51 research outputs found
Motor Function Measure (MFM) Score percentile curves in patients with Myotonic Dystrophy Type 1 (DM1)
No full textMyotonic dystrophy is a progressive neuromuscular disease. Myotonic dystrophy type 1 (DM1), or Steinert's disease, can be classified into four phenotypes: congenital (at birth), childhood-onset (between 1 and 10 years old), adult-onset or classic (10 to 30) and late-onset asymptomatic (20 to 70). Nevertheless, interindividual variability of symptoms even in the four set phenotypes is vast and information on the natural course of disease sparse. The Motor Function Measure (MFM) scale is a standardized quantitative functional examination scale suitable for the whole gravity spectra of neuromuscular diseases including DM1. So far, no percentile curves for the MFM exist for this disease
Zeolite: An emerging tool for mine reclamation
No full textTailings sites left from mining operations contain heavy metals which have the potential to bioaccumulate and leech into the surrounding soil and watersheds. Although some heavy metals are essential for biological processes, higher concentrations can be toxic and negatively impact nearby ecosystems and human health. Current tailings reclamation processes are often insufficient in preventing heavy metal bioaccumulation or too expensive and time demanding to be realistically incorporated into mine reclamation strategies. Absorbent porous minerals have been used in industrial wastewater management to remove contaminants. In this study we used one such absorbent mineral, zeolite, to test its ability in neutralizing lead, arsenic and cadmium metals in gold and copper mine tailings. We compared three different concentrations of zeolite in tailings soil and the subsequent effects on plant growth. Although treatment differences in plant biomass was not statistically significant, forthcoming data on heavy metal uptake by the plants will offer more detailed information on the zeolites affect on plant growth.Supervisor Lauchlan Frase
Propriété intellectuelle - Propriété littéraire et artistique - Chronique rédigée par Centre d'études et de coopération juridique interdisciplinaire (UR 21665)
No full textLe CECOJI (Centre d'Études et de Coopération Juridique Interdisciplinaire) est une équipe d'accueil de la Faculté de Droit de Poitiers se consacrant à l'étude pluridisciplinaire de sujets originaux, en lien notamment avec les nouvelles technologies et les libertés fondamentales. Il publie à La Semaine Juridique entreprise et affaires une chronique biannuelle en propriété littéraire et artistique. Sous la direction de Tanja Petelin et Alexandre Zollinger, la présente chronique a été rédigée par Leslie Amrane (ATER), Dominique Bougerol (maître de conférences), Sandrine Delayen (docteur en droit), Anas Fourka (allocataire de recherche), Marie-Eugénie Laporte-Legeais (professeur), Fabien Marchadier (professeur), Tanja Petelin (maître de conférences), Alexandre Portron (maître de conférences), Olivier Salomon (docteur en droit), et Alexandre Zollinger (maître de conférences).Avec la collaboration des étudiants du Master 2 en Droit des propriétés intellectuelles (Violaine Martin, Johan Raveau, Marina Perdigao Morais Souza, Solenn Veillard). Coordination : Vassili Bézier (ATER), Anas Fourka (allocataire de recherche), Lisa Pinamonti (allocataire de recherche).International audienceCette chronique couvre l'année 2021. Elle apporte un éclairage sur les notions et mécanismes utiles de la propriété littéraire et artistique - exceptions, originalité, droit moral, contrats... - tant dans l'ordre interne que dans l'ordre européen et international
Zeolite: An emerging tool for mine reclamation
No full textTailings sites left from mining operations contain heavy metals which have the potential to bioaccumulate and leech into the surrounding soil and watersheds. Although some heavy metals are essential for biological processes, higher concentrations can be toxic and negatively impact nearby ecosystems and human health. Current tailings reclamation processes are often insufficient in preventing heavy metal bioaccumulation or too expensive and time demanding to be realistically incorporated into mine reclamation strategies. Absorbent porous minerals have been used in industrial wastewater management to remove contaminants. In this study we used one such absorbent mineral, zeolite, to test its ability in neutralizing lead, arsenic and cadmium metals in gold and copper mine tailings. We compared three different concentrations of zeolite in tailings soil and the subsequent effects on plant growth. Although treatment differences in plant biomass was not statistically significant, forthcoming data on heavy metal uptake by the plants will offer more detailed information on the zeolites affect on plant growth.Supervisor Lauchlan Frase
«Sont-elles des royalistes ? Genre, engagements et royalismes en Bretagne »
No full textInternational audienceUnlike the women who embraced the Revolution to become among the essential personages in the history of this era, those women who repudiated the Revolution, opposing change, have attracted significantly less scholarly interest. Little studied, this second group remains associated with the most prominent figures among former nobles still attached to their earlier privileges, as well as to the “fanatics” in the forefront of religious resistance. Since the royalism of women associated with the former nobles seems in large measure self-explanatory, as does that of those animated by religious sentiment seemingly removed from strictly political issues, the actual relationship of these groups of women to the monarchy has been relatively unexplored. In this article, the author focuses on those women who did not belong to the former privileged category, and who in Brittany, evolved in the circumstances of latent civil war, a condition that opened up exceptional possibilities of action. By researching how non-noble Breton women were able to manifest their attachment to royalty, the author seeks to examine through the perspectives of gender the contours and forms of royalism in the Revolution. With this still neglected subject, the author will lay the groundwork for future research, guided above all by the question of sources and methods of analysis.À la différence des citoyennes, devenues des actrices incontournablesde l’histoire de la Révolution, celles qui ont rejeté cette qualité,en s’opposant au changement, ont suscité moins d’analyses. Peuétudiées, elles demeurent associées aux figures les plus visibles –des ci-devant nobles attachées à leurs anciennes prérogatives, aux« fanatiques », fers de lance des résistances religieuses. Leur relationà la monarchie n’a guère été sondée, le royalisme des premièressemblant relever de l’évidence, tandis que les secondes paraissaientéloignées des enjeux proprement politiques. Pour contourner cetteimpasse, nous proposons de mettre la focale sur des femmes n’appartenantpas aux anciennes catégories privilégiées et évoluant, enBretagne, dans un contexte de guerre civile larvée qui leur ouvredes possibilités d’action peu ordinaires. En recherchant commentles Bretonnes non nobles ont pu manifester leur attachement à laroyauté, nous voulons questionner par les marges et par les outilsdu genre les contours et les formes du royalisme dans la Révolution.Face à ce chantier encore en friche, nous entendons poser desjalons pour de futures recherches, guidés avant tout par la questiondes sources et des méthodes d’analyse
Approximate Bayesian Computation applied to time series of population genetic data disentangles rapid genetic changes and demographic variations in a pathogen population
No full textInternational audienceAdaptation can occur at remarkably short timescales in natural populations, leading to drastic changes in phenotypes and genotype frequencies over a few generations only. The inference of demographic parameters can allow understanding how evolutionary forces interact and shape the genetic trajectories of populations during rapid adaptation. Here we propose a new Approximate Bayesian Computation (ABC) framework that couples a forward and individual-based model with temporal genetic data to disentangle genetic changes and demographic variations in a case of rapid adaptation. We test the accuracy of our inferential framework and evaluate the benefit of considering a dense versus sparse sampling. Theoretical investigations demonstrate high accuracy in both model and parameter estimations, even if a strong thinning is applied to time series data. Then, we apply our ABC inferential framework to empirical data describing the population genetic changes of the poplar rust pathogen following a major event of resistance overcoming. We successfully estimate key demographic and genetic parameters, including the proportion of resistant hosts deployed in the landscape and the level of standing genetic variation from which selection occurred. Inferred values are in accordance with our empirical knowledge of this biological system. This new inferential framework, which contrasts with coalescent-based ABC analyses, is promising for a better understanding of evolutionary trajectories of populations subjected to rapid adaptation
Testing municipal inventories to explore local geoheritage in the Chablais UGGp, France.
No full textInternational audienceRecognized for its geological heritage of international importance that tells the story of the formation of the Alps, and also of the last great glaciation, the Chablais UNESCO Global Geopark, France, has a formal inventory of 85 geosites. These major sites of scientific interest, of which certain are included in the French geoheritage inventory for their regional, national or international interest, have been selected using a robust methodology.To explore and share how geoheritage shapes the everyday lives of its inhabitants, its culture, local economy and future development, a new initiative has been undertaken. Working at the municipality scale, over a five-month period, a local inventory was established on the « small geoheritage » (different from the national method for the « major geoheritage »). A threefold approach was applied: a structured inventory established by the Chablais UGGp supported by the Scientific Advisory Committee, discussions and visits with local heritage associations, engagement with the school and the local inhabitants. This led to the creation of a trial inventory sheet that was carefully prepared from existing methodologies and tested in two municipalities of the Chablais UGGp. The objective is to develop and improve this basic tool applicable in all municipalities.However, the importance of the project goes beyond the data collection. The interest of the project is being able to share local information, raise awareness and understanding about local geological heritage and improve its conservation. This was particularly interesting to explore because the municipalities concerned by this project do not necessarily feature major landscaped geosites that are promoted Geopark sites. The project allowed stronger bonds to be built between the local population, their heritage and the Geopark
Temporal genetic signatures of rapid demographic changes caused by directional selection, the case of a pathogen population overcoming plant resistance: [Oral presentation]
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Demographic and genetic consequences of a rapid adaptation event in the poplar rust pathogen: [Oral Presentation]
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