2,729 research outputs found
Unmarried women in Haarlem, the Netherlands, 1820-1850, 1984
No full textIndependence and status of unmarried women in the first half of the 19th century, with special attention to women living with other women. Data about unmarried women in Haarlem from: ( 1 ) the general population census in 1829, ( 2 ) the general population census in 1939, ( 3 ) a register of people settling in Haarlem covering 1821-1850 ( and from municipal archives and other sources ) were collected. These data are analyzed with respect to demographic aspects, motherhood, employment, wages, religion, housing, ways of living with other people, legal status and social class
Variations on the Author
No full text“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
I don't think we are alone; interview
No full textThere are scores of earth-like planets outside our solar system. Dr Daphne Stam (faculty of Aerospace Engineering) wants to launch a space telescope to search for life on these planets.Space EngineeringAerospace Engineerin
De merkwaardige geschiedenis van de stoel van Stam
No full textEen spannend verhaal over de merkwaardige en gecompliceerde geschiedenis van de achterpootloze stoel, Mart Stam, Marcel Breuer, Breuer-Stam hybriden, auteursrechten en licenties.ArchitectureArchitecture and The Built Environmen
Functional brain networks in multiple slerosis: linking structural pathology to clinical disability
No full textStam, C.J. [Promotor]Polman, C.H. [Promotor]Hillebrand, A. [Copromotor]Barkhof, F. [Copromotor
The effect of initial linkage disequilibrium and natural selection in pooled populations : experiments with Tribolium and simulation
No full textIn chapter 2 a number of the mechanisms are discussed through which genetic polymorphisms can be maintained in natural populations: overdominance, frequency dependent selection and neutral alleles with associative overdominance. The overdominance model is emphasized because overdominance is also the basic feature of the associative overdominance model. Different theoretical relationships between number of heterozygous loci and fitness are explored, including their implications with regard to mean population fitness and selection coefficients at individual loci in an ideal population. From these, King's threshold model for multiple gene action on fitness proved to be the most satisfactory in all respects: it accomodates fairly high selection coefficients at individual loci without implying too heavy a load; it further explains different inbreeding depressions for different organisms and for different environments, as well as genotype by environment interaction. The model of associative overdominance, with the incorporation of King's threshold model for multiple gene action, has been chosen as an operational hypothesis for explanation of my experimental results (chapter 3) and as a basis for the simulation study (chapter 4).Chapter 2 further discusses the implications of associative overdominance (which is a result of overall linkage disequilibrium in finite populations) when linkage disequilibrium is generated artificially by using a small sample to found a new population. In this situation pseudo-frequency dependent selection is expected to occur at selectively neutral loci. An experimental design is proposed which distinguishes between apparent and real frequency dependent selection.Chapter 3 presents the experiments: individuals from two laboratory stocks of Tribolium castaneum HERBST, together with their F 1 , were used to initiate a set of polymorphic populations (for the black locus) with different frequencies of the marker allele. These experiments, jointly taken, indicate that the black locus itself is selectively neutral under the current experimental conditions and rule out the possibility of real frequency dependent selection. There was however apparent selection against the mutant allele due to initial linkage disequilibrium. This linkage disequilibrium is described in terms of the different genotypic backgrounds of the components (wild type and mutant stock and F 1 ) of the founder population: in the mutant stock there is an excess of homozygosity which may be randomly distributed over the chromosomes or may be partially or wholly concentrated in a chromosome region near the marker locus. This confirms the expectation formulated in the Introduction (chapter 1). The initial linkage disequilibrium, in these experiments is not so much due to small samples from the founder stocks as to the different genotypic backgrounds of the founder stocks, and, with respect to neutral loci, implies associative dominance rather than associative overdominance. The apparent decrease in selection against the b allele is a result of the approach to linkage equilibrium.A comparison of the fitness differences among the original marker genotypes (wild type, mutant black and F 1 ) on the one hand and the marker genotypes of an F 2 population on the other band, showed that the fitness loci closely linked to the marker locus and the joint non-linked fitness loci made approximately equal contributions to the fitness contrast between the two founder stocks (i.c. a lower fitness of the mutant stock). It also showed that, under the current experimental conditions, differential viability only played a minor role, if any, in the gene frequency changes of the b allele in the pooled populations.Chapter 4 presents a computer model for (stochastic) simulation of the population experiments. This model is based on the hypothesis of overdominance at the chromosomal level and on the assumption that only the marker chromosome contributes to the fitness difference between the founder stocks. For this purpose FRASER'S technique of binary representation of genotypes was adopted.After correction for some discrepancies between the simulation model and the experiments (in the simulation only the marker chromosome is considered and selection acts through differential viability), the results of simulation proved to be in fairly good agreement with the experimentally obtained results. The simulation model can readily be adapted to other situations, e.g. both founder stocks being 'inbred', tracking the gene frequencies at more than one neutral locus, and any arbitrary function relating the number of heterozygous loci to fitness.The final conclusion from both the experiments and the simulation study is, that after introducing the relatively 'inbred' mutant stock into the wild type population, a great deal of the genetic material of the mutant stock is lost by natural selection. For practical breeding this implies a risk of losing part of the genetic material, as a result of natural selection, from small samples of (relatively) inbred populations which are introduced into a breeding stock. Of course, the breeder may artificially select in favour of a fitness-neutral character introduced by the 'fresh' genetic material; however, the effect of artificial selection may be greatly reduced when (in the initial generations) natural selection outweighs artificial selection, since natural selection 'acts' against the desired character through linkage disequilibrium with fitness loci
Central Station and issues of identity in film form and critical debates
No full textDissertação (mestrado) - Universidade Federal de Santa Catarina, Centro de Comunicação e Expressão, Programa de Pós-graduação em Letras/Inglês e Literatura Correspondente, Florianópolis, 2009O presente trabalho trata de questões relacionadas à construção de uma identidade cultural brasileira no filme Central do Brasil, dirigido por Walter Salles, a partir da perspectiva fílmica e também relacionada aos debates críticos que o filme gerou em resenhas americanas e brasileiras. Argumenta-se que o filme é uma metáfora da busca por identidade, argumento usado pelo próprio diretor. Esta busca se dá no nível pessoal, no caso das personagens principais, Dora e Josué, e nacional, já que o filme encoraja a associação da jornada das personagens a uma busca pela identidade nacional brasileira. A pesquisa buscou encontrar os elementos fílmicos que remetem a essa hipótese de que o filme é uma metáfora da busca por identidade, bem como de que forma (e se) os debates críticos gerados a partir do filme identificaram essa questão da busca. Para teorias de identidade, autores como Stuart Hall, Zygmunt Bauman e Robert Stam foram usados. Para teoria fílmica foram usados trabalhos de David Bordwell e Marcel Martin. Para estudos em cinema brasileiro, leituras de trabalhos de Luiz Zanin Oricchio, Robert Stam e Sidney Ferreira Leite foram realizadas. A análise mostrou que o filme, de fato, traz elementos que podem ser relacionados à metáfora da busca por identidade.This research addresses questions related to the construction of a Brazilian cultural identity in the film Central Station, directed by Walter Salles, from the perspective of film form, and concerning the critical debates prompted by the film in Brazilian and American reviews. The film is argued to be, by the director himself, a metaphor for the search for identity, both personal, in the case on the main characters, Dora and Josué, and national, since the film encourages the association of the characters' journey to a search for a Brazilian identity. What this research sought to find were the elements in film form that relate to this hypothesis of the film as a metaphor for the search of identity, and how and if the critical debates prompted by the film identified the issue of identity. For the issue of identity, critics such as Stuart Hall, Robert Stam, and Zygmunt Bauman were invoked. For Film Studies, theorists such as Bordwell and Marcel Martin were used. For readings in Brazilian Cinema, the works of Luiz Zanin Oricchio, Robert Stam and Sidney Ferreira Leite were used. The analysis showed that the film, indeed, brings elements that can be related to a metaphor for the search for identity
Perceived need for information and treatment decision-making in patients with hematological malignancies: not "one size fits all"
No full textVerdonck-de Leeuw, I.M. de [Promotor]Zweegman, S. [Promotor]Stam, F. [Copromotor]Zuuren, F.J. van [Copromotor
Entrepreneurship and innovation policy
No full textWhat is meant by entrepreneurship, innovation and economic growth is often not clear or very idiosyncratic. This paper starts with a discussion of the nature of entrepreneurship and its relation to innovation. The second section provides an overview of theory and empirical research on the relation between entrepreneurship, innovation and economic growth. The paper continues with a study on entrepreneurship and innovation in the Netherlands in an international and historical perspective. After these conceptual, theoretical and empirical investigations, we turn to policy issues
<i>stam</i> is required to properly localise FGFR/Btl and fully activate FGFR signalling.
No full text<p>A–C. Localisation of Btl in wild type and mutant tracheal cells. High magnification pictures of wild type (A), <i>stam</i> (B) and <i>hrs</i> (C) MARCM mutant cells in the ASP. Scale bar equals 15 µm. Mutant cells were visualised <i>via</i> the expression of <i>UAS-btl-GFP</i> (green). The tracheal cells were visualised with RFP-moesin (red). White arrow indicates the presence of Btl at the cell membrane in wild type cells while yellow arrows indicate Btl as dotted structures. The dotted structures are dramatically enlarged in <i>stam</i> and <i>hrs</i> mutant cells as compared to <i>wild type</i> cells. D–F. <i>pointed</i> expression in wild type and <i>stam</i> mutant tracheal cells. Scale bars: 15 µm. <i>pointed</i> expression is restricted to the distal part, the tip, of a wild type ASP (D–D″). In a <i>stam</i> mutant clone located at the proximal part of the ASP, <i>pointed</i> expression is unchanged (E–E″). When the <i>stam</i> clone is positioned close to or at the distal tip of the ASP: <i>pointed</i> expression is lost (F–F″). Dotted lines showed the position of the <i>stam</i> mutant cells in the ASP (E′, F′). Arrows indicate the distal tip of the ASP (E″, F″).</p
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