96,738 research outputs found
Unary FA-presentable semigroups
No full textAutomatic presentations, also called FA-presentations, were introduced to extend nite model theory to innite structures whilst retaining the solubility of interesting decision problems. A particular focus of research has been the classication of those structures of some species that admit automatic presentations. Whilst some successes have been obtained, this appears to be a dicult problem in general. A restricted problem, also of signicant interest, is to ask this question for unary automatic presentations: auto-matic presentations over a one-letter alphabet. This paper studies unary FA-presentable semigroups. We prove the following: Every unary FA-presentable structure admits an injective unary automatic presentation where the language of representatives consists of every word over a one-letter alphabet. Unary FA-presentable semigroups are locally nite, but non-nitely generated unary FA-presentable semigroups may be innite. Every unary FA-presentable semigroup satises some Burnside identity.We describe the Green's relations in unary FA-presentable semigroups. We investigate the relationship between the class of unary FA-presentable semigroups and various semigroup constructions. A classication is given of the unary FA-presentable completely simple semigroups.Peer reviewe
Hypomorphic Mutations in the Central Fanconi Anemia Gene FANCD2 Sustain a Significant Group of FA-D2 Patients with Severe Phenotype. Running title : FA-D2 phenotype and FANCD2 mutations
No full textPremi a l'excel·lència investigadora. Àmbit de les Ciències de la Salut. 2008FANCD2 is an evolutionarily conserved Fanconi anemia (FA) gene that plays a central role in DNA double-strand type damage responses. Using complementation assays and immunoblotting, a consortium of American and European groups assigned 29 FA patients from 23 families and 4 additional unrelated patients to complementation group FA-D2. This amounts to 3 to 6% of FA patients registered in various datasets. Malformations are frequent in FA-D2 patients and hematological manifestations appear earlier and progress more rapidly when compared to patients from all other FA groups combined, as represented by the International Fanconi Anemia Registry, IFAR. FANCD2 is flanked by two pseudogenes. Mutation analysis revealed the expected total of 66 mutated alleles, 34 of which result in aberrant splicing patterns. Many mutations are recurrent and have ethnic associations and shared alleles. There were no biallelic null mutations so that residual FANCD2 protein of both isotypes was observed in all patients' cell lines available. These analyses suggest that unlike in a knock-out mouse model, total absence of FANCD2 is not existing in FA-D2 patients due to constraints on viable combinations of FANCD2 mutations. Although hypomorphic mutations are involved, the result generally is a relatively severe form of FA
Identification of biochemical defects in pancreatic islets of fa/fa rats: a developmental study
No full textAdult obese (fa/fa) Zucker rats hypersecrete insulin in response to glucose and other secretagogues. Functional changes in islet alpha 2-adrenoceptors (8) and glycolytic regulation (9) have been reported. In this study, the development of these biochemical lesions in islets isolated from suckling (3 week old) and weanling (5 week old) lean and fa/fa rats was investigated and compared to results in adult animals. Glucose (15 mM)-induced insulin secretion was inhibited by mannoheptulose (MH) in lean (n = 8) but not fa/fa (n = 10) adult rats, indicating loss of sensitivity of glucokinase to competitive inhibition. Sensitivity to MH was somewhat reduced in the islets of 3- and 5-week-old fa/fa (n = 7 and 12) compared to lean (n = 15 and 9) rats, requiring 30-100 fold higher concentrations to achieve significant inhibition. At 3 weeks of age fa/fa rats did not differ from lean controls in either islet insulin content or body weight, but both parameters were increased in fa/fa rats by 5 weeks. The presence of altered alpha 2-adrenoceptor function in fa/fa rats could not be confirmed in this study. Unlike the previous report, prazosin did not antagonize alpha 2-agonist mediated inhibition of insulin secretion. The presence of defective regulation of the glycolytic pathway by mannoheptulose in suckling and weanling rats may contribute to development of hyperinsulinemia in fa/fa rats.LR: 20061115; PUBM: Print; JID: 9305691; 0 (Receptors, Adrenergic, alpha); 11061-68-0 (Insulin); 50-99-7 (Glucose); 654-29-5 (Mannoheptulose); EC 2.7.1.2 (Glucokinase); ppublishSource type: Electronic(1
Appropriate Similarity Measures for Author Cocitation Analysis
No full textWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
Plasma concentrations (g/100 g FA) of selected FA in mice after dietary intervention for 12 weeks<sup>1</sup>.
No full textPlasma concentrations (g/100 g FA) of selected FA in mice after dietary intervention for 12 weeks1.</p
Huangdi nei jing Ling shu zhu zheng fa wei
No full textV.1-12. 黃帝内經素問註證發微 : 九卷 -- v.13-20. 黃帝内經靈樞註證發微 : 九卷, 補遺.V.1-12. Huangdi nei jing Su wen zhu zheng fa wei : jiu juan -- v.13-20. Huangdi nei jing Ling shu zhu zheng fa wei : jiu juan, bu yi.馬蒔註證.綫裝.框20.6x13.8公分, 10行22字. 白口, 四周單邊, 單黑魚尾. 版心上鐫子目名, 中鐫卷次, 下鐫葉次.書名頁刻"黃帝内經素問靈樞合編, 馬元臺先生註, 大文堂藏板"《黃帝内經靈樞註證發微》第十卷為"補遺"前有嘉慶十年[1805]鮑漱芳序, 言刻書事.《中國中醫古籍總目》(00009)著錄.鈐"莊兆祥印", "莊兆祥".Xian zhuang.Kuang 20.6 x 13.8 gong fen, 10 hang 22 zi. Bai kou, si zhou dan bian, dan hei yu wei. Ban xin shang juan zi mu ming, zhong juan juan ci, xia juan ye ci.Detailed notes in vernacular field only.Detailed notes in vernacular field only.Detailed notes in vernacular field only.Detailed notes in vernacular field only.Ma Shi zhu zheng.Qian "Zhuang Zhaoxiang yin", "Zhuang Zhaoxiang"
Cai ji xian zhe cha sheng si mi fa
No full text趙濂著.綫裝.框14.9x10.4公分, 12行40字, 無界行. 白口, 左右雙邊, 單黑魚尾. 版心中鐫卷次, 下鐫葉次.分上, 中, 下卷.卷三卷端題為"見証實錄"書名頁刻"光緖九年[1883]鐫"封面題簽署"影印古本醫學叢書之九, 上海中醫書局發行"《中國中醫古籍總目》(05869)著錄.附載: 採集先哲察生死秘法 / 趙濂編輯.鈐"莊兆祥印", "莊兆祥".Xian zhuang.Kuang 14.9 x 10.4 gong fen, 12 hang 40 zi, wu jie hang. Bai kou, zuo you shuang bian, dan hei yu wei. Ban xin zhong juan juan ci, xia juan ye ci.Fen shang, zhong, xia juan.Juan san juan duan ti wei "Jian zheng shi lu"Shu ming ye ke "Guangxu jiu nian [1883] juan"Feng mian ti qian shu "Ying yin gu ben yi xue cong shu zhi jiu, Shanghai Zhong yi shu ju fa xing"Detailed notes in vernacular field only.Zhao Lian zhu.Fu zai: Cai ji xian zhe cha sheng si mi fa / Zhao Lian bian ji.Qian "Zhuang Zhaoxiang yin", "Zhuang Zhaoxiang"
Dispelling the Myths Behind First-author Citation Counts
No full textWe conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued
use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation
counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more
sophisticated methods
Delta-like and gtl2 are reciprocally expressed, differentially methylated linked imprinted genes on mouse chromosome 12
No full textThe distal portion of mouse chromosome 12 is imprinted. To date, however, Gtl2 is the only imprinted gene identified on chromosome 12. Gtl2 encodes multiple alternatively spliced transcripts with no apparent open reading frame. Using conceptuses with maternal or paternal uniparental disomy for chromosome 12 (UPD12), we found that Gtl2 is expressed from the maternal allele and methylated at the 5' end of the silent paternal allele. A reciprocally imprinted gene, Delta-like (Dlk), with homology to genes involved in the Notch signalling pathway was identified 80kb upstream of Gtl2. Dlk was expressed exclusively from the paternal allele in both the embryo and placenta, but the CpG-island promoter of Dlk was completely unmethylated on both parental alleles. Rather, a paternally methylated region was identified in the last exon of the active Dlk allele. The proximity, reciprocal imprinting and methylation in this domain are reminiscent of the co-ordinately regulated Igf2-H19 imprinted domain on mouse chromosome 7. Like H19 and Igf2, Gtl2 and Dlk were found to be co-expressed in the same tissues throughout development, though not after birth. These results have implications for the regulation, function and evolution of imprinted domains
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