787 research outputs found
A jurisprudência portuguesa dos tribunais superiores sobre exoneração do passivo restante (Breves notas sobre a admissão da exoneração e a cessão de rendimentos em particular)
No full textDesde 2004 que o Código da Insolvência e Recuperação de Empresas apresenta dois modelos insolvenciais para o tratamento da insolvência de pessoas singulares: por um lado, o modelo reeducativo, encarnado no plano de pagamentos; por outro o fresh start, consagrado com a exoneração do passivo restante. Esta última solução tem sido a opção da esmagadora maioria das pessoas singulares insolventes que, desde 2011, superam o número de processos de pessoas coletivas. Todavia, o sistema português tem sido criticado, não só pelo Memorando da Troika assinado entre o Estado Português, o BCE, a Comissão Europeia e o FMI, como pela própria doutrina e jurisprudência, pondo em evidência a necessidade de alteração do regime relativo às pessoas singulares. Aliás, tal exigência constava do referido Memorando, sem que o Governo português tenha adotado quaisquer medidas. Por outro lado, a recomendação da UE de março de 2014, relativa à recuperação e à insolvência, refere também a necessidade de redução do limite temporal de insolvências de pessoas singulares, nomeadamente no que concerne aos períodos de cessão dos rendimentos aos credores.
Nesta sede, verificamos que o regime português da insolvência, que conta já com mais de uma década de vigência, continua a apresentar fragilidades a nível da aplicação das normas, especialmente em dois pontos particulares – por um lado, a interpretação dos requisitos de acesso, que foi inicialmente feita de forma muito rígida pelos tribunais de 1.ª instância, impedindo o acesso à exoneração e, por outro, a concessão dos rendimentos necessários durante o período de cessão aos credores que, normalmente, desvaloriza as verdadeiras necessidades dos insolventes, dando um caráter punitivo, que o legislador não pretendeu atribuir, à insolvência. Este texto visa, pois, analisar brevemente a evolução jurisprudencial dos tribunais superiores na última década.info:eu-repo/semantics/publishedVersio
Biomarkers, human health
No full textThe term “biomarker” comes from the Greek term “βιο-“, meaning life, in combination with “mark”, Old English of “mearcere”, meaning “writer, notary”, or literally “one who marks”. In scientific literature the word first emerged in the 1970s, but the concept has been part of biomedical research for decades. Various definitions were established over the years, the simplest describes it as a “biological endpoint (or change of) measured in the organism” used as an indicator in clinical practice, drug development and risk assessment research. As a result, several subtypes have been defined according to the field/subject of the study in question. © 2024 Elsevier Inc. All rights reserved.Filipa Esteves work is supported by Fundação para a Ciência e Tecnologia Filipa Esteves and by the European Social Fund (ESF), grant number UI/BD/150783/2020
Relatório de Estágio de Alexandra Filipa Guedes Pinto
No full textO presente relatório da prática educativa supervisionada para a obtenção do grau de Mestre no
âmbito do Mestrado em Educação Pré-Escolar surge como o culminar de um longo processo de
crescimento da mestranda a nível pessoal e profissional, bem como se propõe a abordar, de forma
crítica e reflexiva, o processo desenvolvido no decorrer dos estágios profissionalizantes
realizados na valência de Creche e de Educação Pré-Escolar.
De salientar que esta formação abrangeu a integração da uma articulação entre os referenciais
teóricos e legais, numa perspetiva contínua de investigação e reflexão. Todas as experiências
decorridas na prática, sustentadas num ciclo dinâmico e em espiral de processos de observação,
planificação, ação, avaliação e reflexão, que constituem a metodologia de investigação-ação,
contribuíram para uma ação inovadora, reflexiva e com sentido para todos os intervenientes. A
mestranda desenvolveu saberes profissionais que se transformaram numa ação sustentada pelas
pedagogias de cariz participativo, envolvendo as crianças como sujeitos ativos na construção das
suas aprendizagens, tendo sempre por base os seus interesses e necessidades, de forma a construir
um ambiente que promova aprendizagens significativas, numa perspetiva globalizante e integradora.
Para além do mencionado, todas as ações desenvolvidas se ancoraram numa postura crítica e reflexiva
que permitiu à mestranda compreender problemáticas emergentes da prática educativa, investigando-as
e refletindo sobre, na e para ação (Schön, 1987, citado por Alarcão, 1996), desenvolvendo uma
transformação de si mesma, enquanto sujeito em formação e proporcionando verdadeiras oportunidades
de aprendizagem e crescimento. A partilha de experiências e a colaboração estabelecida entre a
díade, as educadoras cooperantes e as supervisoras institucionais, contribuíram para o
desenvolvimento pessoal e profissional da mestranda, enquanto futura Educadora de Infância..This report of the supervised educational practice for the recognition of the Master's degree in
Pre-School Education is the culmination of a long process of growth of the master student at a
personal and professional level, and proposes to address, critically and reflectively, the process
developed during the professional internships carried out in the nursery school and pre-school
education.
It should be noted that this training included the integration of an articulation between
theoretical and legal references, in a continuous perspective of research and reflection. All the
experiences in practice, were supported by a dynamic and spiral cycle of observation, planning,
action, assessment and reflection processes, which constitute the action research methodology,
contributed towards an innovative, reflective and meaningful action for all those involved.
The student developed professional knowledge that was transformed into an action supported by
participatory pedagogies, involving children as active subjects in the construction of their
learning, always based on their interests and needs, in order to build an environment that promotes
significant learning, from a global and integrative perspective.
In addition to the above, all the actions developed were anchored in a critical and reflective
attitude that allowed the student to understand problems emerging from educational practice,
investigating them and reflecting on, in and for action (Schön, 1987, cited by Alarcão, 1996),
developing a transformation of herself, as a subject in training and providing real opportunities
for learning and growth.
The sharing of experiences and the collaboration established between the dyad, the cooperating
educators and the institutional supervisors contributed to the personal and professional
development of the master's student, as a future Early Childhood Educator
Some Thoughts on Urban Sketching
No full textThe CRP department recognizes the importance of sketching as graphic thinking and a means to learn from what we see. Filipa Antunes, a renowned urban sketcher and artist who recently exhibited at the Louvre in Paris, presents some thoughts on how she approaches sketching as both a rational and an emotional process. All illustrations in this article are by the author. Follow Filipa\u27s work at https://www.facebook.com/DesenhoFilipaOliveiraAntunes
Biological effects of thermal water-associated hydrogen sulfide on human airways and associated immune cells: Implications for respiratory diseases
No full textNatural mineral (thermal) waters have been used for centuries as treatment for various diseases. However, the scientific background of such therapeutic action is mostly empiric and based on knowledge acquired over time. Among the various types of natural mineral waters, sulfurous thermal waters (STWs) are the most common type in the center of Portugal. STWs are characterized by high pH, poor mineralization, and the presence of several ions and salts, such as bicarbonate, sodium, fluoride, silica, and carbonate. Furthermore, these waters are indicated as a good option for the treatment of various illnesses, namely respiratory diseases (e.g., allergic rhinitis, asthma, and chronic obstructive pulmonary disease). From the sulfide species present in these waters, hydrogen sulfide (H2S) stands out due to its abundance. In healthy conditions, H2S-related enzymes (e.g., cystathionine β-synthase and cystathionine γ-lyase) are expressed in human lungs, where they have mucolytic, antioxidant, anti-inflammatory, and antibacterial roles, thus contributing to airway epithelium homeostasis. These roles occur mainly through S-sulfhydration, a post-translational modification through which H2S is able to change the activity of several targets, such as ion channels, second messengers, proteins, among others. However, in respiratory diseases the metabolism of H2S is altered, which seems to contribute somehow to the respiratory deterioration. Moreover, H2S has been regarded as a good biomarker of airway dysfunction and severity, and can be measured in serum, sputum, and exhaled air. Hence, in this review we will recapitulate the effects of STWs on lung epithelial-immune crosstalk through the action of its main component, H2S
Commitment, sexual satisfaction and relational satisfaction during military deployment : a comparative study
No full textOrientação: Ana Filipa Gordino Beato ; coorientação: Renato Emanuel Carvalho Pessoa dos SantosCurrent literature studding Long Distance Relationship (LDR) originated by military
deployment is mainly focused on at home partner’s perspective and the associations between
geographical separation and relational satisfaction. Little is known about the role that
commitment and sexual satisfaction play in the relationship and the perspective of the deployed
military members in comparison with those living a relationship based on a daily contact with
their partners. Objective: The main purpose of this cross-sectional and comparative study was
to compare diverse relational variables, such as commitment, relational satisfaction and sexual
satisfaction between Portuguese military members in military deployment, i.e., experiencing a
Long Distance Relationship (LDR) and those who maintained a Geographically Close
Relationship (GCR). Design and Method: Participants in Long Distance Relationships
(n=172) were Portuguese military members deployed in Afghanistan (n=72), Central-African
Republic (n=86) and São Tomé and Príncipe (n=15). The ones that were in a GCR (n=256)
were also Portuguese military members, but on normal duty in different Military Units and
Bases in the Portuguese Territory. All voluntary participants were in a romantic relationship
and completed an online survey, that included the Investment Model Scale (Rodrigues & Lopes,
2013), the New Sexual Satisfaction Scale (Pechorro et al., 2014) and items assessing
Communication satisfaction, previously used in exploratory studies with Portuguese military
members and their partners. LDR and GCR data was collected simultaneously, three months
after deployment. Bivariate correlations were used to analyze the associations between
variables, independent samples T-test was applied to compare the samples according the
variables of interest, and simple and sequential mediations were performed to check for the
predicted models. Results: The findings suggest that the military members in LDR had
significantly higher levels of commitment, relational and sexual satisfaction than those in GCR.
No differences were found in the degree of relational investment. Additionally,
communicational satisfaction and relational satisfaction were identified as significant indirect
mediators of the relationship between the group (LDR vs GCR) and commitment and the group
(LDR vs GCR) and sexual satisfaction. Conclusions: Overall, the results are in line with
previous research that evidenced an increased overall satisfaction with various relational factors
when partners are living a Long Distance Relationship
O impacto do Aeroporto Francisco Sá Carneiro no desenvolvimento da região norte
No full textOrientação: Filipa Cristina Henriques Lopes dos Reis ;
co-orientação: José Manuel Ivo Carvalho VicenteO aeroporto é cada vez mais o elo de ligação entre a região e o resto do mundo,
servindo como impulsionador económico, social e cultural. Um aeroporto é tão mais eficiente
quanto melhor for a sua inserção no meio que o rodeia. Esta premissa é uma obrigatoriedade
nos tempos que decorrem e fruto de uma crise económica mundial que se tende a arrastar.
Como é sabido, a Região Norte de Portugal é fortemente povoada por população
migratória, que anualmente regressa a Portugal, sendo também cada vez mais um ponto de
interesse para os turistas de todo o Globo. A ligação aérea por intermédio do Aeroporto
Francisco Sá Carneiro é um fator de sucesso na Região Norte, contribuindo assim para um
desenvolvimento mútuo.
Desde a liberalização do espaço aéreo no Continente Europeu e com a chegada de
companhias Low-Cost a Portugal, se verificou na Região Norte um aumento exponencial a
nível turístico e por conseguinte comercial.
Este trabalho procurará dar resposta ao real impacto do Aeroporto Francisco Sá
Carneiro, também denominado como Aeroporto do Porto, no desenvolvimento da Região
Norte. A Catchment Area do mesmo, vai para além dos limites fronteiriços de Portugal, sendo
que cada vez mais, e, fruto da intermodalidade, se alarga ao país vizinho, proporcionando
assim novas oportunidades.The airport is increasingly the link between the region and the world, serving as an
economic, social and cultural driver. An airport is so efficient the better their integration into
its environment. This premise is an obligation in modern times due to a global economic crisis
that tends to drag.
As is known, the Northern Region of Portugal is heavily populated by migratory
population, which annually returns to Portugal, it's also increasingly a point of interest for
tourists from around the globe. The air link through Francisco Sá Carneiro Airport is a
success factor in the North, thus contributing to a mutual development.
Since the liberalization of airspace in the European Continent and the arrival of Low-
Cost airlines to Portugal, was found in the North Region an exponential increase in tourism
and therefore commercial.
This paper will address the real impact of Francisco Sá Carneiro Airport, also known
as Oporto Airport, regarding the development of the Northern Region. The Catchment Area of
it, goes beyond the boundaries of Portugal border, and increasingly, as a result of
intermodality, extends to the neighboring country, thus providing new opportunities
"Ready for BioData Management?" Training Data Stewards for Life Sciences: DS Lab 1, hosted by BioData.pt | ELIXIR PT
No full textThis training session is part of "Ready for BioData Management?" Training Data Stewards for Life Sciences, hosted by BioData.pt | ELIXIR PT.
The first part, "Ready for BioData Management?" Training Data Stewards for Life Sciences: Intro Course, is available here.
Lecture
Author
Affiliation
Assignment 1
Filipa Pereira
FCT | FCCN
Showcase: Best practices on data management at IGC
Tiago Paixão
BioData.pt | IGC
Pitch on main difficulties when filling a Data Management Plan:
Participants presented the DMP prepared during assignment 1, explaining the associated project, datasets, data types, and main difficulties and suggestions when using BioData.pt DSW.
Trainees
Data Management Plans & Assignment Feedback
Filipa Pereira
FCT | FCCN
Pitch based on the developed draft for institutional DM policies:
Participants described the main topics of a draft of their institutional policies, prepared during assignment 1, and explained the main requirements, difficulties, and existing policies.
Trainees
Institutional Policies on RDM & Exercise:
Group exercise: Responsibility of different stakeholders
Filipa Pereira
FCT | FCCN
LEARN Project Survey: Compare results with RDM Forum WG
Filipa Pereira
FCT | FCC
A arquitetura e os sentidos: o caso da obra de Álvaro Siza
No full textOrientação: Lígia Paula Simões Esteves Nunes Pereira da SilvaA dissertaçã o realizada no â mbito do Mestrado Integrado em Arquitetura, na
Universidade Lusó fona do Porto começa por retratar o tema da Arquitetura e os Sentidos
nomeadamente a visã o, o tato, o paladar, o olfato e a audiçã o e como foram abordados ao
longo da histó ria da arquitectura, como se chega até algumas soluçõ es arquitetó nicas e o
porquê da necessidade de alguns arquitetos abordarem formas de experienciar arquitetura.
Estuda-se cada sentido e a forma como cada um pode influenciar a perceçã o do espaço ao
estimulá -los.
A pesquisa é focada na aná lise de trê s casos de estudo de obras de Siza Vieira,
especificamente a Casa de Chá da Boa Nova, a Piscina das Maré s, ambas localizadas em Leça
da Palmeira e o Museu de Arte Contemporâ nea de Serralves situado no Porto.
Por ú ltimo reflete-se sobre a importâ ncia dos sentidos na concretizaçã o de um projeto
pela forma como o Homem se relaciona com os espaços.
Palavras chave: Á lvaro Siza Vieira, Arquitetura, Sentidos, HomemThe dissertation carried out within the scope of the Integrated Master in Architecture, at
Universidade Lusó fona do Porto, begins by portraying the theme of Architecture and the
Senses, namely vision, touch, taste, smell and hearing and how they have been approached
throughout the history of architecture, how to arrive at some architectural solutions and why
the need for some architects to approach ways of experiencing architecture.
Each sense is studied and the way in which each one can influence the perception of space
by stimulating them.
The research is focused on the analysis of three case studies of works by Siza Vieira,
specifically the Boa Nova Tea House, the Piscina das Maré s, both located in Leça da Palmeira,
and the Serralves Museum of Contemporary Art located in Porto.
Finally, it reflects on the importance of the senses in the realization of a project by the way
Man relates to spaces.
Keywords: Á lvaro Siza Vieira, Architecture, Senses, Man
Transcriptome profiling in Spinocerebellar ataxia type 2: a focus on RNA-binding proteins
No full textSpinocerebellar ataxia type 2 (SCA2) is a rare autosomal dominant neurodegenerative disease first described in 1971 and characterized by cerebellar ataxia and slow saccades. It is caused by a gain-of-function mutation of ATXN2, which encodes the ataxin-2 protein. Ataxin 2 is a multi-functional RNA-binding protein (RBP), and many of its related biological pro cesses, such as calcium homeostasis and lipid metabolism, have been implicated in SCA2 path ophysiology. However, ataxin-2’s RNA-binding function, through which it interacts with vari ous facets of the RNA metabolism system, has yet to be directly linked to SCA2. This thesis’ main objective was to analyze the cerebellar transcriptome of the novel transgenic SCA2 mouse model, TG-SCA-Q129, with a focus on genes encoding RBPs, to un cover whether or not SCA2 might be characterized by a dysfunction of RNA metabolism, as it pertains to its presentation in this mouse model. Eighty-four differentially expressed genes were identified between two lines of trans genic mice compared against wild-type mice, such as Alyref and Aptx, and an analysis of the functions of their encoded RBPs indicated an abundance of functions related to known SCA2 mechanisms, but also to mRNA processing and DNA repair. Gene ontology and weighted gene co-expression network analyses of the whole tran scriptome of the transgenic animals were also conducted, identifying not only known mecha nisms of SCA2, but also inflammation in the cerebellum of the transgenic line with a prominent motor phenotype, and alterations in synaptic vesicle endocytosis. In conclusion, the results from this thesis point to RNA metabolism being a core mech anism in SCA2, and identify DNA repair, pre-mRNA processing, neuroinflammation, and syn aptic vesicle endocytosis as warranting further research to verify whether they might also char acterize SCA2.A Ataxia Espinocerebelosa Tipo 2 (SCA2) é uma doença neurodegenerativa autossó mica dominante descrita pela primeira vez em 1971 e caraterizada por uma ataxia cerebelar e sacadas lentas. É causada por uma mutação de ganho de função no gene ATXN2, correspon dendo a proteína ataxina-2. A ataxina-2 é uma proteína multifuncional de ligação ao RNA (RBP), e vários processos biológicos em que atua já foram identificados em SCA2. No entanto, a sua capacidade de ligação ao RNA, pela qual interage com várias facetas do sistema de me tabolismo de RNA, ainda não foi associado a SCA2. Assim, o principal objetivo desta tese é analisar o transcritoma cerebelar de um novo modelo transgénico de SCA2 em Mus musculus, TG-SCA2-Q129, com um foco em genes co dificantes de RBPs, para verificar se a SCA2 pode ser caracterizada por uma disfunção do metabolismo do RNA. Oitenta e quatro genes diferencialmente expressos foram identificados em duas linhas de animais transgénicos comparados a controlos wild-type, tais como Alyref e Aptx, e uma aná lise das funções dos RBPs que codificam indica não só uma abundância de funções relaciona das a mecanismos conhecidos da SCA2, mas como também ao processamento de mRNAs e o reparo de DNA. Também foram feitas análises de ontologia genética e de redes modulares de coexpres são génica no transcriptoma inteiro deste modelo, identificando não apenas mecanismos pre viamente associados a SCA2, como também inflamação no cerebelo na linha de animais com um maior fenótipo motor, e alterações na endocitose de vesículas sinápticas. Em conclusão, os resultados desta tese indicam que o metabolismo do RNA é um me canismo central da SCA2, e identificam mecanismos de reparação do DNA, processamento de pre-mRNAs e endocitose de vesículas sinápticas como novos alvos de investigação, e cujo estudo deverá ser desenvolvido de modo a verificar se também caracterizam a SCA2
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