1,721,174 research outputs found
From the Adriatic to the Atlantic: Migration and Cultural Identity between Italy and Canada
No full textThe Jumonji family: past, present and future of histone demethylases in cancer.
No full textThe first Jumonji gene was cloned in 1995 by Takeuchi et al. [Takeuchi T, Yamazaki Y, Katoh-Fukui Y, Tsuchiya R, Kondo S, Motoyama J, Higashinakagawa T. Gene trap capture of a novel mouse gene, jumonji, required for neural tube formation. Genes Dev 1995; 9: 1211-22.]. Several genes sharing similar biological features have since been discovered, and are currently grouped into the JMJ family. Interestingly, their deregulation has been associated with cardiac disease, obesity, neurological disorders and cancer. One of the mechanisms underlying their function is gene expression modulation via histone post-translational modifications (PTMs). Increasing evidence of Jumonji deregulation in tumours such as colon, prostate, haematological and breast cancer is continually emerging, hence the need to acquire a better understanding. The Genesapiens.org database of patient arrays allows target expression levels to be investigated in a wide range of cancers, corroborating and extending the role of the JMJ family. Here, we provide an overview of the expression profile and regulation of JMJ family members in cancer, examining the most recent literature in the light of analyses drawn from this database
Comment on: MiR-877-5p suppresses cell growth, migration and invasion by targeting cyclin dependent kinase 14 and predicts prognosis in hepatocellular carcinoma
No full textTargeting epigenetic networks with polypharmacology: a new avenue to tackle cancer.
No full textThe term 'epigenetic' fuses old and new concepts that refer to the modulation of gene expression in cellular heritability, fate, development and programming-reprogramming other than the DNA sequence itself. Epigenetic control of transcription is regulated by enzymes that mediate covalent modifications at gene-regulatory regions and histone proteins around which chromosomal DNA is wound. Many of the enzymes that mediate chromatin epigenetic reactions are deregulated in diseases such as cancer. Thus, small-molecule inhibitors that target chromatin-modifying enzymes represent a novel option for treatment, and DNA methyltransferase and histone deacetylase inhibitors have been approved for cancer treatment. Moreover, other classes of epi-enzymes (MS-275, SAHA) have been demonstrated to have strong disease association, and are currently being targeted for modulation. An epigenetic poly-pharmacological approach targeting multiple chromatin-modifying enzymes may represent a 'smart' option to treat cancer versus the current view on the selective and single pharmacological targeting of epigenetic enzymes
Comment on: LncRNA SBF2-AS1 promotes hepatocellular carcinoma metastasis by regulating EMT and predicts unfavorable prognosis
No full textThe last worldwide evaluation on HCC impact and alarm refer to 20121
with dramatic information in
term of incidence rate and survival outcome. Despite the fact that more than 6 years are passed, the HCC
represents, still nowadays, one of the main oncological diseases in terms of incidence and negative survival
rate with worrying incidence also in many industrialized countries2
. Scientific evidence highlights how
antioxidant3
as well as nutraceutical agents4
can reduce the risk to develop the HCC, but it is not enough in
order to fight its progression and metastasis5
. Several mechanisms of action and markers were discovered
for the HCC6
, laying the foundations of the future innovative therapies and diagnosis approaches. In this
scenario, we read with great interest the article of Zhang et al7
. They evaluated and disseminated the role
of the LncRNA SBF2-AS1 in HCC patients. Starting from patients’ data, they focus on the LncRNA SBF2-
AS1 levels via bioinformatics and qPCR approaches. The data outcome correlates with the SBF2-AS1 up
regulation in HCC. Moreover, the authors investigated the clinical features and prognosis in HCC patients
in correlation with the SBF2-AS1 levels. Vein invasion and TNM stage, together with the low survival rate
strongly correlate with the high levels of LncRNA SBF2-AS1. On the other hands, the suppression of SBF2-
AS1 directly reduces the HCC proliferation and invasion acting on EMT pathway. The Zhang et al7
paper is
oriented towards the new frontiers of precision medicine passing by the patients stratification8
. The final
goal of last decade oncology research aims to provide the right therapy to the right patient9,10.
Concerning the fact the LncRNAs associated with HCC molecular mechanisms is grooving11, the LncRNA
SBF2-AS1 should be considered pivotal for as possible new diagnostic marker and therapy in HCC patient.
Indeed SBF2-AS1 could represent a new source as druggable target able for innovative HCC treatment.
Future studies12 should try to elucidate the potential interplay of mechanism in HCC initiation, progression
and fate among the genetic and epigenetic mechanisms
Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Variations on the Author
Full text link“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Appropriate Similarity Measures for Author Cocitation Analysis
Full text linkWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
1999 mass mortality event in the Ligurian Sea: recovery strategies in Eunicella cavolinii.
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