51 research outputs found
Locke o Spinoza: un punto di eresia
No full textRelying on his previous inquiries, the author discusses theories of “consciousness” which were elaborated almost simultaneously by Locke and Spinoza, as a reaction against the Cartesian doctrine of self-certainty. Because of their remarkable analogies and their sharp antithesis, they illustrate a “point of heresy” which, even today, intrinsically divides any project of framing a “psychology” or “philosophy of mind
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Using the balanced scorecard framework /
No full text"... explains the balanced scorecard framework. Since its introduction in the early 1990s, the balanced scorecard framework has become a standard strategy execution and performance measurement system for many for-profit companies as well as for non-profit organizations and public sector entities. Scholars, including the author of this portfolio, Dr. Mark L. Frigo, have continued to refine this framework with cutting-edge managerial and accounting concepts.
Fausto Sozzini, la mortalità d’Adamo e la teologia moderna
No full textFausto Sozzini, Adam's Mortality and Early Modern Theology. In his dispute with Francesco Pucci, Fausto Sozzini argues that man was not created immortal but, being by nature subject to death, he could be made perpetually immune only through divine grace, which was a gift not included in his creation. It has thus been suggested that the Pucci-Sozzini querelle should be read as an expression of the broader debate that opposed the two 'souls' of modern theology, that is the Thomistic and the Augustinian. By reconstructing the late medieval theological debate on the mortality of Adam in the condition of innocence, the Author tries to show that Sozzini's theses are greatly indebted to Duns Scotus' criticisms of Thomas Aquinas
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Measurement of mitochondrial respiratory chain enzymatic activities in Drosophila melanogaster samples
No full textMitochondrial respiratory chain (MRC) dysfunction is linked to mitochondrial disease as well as other common conditions such as diabetes, neurodegeneration, cancer, and aging. Thus, the evaluation of MRC enzymatic activities is fundamental for diagnostics and research purposes on experimental models. Here, we provide a verified and reliable protocol for mitochondria isolation from various D. melanogaster samples and subsequent measurement of the activity of MRC complexes I-V plus citrate synthase (CS) through UV-VIS spectrophotometry. For complete details on the use and execution of this protocol, please refer to Brischigliaro et al. (2021)
Heritabilities and genetic correlations of body condition score and muscularity with productive traits and their trend functions in Italian Simmental cattle
No full textWith the aim to study the genetics of energy and muscle balance in the Italian Simmental breed, the objectives of this study were: i) the estimation of the genetic parameters for body condition score (BCS) and muscularity (MU) score; ii) the estimation of genetic correlations of BCS and MU with productive traits; iii) the estimation of the expected pattern of BCS and MU over lactation. A total of 47,839 records of first-parity lactating cows, collected from 1999 to 2007 in 2794 herds, were used. Two-trait animal models were analyzed using restricted maximum likelihood (REML) procedures to estimate (co)variance components. The expected patterns of BCS and MU along the lactation of first parity cows were estimated from the solutions of DIM fixed effect obtained from an univariate mixed model for both the traits. The heritability estimated was 0.18 for BCS, 0.38 for MU, and ranged from 0.13 to 0.18 for yield traits. The genetic correlations between BCS, MU and yield traits were negative (-0.17 to -0.63). The genetic correlation between BCS and MU was strongly positive (0.88), indicating that cows that genetically tend to have high BCS are more likely to have high values of MU. The genetic parameters estimated suggested that selection for BCS and MU in dual purpose breeds may be possible, and BCS may indirectly improve MU. The expected patterns for BCS and MU showed the trend of these two traits along the lactation and can help farmers in planning the best management of the lactating cows
CG7630 is the Drosophila melanogaster homolog of the cytochrome c oxidase subunit COX7B
No full textThe mitochondrial respiratory chain (MRC) is composed of four multiheteromeric enzyme complexes. According to the endosymbiotic origin of mitochondria, eukaryotic MRC derives from ancestral proteobacterial respiratory structures consisting of a minimal set of complexes formed by a few subunits associated with redox prosthetic groups. These enzymes, which are the “core” redox centers of respiration, acquired additional subunits, and increased their complexity throughout evolution. Cytochrome c oxidase (COX), the terminal component of MRC, has a highly interspecific heterogeneous composition. Mammalian COX consists of 14 different polypeptides, of which COX7B is considered the evolutionarily youngest subunit. We applied proteomic, biochemical, and genetic approaches to investigate the COX composition in the invertebrate model Drosophila melanogaster. We identified and characterized a novel subunit which is widely different in amino acid sequence, but similar in secondary and tertiary structures to COX7B, and provided evidence that this object is in fact replacing the latter subunit in virtually all protostome invertebrates. These results demonstrate that although individual structures may differ the composition of COX is functionally conserved between vertebrate and invertebrate species
Practical Microarchitectural Attacks from Integrated GPUs
No full textDark silicon is pushing processor vendors to add more specialized units such as accelerators to commodity processor chips. Unfortunately this is done without enough care to security. In this paper we look at the security implications of integrated Graphical Processor Units (GPUs) found in almost all mobile processors. We demonstrate that GPUs, already widely employed to accelerate a variety of benign applications such as image rendering, can also be used to “accelerate” microarchitectural attacks (i.e., making them more effective) on commodity platforms. In particular, we show that an attacker can build all the necessary primitives for performing effective GPU-based microarchitectural attacks and that these primitives are all exposed to the web through standardized browser extensions, allowing side-channel and Rowhammer attacks from JavaScript. These attacks bypass state-of-the-art mitigations and advance existing CPU-based attacks: we show the first end-to-end microarchitectural compromise of a browser running on a mobile phone by orchestrating our GPU primitives. While powerful, these GPU primitives are not easy to implement due to undocumented hardware features. We describe novel reverse engineering techniques for peeking into the previously unknown cache architecture and replacement policy of the Adreno 330, an integrated GPU found in many common mobile platforms. This information is necessary when building shader programs implementing our GPU primitives. We conclude by discussing mitigations against GPU-enabled attackers
My Digital Life : 2003 Onward
No full textThis experience report describes a project the author started 12 years ago to track several aspects of his life and the reality around him. Unlike several related projects, this project is conducted manually using a self-crafted digital framework. Here, the author describes the project's architecture, also noting different life perspectives he developed and depicted using different media. Finally, he explores the motivations and challenges of manual lifelogging.</p
A MEDIUM RESOLUTION SNP ARRAY BASED COPY NUMBER VARIANTS SCAN IN BROWN SWISS DAIRY CATTLE
No full textRecent reports indicate copy number variations (CNVs) to be functionally significant. This study presents a medium resolution map of CNV regions (CNVRs) in Brown Swiss dairy cattle, from to this day, the largest CNV genome scan in any cattle breed. We genotyped 1,342 bulls and after quality filtering on males we called CNVs with PennCNV and with “Copy Number Analysis Module” (CNAM) of SVS7 software (Goldenhelix) for a total of 46,728 loci anchored on the UMD3.1 assembly. We corrected for sequence composition flanking each SNP and employed principal component analysis for CNAM to correct for technical background noise to reduce false positive calls. PennCNV and SVS7 identified a total of 5,099 and 1,289 CNVs segregating in 632 and 651 bulls respectively. These were summarized at the population level into 1,101 (220 losses, 774 gains, 107 complex) and 277 (185 losses, 56 gains and 36 complex) CNVRs, covering 682 Mb (27.14%) and 33.7 Mb (1.35%) of the autosome, respectively. We then obtained the consensus between the two CNV scans using the approaches suggested by Redon et al. (2006), union set, and by Wain et al. (2009), intersection, covering 146 Mb (5.88%) and 17.1 Mb (0.68%), respectively. CNVRs were annotated with the bovine Ensembl gene set v69 and tested for enrichment of GO terms using DAVID database. Consensus CNVRs are enriched for protein-coding genes.
Go analysis identified genes (Bonferroni corrected) in the CNVRs related to cytoplasm, intercellular part, cellular processes, cytoplasmic part, and intracellular organelles.
Acknowledgement. This study funded by EC-FP7/2007-2013, agreement n°222664, “Quantomics”
Identification and validation of copy number variants in Italian Brown Swiss dairy cattle using Illumina Bovine SNP50 Beadchip®
No full textThe determination of copy number variation (CNV) is very important for the evaluation of genomic traits in several species because they are a major source for the genetic variation, influencing gene expression, phenotypic variation, adaptation and the development of diseases. The aim of this study was to obtain a CNV genome map using the Illumina Bovine SNP50 BeadChip data of 651 bulls of the Italian Brown Swiss breed. PennCNV and SVS7 (Golden Helix) software were used for the detection of the CNVs and Copy Number Variation Regions (CNVRs). A total of 5,099 and 1,289 CNVs were identified with PennCNV and SVS7 software, respectively. These were grouped at the population level into 1101 (220 losses, 774 gains, 107 complex) and 277 (185 losses, 56 gains and 36 complex) CNVR. Ten of the selected CNVR were experimentally validated with a qPCR experiment. The GO and pathway analyses were conducted and they identified genes (false discovery rate corrected) in the CNVR related to biological processes cellular component, molecular function and metabolic pathways. Among those, we found the FCGR2B, PPARα, KATNAL1, DNAJC15, PTK2, TG, STAT family, NPM1, GATA2, LMF1, ECHS1 genes, already known in literature because of their association with various traits in cattle. Although there is variability in the CNVRs detection across methods and platforms, this study allowed the identification of CNVRs in Italian Brown Swiss, overlapping those already detected in other breeds and finding additional ones, thus producing new knowledge for association studies with traits of interest in cattle
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