIAN INTEGRASI ICT DALAM PEMBELAJARAN MATEMATIKA UNTUK MENINGKATKAN KETERAMPILAN ABAD 21
Get PDFTuntutan siswa dalam penguasaan keterampilan abad 21 (kompetensi 4C) perlu diintegrasikan dengan pelaksanaan pembelajaran yang mendukung peningkatan kemampuan tersebut, salah satunya melalui pembelajaran matematika. Kehidupan modern berbasis ICT menjadi dasar pentingnya integrasi ICT dalam pembelajaran matematika sehingga dapat menghantarkan siswa pada ketercapaian peningkatan keterampilan abad 21. Oleh karenanya, pengkajian serta analisis mengenai tren penelitian pada topik tersebut diperlukan untuk menghasilkan ide baru penelitian dengan memanfaatkan metode Systematic Literature Review (SLR). Analisis isi dilakukan terhadap artikel yang berasal dari jurnal terindeks Scopus atau SINTA (1 dan 2), wilayah penelitiannya di Indonesia dengan rentang tahun 2016-2023 serta fokus penelitiannya adalah penggunaan ICT dalam integrasi keterampilan 4C pada pembelajaran matematika. Dari hasil penelitian diperoleh bahwa selama delapan tahun terakhir, jumlah publikasi yang berfokus pada topik tersebut meningkat. Di antara publikasi tersebut, desain penelitian paling dominan adalah kuantitatif dengan quasi eksperimen. Selain itu, siswa kelas 8 dan materi dalam lingkup geometri menjadi mata pelajaran dan bahan penelitian yang paling banyak dijadikan fokus penelitian. Dominasi penggunaan ICT sebagai media pembelajaran adalah geogebra yang bertujuan untuk menghasilkan suatu produk dengan mendesain pembelajaran melalui platform tersebut. Teknik pengumpulan data dan analisis data yang paling dominan digunakan berturut-turut adalah instrumen pre-test & post-test, t-test, skala likert, uji n-gain.Students' demands in mastering 21st-century skills (4C competencies) need to be integrated with the implementation of learning that supports the improvement of these abilities, one of which is through learning mathematics. Modern life based on ICT is the basis for the importance of ICT integration in mathematics learning so that it can lead students to the achievement of improving 21st-century skills. Therefore, a review and analysis of research trends on this topic is needed to generate new research ideas by utilizing the Systematic Literature Review (SLR) method. Content analysis was conducted on articles from Scopus or SINTA-indexed journals (1 and 2), the research area was in Indonesia with a range of 2016-2023, and the research focus was on the use of ICT in the integration of 4C skills in mathematics learning. The results showed that over the last eight years, the number of publications focusing on the topic has increased. Among these publications, the most dominant research design is quantitative with quasi-experiments. In addition, grade 8 students and materials within the scope of geometry are the subjects and research materials that are most commonly used as the focus of research. The dominant use of ICT as learning media is geogebra which aims to produce a product by designing learning through the platform. The most dominant data collection and data analysis techniques used in a row are pre-test & post-test instruments, t-test, Likert scale, n-gain test
PENGARUH MODEL PEMBELAJARAN PROBLEM BASED LEARNING TERHADAP PENINGKATAN KEMAMPUAN LITERASI MATEMATIKA
No full textLiterasi matematika merupakan kemampuan yang sangat penting bagi siswa di era pendidikan abad 21. Hal ini merupakan hasil dari kebutuhan untuk mengatasi berbagai kendala yang dihadapi masyarakat di dunia saat ini, namun kenyataannya siswa Indonesia memiliki kemampuan literasi matematika yang masih rendah. Oleh sebab itu, penelitian ini bertujuan untuk mengetahui apakah penerapan model problem based learning mempengaruhi kemampuan literasi matematika siswa dalam pembelajaran matematika. Metode eksperimen semu dengan desain One group pretest posttest dipilih untuk digunakan dalam penelitian ini. Seluruh siswa kelas VII di salah satu SMPN di Yogyakarta menjadi populasi dalam penelitian. Sebanyak 29 siswa kelas VII C menjadi sampel penelitian. Tes tertulis yang memuat indikator kemampuan literasi matematika pada materi luas permukaan prisma dan limas digunakan sebagai alat untuk mengumpulkan data. Uji Wilcoxon digunakan untuk menguji hipotesis dengan menggunakan software SPSS. Hasil penelitian menunjukkan bahwa penggunaan model problem based learning memberikan dampak positif terhadap kemampuan literasi matematika siswa. Selain itu, jawaban siswa menjadi lebih sistematis setelah diberikan perlakuan. Mathematical literacy is a very important ability for students in the 21st century education era. This is the result of the need to overcome various obstacles faced by society in the world today, but in reality Indonesian students have low mathematical literacy skills. Therefore, this study aims to determine whether the application of the problem-based learning model affects students' mathematical literacy skills in learning mathematics. One group pretest posttest design was chosen to be used in this study. All seventh grade students in one of the public junior high schools in Yogyakarta became the population in the study. A total of 29 students of class VII C became the research sample. Written tests containing indicators of mathematical literacy skills on the surface area of prisms and pyramids were used to collect data. Wilcoxon test was used to test the hypothesis using SPSS software. The results showed that the use of problem-based learning model had a positive impact on students' mathematical literacy skills. In addition, students' answers became more systematic after the treatment
Structural, optical, and electrical properties of Zn(1-x)MgxO nano-compounds and ZnO/Zn(1-x)MgxO heterostructures
Get PDFIn this study, the structural, thermal, optical, electrical and magnetic properties of Zn(1-x)MgxO (x = 0.0, 0.1, 0.3, 0.5) nano-compounds obtained by the addition of MgO to pure ZnO nano-compounds obtained by solid state reaction were investigated in detail. These nanomaterials were deposited by spin coating technique in hetero-structure of ZnO/Zn(1-x)MgxO. It was found by detailed structure solution that the crystal systems of nano materials obtained with MgO additive remained hexagonal, but the space group was transferred from P63mc to P6/mmm. The thermal gravimetry analysis shows the stability of prepared nanomaterials, the UV-Vis spectroscopy shows that the bandgap of the prepared was decreased from 3.02 to 2.52 eV with the Mg doping percentage. The Magnetization measurements at room temperature showed that all four of these Zn(1-x)MgxO nanostructures exhibited soft ferromagnetic behavior. The analysis of the ZnO/Zn(1-x)MgxO heterostructure showed that its band gap was increased from 3.69 to 3.79 eV, its carrier density was decreased from 1.14 x 10(19) to 4.20 x 10(13 )cm(-3) which introduce it as a good material to be used in optoelectronic devices field.Imam Abdulrahman Bin Faisal University, Saudi Arabia [2019190]This work was supported by Imam Abdulrahman Bin Faisal University, Saudi Arabia through Grant No. 2019190. The authors gratefully acknowledge the use of the services and facilities of the Basic and Applied Scientific Research Center (BASRC) at Imam Abdulrahman Bin Faisa
Pneumothorax and pneumomediastinum among COVID-19 patients with mechanical ventilation: a case series
Get PDFThe incidence of pneumothorax is 10% of all COVID-19 patients and increases in patients who develop acute respiratory distress syndrome (ARDS) with mechanical ventilation, responsible for 24% of the population. As many as 60.7% of patients who have complications of pneumothorax or pneumomediastinum lead to mortality. This study was established to determine the potential of early tracheostomy in preventing the occurrence of pneumothorax and pneumomediastinum in COVID-19 and reducing mortality. This research was conducted as a descriptive study by case series of three COVID-19 patients in Jakarta, Indonesia in the span of 2021-2022. Tracheostomy performed within 10 days, did not develop a pneumothorax. Although, the patient did not have any comorbidities, age below 70 years, and coagulopathy problem, there was still a risk of recurrent pneumothorax post COVID-19 after tracheostomy. However, a tracheostomy is a procedure that poses an aerosol risk, so there is concern about the transmission of COVID-19 to medical personnel who perform it. Early tracheostomy has the potential to accelerate the resolution of COVID-19 disease in patients and has a positive impact on lung vitality. It is aimed to prevent hypoxic conditions and optimize the lung recruitment process. In addition, they did not experience complications from COVID-19 in the form of an air leak syndrome such as a pneumothorax or pneumomediastinum
Making Pellets from Rubber Seed Shell Polymer and Young Coconut Fiber Waste as Alternative Fuel
Get PDFThis study examines the effect of the mixture ratio between rubber seed shells and young coconut solid waste on the quality of biobriquette pellets. The pyrolysis method is used to make biobriquettes by converting natural polymer raw materials into carbon. The results showed that the ratio of rubber seed shells to young coconut waste 75:25 with a concentration of 10% adhesive provided the best biobriquette quality with a water content of 3.728%, ash content of 6.861%, volatile matter 13.807%, fixed carbon 75.604% and a calorific value of 7.152 cal/g. the results of this study have good characteristics and are not easily destroyed and do not become moldy when stored for a long time. The use of tapioca flour as an adhesive can improve the quality of the resulting biobriquettes
Registro de la presencia del sabalote Chanos chanos (Forsskål, 1775) (Gonorynchiformes: Chanidae) en el río Shatt al-Arab/ Arvand, Basora y las aguas marinas de Irak, con notas sobre su tolerancia al agua dulce
Get PDFIn the present study, two specimens of the milkfish Chanos chanos (380 and 390 mm TL) are described from the marine waters of Iraq and another four specimens from the Shatt al-Arab River at Abu alKhaseeb City, south of Iraq (310-312.5 mm TL). Both localities represent a new range extension for the milkfish, but those from Shatt al-Arab River represent the maximum distance for this species to ascend. Morphometric and meristic data are provided and compared with other specimens of this species from other parts of the world. A note is given about the tolerance to freshwater habitats about 65 km away from the sea.En este estudio, se describen dos especímenes de sabalote Chanos chanos (LT 380 y 390 mm) en aguas marinas de Irak y otros cuatro del río Shatt al-Arab/Arvand en la ciudad de Abu alKhaseeb, al sur de Irak (LT 310-312,5 mm). Ambas localidades significan una extensión del rango de distribución para el sabalote y la de Abu al-Khaseeb representa la distancia máxima para que esta especie ascienda por el río. Se proporcionan y comparan datos morfométricos y merísticos con especímenes de otras partes del mundo. Se incide sobre la tolerancia en hábitats dulceacuícolas a 65 km del mar
Influence of nozzle area ratio on the gas-particle flow for single-hose dry ice blasting nozzle
No full textIn this paper, a numerical study was performed to examine the effect of divergent nozzle length of single-hose dry ice blasting on the development of acoustic power level. The active working medium is the mixture of solid dry ice particles and compressible air fluid at the inlet section. The two-dimensional planar model was solved using the finite volume method. The model has been verified theoretically by comparing to four different properties which are pressure ratio, density ratio, temperature ratio, and Mach number ratio over different nozzle area ratios (NARs). The results are presented in the quantitative and qualitative morphological views. The result shows that a more significant value of the NAR gives the highest value of velocity and acoustic power level along the nozzle cavity, of which 560 m s−1 and 146.2 dB, respectively. Besides, turbulence intensity is the most significant influencing factor for the acoustic power level development along the nozzle cavity since the trend of acoustic power level and turbulence intensity are the same. The characteristic of particle gas flow provides a novelty approach to determine the most significant influence factor of the performance and the noise emission
