133,184 research outputs found
On the molecular mechanisms driving pain perception and emergent collective behaviors
No full textA stochastic model to investigate the microscopic processes which trigger the sensation of pain is considered. The model, presented in Di Patti and Fanelli [Di Patti F, Fanelli D. Can a microscopic stochastic model explain the emergence of pain cycles in patients? J Stat Mech 2009. doi:10.1088/1742-5468/2009/01/P01004], accounts for the action of analgesic drug and introduces an effect of competition with the inactive species populating the bloodstream. Regular oscillations in the amount of bound receptors are detected, following a resonant amplification of the stochastic component intrinsic to the system. The condition for such oscillations to occur are here studied, resorting to combined numerical and analytical techniques. Extended and connected patches of the admissible parameters space are detected which do correspond to the oscillatory behaviors. These findings are discussed with reference to the existing literature on patients' response to the analgesic treatment. © 2009 Elsevier B.V. All rights reserved
Correction to: Curve of Spee modification in different vertical skeletal patterns after clear aligner therapy: a 3D set-up retrospective study (Progress in Orthodontics, (2024), 25, 1, (5), 10.1186/s40510-023-00503-1)
No full textCorrection to: Prog Orthod.25, 5 (2024) https://doi.org/10.1186/s40510-023-00503-1. Following publication of the original article [1], the authors identified an error in the author names of the author group as the given name and family name were erroneously transposed. The incorrect author names are: Ciavarella Domenico, Fanelli Carlotta, Suriano Carmela1, Campobasso Alessandra, Lorusso Mauro, Ferrara Donatella, Maci Marta, Esposito Rosa and Tepedino Michele The correct author names are: Domenico Ciavarella, Carlotta Fanelli, Carmela Suriano, Alessandra Campobasso, Mauro Lorusso, Donatella Ferrara, Marta Maci, Rosa Esposito and Michele Tepedino The author group has been updated above and the original article [1] has been corrected
Are public health policies keeping up with shifting scientific consensus? the case of vitamin D
No full textArguing that vitamin D can help avoid bad COVID outcomes is widely dismissed as misinformation. Yet the latest results of the covidConsensus.org project tell a different story, says Daniele Fanelli (LSE)
Is spinal anaesthesia a suitable technique for ultra-short outpatient procedures?
No full textSpinal anaesthesia is an easy and reliable technique. Factors limiting its use in the ambulatory setting include delayed ambulation, risk of urinary retention and pain after block regression. On the contrary, general anaesthesia with fast-acting drugs provides a fast recovery that facilitates an early discharge. Although recovery after spinal anaesthesia has been improved by reducing the dose of the commonly used longacting local anaesthetics, discharge times are still prolonged compared with general anaesthesia. 2-Chloroprocaine is an amino-ester local anaesthetic with a very short half-life and a favourable evolution of spinal block for ultra-short outpatient procedures. Moreover, the preservative free 2-chloroprocaine solution showed a very low risk of urinary retention and transient neurological symptoms when compared with bupivacaine and lidocaine. The aim of this article is to evaluate if the neuraxial administration of short-acting local anaesthetics renders spinal anaesthesia a suitable technique for ultra-short surgical procedure
A prospective, double-blinded, randomized, clinical trial comparing the efficacy of 40 mg and 60 mg hyperbaric 2% prilocaine versus 60 mg plain 2% prilocaine for intrathecal anesthesia in ambulatory surgery.
No full textThe Role of Income Distribution in the Diffusion of Corporate Social Responsibility
No full textThe purpose of this paper is to investigate the link between CSR growth and income distribution. We present a general equilibrium model where social responsibility enters both firms' and consumers' decisions. The model admits the existence of multiple equilibria, each of them characterized by a different diffusion of CSR. We study the conditions under which there exists a virtuous circle which ties increases in the diffusion of CSR to reductions in income inequality and viceversa. Under certain circumstances, any policy which promotes the diffusion of CSR induces a reduction of income inequality. By contrast, when such conditions are not satisfied, only redistributive policies may generate the virtuous circle
Risk of Crimean Congo haemorrhagic fever virus (CCHFV) introduction and spread in CCHF-free countries in southern and Western Europe: A semi-quantitative risk assessment
No full textCrimean-Congo hemorrhagic fever (CCHF) is a severe tick-borne viral zoonotic disease caused by Crimean-Congo hemorrhagic fever virus (CCHFV). The disease is usually asymptomatic in domestic and wild animals, both of which may act as reservoirs of the virus. CCHF is endemic in parts of Africa, Asia, the Middle East and Eastern Europe. During the last decade, the emergence or re-emergence of CCHF was described in several countries in the Eastern Mediterranean Region, with an increasing risk of extension into new areas. Given the public health importance, this study undertakes a semi-quantitative risk assessment to analyse the likelihood of entry and exposure of CCHFV into 9 CCHF-free countries in Southern and Western Europe. Based on a framework outlining the probability of the virus entry and exposure, the risk estimates were assessed for each individual country. The risk assessment was performed using information from public databases and the available scientific literature. The likelihood of entry was conducted considering 3 main pathways: infected tick vectors, wildlife and livestock. The likelihood of exposure was assessed considering the probability of survival of the infected ticks once introduced in CCHF-free countries (depending on abiotic and biotic factors), and the exposure of resident uninfected susceptible ticks to infected imported wildlife and livestock. The risk estimates (combined CCHFV introduction and exposure) were low for the majority of the countries (Austria, Belgium, Germany, Luxembourg, Netherlands, Slovenia and Switzerland) and medium for France and Italy, if accounting only for animal health consequences. Considering the public health consequences only, the risks were rated low for all the countries, except for Italy where it was assessed to be medium
Location of eigenvalues of three-dimensional non-self-adjoint Dirac operators
No full textWe prove the absence of eigenvalues of the three-dimensional Dirac operator with non-Hermitian potentials in unbounded regions of the complex plane under smallness conditions on the potentials in Lebesgue spaces. Our sufficient conditions are quantitative and easily checkable
Structural Aspects of the Luteinizing Hormone Receptor: Information from Molecular Modeling and Mutagenesis
No full textThe luteinizing hormone receptor (LHR) is a member of the superfamily of G protein-coupled receptors and, in humans, binds two closely related ligands, members of the heterodimeric glycoprotein hormone family. This receptor is an essential component of the reproductive axis in males and females, and a number of naturally occurring pathophysiologic activating and inactivating mutations have been described. This review deals with the current state of knowledge of the structure of LHR based on molecular modeling and the supporting experimental data from engineered and naturally occurring mutations
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