1,720,972 research outputs found
The effect of mineralized water and bovine gelatine on extrinsic coagulation system
No full textEkstrensek pıhtılaşma sisteminde bazı proteinlere postranslasyonel modifikasyonla karboksil grubu bağlanır. Bu reaksiyon için K vitamini gereklidir. Çünkü karboksilazların koenzimi K vitaminidir. 1990’ lü yılların başından beri bilinen bu mekanizma tromboza bağlı MI, serebrovaskuler, periferal damar hastalığı olan kişilerin tedavisinde kullanılmaktadır. Bu tedavinin amacı K vitaminini baskılayarak pıhtı oluşumunu, kanamaya sebebiyet vermeden engellemektir. Tedavide kullanılan ilaçların doz ayarı ekstrensek pıhtılaşma sisteminin göstergesi olan protrombin zamanı testi(PTZ) ile takip edilir. Tedavinin etkinliğinde diyet önemlidir. Bu çalışmada; kandaki kalsiyum iyonunun pıhtılaşma sisteminde etkisini dikkate alarak, ayrıca jelatinle yapılmış pıhtılaşma ile ilgili çesitli çalışmalar incelenerek mineralli suların ve jelatinin ekstrensek pıhtılaşma zamanına etkisini araştırmayı amaçladık. PTZ testi için gerekli olan doku faktörü kuzu akciğerinden elde edildi. Plazmaya ilave edilen mineralli sular ve sığır jelatininin etkisi Quick metodu ile ölçülen PTZ testi ile değerlendirildi. Sığır jelatini konsantrasyonu arttıkça pıhtılaşma arttı. Jelatin konsantrasyonlarından %1 ile %2,5 arasında pıhtı oluşumunun en yüksek düzeyde olduğu görüldü. 13 farklı mineralli su kullanıldı. 5’inin pıhtı oluşumunun kısalttığını diğerlerinin ise pıhtı oluşumunu geciktirdiği görüldü. Mineralli su ve sığır jelatini karışım kombinasyonunda PTZ etkisinde MS5 suyun pıhtı oluşumunda sinerjst etki görüldü, diğer mineralli sular ise pıhtı oluşumunda antagonist etki gösterdi. SPSS spearman kolerasyon analizinde mineralli suların PTZ etkisi ile kalsiyum miktarları arasında anlamlı bir ilişki bulunmadı. Mineralli su-jelatin kombinasyonu ile pıhtı oluşumu yönünden potasyum miktarları arasında anlamlı bir ilişki bulundu (p<0,05). Ayrıca DF ve jelatinin protein bantlarının molekül ağırlıklarının SDS PAGE’de 220 ile 45 kDa arasında olduğu görüldü. Sonuç olarak; in vitro şartlarda ekstrensek pıhtılaşma sistemi ile ilgili yapılan bu çalışmanın, in vivo yapılacak çalışmalara ışık tutacak nitelikte olduğunu düşünmekteyiz.In extrinsic coagulation system carboxly group is attached to proteins with posttranslational modifications. Fort his reaction vitamin K is necessary. Because the coenzyme of carboxylases is vitamin K. Known since the early 1990?s this mechanism has been used for the treatment of patients with MI related with thrombosis, cerebrovascular, peripheral vascular disease. The aim of this treatment by suppressing vitamin K is to prevent clot formation without causing bleeding. The dosage adjustment of drugs used in the treatment is followed by the prothrombin time test (PTZ) which is the indication of extrinsic coagulation system. Diet is important in the effectiveness of treatment. In this research we aimed to search the effect of mineral waters and beef gelatin to extrinsic coagulation time by considering the effect of calcium ion in blood in the coagulation system. Tissue factor required for PTZ test derived from lamb lung. The effect of mineral water and bovine gelatin added to plasma was evaluated by PTZ test measured by quick method. As the concentration of bovine gelatin increased, the coagulation increased. In gelatin concentrations between %1 and %2,5 clot formation was observed to be the highest. 13 different mineral waters were used. 5 of them were observed to shorten the clot formation and the others delay the clot formation. In the combination of mineral water and bovine gelatin under the PTZ effect the synergist effect of MS5 water was observed in clot formation. Other mineral waters showed an antagonistic effect to the clot formation. In the analyses of SPSS spearman correlation and calcium amount in the mineral waters with the effect of PTZ no significant relation was found. A significant relation found between mineral watergelatin combination and potassium amount in terms of clot formation. (p<0,05). Besides DF and molecular weights of gelatin protein bands was observed in SDS PAGE between 220 and 45 kDa. As a result we think that this research which was about extrinsic clot formation in vitro conditions has the quality to shed light to the researches in vivo conditions
Determining the point of view of patients applying to the pharmacy to clinical aromatherapy and the role of the clinical pharmacist in aromatherapy applications
No full textKlinik aromaterapi, kimyasal yapılarından ötürü güçlü fizyolojik etkilere sahip olan uçucu ve sabit yağların spesifik semptomlar üzerinde tedavi amacıyla kullanılmasıdır. Klinik aromaterapinin bir tamamlayıcı ve alternatif tedavi yöntemi olarak popülaritesi gün geçtikçe artmaktadır. Eczaneler ise kaliteli ve güvenli uçucu yağların ve majistral aromaterapötik ürünlerin arzında, konuyla ilgili doğru bilgi ve danışmanlığın sağlanmasında ve medikal aromaterapötik ürün geliştirilmesinde kritik role sahiptir. Çalışmamızda Kadıköy bölgesinde bulunan bir semt eczanesinde Şubat 2020- Mayıs 2020 tarihleri arasında 18 yaş ve üzeri 101 kişiye anket uygulanmıştır. Bu anket ile katılımcıların aromaterapi bilgi düzeyi tespit edilmiş ve aromaterapiyi tercih ettiği durumlar hakkında bilgi toplanmıştır. Sonuçlar katılımcıların demografik verileriyle birlikte değerlendirilerek klinik aromaterapiye bakış açıları tespit edilmiş ve aromaterapinin kullanımında klinik eczacının rolü değerlendirilmiştir.Clinical aromatherapy is the use of essential and fixed oils, which have strong physiological effects due to their chemical structure, to treat specific symptoms. As a complementary and alternative treatment method of clinical aromatherapy, its popularity is increasing day by day. Pharmacies, on the other hand, have a critical role in the supply of quality and safe essential oils and magistral aromatherapeutic products, providing accurate information and consultancy on the subject and developing medical aromatherapeutic products. In our study, a questionnaire was applied to 101 people, aged 18 and over, between February 2020 and May 2020 in a district pharmacy in the Kadıköy region. With this questionnaire, the level of knowledge of the aromatherapy participants was determined and information about the situations in which they preferred aromatherapy was collected. The results were evaluated together with the demographic data of the participants, and their perspectives on clinical aromatherapy were determined and the role of the clinical pharmacist in the use of aromatherapy was evaluated
Nanotechnology in nutraceuticals delivery for the prevention and treatment of cancer
No full textNanotechnology has received significant progress in the field of oncology in recent years. Nanomedicine is at the forefront to limit the shortcomings associated with traditional or conventional chemotherapeutic agents and chemotherapies. Nutraceutical delivery through nanotechnology has made great advancement in the field of oncology. Nutraceuticals are any food containing substances that have some medicinal benefits. They prevent the cancer progression by different mechanisms and are delivered to their target cancer cells without causing harm to healthy/normal cells. There have been multiple implications and advancement to the use of nanotechnology in delivering nutraceuticals to prevent and treat cancer. Nanotechnology-based formulations that include different kinds of polymeric, lipid and inorganic formulations have been explored to enhance nutraceuticals' bioavailability and anticancer potential. To exploit their full potential, further preclinical and clinical studies are required to be carried out
Determination of mycotoxins by HPLC, LC-MS/MS and health risk assessment of the mycotoxins in bee products of Turkey
No full textThe aim of this study is to determine the levels of deoxynivalenol (DON), HT-2 toxin (HT2), T-2 toxin (T2), and ochratoxin A (OTA) in bee products (bee pollen, propolis, honey and royal jelly) available in Turkey. In addition, exposure and health risk assessments were performed to identify the potential health risk of these mycotoxins. The mycotoxins were analyzed by high-performance liquid chromatography (HPLC) with a UV detector and positive samples were confirmed with liquid chromatography-tandem mass spectrometry (LC-MS/MS). The most common mycotoxins in all bee products were DON and T-2 toxin, with mean concentrations of 1.601 and 0.704 µg/per kg dry sample, respectively, followed by OTA and HT-2 toxin. It was determined that the mycotoxins taken as a result of consuming bee products in specified amounts do not pose a risk to health
Antioxidant Activities, Phenolic Contents and Electronic Nose Analysis of Black Garlic
Full text linkBlack garlic is a processed garlic product with a moisture-controlledhigh temperature heat treatment for a long time. In order to determine thesecondary metabolites of black garlics treated in the study, firstly, in vitroantioxidant activities of black garlics purchased from Edovital company,Kastamonu, Turkey were determined, followed by qualitative and quantitativemeasurement of the phenolic compound content by HPLC and finally theelectronic nose analysis of the content of nebulizer vapors in wood vinegar extractof black garlics were done successfully. Chlorogenic acid, vanillic acid, benzoicacid, gallic acid contents in detected 13 phenolic acids were quitely high. Allquantitative results were expressed as mg gallic acid equivalent (GAE) per g drymatter of black garlic sample. ABTS and DPPH antioxidant activities were verylow according to BHT standart and 2-Methylene-4-pentenal (18%) and Furfural(25%) were detected in high amount with electronic nose in nebulvapor contentsof black garlic wood vinegar extract
Fragrance Component Analysis for Nebulvapours of European Anchovy Oils by Using Colorimetric Printing and Electronic Nose
Full text linkAnalysis of odor components about biochemicals find the widespace in the evaluation of flavor parameters and anchovies as biologicalmaterials. Food dye solutions as printer's inks were sprayed on to the fabricthroughout the printing operation and skin oil vapors of anchovy weresimultaneously sent to the paper hopper of printer intensely via a nebulizerdevice. Before and after dyeing process, images of tela fabric were taken bysmartphone and analyzed by software in the smartphone for the purpose ofdetermination of colorimetric fragrance component concentrations andvisual odor profile in range of visible region. The ten major ingredientcontents (with relative percentages) (aldehyde compounds intensely such as2,4-heptadienal (23%), (E,E)-2,4-nonadienal (17%)) of anchovy skinessential oils were determined. For colorimetric printing analysis viasmartphone, LOD and LOQ were 1 ppm and 3 ppm, respectively.Methodology can be used in the analysis of toxic components that interactwith foods
Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Variations on the Author
Full text link“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Appropriate Similarity Measures for Author Cocitation Analysis
Full text linkWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
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