37 research outputs found
Musée du dessinateur de fabrique, ou, Matériaux et archives du manufacturier,
No full text"Il paraîtra un Cahier tous les mois." Contains Cahiers 7 to 12 bound together.Mary Ann Beinecke Decorative Art Collection. Sterling and Francine Clark Art Institute Library.Mode of access: Internet
In vitro lipolysis tests on lipid nanoparticles: Comparison between lipase/co-lipase and pancreatic extract
No full textPrior stimulation of the endocannabinoid system prevents methamphetamine-induced neurotoxicity in the striatum through activation of CB2 receptors
No full textMethamphetamine toxicity is associated with cell death and loss of dopamine neuron terminals in the striatum similar to what is found in some neurodegenerative diseases. Conversely, the endocannabinoid system (ECS) has been suggested to be neuroprotective in the brain, and new pharmacological tools have been developed to increase their endogenous tone. In this study, we evaluated whether ECS stimulation could reduce the neurotoxicity of high doses of methamphetamine on the dopamine system. We found that methamphetamine alters the levels of the major endocannabinoids, anandamide (AEA) and 2-arachidonoyl glycerol (2-AG) in the striatum, suggesting that the ECS participates in the brain responses to methamphetamine. Δ9-tetrahydrocannabinol (THC), a cannabis-derived agonist of both CB1 and CB2 cannabinoid receptors, or inhibitors of the main enzymes responsible for the degradation of AEA and 2-AG (URB597 and JZL184, respectively), blunted the decrease in striatal protein levels of tyrosine hydroxylase induced by methamphetamine. In addition, antagonists of CB2, but not of CB1, blocked the preventive effects of URB597 and JZL184, suggesting that only the former receptor subtype is engaged in neuroprotection exerted by ECS stimulation. Finally, we found that methamphetamine increases striatal levels of the cytokine tumor necrosis factor alpha, an effect that was blocked by ECS stimulation. Altogether, our results indicate that stimulation of ECS prior to the administration of an overdose of methamphetamine considerably reduces the neurotoxicity of the drug through CB2 receptor activation and highlight a protective function for the ECS against the toxicity induced by drugs and other external insults to the brain
The buck is finished
No full text"The buck is finished. The snowfield has been thoroughly vacuumed up so pellets will not complicate the next stage.
On the left is a restaurant-style bun warmer. Automotive clay produced by Chavant, Inc. will be put into the bunwarner, heated to 135 F degrees so it is soft and pliable, then applied over the buck to a depth of 2" to 6"--more if necessary. this clay is oil-based with a lot of wax .. As it cools it can be tooled and carved. Heated clay is usually
applied with a glove to protect the skin from burns." -- Laura H. Chapma
ChemInform Abstract: Organylbis(diisopropylamino)boranes as Precursors of Organyldichloroboranes: Application to the Synthesis of Secondary Amines.
No full textChemInform Abstract: Preparation of New Polyfunctional Diorganozincs Using a Boron-Zinc Exchange Reaction.
No full textUn auditorium pour Grenoble: salle de spectacle (1600 pers.); salle de répétition; foyer (expo. itinérante); parkings et commerces - Pl. René Chavant, F-Grenoble
No full textSAR-DCote: 1990.025Archive: MEM.1/1A4 verticalGroupe de suivi: Snozzi Luigi; Botta Mario; Vacchini Livi
Chemical diffusivity of boron in melts of haplogranitic composition
No full textChemical diffusivities of B in synthetic melts of haplogranitic composition have been measured by the diffusion couple technique at 1 atm between 1200–1600°C. The compositional profiles were measured by ion microprobe and modelled using the Boltzmann-Matano formalism to retrieve compositionally dependent interdiffusion coefficients.
At the experimental conditions, B2O3 is found to exchange primarily with SiO2 and the interdiffusion coefficient increases with increasing replacement of Si by B in the melt. No isotopic fractionation of boron was observed in the diffusion zone at the experimental conditions. The compositional dependence of diffusivity increases with decreasing temperature. The activation energy of diffusion (~70 kcal) is similar to that for viscous flow in melts of the same composition and is relatively insensitive to B content between 1–10 wt% B2O3 in the melt. However, the addition of the initial 1 wt% B2O3 to a haplogranitic melt appears to dramatically lower the activation energy for these processes from ~ 100 kCal to ~70 kCal. Thus, common geochemical concentrations of B may affect petrogenesis of granitic rocks by their influence on these transport properties. Some implications of these results for crystal growth and dissolution in B-bearing melts and boron isotopic variation of granitic melts have been discussed. If diffusion is the rate-limiting process, boron isotopic heterogeneity may be maintained in granitic melts at magmatic temperatures on time scales of millions of years on a millimeter scale. The influence of small amounts of B on transport properties may also contribute toward resolution of an enigma regarding emplacement mechanisms of peraluminous granites
ChemInform Abstract: Preparation of Functionalized Dialkylzincs via a Boron-Zinc Exchange. Reactivity and Catalytic Asymmetric Addition to Aldehydes.
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