62 research outputs found
Reproductive Performance Of Pregnant Rats And Embryotoxic Effects Of Ciprofloxacin
No full textTo observe the effect of ciprofloxacin on both pregnancy and physical development of fetuses, the drug was orally administered to thirty pregnant rats at doses of 20 and 40 mg/kg body weight from day-1 to day-19 of gestation. The intact rat fetuses were isolated on day-19 of gestation. Ciprofloxacin induced general changes in the reproductive performance of female rats and significant alterations in the development of the skeletal parameters of fetuses.6117980Barrow, M.V., Taylor, W.J., A rapid method for detecting malformations in rat fetuses (1967) J Morphol, 127, pp. 291-306Berkovitch, M., Pastuszak, A., Gazarian, M., Lewis, M., Koren, G., Safety of the new quinolones in pregnancy (1994) Obstet Gynecol, 84, pp. 535-538Danisovicova, A., Brezina, M., Belan, S., Kayserova, H., Kaiserova, E., Hruskovic, I., Orosova, K., Matheova, E., Magnetic resonance imaging in children receiving quinolones: No evidence of quinolone-induced arthropathy. A multicenter survey (1994) Chemotherapy, 40, pp. 209-214Dawson, A.B., Note on the staining of skeleton of cleared skeletal specimens with alizarin red S (1926) Stain Technol, 1, pp. 123-124Del Fiol, F., Gerenutti, M., Groppo, F.C., Antibiotics and pregnancy (2005) Pharmazie, 60, pp. 483-493Gerenutti, M., De-Souza Spinosa, H., Bernard, M.M., Algumas Considerações sobre a toxicologia do desenvolvimento (1991) Com. Cient. da Fac. Méd. Vet. e Zoot. da Universidade de São Paulo, 1, pp. 27-29Grady, R., Safety profile of quinolone antibiotics in the pediatric population (2003) Pediatr Meet Dis J, 22, pp. 1128-1132Hooton, T.M., Stamm, W.E., Diagnosis and treatment of uncomplicated urinary tract infection (1997) Infect Dis Clin North Am, 11, pp. 551-581Lemonica, I.P., Damascene, D.C., Di-Stasi, L.C., Study of the embryo-toxic effects of an extract of rosemary (Rosmarinus officinalis L.) (1996) Braz J Med Biol Res, 29, pp. 223-227Loebstein, R., Addis, A., Ho, E., Andreou, R., Sage, S., Donnenfeld, A.E., Schick, B., Koren, G., Pregnancy outcome following gestational exposure to fluoroquinolones: A multicenter prospective controlled study (1998) Antimicrob Agents Chemother, 42, pp. 1336-1339Nagai, A., Miyazaki, M., Morita, T., Furubo, S., Kizawa, K., Fukumoto, H., Sanzen, T., Kawamura, Y., Comparative articular toxicity of garenoxacin, a novel quinolone antimicrobial agent, in juvenile beagle dogs (2002) J Toxicol Sci, 27, pp. 219-228Saravanos, K., Duff, P., The quinolone antibiotics (1992) Obstet Gynecol Clin North Am, 19, pp. 529-537Sterz, H., Lehmann, H., A critical comparison of the freehand razor-blade dessection method according to Wilson with an in-situ sectioning method for the rat fetuses (1985) Teratog Carcinog Mutagen, 5, pp. 347-354Vickery, B.H., Bennett, J.P., Rats and mice (1970) Reproduction and Beeding Techniques for Laboratory Animals, pp. 299-315. , Hafez ESE (ed). Philadelphia: Lea and FebigerYabe, K., Yoshida, K., Yamamoto, N., Nishida, S., Ohshima, C., Sekiguchi, M., Yamada, K., Furuhama, K., Diagnosis of quinolone-induced arthropathy in juvenile dogs by use of magnetic resonance (MR) imaging (1997) J Vet Med Sci, 59, pp. 597-59
Arkhanka, mon berceau !
No full textThe author is using documents from a personal archive and tells a story based on anecdotes as well as edited memoirs of her mother Nadezhda Reformatskaya . She had the fortune to spend her youth in one of the last small Russian country homes. Lively accounts ofprovincial country life at the beginning ofthe twentieth century give way to dramatic scenes of the conscription to send troops to the frontline of the First World War. The title of the article paraphrases the lines from a poem by A. N. Nekrasov “ On the Volga” (1860).Reformatskaâ Mariâ Aleksandrovna, Groppo Armelle. Arkhanka, mon berceau !. In: Revue Russe n°50, 2018. Miscélanées. La Russie de 1869 à nos jours... pp. 159-177
Le cas Schafranek : un historien devant la justice
No full textBruno Groppo, "The Schafranek Case" : An Historian before the Bar
Since 1991, the Austrian historian Hans Schafranek is the object of a legal action that concerns all historians of modern history. Author of a book about the deportation from the Soviet Union of hundreds of German and Austrian antifascists to Nazi Germany between 1937 and 1941, he has been brought to court and convicted of using archival documents open to any researcher, documents calling into question a political official who, previously, hotly denied that the deportations took place. Even the decision of the court of appeals, favorable to the defendant, in part of a dangerous precedent with respect to the freedom to do research and publish in the field of contemporary history. The scientific community in Germany and Austria has mobilized in defense of Schafranek and this freedom to do research.Groppo Bruno. Le cas Schafranek : un historien devant la justice. In: L'Homme et la société, N. 116, 1995. Les passions de la recherche (II) : L'allemagne revisitée. pp. 77-90
EMPIRICAL ESSAYS IN DEVELOPMENT ECONOMICS
No full textIn developing countries, where formal credit and insurance markets are incomplete or non-existent, households use informal mechanisms to increase their consumption, savings and insurance possibilities. This dissertation studies two of these informal devices: participation in Rotating Savings and Credit Associations (roscas), and internal migration. I mainly follow an empirical approach, using the Indonesia Family Life Survey dataset (IFLS).
In particular, I analyze the effect of mothers’ participation in roscas on children secondary or tertiary school enrollment: taking into account the endogeneity of maternal participation in roscas, I find that maternal participation significantly increases the probability of children’s school enrollment. The results show a negative correlation between the unobservables determining rosca participation and the unobservables determining schooling. This can be interpreted as evidence that in households that are more vulnerable to shocks, mothers invest less in their children’s education, while increasing their participation in roscas, as an insurance and savings device.
The subsequent chapter analyzes the determinants of internal migration in Indonesia, distinguishing between ‘individual migration’ and ‘family migration’, where the first relates to movements which individuals undertake alone, while the latter indicates movements they undertake with their families. The estimates, performed on men and women samples separately, highlight that individual and family migration have very distinct determinants. For instance, an increase in household wealth (proxied by the value of land owned) does not influence the probability of individual migration, while significantly reducing the probability of family moves. The results also show that, among men, individuals whose households have intermediate levels of income are less likely to move alone, compared to those in the extreme of the households' income distribution. This is consistent with the predictions of the New Economics of Labour Migration.
The final chapter (joint with M. Mendola, Università degli Studi di Milano Bicocca) studies the impact of internal migration on the consumption growth of origin households. We are able to disentangle the impact of current and return migration, while taking into account the endogeneity of internal migration. We find that having current internal migrants does not exert a statistically significant impact on origin households’ consumption growth, while having return internal migrants significantly reduces per capita consumption growth at origin. The IFLS data suggest that the negative effect of return migration on consumption growth is likely to be explained by a lower income potential of returning migrants with respect to current migrants and non-migrants
The action of anti-inflammatory agents in healthy temporomandibular joint synovial tissues is sex-dependent
No full textEffect Of Betamethasone And Diclofenac Sodium On Serum And Tissue Concentration Of Amoxicillin. In Vivo Study In Rats
No full textObjective: Antimicrobial agents in combination with anti-inflammatory drugs have been usually prescribed in both Medicine and Dentistry. However, few scientific reports support this clinical practice. The aim of this study was to evaluate the effect of betamethasone and diclofenac sodium on serum and tissue concentration of amoxicillin in rats. Methods: Four polyurethane sponges were implanted in the back skin of 48 rats. After seven days the animals were divided into 6 groups (n=8). Group 1: amoxicillin (25 mg/kg); G2: diclofenac sodium (2.5 mg/kg); G3: betamethasone (0.1 mg/kg); G4: diclofenac sodium and amoxicillin; G5: betamethasone and amoxicillin; and G6: 0.9% sodium chloride solution (1.0 mL - control group). All drugs were administered in a single dose. After 90 minutes, the granulomatous tissues of each animal were surgically removed and weighed. Blood was collected from cervical plexus, centrifuged and 10μL of serum was placed on paper discs. In order to estimate amoxicillin concentration, serum and granulomatous tissues were separately submitted to microbiological assay, which used 108cfu/mL of Staphylococcus aureus ATCC 25923 (penicillin-susceptible strain). After incubation (18 hours, 37°C) the inhibition zones were measured and compared to a regression curve. Results: No inhibition zones were observed for groups 2, 3 and 6. Tissue and serum concentrations of both G1 (4.14μ g/g and 2.06μ g/mL, respectively) and G5 (3.87μ g/g and 1.70μ g/mL, respectively) showed statistically significant differences (Kruskal-Wallis, p<0.05) in comparison to G4 (1.45μ g/g and 0.41μ g/mL, respectively). G1 and G5 did not differ significantly (p>0.05). Conclusion: Considering single doses, betamethasone did not interfere with amoxicillin levels but diclofenac sodium reduced both tissue and serum levels of amoxicillin in rats.145319323Agarwal, G., Awasthi, S., Kabra, S.K., Kaul, A., Singhi, S., Walter, S.D., Three day versus five day treatment with amoxicillin for non-severe pneumonia in young children: A multicentre randomised controlled trial (2004) BMJ, 328, p. 791Alexander, R.E., Throndson, R.R., A review of perioperative corticosteroid use in dentoalveolar surgery (2000) Oral Surg Oral Med Oral Pathol Oral Radiol Endod, 90, pp. 406-415Baglie S, Groppo FC, Mattos-Filho TR. Tissue pharmacokinetic of amoxicillin. An experimental design in rats. Braz J Infect Dis. 2000;4:197-203Bantar, C., Nicola, F., Fernandez Canigia, L., Arenoso, H.J., Soutric, J., Montoto, M., A pharmacodynamic model to support a 12-hour dosing interval for amoxicillin/sulbactam, a novel oral combination, in the treatment of community-acquired lower respiratory tract infections (2000) J Chemother, 12, pp. 223-227Charles, B.G., Chulavatnatol, S., Simple analysis of amoxicillin in plasma by high performance liquid chromatography whit internal standardization and ultraviolet detection (1993) Biomed Chromatogr, 7, pp. 204-207Dajani, A.S., Bawdon, R.E., Berry, M.C., Oral Amoxicillin as prophylaxis for endocarditis: What is the optimal dose? (1994) Clin Infect Dis, 18, pp. 157-160Dajani, A.S., Taubert, K.A., Wilson, W., Bolger, A.F., Bayer, A., Ferrieri, P., Prevention of bacterial endocarditis: Recommendations by the American Heart Association (1997) J Am Dent Assoc, 128, pp. 1142-1151Garbutt, J.M., Goldstein, M., Gellman, E., Shannon, W., Littenberg, B., A randomized, placebo-controlled trial of antimicrobial treatment for children with clinically diagnosed acute sinusitis (2001) Pediatrics, 107, pp. 619-625Georgopoulos, A., Borek, M., Ridl, W., Randomized, double-blind, double-dummy study comparing the efficacy and safety of amoxycillin 1 g bd with amoxycillin 500 mg tds in the treatment of acute exacerbations of chronic bronchitis (2001) J Antimicrob Chemother, 47, pp. 67-76Gordon, R.C., Regamey, C., Kirby, W.M.N., Comparative clinical pharmacology of amoxicillin and ampicillin administered orally (1972) Antimicrob Agents Chemother, 1, pp. 504-507Groppo, F.C., Mattos-Filho, T.R., Del-Fiol, F.S., Bioassay of amoxicillin in rats (2000) Biol Pharm Bull, 23, pp. 1033-1035Groppo, F.C., Simões, R.P., Ramacciato, J.C., Rehder, V., Andrade, E.D., Mattos-Filho, T.R., Effect of sodium diclofenac on serum and tissue concentration of amoxicillin and on staphylococcal infection (2004) Biol Pharm Bull, 27, pp. 52-55Huisman-de-Boer, J.J., van den Anker, J.N., Vogel, M., Goessens, W.H., Schoemaker, R.C., Groot, R., Amoxicillin pharmacokinetics in preterm infants with gestational ages of less than 32 weeks (1995) Antimicrob Agents Chemother, 39, pp. 431-434Koneman, E.W., Allen, S.D., Janda, W.M., Schreckenberger, P.C., Winn Jr., W.C., (1997) Color atlas and textbook of diagnostic microbiology, , Philadelphia: J.B. Lippincott Company;Margarit, F., Moreno-Dalmau, J., Obach, R., Peraire, C., Pla-Delfina, J.M., Intestinal absorption kinetics of a series of aminopenicillins and azidocillin. A comparative study in the rat (1991) Eur J Drug Metab Pharmacokinet, 3, pp. 102-107Martindale, W., (1996) The Extra Pharmacopoeia, pp. 125-129. , 31th ed. London: Royal Pharmaceutical Society PressMoore, T.D., Horton, R., Utrup, L.J., Miller, L.A., Poupard, J.A., Stability of amoxicilin-clavulanate in bactec medium determined by high-performance liquid chromatography and bioassay (1996) J Clin Microbiol, 34, pp. 1321-1322Moore, V.A., Irwin, W.J., Timmins, P., Chong, S., Dando, S.A., Morrison, R.A., A rapid screening system to determine drug affinities for the intestinal dipeptide transporter 1: System characterization (2000) Int J Pharm, 210, pp. 15-27Park, S.N., Yeo, S.W., Effects of antibiotics and steroid on middle ear mucosa in rats with experimental acute otitis media (2001) Acta Otolaryngol, 121, pp. 808-812Peris-Ribera, J.E., Torres-Molina, F., Garcia-Carbonell, M.C., Aristorena, J.C., Pla-Delfina, J.M., Pharmacokinetics and bioavailability of diclofenac in the rat (1991) J Pharmacokinet Biopharm, 19, pp. 647-665Plant, J.E., Higgs, G.A., Easmon, C.S.F., Effects of anti-inflammatory agents on chronic Salmonella typhimurium infection in a mouse model (1983) Infect Immun, 42, pp. 71-75Prevot, M.H., Jehl, F., Rouveix, B., Pharmacokinetics of a new oral formulation of amoxicillin (1997) Eur J Drug Metab Pharmacokinet, 22, pp. 47-52Rodriguez, A.F., Kaplan, S.L., Hawkins, E.P., Mason Jr., E., Effect of dexamethasone or hwa-138 in combination with antibiotics in experimental haemophilus influenzae type b infection (1991) Antimicrob Agents Chemother, 35, pp. 1980-1984Scholer, D.W., Ku, E.C., Boettcher, I., Schweizer, A., Pharmacology of diclofenac sodium (1986) Am J Med, 80, pp. 34-38Siaperas, P., Pefanis, A., Iliopoulos, D., Katsarolis, I., Kyroudi-Voulgari, A., Donta, I., Evidence of less severe aortic valve destruction after treatment of experimental staphylococcal endocarditis with vancomycin and dexamethasone (2001) Antimicrob Agents Chemother, 45, pp. 3531-3537Sugawara, M., Saitoh, H., Iseki, K., Miyazaki, K., Arita, T., Contribution of passive transport mechanisms to the intestinal absorption of betalactam antibiotics (1989) J Pharm Pharmacol, 42, pp. 314-318Terada, T., Saito, H., Mukai, M., Inui, K.I., Recognition of beta-lactam antibiotics by rat peptide transporters, PEPT1 and PEPT2, in LLC-PK1cells (1997) Am J Physiol, 273, pp. 706-711Van Pelt, L.F., Ketamine and xylazine for surgical anesthesia in rats (1977) J Am Vet Med Assoc, 171, pp. 842-844Verba, V., Sakiniene, E., Tarkowski, A., Beneficial effect of glucocorticoids on the course of haematogenously acquired Staphylococcus aureus nephritis (1997) Scand J Immunol, 45, pp. 282-286Westphal, J.F., Brogard, J.M., Jehl, F., Carbon, C., Assessment of the role of enterocyte ion exchange in the intestinal absorption of amoxicillin, based on a study of the interaction with amiloride (1995) Pathol Biol, 43, pp. 590-595Yoshizumi, O.M., Lee, G.C., Equi, R.A., Kim, I.T., Pitchekian-Halabi, H., Adamu, S.A., Timing of dexamethasone treatment in experimental Staphylococcus aureus endophthalmitis (1998) Retina, 18, pp. 130-13
Tissue Pharmacokinetics Of Amoxicillin. An Experimental Design In Rats.
No full textAmoxicillin is used as the drug of first choice in many situations in medicine and dentistry, in spite of several reports regarding bacterial resistance. There is little data about the tissue concentration of this antimicrobial agent. Serum levels of amoxicillin have been evaluated in detail, but tissue levels have not. This study was carried out to determine the tissue concentration of amoxicillin during the first 10 h after administration. Four polyurethane sponges were implanted in the backs of 54 male rats. After 14 days, they received 40 mg/kg of po amoxicillin suspension. The animals were killed in groups of 6 at 15, 30, 60, 90, 120, 240, 360, 480 and 600 min after the administration. Serum, placed on paper discs, and granulomatous tissue were assayed by a microbiological method using Mueller Hinton agar inoculated with 108 cfu of Staphylococcus aureus (ATCC 25923). After 18 h of incubation, the inhibition zones were measured. It was observed that the drug in the serum and the tissue reached higher concentrations than MIC and MBC within a period of 30 min and 8 h following administration. We conclude that this method can allow determination of antibiotic tissue concentration without the need for infecting the animal and, therefore, without the associated animal pain and suffering in presently used models.4419720
Antibiotics And Pregnancy
No full textLike anybody else, pregnant women are susceptible to infections. The correct treatment of these women, however, must consider along with pathogens, the infection site and antibiotic pharmacokinetics, the fetus and possible side effects to the child. When prescribing over this special condition, the physician must remember that the prescription will affect two organism and the drug must treat the mother without affecting the fetus. Beta-lactams having a long history of use without significant deleterious effects on the fetuses still are the safest choice during pregnancy. However, considering the constant increase of multi-resistant microorganisms, the physician has been forced to use different antimicrobial agents. Usually, data regarding safety during pregnancy are very limited, which causes serious doubts during prescription. In addition, many studies regarding the safe use of antibiotics during pregnancy are inconclusive or demand more evidence. The present study is a wide revision regarding the use of antibiotics during pregnancy, considering their pharmacokinetics and the clinical experience in recent years. It also intends to assist the physician during prescription and to give information to the pharma-cists to help pregnant women.607483493Ahlfors, C.E., Unbound bilirubin associated with kernicterus: A historical approach (2000) J Pediatr, 137, pp. 540-544Andrade, S.E., Gurwitz, J.H., Davis, R.L., Chan, K.A., Finkelstein, J.A., Fortman, K., McPhillips, H., Platt, R., Prescription drug use in pregnancy (2004) Am J Obstet Gynecol, 191, pp. 398-407Aselton, P., Jick, H., Milunsky, A., Hunter, J.R., Stergachis, A., First-trimester drug use and congenital disorders (1985) Obstet Gynecol, 65, pp. 451-455(2004) Ketek - Telithromycin, , http://www.fda.gov/cder/foi/label/2004/21144_ketek_lbl.pdf, searched May, 2004(2004) Rulide - Approved Product Information 2000, , http://www.pharma.aventis.com.au/corporate/products/pi/ Rulide%20and%20Rulide%20D.pdf, searched DecemberBeard, C.M., Noller, K.L., O'Fallon, W.M., Kurland, L.T., Dahlin, D.C., Cancer after exposure to metronidazole (1988) Mayo Clin Proc, 63, pp. 147-153Berkovitch, M., Pastuszak, A., Gazarian, M., Lewis, M., Koren, G., Safety of the new quinolones in pregnancy (1994) Obstet Gynecol, 84, pp. 535-538Bibler, M.R., Frame, P.T., Hagler, D.N., Bode, R.B., Staneck, J.L., Clinical evaluation of efficacy, pharmacokinetics, and safety of teicoplanin for serious gram-positive infections (1987) Antimicrob Agents Chemother, 31, pp. 207-212Birkenfeld, A., Anteby, S.O., The effect of ampicillin and colistin on post-Caesarean section endometritis with identification of possible risk factors (1983) Aust N Z J Obstet Gynaecol, 23, pp. 204-207Blanchard, M., Oppliger, R., Bucher, U., Positive direct Coombs' test in acute leukemias and other hemoblastoses: Relation to clavulanic acid-containing antibiotics? (1989) Schweiz Med Wschr, 14-119, pp. 39-45Boobis, A.R., Lewis, P., Drugs in pregnancy. Altered pharmacokinetics (1982) Br J Hosp Med, 28, pp. 566-573Briggs, G.G., Freeman, R.K., Yaffe, S.J., (2002) Drugs in Pregnancy and Lactation. 6th Ed., pp. 284-312. , Baltimore: Williams & Wilkins(2004) Bristol-Myers Squibb Company: AzactamR, , http://www.fda.gov/cder/foi/label/2002/50580slr033lbl.pdf, searched May 2004Bryskier, A., Ketolides-telithromycin, an example of a new class of antibacterial agents (2000) Clin Microbiol Infect, 6, pp. 661-669Bush, M.R., Rosa, C., Azithromycin and erythromycin in the treatment of cervical chlamydial infection during pregnancy (1994) Obstet Gynecol, 84, pp. 61-63Campoli-Richards, D.M., Brogden, R.N., Faulds, D., Teicoplanin - A review of its antibacterial activity, pharmacokinetic properties and therapeutic potential (1990) Drugs, 40, pp. 449-486Chambers, H.S., Antimicrobial agents: Protein synthesis inhibitors and miscellaneous antibacterial agents (1996) Goodman &Gilman's the Pharmacological Basis of Therapeutics, 9 th Ed., pp. 1239-1272. , Hardman JG, Gilman AG, Limbird LE (ed.) , McGraw-HillChan, K.W., Ng, W.L., Gentamicin nephropathy in a neonate (1985) Pathology, 17, pp. 514-515Chastre, J., Brun, P., Fourtillan, J.B., Soler, P., Basset, G., Manuel, C., Trouillet, J.L., Gibert, C., Pulmonary disposition of roxithromycin (RU 28965), a new macrolide antibiotic (1987) Antimicrob Agents Chemother, 31, pp. 1312-1315Chimura, T., Morisaki, N., Funayama, T., Matsuo, M., Clinical studies on aztreonam in perinatal use (1990) Jpn J Antibiot, 43, pp. 696-699Christensen, B., Which antibiotics are appropriate for treating bacteriuria in pregnancy? (2000) J Antimicrob Chemother, 46 (SUPPL. 1), pp. 29-34Clark, P., Aztreonam (1992) Obstet Gynecol Clin North Am, 19, pp. 519-528Clemett, D., Markham, A., Linezolid (2000) Drugs, 59, pp. 815-827Conway, N., Birt, B.D., Streptomycin in pregnancy: Effect on the foetal ear (1965) Br Med J, 31, pp. 260-263Czeizel, A.E., Rockenbauer, M., A population-based case-control teratologic study of oral oxytetracycline treatment during pregnancy (2000) Eur J Obstet Gynecol Reprod Biol, 88, pp. 27-33Czeizel, A.E., Rockenbauer, M., Olsen, J., Use of antibiotics during pregnancy (1998) Eur J Obstet Gynecol Reprod Biol, 81, pp. 1-8Czeizel, A.E., Rockenbauer, M., Sorensen, H.T., Olsen, J., Teratogenic evaluation of oxacillin (1999) Scand J Infect Dis, 31, pp. 311-312Czeizel, A.E., Rockenbauer, M., Sorensen, H.T., Olsen, J., A population-based case-control teratologic study of oral erythromycin treatment during pregnancy (1999) Reprod Toxicol, 13, pp. 531-536Czeizel, A.E., Rockenbauer, M., Olsen, J., Sorensen, H.T., A teratological study of aminoglycoside antibiotic treatment during pregnancy (2000) Scand J Infect Dis, 32, pp. 309-313Czeizel, A.E., Rockenbauer, M., Olsen, J., Sorensen, H.T., Oral phenoxymethylpenicillin treatment during pregnancy. Results of a population-based Hungarian case-control study (2000) Arch Gynecol Obstet, 263, pp. 178-181Czeizel, A.E., Rockenbauer, M., Sorensen, H.T., Olsen, J., A population-based case-control teratologic study of oral chloramphenicol treatment during pregnancy (2000) Eur J Epidemiol, 16, pp. 323-327Czeizel, A.E., Rockenbauer, M., Sorensen, H.T., Olsen, J., The teratogenic risk of trimethoprim-sulfonamides: A population based case-control study (2001) Reprod Toxicol, 15, pp. 637-646Czeizel, A.E., Rockenbauer, M., Sorensen, H.T., Olsen, J., Use of cephalosporins during pregnancy and in the presence of congenital abnormalities: A population-based, case-control study (2001) Am J Obstet Gynecol, 184, pp. 1289-1296Czeizel, A.E., Rockenbauer, M., Sorensen, H.T., Olsen, J., A population-based case-control teratologic study of ampicillin treatment during pregnancy (2001) Am J Obstet Gynecol, 185, pp. 140-147Czeizel, A.E., Rockenbauer, M., Sorensen, H.T., Olsen, J., Augmentin treatment during pregnancy and the prevalence of congenital abnormalities: A population-based case-control teratologic study (2001) Eur J Obstet Gynecol Reprod Biol, 97, pp. 188-192Danisovicova, A., Brezina, M., Belan, S., Kayserova, H., Kaiserova, E., Hruskovic, I., Orosova, K., Matheova, E., Magnetic resonance imaging in children receiving quinolones: No evidence of quinolone-induced arthropathy. 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The Influence Of Altered Occlusion On Pro-inflammatory Cytokine Levels In The Tmj Synovial Tissues Of Rats
No full textObjective The aim of this study was to evaluate whether altered occlusion affects both the condylar cartilage thickness and the cytokine levels of the TMJs of rats. Design Thirty adult-male rats (n = 30) were randomly assigned to three experimental conditions: a control group that underwent sham operations with unaltered occlusion; an FPDM group that underwent functional posterior displacement of the mandible that was induced by an incisor guiding appliance; and an iOVD group in which the increased occlusal vertical dimension was induced in the molars. The rats were subjected to the FPDM or iOVD model for 14 days and then killed. Both the right and left TMJs were removed and randomly assigned to examination with staining or immunoassay techniques. Toluidine blue staining was used to measure the thicknesses of the four layers of the articular cartilage (i.e., the fibrous, proliferating, mature, and hypertrophic layers). ELISA assays were used to assess the concentrations of the pro-inflammatory cytokines IL-1α, IL-1β, IL-6, and tumour necrosis factor (TNF-α). The measurements of the articular cartilage layers and cytokine concentrations were analyzed with ANOVA and Tukey's tests and Kruskal-Wallis and Dunn tests, respectively (α = 5%). Results The thickness of articular cartilage in the FPDM group (0.3 ± 0.03 mm) was significantly greater than those of the control (0.2 ± 0.01 mm) and iOVD (0.25 ± 0.03 mm) groups. No significant difference was observed between the control and iOVD groups. The four articular cartilage layers were thicker in the FPDM group than in the control and iOVD groups, and the latter two groups did not differ one from each other. Both the FPDM and iOVD groups exhibited higher cytokine levels than did the control (p < 0.05) group. Compared to the FPDM group, the iOVD group exhibited significantly higher levels of IL-1β and TNF-α. Conclusion Both models induced inflammation in the TMJ and caused significant structural changes in the TMJ and surrounding tissues. © 2014 Elsevier Ltd.591111641171Xie, Q., Li, X., Xu, X., The difficult relationship between occlusal interferences and temporomandibular disorder - Insights from animal and human experimental studies (2013) J Oral Rehabil, 40 (4), pp. 279-295Kuang, B., Dai, J., Wang, Q.Y., Song, R., Jiao, K., Zhang, J., Combined degenerative and regenerative remodeling responses of the mandibular condyle to experimentally induced disordered occlusion (2013) Am J Orthod Dentofacial Orthop, 143 (1), pp. 69-76Liu, C., Kaneko, S., Soma, K., Effects of a mandibular lateral shift on the condyle and mandibular bone in growing rats (2007) Angle Orthod, 77 (5), pp. 787-793Wattanachai, T., Yonemitsu, I., Kaneko, S., Soma, K., Functional lateral shift of the mandible effects on the expression of ECM in rat temporomandibular cartilage (2009) Angle Orthod, 79, pp. 652-659Owtad, P., Potres, Z., Shen, G., Petocz, P., Darendeliler, M.A., A histochemical study on condylar cartilage and glenoid fossa during mandibular advancement (2011) Angle Orthod, 81 (2), pp. 270-276Satoh, K., Ogura, N., Akutsu, M., Kuboyama, N., Kuyama, K., Yamamoto, H., Expression of cyclooxygenase-1 and -2 in IL-1beta-induced synovitis of the temporomandibular joint (2009) J Oral Pathol Med, 38 (7), pp. 584-590Kaneyama, K., Segami, N., Nishimura, M., Suzuki, T., Sato, J., Importance of proinflammatory cytokines in synovial fluid from 121 joints with temporomandibular disorders (2002) Br J Oral Maxillofac Surg, 40 (5), pp. 418-423Tanimoto, K., Iwabuchi, Y., Tanne, Y., Kamiya, T., Inubushi, T., Kunimatsu, R., Interleukin-1 beta affects cyclooxygenase-2 expression and cartilage metabolism in mandibular condyle (2011) Arch Oral Biol, 56 (11), pp. 1412-1418Farias-Neto, A., Martins, A.P., Sánchez-Ayala, A., Rabie, A.B., Novaes, P.D., Rizzatti-Barbosa, C.M., The effect of posterior tooth loss on the expression of type II collagen, IL-1β and VEGF in the condylar cartilage of growing rats (2012) Arch Oral Biol, 57 (11), pp. 1551-1557Figueroba, S.R., Desjardins, M.P., Nani, B.D., Ferreira, L.E., Rossi, A.C., Santos, F.A., Effect of diazepam on temporomandibular joints in rats with increased occlusal vertical (2014) Br J Oral Maxillofac Surg, 52 (5), pp. 438-444Sun, L., Wang, M., He, J., Liu, L., Chen, S., Widmalm, S.E., Experimentally created nonbalanced occlusion effects on the thickness of the temporomandibular joint disc in rats (2009) Angle Orthod, 79 (1), pp. 51-53Mao, J.J., Rahemtulla, F., Scott, P.G., Proteoglycan expression in the rat temporomandibular joint in response to unilateral bite raise (1998) J Dent Res, 77, pp. 1520-1528Yamamoto, M., Involvement in morphological changes of the articular cartilage of rat temporomandibular joint induced by experimental malocclusion (1994) Fukuoka Igaku Zasshi, 85, pp. 78-90Cholasueksa, P., Warita, H., Soma, K., Alterations of the rat temporomandibular joint in functional posterior displacement of the mandible (2004) Angle Orthod, 74 (5), pp. 677-683Farias-Neto, A., Martins, A.P., Figueroba, S.R., Groppo, F.C., De Almeida, S.M., Rizzatti-Barbosa, C.M., Altered mandibular growth under functional posterior displacement in rats (2012) Angle Orthod, 82 (1), pp. 3-7Li, Y., Zhang, Z., Wu, S., Qiao, Y., A novel experimental design model for increasing occlusal vertical dimension (2010) J Craniofac Surg, 21 (2), pp. 450-457Zhang, X., Dai, J., Lu, L., Zhang, J., Zhang, M., Wang, Y., Experimentally created unilateral anterior crossbite induces a degenerative ossification phenotype in mandibular condyle of growing Sprague-Dawley rats (2013) J Oral Rehabil, 40 (7), pp. 500-508Kiliaridis, S., Thilander, B., Kjellberg, H., Topouzelis, N., Zafiriadis, A., Effect of low masticatory function on condylar growth: A morphometric study in the rat (1999) Am J Orthod Dentofacial Orthop, 116 (2), pp. 121-125Miehe, B., Fanghänel, J., Kubein-Meesenburg, D., Nägerl, H., Schwestka-Polly, R., Masticatory musculature under altered occlusal relationships - A model study with experimental animals (1999) Ann Anat, 181 (1), pp. 37-40Rabie, A.B., She, T.T., Hägg, U., Functional appliance therapy accelerates and enhances condylar growth (2003) Am J Orthod Dentofacial Orthop, 123 (1), pp. 40-48Mao, J.J., Rahemtulla, F., Scott, P.G., Proteoglycan expression in the rat temporomandibular joint in response to unilateral bite raise (1998) J Dent Res, 77 (7), pp. 1520-1528Fuentes, M.A., Opperman, L.A., Buschang, P., Bellinger, L.L., Carlson, D.S., Hinton, R.J., Lateral functional shift of the mandible: Part I. 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Pulmonary resection
No full textO autor faz uma avaliação dos modernos métodos de ressecção pulmonar, seus tipos e suas indicações. Analisa também os cuidados básicos, indispensáveis no Pré e Pós-operatório.The author points out some aspects of the modern methods of pulmonar resection and their main uses. The basic atention that must be avaiable during the pre and postoperative periods are also analised by the author
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