1,721,143 research outputs found
Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Variations on the Author
Full text link“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Long-term in vivo host immune modulation following CD19-CAR-T cell therapy in diffuse large B-cell lymphoma and B-lineage ALL patients
Full text linkChimeric antigen receptor (CAR)-T cells represent a potentially curative strategy for patients with advanced relapsed or refractory (R/R) B-cell malignancies. However, little is known about the in vivo effects of this treatment on the patients' immune lymphocyte populations. In this study, we investigated the effects of Axi-cel and Tisa-cel administration in the control of R/R diffuse large B-cell lymphoma (DLBCL) and B-lineage acute lymphoblastic leukemia (B-ALL), with a primary focus on the immunomodulatory changes induced over time on the host immune system of treated patients. Despite the short in vivo persistence of CAR+ cells, we could document a constant and significant increase over time of CD3+, CD4+, CD8+ and NK cells, associated with an increased capacity of T lymphocytes to produce IFNγ and TNFα. The results obtained also highlight the fact that different co-receptors endow T cells with different functions: the presence of 4-1BB or CD28 domain affects T cells function and fate and our results suggest that infusion with Tisa-cel product induces a bigger expansion of T lymphocytes compartment, which is also found to be functionally more active in producing immunomodulatory cytokines, compared to Axi-cel. We, furthermore, confirmed the prominent role of plasmatic IL-6 in mediating CRS, but we also emphasized the involvement of plasmatic IL-8 in ICANS pathophysiology. IL-8, moreover, emerged as a new early indicator of clinical response, as high IL-8 levels at T3d resulted associated with partial or absent response evaluated at day 30 and month 3. Taken together, these findings show that CAR-T cells are capable to exert a modulation and activation of host immune system, highlighted the differences induced by different product phenotypes and shed light on the role of IL-6 and IL-8 in adverse events
Appropriate Similarity Measures for Author Cocitation Analysis
Full text linkWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
Investigation on the detergent role in the function of secondary quinone in bacterial Reaction Centers
No full textPotential of biocontrol agents, antioxidant compounds and natural extracts on aflatoxin containment: a simple and highthroughput procedure
No full textAflatoxin B1 is considered one of the most dangerous mycotoxin for humans and animals health. Moreover severe economic losses may be encountered due to its possible contamination of food and feed during each step of their transformation process (from field to table). Preventing fungal infection/ toxin contamination of crops in the field is considered the preferred strategy to cope with the “aflatoxin risk”.
Biocontrol by competitive inhibition using atoxigenic (afla–) Aspergillus flavus strains has been shown to be an effective method in aflatoxin containment in peanuts, maize and cottonseed(1). Naturally occurring populations of afla– strains are considered reservoirs from which to select the strongest biocompetitors. However, the selection of biocontrol strains is not an easy task, due both to the small amount of afla– strains and to the various environmental conditions that may affect their efficacy in the field(2). High throughput procedures are therefore desirable to screen large amount of isolates in order to identify “good competitors”. Moreover, as field trials required to assess their efficiency are expensive and laborious, reconstruction experiments have been generally performed under laboratory conditions to investigate the biological mechanisms underlying the efficacy of afla– strains in preventing aflatoxin production and/or to give a preliminary indication of strain performance when released in the crops.
We developed a simple and inexpensive fluorescence-based procedure that may be used: 1) to scale-up the screening process(3) and also 2) to increase knowledge on the mechanisms interfering with mycotoxin production during intraspecific competition and 3) to analyze the effect of natural and/or synthetic compounds for their possible effects on aflatoxin biosynthesis.
Here we give a report of our results concerning the evaluation of the potential of afla– strains, colonizing the corn fields of the Po Valley, in reducing aflatoxin accumulation, and show some preliminary evidence that suggest the possible use of antioxidants as part of an additional strategy to contain aflatoxin contamination of food and feed commodities. Conversely the procedure may be used to uncover the presence of antioxidant agents in complex mixtures deriving from natural sources
Dispelling the Myths Behind First-author Citation Counts
Full text linkWe conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued
use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation
counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more
sophisticated methods
koamabayili/VECTRON-author-checklist: VECTRON author checklist
No full textWe have done our best to complete the author checklist relating to the use of animals in the hut study. Note that the objective for the hut study was to evaluate the IRS treatment applications for residual efficacy against Anopheles mosquitoes, including the local An. coluzzii mosquito population. Cows were only used to attract mosquitoes into the huts and no tests were carried out directly on the cows. The author checklist is intended for use with studies where experiments are carried out on animals, which is why we have had such difficulty in completing this for the hut study, as many of the questions do not relate to how the cows were used
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