1,721,122 research outputs found
High-Frequency Stimulation of Both Zona Incerta and Subthalamic Nucleus Induces a Normalization of Basal Ganglia Metabolic Activity in Experimental Parkinsonism
No full textHigh-frequency stimulation (HFS) of the subthalamic nucleus( STN) alleviates dramatically motor symptoms in Parkinson's disease, and recently it has been suggested that zona incerta (ZI) stimulation might be as beneficial to patients. We used in situ cytochrome oxidase (Col) mRNA hybridization to investigate and compare the effects of HFS of the STN and the ZI on metabolic activity of the STN, globus pallidus (GP), and substantia nigra reticulata (SNr) in normal rats as well as in rats with 6 -hydroxydopamine (6-OHDA) lesion, an animal model of Parkinson's disease. In normal rats, HFS of the STN, as well as of the ZI, induced a significant decrease in Col mRNA expression within the STN and SNr but an increase within the GP. In 6-OHDA rats, HFS of the STN reversed dopamine denervation-induced changes in the expression of Col mRNA in the STN, SNr, and GP. Similar results were obtained with HFS of the ZI except for the STN, which showed only a trend toward nomlization. These data suggest that the ZI, as well as the STN, are implicated in the functional mechanism of HFS supporting the involvement of GABA transmission for the reduction of neuronal activity in the basal ganglia output structures
Magnetic resonance imaging characterisation of an α-synuclein model of Parkinson’s disease
No full textThis folder contains data used in the paper:Magnetic resonance imaging characterisation of an α-synuclein model of Parkinson’s disease Chirine KATRIB, Hector HLADKY, Kelly TIMMERMAN, Nicolas DURIEUX, Nathalie DUTHEIL, Erwan BEZARD, David DEVOS, Charlotte LALOUX and Nacim BETROUNI.To be pubished in European Journal of Neuroscience (Update October 2024).Please contact the corresponding author if you need further details about this work and dataNacim Betrouni, PhDFrench Natinal Institute of Health and Medical Research (INSERM)Lille NeuroScience & [email protected] DATASET IS ARCHIVED AT DANS/EASY, BUT NOT ACCESSIBLE HERE. TO VIEW A LIST OF FILES AND ACCESS THE FILES IN THIS DATASET CLICK ON THE DOI-LINK ABOV
Going Beyond Counting First Authors in Author Co-citation Analysis
Get PDFThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Variations on the Author
Get PDF“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
How Lazy Reading and Semantic Sloppiness May Harm Progress in Synucleinopathy Research
No full textWhile confronted with the increasing complexity of the neurobiology of Parkinson’s disease (PD), we face the ever-increasing sloppiness of the conceptual definitions associated with poor methodological characterizations and the use of unacknowledged proxies, all of which are harmful contributors to the overall slow progress of PD research. In this opinion paper, I share part of my frustration, acknowledge how I participate in this trend, and propose a simple remedy. Fighting against semantic or conceptual sloppiness is of paramount importance, notably for the benefit of newcomers to the field who otherwise would take for granted the classic assertions found ad nauseam in the literature
Appropriate Similarity Measures for Author Cocitation Analysis
Get PDFWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
Experimental reappraisal of continuous dopaminergic stimulation against L‐dopa‐induced dyskinesia
No full text
- …
