31 research outputs found
Prostaglandin F receptor expression in intrauterine tissues of pregnant rats
No full textIn this investigation, we studied the expression and localization of rat prostaglandin F (FP) receptor in uterine tissues of rats on gestational Days 10, 15, 18, 20, 21, 21.5 and postpartal Days 1 and 3 using Western blotting analysis, real-time PCR, and immunohistochemistry. A high level of immunoreactivity was observed on gestational Days 20, 21, and 21.5 with the most significant signals found on Day 20. FP receptor protein was expressed starting on gestational Day 15, and a fluctuating unsteady increase was observed until delivery. Uterine FP receptor mRNA levels were low between Days 10 and 18 of gestation (p < 0.05). The transcript level increased significantly on Day 20 and peaked on Day 21.5 just before labor (p < 0.05). There was a positive correlation between FP receptor mRNA expression and serum estradiol levels (rs = 0.78; p < 0.01) along with serum estradiol/progesterone ratios (rs = 0.79; p < 0.01). In summary, we observed an increase FP receptor expression in rat uterus with advancing gestation, a marked elevation of expression at term, and a concominant decrease during the postpartum period. These findings indicate a role for uterine FP receptors in the mediation of uterine contractility at term
Systemic rifampicin treatment accelerates inferior alveolar nerve regeneration: an experimental animal study
No full textPhysician and Patient Preferences for Oral Anticoagulation Therapy Decision Making in Atrial Fibrillation: Results From a National Best–Worst Scaling Survey in Türkiye
No full textAtrial fibrillation (AF) is the most common cardiac dysrhythmia and a common cause of ischemic stroke. Stroke prevention with oral anticoagulation (OAC) is the cornerstone of AF management. Patients and their treating physicians may have different views on different attributes of OACs. The objective of this study was to quantify the relative importance that patients and physicians in Turkey place on different OAC attributes when making treatment decisions in AF. A cross-sectional survey was administered to AF patients (≥ 50 years) receiving OAC and practising cardiologists, including residents with ≥ 2 years of experience in Turkey. For both patients (N 230; 50 male) and physicians (N 194; 74 male), the most important attributes for OAC treatment decision making in AF were “success in preventing stroke” (57 and 73.9 or overall importance, respectively) and “risk of major bleeding” (20 and 23.4, respectively). For patients, other attributes were much less important, but not altogether unimportant: reversal agent availability (7), monitoring (5), food or drug interactions (3), minor bleeding (3), and ease of swallowing (2). For physicians, among the other attributes, only the need for monitoring (1.3) had a relative importance of > 1. For all Turkish participants, efficacy and safety were found to be the most important attributes influencing OAC choice in AF with these two attributes accounting for 77 and 97.3 of overall importance for patients and physicians, respectively. Certain considerations, especially reversal agent availability and monitoring appear to be more important to patients than to physicians This is the first study to use BWS to quantify patient and physician preferences for OAC treatments in AF in Turkey. © 2024 The Author(s). Clinical Cardiology published by Wiley Periodicals, LLC.The Yeditepe University Open Access System is a compendium of indexed publications. Copyright and usage rights may be held by publishers and/or authors. The collection was established for the scientific publications prepared by Yeditepe University academicians and is to be found in the institutional archive
Alendronate and pamidronate induce cytotoxicity and apoptosis in cultured human gingival fibroblasts
No full textAn economic analysis of tobacco control policies in Turkey
No full textTo evaluate the costs and benefits of various anti-smoking policy alternatives including taxation and four cessation programs, accounting for the demographic projections in 2011-2050 in Turkey. Demographic projections are combined with incidence and mortality rates of four major cigarette related diseases, price elasticity of cigarette demand and unit costs of nonprice measures to reduce demand in order to estimate the net present discounted values of policy alternatives. Among policy alternatives that yield the same amount of cigarette consumption, cessation programs yield lower costs to households and the society at large than taxation, while taxation is preferred by the public sector. Net benefit to the public sector as a function of the tax rate is a single-peaked Laffer curve. The public sector can obtain the highest net benefit if it raises the special consumption tax rate from its current level by nearly 9 percentage points. Although intervention programs emerge as the preferred anti-smoking alternatives, more research is needed on estimating the cost-effectiveness and social desirability of taxation and intervention programs in Turkey.
The extrusion of root canal cement containing paraformaldehyde into the inferior alveolar nerve canal resulting in infection and numbness
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