141,375 research outputs found
Een christeligh lijkpredikan vthöffuer Catharina Rudbeckia
No full textDedikaatio: Malin Carls d. Hysing.Arkit: A-C4 D2.Personalia. [Latinankielinen runo] / Petrus Olai Dalekarlus. [Latinankielinen runo] / Johannes Georgii G. [=Gezelius?]. [Latinankielinen runo] / Andreas Erici VVal. [Ruotsinkielinen runo] / P. E. W. [= Peder Eriksson Wald]
Drepanoistodus iommii Rasmussen & Eriksson & Lindskog 2021, sp. nov.
No full textDrepanoistodus iommii sp. nov. urn:lsid:zoobank.org:act: 0E2832F5-672E-4FAE-B5A5-CBA5DE1A4824 Fig. 6E–H partim Drepanoistodus aff. basiovalis – Mellgren & Eriksson 2010: fig. 7m (only). Drepanoistodus cf. basiovalis – Mellgren et al. 2012: fig. 5e. Diagnosis A Drepanoistodus species characterised by a geniculate element with distinct keels on the cusp and upper margin of the base; a straight basal margin; a straight to weakly rounded (convex) anterior margin and cusp which is approximately twice the length of the upper margin of the base. Etymology Named in honour of legendary guitarist Tony Iommi, founding member of heavy metal band Black Sabbath. Material examined Ten geniculate elements including eight from the Lynna section. Holotype, geniculate element (Fig. 6E–F); LO 12479T. Type locality River bank near the mouth of Lynna River, village of Kolchanovo, St. Petersburg region, Russia (60°00′39″ N, 32°33′49″ E). Type stratum Approximately 10 cm above the local base of the Lynna Formation, sample LY 12-16. Lower part of the Lenodus variabilis Zone. Description Cusp reclined and straight with distinct keels developed on the anterior (upper) and posterior (lower) margins. A median, longitudinal carina is developed on both sides of the cusp, but it is especially distinct on the inner side. Base is characterised by a straight or almost straight basal margin and a distinct keel on the upper margin. Whereas this keel is slightly convex, the upper margin below the keel is straight. Anterior margin is usually straight or weakly rounded (convex), but occasionally, it is strongly rounded. Angle A between the cusp and upper margin of the base is ca 30° (mean) with a standard deviation at 4.2 (Fig. 5B), and the mean ratio between length of the free upper margin (b) and the free cusp (c) is 0.54 (standard deviation 0.10). Remarks In the PCA plot (Fig. 4), the population of D. iommii sp. nov. is situated in the upper right corner, separated from the D. basiovalis population as well as the other two new species populations described herein. The vectors in the biplot demonstrate that this is mainly due to the straight basal margin, the relatively long upper margin (high b/c values), and the usually straight anterior margin in D. iommii sp. nov., which is in accordance with the characters diagnosed above. The hypothesis that the population of D. iommii sp. nov. is morphologically different from the D. basiovalis population is supported by the PERMANOVA test (Fig. 5A), which shows that the probability that the two populations are the same is exceedingly low (p (same) = 1.00E- 04). Occurrence The L. antivariabilis Zone (sample LY12-9) to the L. variabilis Zone (sample LY12-21b). Outside the St. Petersburg region, D. iommii sp. nov. has been recorded from the L. variabilis Zone at the Hällekis quarry in Västergötland, Sweden (Mellgren & Eriksson 2010; referred to as D. aff. basiovalis) and from the L. pseudoplanus Zone or E. suecicus Zone of the island Osmussaar, Estonia (Mellgren et al. 2012; reported as D. cf. basiovalis).Published as part of Rasmussen, Jan Audun, Eriksson, Mats E. & Lindskog, Anders, 2021, Middle Ordovician Drepanoistodus (Vertebrata, Conodonta) from Baltica, with description of three new species, pp. 106-134 in European Journal of Taxonomy 774 on pages 119-120, DOI: 10.5852/ejt.2021.774.1533, http://zenodo.org/record/555714
Aggregated Demand-Side Energy Flexibility : Residential Assets Potential FCR-D Revenues and Energy Forecast Optimization
No full textToday, power grids are designed as a traditional large-scale centralized generation. However, as more renewable asynchronous resources are integrated, the share of rotating synchronous machines decreases. These asynchronous resources lack the inherent inertia from conventional generation, resulting in new challenges in power grid management. Without proper measures, the frequency might deviate significantly during system disruptions. During a frequency deviation, the power system operator activates power reserves to mitigate and maintain the balance. Currently, these reserves the vast majority of hydropower. New technologies for providing these reserves are needed with increasing intermittent power generation. One potential technical asset to reduce these challenges resides in demand-side energy flexibility. Demand-side energy flexibility for residential has mostly been large, but disregarded resources since small individual consumers lack the required capacity to provide ancillary services. This necessitates the need for aggregation as a possible solution. This master thesis aims to investigate the economic potential for utilizing demand response, battery energy storage systems, and electric vehicle charging as a resource for frequency containment reserves to stabilize the power system. The thesis investigates the demand-flexibility for each asset based on residential behavior to determine the complete potential regarding requirements set by the system operator. The study also investigates how ABB AbilityTM OPTIMAX®, as an optimization tool, could optimize the model’s energy demand to generate increased energy cost savings. The results of the investigation’s indicate great potential for all assets when aggregated, especially the aggregation of the battery energy storage system and the wastewater heat pump system. The study showed the tool ABB AbilityTM OPTIMAX®’s energy-saving potential, especially when integrating the model with photovoltaic generation with battery energy storage systems. Observations that led to further discussions included whether oversizing assets could be an option to increase demand flexibility and revenue. Dagens elnät är konstruerat som en storskalig centraliserad production. Men,när integration av förnyelsebar och asynkrona prodcunter ökar, minskar andelenroterande synkrona generatorer. Dessa asynkrona system tillhandahåller dennaturliga trögheten som konventionella system med roterande massa. Dettamedför nya utmaningar för hantering och kontroll av elnätet. Utan tillräckligaåtgärder kan frekvensen avvika betynade vid ett systemfel. Vid händele av ettsystemfel aktiverar kraftsystemoperatören olika stödtjänster för att minimeraoch balansera frekvensen. I dagsläget står vattenkraften för den absolut störstaandelen av stödtjänster. Med en fortsatt ökande andel av förnyelsebara energislag,kommer det att krävas ytterligare teknologier. En möjligt teknisk lösning äratt utnyttja den redan befintliga förbrukningsflexibiliteten i bostadshus. Närman tidigare räknat på förbrukningsflexibiliteten i bostadshus har man oftabortsett från små och mindre laster då dessa enskilda laster ofta saknar denkapacitet som krävs för att bidra på balansmarknade, vilket kan lösas genomatt aggregera dessa mindre, individuella laster. Målet med detta examensarbeteär att undersöka den ekonomiska potentialen genom att utnyttja den befintligaoch outnyttjade förbrukningsflexibiliteten hos laster i ett bostadsområde genomatt som en resurs bidra med stödtjänster till elnätet . Dessa laster är ventilation,spillvattenvärmepump, belysning, elbilsladdning och batterilagring. För attbestämma den total tillgängliga kapaciteten undersöker även studien varje enskildtillgångs förbrukningsflexibilitet, vilket beror av boendes vanor, väderlek, mm.Slutligen undersöker även studien möjliga energikostnadsbesparingar med attanvända ABBs optimeringsprogram ABB Ability™ OPTIMAX®. Resultatenfrån stuiden visar på stora potentiella ekonomiska inkomster för alla tillgångar,speciellt för batteri system samt spillvattenvärmepumpen. Studien visade ävenpå goda energikostnadsbesparingar genom att använda ABB Ability™ OPTIMAX®,speciellt vid integrering av solcellsproduktion och batteri systemen. Observationersom ledde till ytterligare diskussioner var om överdimensionering av tillgångarkan vara ett alternativ för att öka förbrukningsflexibiliteten och de potentiellaintäkterna.3
Aggregated Demand-Side Energy Flexibility : Residential Assets Potential FCR-D Revenues and Energy Forecast Optimization
No full textToday, power grids are designed as a traditional large-scale centralized generation. However, as more renewable asynchronous resources are integrated, the share of rotating synchronous machines decreases. These asynchronous resources lack the inherent inertia from conventional generation, resulting in new challenges in power grid management. Without proper measures, the frequency might deviate significantly during system disruptions. During a frequency deviation, the power system operator activates power reserves to mitigate and maintain the balance. Currently, these reserves the vast majority of hydropower. New technologies for providing these reserves are needed with increasing intermittent power generation. One potential technical asset to reduce these challenges resides in demand-side energy flexibility. Demand-side energy flexibility for residential has mostly been large, but disregarded resources since small individual consumers lack the required capacity to provide ancillary services. This necessitates the need for aggregation as a possible solution. This master thesis aims to investigate the economic potential for utilizing demand response, battery energy storage systems, and electric vehicle charging as a resource for frequency containment reserves to stabilize the power system. The thesis investigates the demand-flexibility for each asset based on residential behavior to determine the complete potential regarding requirements set by the system operator. The study also investigates how ABB AbilityTM OPTIMAX®, as an optimization tool, could optimize the model’s energy demand to generate increased energy cost savings. The results of the investigation’s indicate great potential for all assets when aggregated, especially the aggregation of the battery energy storage system and the wastewater heat pump system. The study showed the tool ABB AbilityTM OPTIMAX®’s energy-saving potential, especially when integrating the model with photovoltaic generation with battery energy storage systems. Observations that led to further discussions included whether oversizing assets could be an option to increase demand flexibility and revenue. Dagens elnät är konstruerat som en storskalig centraliserad production. Men,när integration av förnyelsebar och asynkrona prodcunter ökar, minskar andelenroterande synkrona generatorer. Dessa asynkrona system tillhandahåller dennaturliga trögheten som konventionella system med roterande massa. Dettamedför nya utmaningar för hantering och kontroll av elnätet. Utan tillräckligaåtgärder kan frekvensen avvika betynade vid ett systemfel. Vid händele av ettsystemfel aktiverar kraftsystemoperatören olika stödtjänster för att minimeraoch balansera frekvensen. I dagsläget står vattenkraften för den absolut störstaandelen av stödtjänster. Med en fortsatt ökande andel av förnyelsebara energislag,kommer det att krävas ytterligare teknologier. En möjligt teknisk lösning äratt utnyttja den redan befintliga förbrukningsflexibiliteten i bostadshus. Närman tidigare räknat på förbrukningsflexibiliteten i bostadshus har man oftabortsett från små och mindre laster då dessa enskilda laster ofta saknar denkapacitet som krävs för att bidra på balansmarknade, vilket kan lösas genomatt aggregera dessa mindre, individuella laster. Målet med detta examensarbeteär att undersöka den ekonomiska potentialen genom att utnyttja den befintligaoch outnyttjade förbrukningsflexibiliteten hos laster i ett bostadsområde genomatt som en resurs bidra med stödtjänster till elnätet . Dessa laster är ventilation,spillvattenvärmepump, belysning, elbilsladdning och batterilagring. För attbestämma den total tillgängliga kapaciteten undersöker även studien varje enskildtillgångs förbrukningsflexibilitet, vilket beror av boendes vanor, väderlek, mm.Slutligen undersöker även studien möjliga energikostnadsbesparingar med attanvända ABBs optimeringsprogram ABB Ability™ OPTIMAX®. Resultatenfrån stuiden visar på stora potentiella ekonomiska inkomster för alla tillgångar,speciellt för batteri system samt spillvattenvärmepumpen. Studien visade ävenpå goda energikostnadsbesparingar genom att använda ABB Ability™ OPTIMAX®,speciellt vid integrering av solcellsproduktion och batteri systemen. Observationersom ledde till ytterligare diskussioner var om överdimensionering av tillgångarkan vara ett alternativ för att öka förbrukningsflexibiliteten och de potentiellaintäkterna.3
How Many Danish Jobs Can (Potentially) Be Done Elsewhere?
No full textThis paper employs a new survey technique to arrive at estimates of the proportion of jobs with the characteristic that they can be performed elsewhere than currently, in particular in other countries. The results from the survey which was carried out in November 2008 indicate that the proportion of current jobs with offshorability characteristics in Denmark is in the 20 to 30 percent range. Danish jobs that could potentially be carried out elsewhere are primarily found in the services sector (financial and business services) and they are typically performed by employees from the middle of the wage distributionJobs; offshorability; outsourcing
MeSH term explosion and author rank improve expert recommendations
No full textInformation overload is an often-cited phenomenon that reduces the productivity, efficiency and efficacy of scientists. One challenge for scientists is to find appropriate collaborators in their research. The literature describes various solutions to the problem of expertise location, but most current approaches do not appear to be very suitable for expert recommendations in biomedical research. In this study, we present the development and initial evaluation of a vector space model-based algorithm to calculate researcher similarity using four inputs: 1) MeSH terms of publications; 2) MeSH terms and author rank; 3) exploded MeSH terms; and 4) exploded MeSH terms and author rank. We developed and evaluated the algorithm using a data set of 17,525 authors and their 22,542 papers. On average, our algorithms correctly predicted 2.5 of the top 5/10 coauthors of individual scientists. Exploded MeSH and author rank outperformed all other algorithms in accuracy, followed closely by MeSH and author rank. Our results show that the accuracy of MeSH term-based matching can be enhanced with other metadata such as author rank
The N-methyl-D-aspartate receptor subunit NR3A : cloning, expression and interacting proteins
No full textThis thesis focuses on the subunit NR3A, which together with subunits NR1, NR2A-NR2D and NR3B builds the excitatory glutamate receptor N-methyl-D-aspartate (NMDA). The receptor is most likely a tetramer, containing at least one NR1, probably two NR2 and sometimes one NR3 subunit. NR3A is highly expressed during development and present at moderate levels in the adult brain. Both NR3A and NR3B have an attenuating effect on NMDA receptor currents, when incorporated into the receptor complex.In study I we cloned and sequenced the human NR3A subunit, which at the time only had been described in rat. We found the homology between the rat and human sequences to be high, and most potential phosphorylation and glycosylation sites to be conserved. In contrast to rat tissue, we did not detect the longer splice variant of NR3A in the human central nervous system. We found NR3A mRNA to be expressed both in the developing human brain and spinal cord, with prominent staining of the cortical plate, ventricular zone and the dorsal half of the spinal cord as well as the neuroepithelial layer surrounding the central canal. Interestingly, the neuroepithelial layer expressed very low levels of NR1 mRNA, suggesting that NR3A might have replaced one of the NR1 subunits in NMDA receptors in this area. In study II we investigated the occurrence of NR3A mRNA and protein in adult human brain, its association with the other NMDA receptor subunits and the subunits solubility. We found NR3A mRNA and protein to be expressed in adult human brain, especially in layers II/III and V of cerebral cortex and in thalamus and pons. Expression was low or undetectable in caudate nucleus, claustrum, cerebellum and spinal cord. Further we found NR3A to be associated with NR1, NR2A and NR2B in adult human cortex, and to some extent in the spinal cord. NR3A showed a different solubility profile to the other NMDA receptor subunits, being extracted with milder detergents. Both NR1 and NR3A were found as monomers, dimers and tetramers, as well as in larger protein complexes. In contrast, NR2 subunits were only found in tetramers and in larger protein complexes. This probably reflects the presence of an intracellular pool of unassembled NR1 and NR3A subunits.To learn more about NR3A and its function we screened a fetal human brain cDNA library for proteins interacting with NR3A. Among a number of potentially interesting candidates we choose MAP1S/C19ORF5 and MAP1B for further analysis. The results are presented in study III and IV respectively. We found MAP1S to be highly expressed throughout brain and spinal cord, predominantly in neurons. MAP1S-EGFP over-expressed in cultured hippocampal cells, localizedboth to dendritic shafts and filopodia. Colocalization of MAP1S-EGFP with beta-tubulin III immunoreactivity was prominent, with synapsin and PSD95 immunoreactivity occasional and with NR3A immunoreactivity frequent in dendritic shafts and sparse in filopodia. Judging from the subcellular distribution of MAP1S and NR3A their interaction might be important for transport through shafts or regulation of NR3A-containing receptors in spines. The distribution of MAP1B immunoreactivity resembled that of MAP1S-EGFP, with prominent overlap with beta-tubulin III immunoreactivity, sparse colocalization with synapsin and SAP102 immunoreactivity, and frequent colocalization with NR3A immunoreactivity in dendritic shafts and infrequent colocalization in spines. To address the function of the NR3A-MAP1B interaction, we investigated the expression and distribution of NR3A in MAP1B deficient mice. These mice expressed increased NR3A and decreased NR1 levels compared to wild type, suggesting that NMDA receptors in the MAP1B deficient mice might have an altered subunit composition. NR3A was equally distributed to filopodia in neurons from MAP1B deficient and wild type mice, indicating that MAP1B is not essential for transport of NR3A-containing NMDA receptors to synaptic sites. Instead the interaction might involve regulating the distribution of NR3A-containing receptors between intracellular pools and the cell surface, as well as the distribution between synaptic and extrasynaptic sites.List of scientific papersI. Eriksson M, Nilsson A, Froelich-Fabre S, Akesson E, Dunker J, Seiger A, Folkesson R, Benedikz E, Sundström E. (2002). Cloning and expression of the human N-methyl-D-aspartate receptor subunit NR3A. Neurosci Lett. 321(3):177-81. https://pubmed.ncbi.nlm.nih.gov/11880201II. Nilsson A, Eriksson M, Muly EC, Akesson E, Samuelsson EB, Bogdanovic N, Benedikz E, Sundström E. (2007). Analysis of NR3A receptor subunits in human native NMDA receptors. Brain Res. 1186:102-12. https://pubmed.ncbi.nlm.nih.gov/17997397III. Eriksson M, Samuelsson H, Samuelsson EB, Liu L, McKeehan WL, Benedikz E, Sundström E. (2007). The NMDAR subunit NR3A interacts with microtubule-associated protein 1S in the brain. Biochem Biophys Res Commun. 361(1):127-32. https://pubmed.ncbi.nlm.nih.gov/17658481IV. Eriksson M, Samuelsson H, Björklund S, Tortosa E, Avila J, Benedikz E, Sundström E. (2008). The N-methyl-D-aspartate receptor subunit NR3A interacts with microtubule-associated proteins in the mammalian brain. [Submitted]</p
Cortical neuronal loss and hippocampal sclerosis are not detected by voxel-based morphometry in individual epilepsy surgery patients
No full textVoxel-based morphometry (VBM) has detected differences between brains of groups of patients
with epilepsy and controls, but the sensitivity for detecting subtle pathological changes in single subjects
has not been established. The aim of the study was to test the sensitivity of VBM using statistical parametric
mapping (SPM5) to detect hippocampal sclerosis (HS) and cortical neuronal loss in individual patients.
T1-weighted volumetric 1.5 T MR images from 13 patients with HS and laminar cortical neuronal loss
were segmented, normalised and smoothed using SPM5. Both modulated and non-modulated analyses
were performed. Comparisons of one control subject against the rest (n ¼ 23) were first performed to ascertain
the smoothing level with the lowest number of SPM changes in controls. Each patient was then compared
against the whole control group. The lowest number of SPM changes in control subjects was found
at a smoothing level of 10 mm full width half maximum for modulated and non-modulated data. In the
patient group, no SPM abnormalities were found in the affected temporal lobe or hippocampus at this
smoothing level. At lower smoothing levels there were numerous SPM findings in controls and patients.
VBM did not detect any abnormalities associated with either laminar cortical neuronal loss or HS. This
may be due to normalisation and smoothing of images and low statistical power in areas with larger interindividual
differences. This suggests that the methodology may currently not be suitable to detect particular
occult abnormalities possibly associated with seizure onset zone in individual epilepsy patients with
unremarkable standard structural MRI
Going Beyond Counting First Authors in Author Co-citation Analysis
No full textThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
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