75 research outputs found
Toxicological screening after the REMEDI
No full textThe REMEDI™ will no longer be supported. Therefore, we had to introduce a new procedure for the general unknown screening. We introduced the GC-MS screening procedure published by Maurer et al. (1) and compared its performance with the REMEDI™ for the four different drug classes: antidepressants, antipsychotics, non-opioid analgesics and anticonvulsants.
Half of the urine sample has been hydrolysed by acid hydrolyses and then been combined
with the other half. Trimipramine-d3 has been added as internal standard and liquid-liquid extraction was performed with dichloromethane/ isopropanol/ethylacetate. The organic phase was evaporated and the residue derivatized with acetanhydride/pyridine using microwave energy.
After evaporation, the residue was dissolved in 50 μl toluene/ethylacetat
e and injected into a TraceTM GC 2000 coupled to a MD 800 mass spectrometer (ThermoQuest, San José, USA). With the exception of sertraline, all antidepressants used in Switzerland could be detected with both methods below the concentration usually found in urine after therapeutic use (cU). The GC-MS procedure had a higher sensitivity for all compounds analysed. Many antipsychotic drugs are only minimally excreted in urine as unchanged drug. Therefore, the detection limit of the
parent drug was often much higher than the cU. The metabolites however could be detected
sufficiently. With the exception of amisulpride, sulpiride and tiapride, all antipsychotics had a
higher sensitivity with the GC-MS procedure.
The non-opioid analgesics and anticonvulsants can only incompletely be detected by the REMEDI™. With the GC-MS procedure all acid drugs of the before mentioned drug classes can only be detected in toxic concentrations. The introduction of a second extraction step using an acidic pH did not improve the sensitivity.
In conclusion, the modified GC-MS screening procedure allows a very complete detection of the antidepressants, antipsychotics, non-opioid analgesics and anticonvulsants. The disadvantage of this new procedure is a turnaround time of about 2 hours
Collezionismo lunense: l’autobiografia del Marchese Angelo Alberto Remedi cultore di archeologia e numismatica nell’Archivio di Stato di Massa
No full textSi ripercorrono la formazione e l'attività del marchese Angelo Remedi, studioso e collezionista delle antichità lunensi, attraverso la breve autobiografia conservata nell'Archivio di Stato di Massa
Il marchese Angelo Alberto Remedi e “Il desiderio e il pensiero di dedicarsi agli studi di archeologia”
No full textAttraverso l’autobiografia di Alberto Angelo Remedi, si seguono le vicende formative e l’attività dello studioso che intrattenne relazione con importanti esponenti della cultura del suo tempo. Grazie all’attività di scavo condotta nei propri terreni a Luni, diede vita al primo museo lunense, favorendo lo sviluppo degli studi sulla città romana
Translation of the REMEDI[e]S (Review of potentially inappropriate MEDIcation pr[e]scribing in Seniors) explicit criteria into seminatural language for use in prescription support systems: A multidisciplinary consensus.
No full textBy recovering data in an ordered manner and at the right time, clinical decision support systems (CDSSs) are designed to help healthcare professionals make decisions that improve patient care.The aim of the present study was to translate the REMEDI[e]s tool's explicit criteria, France's first reference list of potentially inappropriate drugs for the elderly, into seminatural language, in order to implement these criteria as alert rules and then enable their computer coding in a CDSS.This work was carried out at Lille University Hospital by a team of clinical pharmacists with expertise in the use of pharmaceutical decision support systems, in collaboration with the authors of the REMEDI[e]s tool. A total of 3 multi-professional consensus meetings were required to discuss the construction of each rule in seminatural language and the coding choices.All REMEDIES criteria (n=104) were translated into seminatural language. This study is the first to have translated the 104 REMEDI[e]s explicit criteria into seminatural language.One of the study's strengths relates to the close collaboration between the authors of the REMEDI[e]s tool and experts in CDSS programming rules; this ensured the exactitude of the seminatural language translations and limited (mis)interpretations.Copyright © 2024 The Author(s). Published by Elsevier Masson SAS.. All rights reserved
IDENTIDADES ACADÉMICAS: DE LA UTOPÍA A LA PRODUCTIVIDAD
No full textEn un trabajo anterior hemos explorado las transformaciones de las identidades institucionales de dos generaciones de psicólogos de la UNAM. Aquellas generaciones fueron los primeros actores de un innovador cambio curricular implementado en la institución en la década de los años setenta y que ha marcado profundamente las identidades académicas de ambas generaciones. Desde entonces ha habido cambios importantes en las formas de gestión institucional particularmente con la implementación de nuevas formas de regulación del trabajo académico que plantean nuevas exigencias a los académicos en términos de evaluación, de productividad y de reconocimiento. Algunas de nuestras preguntas hoy se anudan alrededor de los procesos de reestructuración de las identidades académicas de miembros de distintas generaciones, en función de los nuevos modelos de gestión universitaria. Interesa particularmente observar las distintas dinámicas y “ acomodos” identitarios en función de los procesos y trayectos previos, particularmente en aquellos que construyeron en un primer momento sus identidades académicas encontrando un fuerte sostenimiento en modelos utópicos innovadores y vivieron momentos de dolorosas rupturas y aquellos que ingresaron posteriormente en la universidad, con una ausencia de proyectos institucionales que les pudiera interpelar y constituir nichos para el anclaje de sus identificaciones
Del Solís a Flor de Maroñas: Ubú de Enrique Permuy y repensando el teatro desde la travesía y la frontera
No full textThe 2005 adaptation of Alfred Jarry’s Ubú Rey by Enrique Permuy and Polizonteatro in Flor de Maroñas, a working-class neighborhood in the outskirts of Montevideo, did more than transform the play into a street spectacle. This article explores the connections between the event, which was later replicated in La Teja and other working-class neighborhoods, and a series of poetic and theoretical considerations, including theatre as “journey” and the physical translation of the play to “the border” of Montevideo. This relocation was also a journey to “a cultural frontier,” to the limits and the outside of our lettered, middle-class notions of theatre and theatricality. The author recurs to the notion of “transmodernity” as an alternative to the modern and postmodern aesthetic that predominates within academic circles and renders transmodern theatre invisible. The article also examines the convivial and place-time-specific quality of theatrical productions and the ways in which a long, deep and lively carnivalesque theatrical tradition within working-class neighborhoods makes possible an effective social encounter, exchange, and communication
Impaired Glucose Tolerance in Mice Implanted with High Dose Slow-Release Glibenclamide Pellets
No full text<p>GTTs on WT mice before (A), 2 d (B), 7 d (C), 42 d (D), 95 d (E), and 118 d (F) after implantation of pellets containing high doses of glibenclamide. Each group contained ten mice, except five in (E) and (F). Mice were injected intraperitoneally with glucose (1.5 g/kg). Blood was taken at times indicated and assayed for glucose concentration. In each graph, asterisks indicate control group is significantly different (<i>p</i> < 0.05) from the test group at the specified time point.</p
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Robust Estimation of Integrated Volatility
No full textWe introduce a new method to estimate the integrated volatility (IV) based on noisy high-frequency data. Our method employs the ReMeDI approach introduced by Li and Linton (2021a) to estimate the moments of the microstructure noise and thereby eliminate their influence, and the pre-averaging method to target the volatility parameter. The method is robust: it can be applied when the efficient price exhibits stochastic volatility and jumps, the observation times are random and endogenous, and the noise process is nonstationary, autocorrelated and dependent on the efficient price. We derive the limit distribution for the proposed estimators under infill asymptotics in a general setting. Our simulation and empirical studies demonstrate the robustness, accuracy and computational efficiency of our estimators compared to several alternatives recently proposed in the literature
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Robust Estimation of Integrated and Spot Volatility
No full textWe introduce a new method to estimate the integrated volatility (IV) and the spot volatility (SV) based on noisy high-frequency data. Our method employs the ReMeDI approach introduced by Li and Linton (2022a) to estimate the moments of microstructure noise and thereby eliminate their influence, and the pre-averaging method to target the volatility parameter. The method is robust: it can be applied when the efficient price exhibits stochastic volatility and jumps, the observation times are random, and the noise process is nonstationary, autocorrelated, asymptotically vanishing and dependent on the efficient price. We derive the limit distributions for the proposed estimators under the infill asymptotics in a general setting. Our extensive simulation studies demonstrate the robustness, accuracy and computational efficiency of our estimators compared to several alternative estimators recently proposed in the literature. Empirically, we show that neglecting the complexities of noise and the random observation times yields substantial biases in volatility estimation and may lead to a different intraday volatility pattern
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