1,069 research outputs found
Angiotensin II induces soluble fms-Like tyrosine kinase-1 release via calcineurin signaling pathway in pregnancy
No full textMaternal endothelial dysfunction in preeclampsia is associated with increased soluble fms-like tyrosine kinase-1 (sFlt-1), a circulating antagonist of vascular endothelial growth factor and placental growth factor. Angiotensin II (Ang II) is a potent vasoconstrictor that increases concomitant with sFlt-1 during pregnancy. Therefore, we speculated that Ang II may promote the expression of sFlt-1 in pregnancy. Here we report that infusion of Ang II significantly increases circulating levels of sFlt-1 in pregnant mice, thereby demonstrating that Ang II is a regulator of sFlt-1 secretion in vivo. Furthermore, Ang II stimulated sFlt-1 production in a dose- and time-dependent manner from human villous explants and cultured trophoblasts but not from endothelial cells, suggesting that trophoblasts are the primary source of sFlt-1 during pregnancy. As expected, Ang II-induced sFlt-1 secretion resulted in the inhibition of endothelial cell migration and in vitro tube formation. In vitro and in vivo studies with losartan, small interfering RNA specific for calcineurin and FK506 demonstrated that Ang II-mediated sFlt-1 release was via Ang II type 1 receptor activation and calcineurin signaling, respectively. These findings reveal a previously unrecognized regulatory role for Ang II on sFlt-1 expression in murine and human pregnancy and suggest that elevated sFlt-1 levels in preeclampsia may be caused by a dysregulation of the local renin/angiotensin system
Panahon ng Transisyon: Ang Soap Opera sa Telebisyon 1963-1986
No full textIsinasalaysay ng sanaysay na ito ang kasaysayan ng soap operang telebiswal sa pagitan ng 1963 at 1986, isang yugtong tinatawag ng awtor na “Panahon ng Transisyon.” Dito binakas ang transisyon ng soap opera mula sa radyo patungo sa bagong midyum ng telebisyon noong dekada 60, hanggang 1986, ang taon ng tuluyang pagbagsak ng diktadurang Marcos. Ngunit bago nito, isinalaysay din ang pagsilang ng industriya ng telebisyon sa gitna ng mga nagkukrus na interes ng mga namuhunan ditong pamilyang oligarko sa negosyo at politika. Makikitang produkto ng masigalot na kasaysayan ng Filipinas, at ng kasaysayan ng telebisyon, ang soap opera, sa pagpapatuloy nito, kahit ba ginambala’t binansot ang midyum kalaunan ng diktadura. Pitong soap opera ang itinampok dito na pawang kumatawan sa proseso ng transisyong nabanggit. Period of Transition: Soap Opera on Television, 1963-1986 Abstract: This narrates the history of the televisual soap opera between 1963 and 1986, described by the author as the “Period of Transition.” This traces the transition of the soap opera from radio to the new medium of television during the 60s to 1986, the year of the ouster of the Marcos dictatorship. Foregrounding this is a recounting of the birth of the television industry amidst the intersecting interests of the oligarchic families in politics and business as they invested in it. It will be surmised that the soap opera was a product of the tumultuous history of the Philippines, and the history of television, as it had continued to exist despite the disruption and the consequent hampered growth of the medium during the dictatorship. Seven soap operas are showcased here, representing the aforementioned transition process.
Kasaysayan, Sining, Literatura: Ang Politika ng Panitikan sa Makabagong Panahon
No full textSa realidad ng ating sitwasyong neokolonyal, isinasakatuparan ng araling panliteratura ang minanang tungkuling ginagampanan nito na gawing masunuring sabjek ang indibidwal na may kakayahang mangatwiran. Sinusugpo ng normatibong ideolohiya ang pagsusuri, at tuloy ikinukubli ang karanasan ng eksploytasyon at tunggalian ng mga uri. Sinusupil ang mismong konsepto ng ideolohiya, itinatakwil ang mga konteksto’t praktikang pang- institusyonal na siyang yumayari dito. Gamit ang historistiko’t sintomatikong pagbasa ng nobela ni Lualhati Bautista bilang halimbawa, tinatalakay dito ang pagkakaiba ng ideolohiya ng teksto sa diwa ng awtor dahil sa maraming namamagitang puwersa tulad ng alyenasyon at reipikasyon. Sa bisa ng sari-saring mekanismong pang-interpelasyon, hinuhubog ng teksto ang mga nagbabasa upang maging sabjek na nagsusumikap lutasin sa guniguni ang umiiral na tahasang kontradiksyong panlipunan. Sa gitna ng konkretong awdiyens na taglay ang sapin-saping pagkakaiba sa kultura at wika, ang pagpili ng wikang kasangkapan sa pagbuo ng likhang-sining ay maselang desisyon. Ilugar ito sa proseso ng paghabi ng mga kahulugan ng teksto bilang masalimuot at dinamikong repleksyon ng isang tiyak na conjuncture sa daloy ng kasaysayan ng bansang Pilipinas. Given the reality of our neocolonial situation, the discipline of literary study fulfills its received pedagogical function of converting reason-bearing individuals into obedient subjects. This normative ideology represses criticism, concealing the lived experience of exploitation and class conficts. The concept of ideology itself is suppressed, replaced with accepted terms and approved habits of interpretation. Meanings of art-works are identified with the single author’s identity, thus ignoring or excluding their enabling contexts and institutional practices. Using a symptomatic, historicist reading of Lualhati Bautista’s novel as an example, this essay argues that the ideology of texts differs from that of the author owing to diverse mediating factors. Current forces of alienation and reification intervene. Through their own mechanisms of interpellation, texts transform readers into subjects who attempt to imaginarily resolve real social contradictions. Given our multilingual and multiethnic audience, the choice of language for literary expression becomes crucial in the process of articulating textual meanings as multifaceted, dynamic reflections of specific conjunctures in Philippine history
Panahon ng Transisyon: Ang Soap Opera sa Telebisyon, 1963-1986
No full textIsinasalaysay dito ang kasaysayan ng soap operang telebiswal sa pagitan ng 1963 at 1986, isang yugtong tinatawag ng awtor na Panahon ng Transisyon. Dito binakas ang transisyon ng soap opera mula sa radyo patungo sa bagong midyum ng telebisyon noong dekada 60, hanggang 1986, ang taon ng tuluyang pagbagsak ng diktadurang Marcos. Ngunit bago nito, isinalaysay din ang pagsilang ng industriya ng telebisyon sa gitna ng mga nagkukrus na interes ng mga namuhunan ditong pamilyang oligarko sa negosyo at politika. Makikitang produkto ng masigalot na kasaysayan ng Filipinas, at ng kasaysayan ng telebisyon, ang soap opera, sa pagpapatuloy nito, kahit ba ginambala\u27t binansot ang midyum kalaunan ng diktadura. Pitong soap opera ang itinampok dito na pawang kumatawan sa proseso ng transisyong nabanggit. This narrates the history of the televisual soap opera between 1963 and 1986, described by the author as the Period of Transition. This traces the transition of the soap opera from radio to the new medium of television during the 60s to 1986, the year of the ouster of the Marcos dictatorship. Foregrounding this is a recounting of the birth of the television industry amidst the intersecting interests of the oligarchic families in politics and business as they invested in it. It will be surmised that the soap opera was a product of the tumultuous history of the Philippines, and the history of television, as it had continued to exist despite the disruption and the consequent hampered growth of the medium during the dictatorship. Seven soap operas are showcased here, representing the aforementioned transition process
"I' ll tell you a story that will make you believe" in narratives: the role of metafiction in the novel and in the film Life of Pi
No full textDissertação (mestrado) - Universidade Federal de Santa Catarina, Centro de Comunicação e Expressão, Programa de Pós-Graduação em Inglês: Estudos Linguísticos e Literários, Florianópolis, 2015.Recentes estudos propõem que adaptações cinematográficas sejam entendidas como fonte de criação, os quais refletem contextos e interpretações diferentes do texto em que são baseadas. Nessa dissertação, propõe-se uma análise comparativa do romance Life of Pi (2001), de Yann Martel e do filme homônimo dirigido por Ang Lee (2012). A análise tem como objetivo identificar a presença e o modo em que a metaficção é construída no romance e no filme, e quais são alguns significados produzidos por ela em ambos os textos, tanto o literário quanto o fílmico. A concepção de metafição se baseia nas definições de Linda Hutcheon e Patricia Waugh. Por metaficção, entende-se a ficção consciente de si, que expõe o processo de escrita ao leitor e o convida a ter um papel ativo na construção do significado. Após uma análise comparativa dos dois textos, conclui-se que a metaficção está presente em ambos, tanto tematicamente como estruturalmente. As reflexões sobre narrativas apresentadas pelos personagens, o uso de vários níveis narrativos e de intertextualidade revelam diferentes usos da metafição em ambos. A diferença mais importante entre o romance e o filme Life of Pi está no uso dos níveis narrativos. Enquanto o romance possui um ?autor? sem nome que apresenta a história aos leitores, o filme possui um diretor implícito que deixa pistas de qual versão da história de Pi é ?real? no contexto da narrativa. Essa diferença dá ao romance um final aberto, em que o leitor deve escolher qual versão da história ele acredita, enquanto o filme possui uma resolução para essa questão. O filme, então, pode ser entendido como um testemunho, uma narrativa de trauma de um sobrevivente de um naufrágio e da experiência de migração, enquanto o livro não apresenta uma decisão em relação às versões da história, deixando o leitor aberto a qualquer possibilidade.Abstract : Recent studies propose that Film Adaptations should be understood as sources of creation, which also reflect a different context and interpretation from the text upon which they were based. In this thesis, I propose a comparative analysis of the novel Life of Pi (2001), by Yann Martel, and the homonymous film directed by Ang Lee (2012). The analysis has the objective of identifying the presence and the way in which metafiction is constructed in the novel and in the film, and what are some of the meanings produced by it in both texts, the filmic and the literary. The concept of metafiction was based on the definitions by Linda Hutcheon and Patricia Waugh. It is understood as the self-conscious fictional text, which exposes the writing process to the readers and invites them to have an active role in the construction of meaning. In the comparative analyses of the two texts, I have proved that metafiction is present in the two texts, both thematically and structurally. The reflections of the characters on narrative itself as well as the use of different narrative levels and intertextual references reveal different uses of metanarrative in both film and novel. The most important difference between the novel and the film Life of Pi is in their uses of different narrative levels. While the novel has an unnamed =author? who presents the story to the readers, the film has an implicit director who leaves =clues? of which version of Pi?s story is ?real? in the context of the narrative. This difference gives to the novel an open end, facein which the readers must choose which version of the story they believe in, while the film presents a resolution to this question. The film, thus, can be understood as a testimony narrative, a narrative of the trauma of a survivor from a shipwreck and from the experience of migration, while the novel does not decide for one of the versions of the story, enabling a more inconclusive reading
TRPC6 Up-Regulation in Ang II-Induced Podocyte Apoptosis Might Result from ERK Activation and NF-kappa B Translocation
No full textAngiotensin II (Ang II) has been recognized as an apoptosis inducer in podocytes, but the mechanism of apoptosis induced by Ang II is unclear. Transient receptor potential cation channel 6 (TRPC6) is a calcium channel located in podocyte membrane. The present study evaluated the alteration of TRPC6 expression and the Ca(2+) influx involved in Ang II-induced podocyte apoptosis. The possible pathways related to TRPC6 in Ang II-induced podocyte apoptosis were also investigated. The apoptosis of mouse podocytes (MPC5) was induced by Ang II. The protein level of TRPC6 was increased markedly in response to Ang II stimulation, and the intracellular Ca(2+) concentration was elevated. By transfection with TRPC6 siRNA, Ang II-induced podocyte apoptosis and the transient Ca(2+) influx were inhibited. Treated with extracellular signal-regulated kinase (ERK) pathway specific inhibitor U0126 or nuclear factor-kappa B (NF-kappa B) pathway specific inhibitor ammonium pyrrolidinedithiocarbamate (PDTC) and Ang II, respectively in podocytes, not only was the TRPC6 up-regulation reduced, but the podocyte apoptosis was also decreased. Moreover, the translocation of NF-kappa B in nucleus resulted from Ang II was reduced by treatment with U0126. In conclusion, the enhancement expression of TRPC6 as well as the increased Ca(2+) influx mediated by TRPC6 channels contributed to the podocyte apoptosis. The activation of ERK pathway and subsequent translocation of NF-kappa B was possibly necessary for the up-regulation TRPC6 induced by Ang It. Exp Biol Med 234:1029-1036, 2009Medicine, Research & ExperimentalSCI(E)PubMed31ARTICLE91029-103623
Reusing software tests for configuration testing: A case study of the Hadoop project
No full textConfiguration is an inseparable piece of today’s software development. Due to its dynamic nature and lack of standardized checking procedure, misconfiguration has been one of the dominant factors contributing to software failures in production and wide spread outages. Existing techniques (static validation, system tests, canaries, etc.) for detecting misconfigurations have limitations, either being too coarse grained and unable to precisely exercise the changed configuration value, or not considering the interaction between configuration and software source code. Configuration testing takes pages from traditional software testing practices to test software configurations in a similar vein as how software code is tested.
This thesis makes a first step exploration towards configuration testing, focusing on analyzing feasibility and effectiveness of reusing existing source code tests to test configuration values. Through building a semi-automated infrastructure associating unit tests with configuration parameters, and later run the associated tests against injected correct and incorrect configuration values for each parameter, this thesis shows that reusing existing software test for configuration testing directly could yield an effective rate of 41.7% and 48.8%, for Hadoop Common and HDFS, respectively. Further, this thesis conducts in-depth analysis on tests that cannot be effectively reused, categorizes code patterns of these tests that have false positives or negatives, and provides examples on rewriting these tests.Submission published under a 24 month embargo labeled 'U of I Access', the embargo will last until 2021-12-01The student, Ran Ang, accepted the attached license on 2019-12-07 at 18:18.The student, Ran Ang, submitted this Thesis for approval on 2019-12-07 at 18:24.This Thesis was approved for publication on 2019-12-09 at 10:22.DSpace SAF Submission Ingestion Package generated from Vireo submission #14752 on 2020-02-28 at 17:23:55Made available in DSpace on 2020-03-02T22:15:15Z (GMT). No. of bitstreams: 2
ANG-THESIS-2019.pdf: 332563 bytes, checksum: 5c6b0e2ddb8e223120457924257604ef (MD5)
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Previous issue date: 2019-12-09Embargo set by: Seth Robbins for item 113926
Lift date: 2022-03-02T22:15:21Z
Reason: Author requested U of Illinois access only (OA after 2yrs) in Vireo ETD systemEmbargo set by: Seth Robbins for item 113926
Lift date: 2022-03-02T22:18:25Z
Reason: Author requested U of Illinois access only (OA after 2yrs) in Vireo ETD systemU of I Only Restriction Lifted for Item 113926 on 2022-03-03T10:15:27Z
Ang Babae sa Pook Pagawaan: Mga Espasyo ng Pag-aangkin sa Piling mga Nobela ni Valeriano Hernandez-Peña
No full textABSTRAKNakatuon ang pag-aaral na ito sa pagsusuri sa pampanitikang representasyon ng babae sa pook pagawaan at ang espasyo ng pag-aangkin sa piling mga nobela ni Valeriano Hernandez-Peña. Kung sinasabing ang panitikan ay representasyon ng isinahirayang ugnayan ng mga indibidwal sa kanilang kondisyon ng pag-iral sa lipunan, paano nabibigyan ng pampanitikang representasyon ang babaeng manggagawa sa mga nobela ni Valeriano Hernandez-Peña? Paanong muling nalikha sa mga akda ang mga karanasan ng kababaihang manggagawa – ang pagsasamantala sa tauhan bilang babae at bilang manggagawa? At sa gitna ng mga ito, paano nabibigyan ng ahensiya ang tauhan para baguhin ang kaniyang kalagayan sa nobela? Naging puwersa ang kababaihang manggagawa na kongkretong nagiging materyal ng manunulat sa pagsasahiraya sa unang mga dekada ng siglo 20. Gamit ang alegorikal na pagbasang sumasaklaw sa hanggahang politikal, panlipunan, at historikal, sinikap na bakatin ang ugnayan ng teksto sa konteksto ng ekonomiya, paggawa, at turing sa kababaihan sa unang dekada ng pananakop ng Amerikano, kung kailan umusbong ang mga nobela. Sa pangkalahatan, bagaman karamihan sa mga nobela ni Hernandez-Peña ay tumatalakay sa pag-ibig at nakakahon sa ideolohiya ng patriyarka, may mga guwang sa teksto na nagsilbing daluyan ng mga resistant na imahen/espasyo ng/para sa babaeng manggagawa. Tinatayang mapupunan ng pag-aaral ang mga puwang na naiwan ng ibang manunulat na pumaksa sa kasarian at gayundin, makapagdaragdag sa mga pananaliksik tungkol sa babaeng manggagawa sa ilalim ng kolonyalismong Amerikano. Mga susing salita: nobelang Tagalog, panunuring pampanitikan, babae, manggagawa, panahon ng Amerikano ABSTRACTThe study analyzes how representations in literature relate the imagined and real lives of individuals in society. Because women workers provided a tangible material for Valeriano Hernandez-Peña in re-imagining American colonialism, the article examines how they were recreated in the novels of the author. How did Hernandez-Peña articulate the experiences of the female character and her oppression as a woman and a worker? In the process, how is the character given agency to transform her condition in the novel? Using an allegorical reading that encompasses the political, social, and historical, the researcher outlined connections and correspondences in the context of economics, labor, and prevailing concepts on women during the period. As a whole, even if Hernandez-Peña produced mostly romantic novels confined to the patriarchal ideology, there are crevices in the text where resistant images/spaces of/for women workers flow. The study contributes to the existing research on women workers during American colonialism as well as to the continuing discourses on gender. Keywords: Tagalog novel, literary criticism, women, workers, American perio
Regulation of muscle satellite cell activation and chemotaxis by angiotensin II.
No full textThe role of angiotensin II (Ang II) in skeletal muscle is poorly understood. We report that pharmacological inhibition of Ang II signaling or ablation of the AT1a receptor significantly impaired skeletal muscle growth following myotrauma, in vivo, likely due to impaired satellite cell activation and chemotaxis. In vitro experiments demonstrated that Ang II treatment activated quiescent myoblasts as evidenced by the upregulation of myogenic regulatory factors, increased number of β-gal+, Myf5-LacZ myoblasts and the acquisition of cellular motility. Furthermore, exogenous treatment with Ang II significantly increased the chemotactic capacity of C2C12 and primary cells while AT1a(-/-) myoblasts demonstrated a severe impairment in basal migration and were not responsive to Ang II treatment. Additionally, Ang II interacted with myoblasts in a paracrine-mediated fashion as 4 h of cyclic mechanical stimulation resulted in Ang II-induced migration of cocultured myoblasts. Ang II-induced chemotaxis appeared to be regulated by multiple mechanisms including reorganization of the actin cytoskeleton and augmentation of MMP2 activity. Collectively, these results highlight a novel role for Ang II and ACE inhibitors in the regulation of skeletal muscle growth and satellite cell function
Improved cardiovascular autonomic modulation in transgenic rats expressing an Ang-(1-7)-producing fusion protein
No full textAngiotensin-(1-7) counterbalances Angiotensin II cardiovascular effects. However, it has yet to be determined how cardiovascular autonomic modulation may be affected by chronic and acute elevation of Ang-(1-7). Hemodynamics and cardiovascular autonomic profile were evaluated in male Sprague-Dawley (SD) and transgenic rats (TGR) overexpressing Ang-(1-7) [TGR(A1-7)3292]. Blood pressure (BP) was directly measured while cardiovascular autonomic modulation was evaluated by spectral analysis. TGR received A-779 or vehicle and SD rats received Ang-(1-7) or vehicle and were monitored for 5 hours after i.v. administration. In another set of experiments with TGR, A-779 was infused for 7 days using osmotic mini pumps. Although at baseline no differences were observed, acute administration of A-779 in TGR produced a marked long lasting increase in BP accompannied by increased BP variability (BPV) and sympathetic modulation to the vessels. Likewise, chronic administration of A-779 with osmotic mini pumps in TGR increased heart rate, sympathovagal balance, BPV and sympathetic modulation to the vessels. Administration of Ang-(1-7) to SD rats increased HRV values in 88% accompannied by 8% of vagal modulation increase and 18% of mean BP reduction. These results show that both acute and chronic alteration in the Ang-(1-7)-Mas receptor axis may lead to important changes in the autonomic control of circulation, impacting either sympathetic and/or parasympathetic systems.The accepted manuscript in pdf format is listed with the files at the bottom of this page. The presentation of the authors' names and (or) special characters in the title of the manuscript may differ slightly between what is listed on this page and what is listed in the pdf file of the accepted manuscript; that in the pdf file of the accepted manuscript is what was submitted by the author
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