1,720,982 research outputs found
Confirmed association between monoamine oxidase A molecular polymorphisms and Sudden Infant Death Syndrome.
No full textWe published in the February 2009 issue of Neurogenetics the article “Association of dopamine transporter and monoamine oxidase molecular polymorphisms with Sudden Infant Death Syndrome and stillbirth: new insights into the serotonin hypothesis” . The aim of our work was to investigate the contribution of additional neurotransmitters and related genes, different from the serotonin transporter (SLC6A4, 5-HTT) in the development of SIDS and stillbirth. The main conclusion discussed in the paper was that the frequency of MAOA allele 4R (having increased transcriptional activity) was statistically higher in SIDS and stillbirth than in the Control Group. The conclusions in our article have recently been submitted to criticism by Klintschar and Heimbold with a Letter to the Editor of Neurogenetics. We would kindly reply to their two main observations
Genes regulating neurotransmitters metabolism are associated with the Sudden Infant Death Syndrome and the stillbirth
No full textMolecular genetics confirms the existence of different Management Units belonging to a single phylogenetic lineage within Italian populations of Alosa fallax (Lacepede, 1803)
Full text linkThe twaite shad Alosa fallax (Lacepede, 1803), belonging to the family Clupeidae, is a polytypic species
characterized by both landlocked and anadromous populations. These two forms have been known by historical
times in Italian waters and often considered as distinct taxonomic units. However, taxonomy of Italian shads has
been questioned, since it is based on morphological characteristics, not always reliable.
To clarify the phylogenetic relationships among Italian twaite shad populations, both landlocked and anadromous
ones were investigated by molecular markers, namely mitochondrial Cytochrome b (Cytb) gene sequencing. In
particular, new samples from Lake Omodeo (Sardina Island), Taro and Po Rivers were compared with previously
analyzed populations from Northern and Central Italy. Genetic analyses showed that the landlocked twaite
shad population from Lake Omodeo was characterized by a single Cytb haplotype (A. fallax hap1), whilst the
new samples from Taro River and Po River by two haplotypes (A. fallax hap3 and A. fallax hap5). These three
haplotypes are the most represented both in landlocked and anadromous Italian populations. These additional data
confirmed the occurrence of different Management Units (MUs) belonging to a single phylogenetic lineage within
Italian waters, without evidence of a separation at specific level of the A. fallax group. The Cytb phylogenetic
analysis do not support the existence of a separated species for Italian landlocked populations, as previously
hypothesized
Genotipi ed aplotipi associati al metabolismo di neurotrasmettitori ed eziopatogenesi della SIDS
No full textMolecular barcoding of an atypical ciprinid population assessed by Cytochrome b gene sequencing
No full textA fish population of the carp family Cyprinidae with atypical phenotypic characteristics was observed in one of the main catchments of the Pollino National Park, a valuable, protected area in southern Italy. In this area, the Italian roach Rutilus rubilio (Bonaparte, 1837), a native endemic fish of Tyrrhenean regions, has been introduced in sympatric conditions with Squalius squalus (Bonaparte, 1837) and Telestes muticellus (Bonaparte, 1837). A molecular investigation was carried out to assess the genetic identity of the population with a view to conservation. Direct sequencing of a cytochrome b gene fragment was performed based on 30 individuals of cyprinid fish with atypical phenotype, in addition to 30 S. squalus, 10 T. muticellus, and 30 R. rubilio pure individuals collected in different Italian regions, which served as reference samples. Multiple sequence alignments demonstrated that 50% of atypical-cyprinid haplotypes were maternally inherited from either S. squalus or R. rubilio. No contribution by T. muticellus was determined. Our results indicate an intergeneric hybridization event between S. squalus and R. rubilio, as a consequence of trans-introduction activities of alien species
Efficiency of DNA mini-barcoding to assess mislabeling in commercial fish products in italy: An overview of the last decade
Full text linkThe problem of fish traceability in processed products is still an important issue in food safety. Major attention is nowadays dedicated to consumer health and prevention of possible frauds regulated by national and international laws. For this reason, a technical approach is fun-damental in revealing mislabeling at different levels. In particular, the use of genetic markers has been standardized and DNA barcoding is considered the gold-standard strategy to examine and prevent species substitution. Considering the richness of available DNA databases, it is nowadays possible to rapidly reach a reliable taxonomy at the species level. Among different approaches, an innovative method based on DNA mini barcoding has recently been proposed at an international level. Starting from this evidence, we herein illustrate an investigation dealing with the evolution of this topic in Italy over the last decade. The molecular analysis of 71 commercial fish samples based on mini-COI sequencing with two different primer sets reached an amplification success rate of 87.3 and 97.2%. The investigation revealed four major frauds (5.8%) and four minor ones (5.8%). Results highlighted a decrease in incorrect labeling in Italy from 32% to 11.6% over the last decade, although a recurrent involvement of “endangered” species sensu IUCN was still observed
Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Geni in grado di regolare la sintesi e il metabolismo della serotonina ed eziopatogenesi della SIDS
No full textVariations on the Author
Full text link“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
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