720 research outputs found
Exploiting evolution to treat drug resistance: Combination therapy and the double bind
No full textAlthough many anti cancer therapies are successful in killing a large percentage of tumour cells when initially administered, the evolutionary dynamics underpinning tumour progression mean that often resistance is an inevitable outcome, allowing for new tumour phenotypes to emerge that are unhindered by the therapy. Research in the field of ecology suggests that an evolutionary double bind could be an effective way to treat tumours. In an evolutionary double bind two therapies are used in combination such that evolving resistance to one leaves individuals more susceptible to the other. In this paper we present a general evolutionary game theory model of a double bind to study the effect that such approach would have in cancer. Furthermore we use this mathematical framework to understand recent experimental results that suggest a synergistic effect between a p53 cancer vaccine and chemotherapy. Our model recapitulates the experimental data and provides an explanation for its effectiveness based on the commensalistic relationship between the tumour phenotypes
Andiodrilus nonuya M & Celis, 2012, sp. nov.
No full textAndiodrilus nonuya sp. nov. (Figs 1, 2 A,B, 3 A–C, Table 1) Material examined. Holotype: Clitellate specimen (CA-0013). Locality: Municipality of Belén de Los Andaquíes, rural community of Agua Dulce (01° 20 ’ 34.2 ” N, 75 ° 49 ’ 17.1 ” W), altitude: 280 m above sea level. Collection date: 25 June 2008. Collectors: A. Feijoo, L. Celis. Paratypes: 12 adults (CA-0014), two subadults, 44 juveniles. Locality: Municipality of Florencia, rural community of Alto Canelos (01° 28 ’ 15.4 ”N, 75 ° 32 ’ 49.7 ”W), altitude: 272 m above sea level (1 adult, 6 juveniles). Collection date: 20 June 2008. Locality: Municipality of Florencia, rural community of Balcanes (01° 25 ’ 27.3 ” N, 75 ° 30 ’23.0” W), altitude: 284 m above sea level (1 adult, 10 juveniles). Collection date: 18 June 2008. Locality: Municipality of Belén de Los Andaquíes, rural community of Agua Dulce (01° 20 ’ 29.1 ” N, 75 ° 49 ’09.5” W), altitude: 273 m above sea level (10 adults, 2 subadults, 28 juveniles). Collection date: 23 June 2008. Collectors: A. Feijoo, L. Celis. Etymology. The new species is named in recognition of and homage to the Nonuyas indigenous people who live in the departments of Caquetá and Putumayo, Colombia. Noun in apposition. Description. Endogeic species, with light brown-colored dorsum, milky white belly, and cylindrical body. The length of the conserved holotype is 93.5 mm, with 131 segments. Its diameter is 3.2 mm in the preclitellar region, 4.0 mm in the clitellum, and 3.0 mm in the mid-posterior region. Paratype: 82.5 mm long and 3.0 mm wide. Number of segments: 122. The prostomium is long, thin, and ends in a milky white lobe measuring 0.9 mm. The clitellum is saddle-shaped, located in segments 15–25 (= 11 segments); tubercula pubertatis are between segments ¼ 19 –¼ 24 (Fig. 1). Eight rows of closely paired setae are visible (a, b, c, d) as of segment 4. The distance between setae in the mid-body region (segments 40–50) is aa:ab:bc:cd:dd = 5.4:1.0:5.0: 0.3: 17. The common setae (Fig. 2 A) present a strong curvature with central marks. This thickness then decreases to finally form a sharply defined hook. The ventral setae ab from 18 to 23 are modified as genital setae (Fig. 2 B) about 1.4 mm long, 0.04 mm in diameter. Setae are slightly sigmoid with a strong curvature, continuing rectilinearly to end in a broadened lanceolate tip. Numerous semi-lunar grooves appear after 1 / 2, which then merge in the center forming bordered limits (Fig. 2 B left). The male pores are located in segment 21 and female pores in segment 14. The nephropores are aligned with setae c, d. Three pairs of spermathecal pores were observed on intersegments 6 /7, 7/8, 8/ 9 aligned with seta c. Internal anatomy. The anterior septa are strong and moderately thick between segments 6 and 10. The round muscular gizzard and thick musculature are found in the cavity of segment 6. Three pairs of extramural calciferous glands originate in a short, wide duct that opens dorsally on the back of the esophagus in segments 7–9; the glands are of lamellar structure ("Lamellentaschen") (Fig. 3 A). The esophagus-intestine transition begins in segment 20 and the typhlosole begins in segment 24. This thick Sshaped lamella occupies 1 / 3 of the intestinal space. There are no intestinal caeca. The dorsal blood vessel is moniliform in segments 15–21. There are three pairs of lateral commissures in 7–9 and three pairs of esophageal hearts in 11–13. There is one pair of holonephridia in each segment, located just above the line of setae c, d. Each nephridium of the postclitellar region consists of a single infundibulum and two foldable bands joined to the infundibulum (Fig. 3 B). The voluminous and slightly lobed hypoesophageal testis sacs lie in segment 11, with one pair of seminal vesicles in 12. The deferent ducts are visible, located close to the ventral esophagus, opening in segment 14 into the intraparietal region and flowing into segment 21 to the male pores. The ovaries are in the ventral region of segment 13. Spermathecae (Fig. 3 C) are in segments 7, 8, 9. The sperm duct is short and the ampulla flat and round and has abundant sperm cells. Remarks. Andiodrilus nonuya is closely related to A. icomi Righi, 1971, A. biolleyi Cognetti, 1904, A. guayabero Feijoo, 2008, A. kiri Righi, 1995, A. masigure Feijoo, 2008, A. pixao Righi, 1995, A. xaropi Righi, 1995, and A. cabalensis Righi, 1995, because of the extension of the clitellum and tubercula pubertatis. It is also very closely related to A. xaropi and A. cabalensis because of the presence of three pairs of hearts in 11–13. It differs, however, from the aforementioned species in the distance of the setae aa: ab: bc: cd: dd, the shape and ornamentation of the genital seta, the position and number of segments of the clitellum, the locations of tubercula pubertatis, the shape of spermathecae, and in the origin of the intestine (Table 1). Species Author Length Segments Setal ratio Clitellum Tubercula Spermathecae Male pores Hearts (mm) (no.) aa:ab:bc:cd:dd pubertatis A. nonuya Feijoo 82.5–93.5 122–131 5.4:1.0:5.0: 0.3: 17 saddle, ¼ 19 –¼ 24 Duct long, ampulla 21 11–13 & Celis 15–25 flattenedPublished as part of M, Alexander Feijoo & Celis, Liliana V., 2012, New species of earthworms (Oligochaeta: Glossoscolecidae) in the Amazon region of Colombia, pp. 103-119 in Zootaxa 3458 on pages 105-106, DOI: 10.5281/zenodo.21460
Effect of reinforcing submicron SiC particles on the wear of electrolytic NiP coatings Part 2: Bi-directional sliding
No full textAs-plated and heat-treated electrodeposited NiP and composite NiP-SiC coatings were investigated in bi-directional ball-on-disc sliding tests. All tests were performed under gross slip conditions. Heat treatment decreases the wear volume loss during fretting in ambient air for all coatings investigated. Heat-treated NiP coating has a lower wear volume loss compared to composite NiP-SiC coatings for all sliding tests. The wear rate at the bi-directional sliding test was found to be lower relative to the wear rate at uni-directional sliding test
Chilean Digital Press Coverage of the Relation between Diet and Mental Health
No full textChile has a serious public health problem due to the high prevalence of both unhealthy dietary patterns and mental illnesses. Given that dietary quality is positively associated with the quality of mental health, it is urgent that healthy dietary patterns be promoted among Chileans. The WHO recommends the use of mass media for the dissemination of knowledge about mental health. Since health news affect people’s attitudes and health behaviors, this study analyzed the coverage by three Chilean online newspapers with the largest readership regarding the relation between diet and mental health in 2016. A previously constructed corpus of 2551 news items about food was analyzed quantitatively. The results show that the relevance of the topic diet and mental health was low in all three newspapers. The most frequent type of information was on “foods” and not “nutrients” that “benefit”—not that “damage”—mental health. The quality of the news was poor as a narrow range of sources was found. An individual responsibility frame predominated in the information to the detriment of a public health frame.Fil: Sanchez Sabate, Rubén. Universidad de La Frontera; ChileFil: Zunino, Esteban. Universidad Nacional de Cuyo; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto de Ciencias Humanas, Sociales y Ambientales; ArgentinaFil: Badilla Briones, Yasna. Universidad de La Frontera; ChileFil: Celedón Celis, Natalia. Universidad de La Frontera; ChileFil: Caro Saldías, Daniel. Universidad de La Frontera; Chil
Rinoceronte
No full textMontaje de actuación VII, basado en el texto de Eugenio IonescoDIRECCIÓN de Eduardo Sánchez Medina, ACTORES: Javier Ortiz Vargas, Walter Osvaldo Cano, Juan Esteban Orozco, Paola Milena Barrientos, Juan Carlos Toro, Olda Livis Marín, Lurllorlady Giraldo, Adriana Maria Ospina, ESCENOGRAFÍA Mauricio Celis A., MAQUILLAJE Omar Ochoa, Luces Esteban Orozco, DISEÑO GRAFICO Diana GómezActuación VI
¿Cuáles son los retos que enfrenta la Educación Superior en Colombia para garantizar su pertinencia y calidad en los próximos diez años?
No full textRetos pragmáticos y holísticos para la educación post secundaria colombiana / Juan Esteban Saavedra -- Educación superior para el siglo XXI / Jorge Celis y Mauricio Duque -- Educación superior pertinente y de calidad:diez años de retos / Cecilia María Vélez -- Universidad, autonomía e identidad / Guillermo Hoyos Vásquez."La coyuntura actual de reforma y financiación al sistema de educación superior colombiano presenta una oportunidad especial para debatir sobre la visión que, como sociedad, tenemos de éste. En este número de EGOB ? revista de asuntos públicos, queremos enriquecer esa visión integrando perspectivas académicas y prácticas sobre los principales retos que enfrenta el sistema de educación superior colombiano en la próxima década. Las reseñas investigativas y bibliográfica, el debate, los artículos de la sección Pensar la educación superior y las contribuciones de los estudiantes representan aportes desde diversas disciplinas e instancias de la sociedad al diagnóstico de dichos retos, que podríamos resumir en dos grandes categorías: pragmáticos y holísticos. Los pragmáticos, de carácter principalmente positivo, tienen que ver con la capacidad del sistema de educación superior para recibir, retener y formar, con estándares de calidad, a profesionales y ciudadanos, e incluyen consideraciones financieras, pedagógicas y políticas..."
¿Cuáles son los retos que enfrenta la Educación Superior en Colombia para garantizar su pertinencia y calidad en los próximos diez años?
No full textRetos pragmáticos y holísticos para la educación post secundaria colombiana / Juan Esteban Saavedra -- Educación superior para el siglo XXI / Jorge Celis y Mauricio Duque -- Educación superior pertinente y de calidad:diez años de retos / Cecilia María Vélez -- Universidad, autonomía e identidad / Guillermo Hoyos Vásquez."La coyuntura actual de reforma y financiación al sistema de educación superior colombiano presenta una oportunidad especial para debatir sobre la visión que, como sociedad, tenemos de éste. En este número de EGOB ? revista de asuntos públicos, queremos enriquecer esa visión integrando perspectivas académicas y prácticas sobre los principales retos que enfrenta el sistema de educación superior colombiano en la próxima década. Las reseñas investigativas y bibliográfica, el debate, los artículos de la sección Pensar la educación superior y las contribuciones de los estudiantes representan aportes desde diversas disciplinas e instancias de la sociedad al diagnóstico de dichos retos, que podríamos resumir en dos grandes categorías: pragmáticos y holísticos. Los pragmáticos, de carácter principalmente positivo, tienen que ver con la capacidad del sistema de educación superior para recibir, retener y formar, con estándares de calidad, a profesionales y ciudadanos, e incluyen consideraciones financieras, pedagógicas y políticas..."
Akt1 and -2 inhibition diminishes terminal differentiation and enhances central memory CD8(+) T-cell proliferation and survival
No full textThe authors thank Dr Esteban Celis and Dr Rhea-Beth Markowitz for reviewing the manuscript and for their valuable suggestions and also thank Dr Lei Huang for his suggestions.Peer reviewe
DESARROLLO DEL SISTEMA DE CONTROL Y GUIADO PARA MISISLES DE ARTILLLERÍA SUPERFICIE - SUPERFICIE
No full textTrabajo Fin de Grado leído en la Universidad Rey Juan Carlos en el curso académico 2023/2024. Directores/as: Raúl De Celis FernándezDesarrollo del sistema de control y guiado para un misil de artillería superficie-superficie
Worn out in physicians of the Mandatory Social Service: an experience in the Subred Sur of Bogotá. “Mandatory Social Service: a Christ on His Back”
No full textilustraciones, diagramasIntroducción: En Colombia son escasas las investigaciones que se han preocupado por la salud de los médicos del Servicio Social Obligatorio (SSO). Sería preocupante evidenciar problemas en la salud de este grupo de trabajadores. Materiales y métodos: Esta investigación fue mixta con predominio cualitativo. La población de estudio fueron los médicos que realizaron el SSO en la Subred Sur de Bogotá en el 2023. Del total de médicos SSO, 23 aceptaron participar. Resultados: el 65,2% de los médicos del SSO reportó haber presentado alguna expresión de desgaste. Dentro de estas: ansiedad reportada por el 30,4%, enfermedades osteomusculares señaladas por el 17,3% y cefaleas referidas por el 13,04%. El 74% refirieron dificultades para dormir. En esta investigación se encontró que al aumentar la cantidad de pacientes atendidos por cada médico y disminuir los tiempos de consulta, la Subred Sur está generando una extracción de plusvalor a expensas de la intensificación de los tiempos de trabajo y la cantidad de pacientes atendidos por hora, situación que favorece la presentación del desgaste médico. Los patrones de recuperación de los médicos del SSO fueron insuficientes. Discusión: hay diferentes expresiones de desgaste en los médicos del SSO a pesar de su corta experiencia laboral, desgaste generado por la disminución de los tiempos de atención, las condiciones laborales y el escaso tiempo para la recuperación. La situación de los médicos del SSO es una manifestación de un sistema de salud colombiano mercantilizado y que prioriza la sostenibilidad financiera por encima del derecho a la salud. (Texto tomado de la fuente).Introduction: In Colombia, there is little research that has been concerned with the health of Mandatory Social Service (SSO) physicians. It would be worrisome to evidence problems in the health of this group of workers. Materials and methods: this was a mixed research with qualitative predominance. The study population were the physicians who performed the SSO in the Subred Sur de Bogotá in 2023. Of the total number of SSO physicians, 23 agreed to participate. Results: 65.2% of the SSO physicians reported having presented some expression of wornout. Among these: anxiety reported by 30.4%, musculoskeletal diseases reported by 17.3% and headaches referred by 13.04%. Seventy-four percent reported sleeping difficulties. In this research it was found that by increasing the number of patients seen by each physician and decreasing consultation times, the South Subnetwork is generating an extraction of surplus value at the expense of the intensification of work times and the number of patients seen per hour, a situation that favors the presentation of medical wornout. The recovery patterns of the SSO physicians were insufficient. Discussion: there are different expressions of wornout in SSO physicians in spite of their short work experience, wornnout generated by the decrease in attention times, working conditions and scarce time for recovery. The situation of the SSO physicians is a manifestation of a Colombian health system that is mercantilized and prioritizes financial sustainability over the right to health.MaestríaMagíster en Salud PúblicaEsta fue una investigación mixta con predominio cualitativo que hizo uso del enfoque de SDLT y de los preceptos de la MSL y de la SCL. El enfoque cuantitativo permitió acceder a una parte del problema, datos concretos y objetivables, pero que no podían explicar la totalidad. Mediante el enfoque cuantitativo se obtuvo información relacionada al perfil socio-demográfico de los médicos del SSO.
El enfoque cualitativo (método etnográfico) permitió conocer a profundidad el desgaste en los médicos del SSO, además de complejizarlo e intentar explicarlo.Salud ambiental y labora
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