188 research outputs found
[heading:] Lied gesungen am 15|t|e|n Geburts-Tag des Prinzen Carl zu Fürstenberg. [right side:] J: W: Kalliwoda
No full textf. 2r-2v leer. - Abschrift des Autographs (D-KA Don Mus.Ms. 2849, Donaueschingen 1835). - f.1r unten: "F.K.E.3. N|o 63"Johann Wenzel KalliwodaDiplomatischer Titel: [heading:] Lied gesungen am 15|t|e|n Geburts-Tag des Prinzen Carl zu Fürstenberg. [right side:] J: W: KalliwodaQuelle: Manuscript copyProvenienz: Nachlass KalliwodaBesetzungshinweis: Coro T (2), Coro
Electrical management of heart failure: from pathophysiology to treatment
No full textElectrical disturbances, such as atrial fibrillation (AF), dyssynchrony, tachycardia, and premature ventricular contractions (PVCs), are present in most patients with heart failure (HF). While these disturbances may be the consequence of HF, increasing evidence suggests that they may also cause or aggravate HF. Animal studies show that longer-lasting left bundle branch block, tachycardia, AF, and PVCs lead to functional derangements at the organ, cellular, and molecular level. Conversely, electrical treatment may reverse or mitigate HF. Clinical studies have shown the superiority of atrial and pulmonary vein ablation for rhythm control and AV nodal ablation for rate control in AF patients when compared with medical treatment. Ablation of PVCs can also improve left ventricular function. Cardiac resynchronization therapy (CRT) is an established adjunct therapy currently undergoing several interesting innovations. The current guideline recommendations reflect the safety and efficacy of these ablation therapies and CRT, but currently, these therapies are heavily underutilized. This review focuses on the electrical treatment of HF with reduced ejection fraction (HFrEF). We believe that the team of specialists treating an HF patient should incorporate an electrophysiologist in order to achieve a more widespread use of electrical therapies in the management of HFrEF and should also include individual conditions of the patient, such as body size and gender in therapy fine-tuning
Das Leben des Höchstseligen Durchlauchtigsten Prinzen Albrecht Heinrichs, Prinzen von Braunschweig und Lüneburg etc. / [J. F. W. Jerusalem]
No full textVerfasser am Ende des Vorwortes genanntEnthält Beiträge von: "... Hornbostel ..." und "... v. W."Die Rückseite des Titelblatts ist unbedrucktVorlageform der Veröffentlichungsangabe: Braunschweig, im Verlag der Fürstl. Waisenbuchhandlung 1774
Die Feier der Geburt Des Durchlauchtigsten Herrn Erb-Prinzen zu Sachsen Weimar und Eisenach et[c]. begehen in tiefster Unterthänigkeit die Studirenden der ersten und zwoten Classe des Herzoglichen Gymnasiums zu Weimar
No full textDIE FEIER DER GEBURT DES DURCHLAUCHTIGSTEN HERRN ERB-PRINZEN ZU SACHSEN WEIMAR UND EISENACH ET[C]. BEGEHEN IN TIEFSTER UNTERTHÄNIGKEIT DIE STUDIRENDEN DER ERSTEN UND ZWOTEN CLASSE DES HERZOGLICHEN GYMNASIUMS ZU WEIMAR
Die Feier der Geburt Des Durchlauchtigsten Herrn Erb-Prinzen zu Sachsen Weimar und Eisenach et[c]. begehen in tiefster Unterthänigkeit die Studirenden der ersten und zwoten Classe des Herzoglichen Gymnasiums zu Weimar ([1]
Assessment of mechanical dyssynchrony can improve the new ESC-2021 guidelines for cardiac resynchronization therapy
No full textBackground: In 2021, new guidelines for cardiac resynchronization therapy (CRT) were published by the European society of cardiology (ESC-2021), where the different classes of recommendations were based on a new ECG-based definition of left bundle branch block (LBBB). However, its association with reverse LV remodeling and additive prognostic value remain unknown.Type of funding sources: Public grant(s) – EU funding. Main funding source(s): European Union’s Horizon 2020 research and innovative program under the Marie Sklodowska -Curie grant agreement No. 86074
Comparison of regional blood flow values measured by radioactive and fluorescent microspheres
No full textFluorescent microspheres (FM) have become an attractive alternative to radioactive microspheres (RM) for the measurement of regional blood flow (RBF). The aim of the present study was to investigate the comparability of both methods by measuring RBF with FM and RM. Eight anaesthetised pigs received simultaneous, left atrial injections of FM and RM with a diameter of 15 mum at six different time points. Blood reference samples were collected from the descending aorta. RBF was determined in tissue samples of the myocardium, spleen and kidneys of all 8 animals. After radioactivity of the tissue samples was determined, the samples were processed automatically for measuring fluorescence using a recently developed filter device (SPU). RBF was calculated with both the isotope and spectrometric data of both methods for each sample resulting in a total of 10,512 blood flow values. The comparison of the RBF values yielded high linear correlation (mean r(2) = 0.95 +/- 0.03 to 0.97 +/- 0.02) and excellent agreement (bias 5.4-6.7%, precision 9.9-16.5%) of both methods. Our results indicate the validity of MS and of the automated tissue processing technique by means of the SPU. Copyright (C) 2002 S. Karger AG, Basel
Subepicardial fiber strain and stress as related to left ventricular pressure and volume
No full textIn a mathematical model of the mechanics of the left ventricle (LV) by Arts et al. (1), assuming uniformity of fiber stress ([sigma](f)) and fiber strain ([Delta][epsilon](f)) in the wall during the ejection phase, fiber stress and fiber strain were related to LV cavity pressure (P(lv)), LV cavity volume (V(lv)) and wall volume (V(w)) by the following pair of equations: [sigma](f) = P(lv) (1 + 3 V(lv)/V(w)) and [Delta][epsilon](f) = 1/3 [Delta]ln(1 + 3 V(lv)/V(w)). The ratio of V(lv) to V(w) appeared to be the most important geometric parameter, whereas the actual LV shape was of minor importance. The relationships on fiber strain and stress were evaluated experimentally in six anesthetized open-chest dogs during normal and elevated (volume loading) end-diastolic LV pressure. Subepicardial fiber strain was measured simultaneously in 16 adjacent regions of the LV anterior wall, using optical markers that were attached to the epicardial surface and recorded on video. Changes in V(lv) were measured by use of four inductive coils sutured to the LV in a tetrahedric configuration. V(w) was measured postmortem. During control as well as hypervolemia the following results were found. At the anterior free wall of the LV, the slope of the estimated linear relationship between measured and calculated fiber strain was 1.017 +/- 0.168 (means +/- SD), which is not significantly different from unity. Calculated fiber stress corresponded qualitatively and quantitatively with experimental results reported on isolated cardiac muscle. Calculated subepicardial contractile work per unit of tissue volume was not significantly different from global pump work as normalized to V(w). These findings support the assumption of homogeneity of muscle fiber strain and stress in the left ventricular wall during the ejection phase. Furthermore, average values of fiber stress and strain can be estimated on the basis of measured left ventricular pressure and volum
Nimm zu dieses Festes Feier für dein Herz - Don Mus.Ms. 2849 : Coro maschile; F; StrK WoO 8.23
No full textÜber dem Beginn des Notentextes (vermutlich autograph): "von J: W: Kallidowa"Johann Wenzel KalliwodaQuelle: partly autograph. - Provenienz: Fürstlich Fürstenbergische Hofbibliothek, Donaueschingen[title page:] Lied | gesungen am 15|t|e|n Geburts=Tag des Prinzen | Carl zu Fürstenber
Pathophysiology of dyssynchrony: of squirrels and broken bones
No full textThe genesis of cardiac resynchronisation therapy (CRT) consists of 'bedside' research and 'bench' studies that are performed in series with each other. In this field, the bench studies are crucial for understanding the pathophysiology of dyssynchrony and resynchronisation. In a way, CRT started with the insight that abnormal ventricular conduction, as caused by right ventricular pacing, has adverse effects. Out of this research came the ground-breaking insight that 'simple' disturbances in impulse conduction, which were initially considered innocent, proved to result in a host of molecular and cellular derangements that lead to a vicious circle of remodelling processes that facilitate the development of heart failure. As a consequence, CRT does not only correct conduction abnormalities, but also improves myocardial properties at many levels. Interestingly, corrections by CRT do not exactly reverse the derangements, induced by dyssynchrony, but also activate novel pathways, a property that may open new avenues for the treatment of heart failure
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