73 research outputs found
Omics-based immune profile in first-episode psychosis : revealing biomarkers for understanding schizophrenia pathophysiology
No full textSchizophrenia is a lifelong, severe mental health disorder characterized by significant disability, disrupted psychosocial functioning, and premature mortality. Typically emerging in early adolescence, schizophrenia imposes a substantial healthcare burden worldwide. This thesis provides a comprehensive examination of fluid biomarkers and metabolic pathways during the onset and progression of psychosis, with a particular focus on first-episode psychosis (FEP).The pathophysiology of schizophrenia is linked to neurotransmitter activities such as dopamine, glutamate, and γ-aminobutyric acid, giving rise to several theories including those of dopamine, glutamate, kynurenic acid, and neuroinflammation. There is an urgent need to identify new drug targets to develop more effective medications that goes beyond symptomatic management of psychosis, emphasizing the limitations in current treatments. Omics studies, including proteomics and metabolomics, could revolutionize schizophrenia treatment by offering a more systematic approach to identifying drug response markers and minimizing adverse effects in therapies. Through metabolomics and proteomics analyses of cerebrospinal fluid (CSF) and serum metabolites, this research identifies crucial alterations that indicates the potential of these biomarkers in diagnosing and monitoring schizophrenia and related disorders. Collectively, these studies deepen our understanding of the biological underpinnings of psychosis and support the development of biomarker-based diagnostic and therapeutic strategies. This research highlights the intricacy of schizophrenia, which involves a complex interplay of metabolic, genetic, and inflammatory factors.List of scientific papersI. Shang, Pei, Ada Man-Choi Ho, Maximilian Tufvesson-Alm, Daniel R. Lindberg, Caroline W. Grant, Funda Orhan, Feride Eren, et al. 2022. ‘Identification of Cerebrospinal Fluid and Serum Metabolomic Biomarkers in First Episode Psychosis Patients’. Translational Psychiatry.12 (1): 229. https://doi.org/10.1038/s41398-022- 02000-1. https://doi.org/10.1038/s41398-022-02000-1 II. Eren, Feride, Lilly Schwieler, Funda Orhan, Anna Malmqvist, Fredrik Piehl, Simon Cervenka, Carl M. Sellgren, Helena Fatouros-Bergman, Göran Engberg, and Sophie Erhardt. 2023. ‘Immunological Protein Profiling of First-Episode Psychosis Patients Identifies CSF and Blood Biomarkers Correlating with Disease Severity’. Brain, Behavior, and Immunity. 111 (July): 376–85. https://doi.org/10.1016/j.bbi.2023.04.020. https://doi.org/10.1016/j.bbi.2023.04.020 III. Eren, Feride, Lilly Schwieler, Funda Orhan, Anna Malmqvist, Fredrik Piehl, Simon Cervenka, Carl M. Sellgren, Helena Fatouros-Bergman, Göran Engberg, and Sophie Erhardt. 2023. ‘Preanalytic Handling of Clinical Blood Samples in Assessing Immunological Proteins – Role of Storage Duration’. Brain, Behavior, and Immunity. 114 (November): 163–64. https://doi.org/10.1016/j.bbi.2023.08.013. https://doi.org/10.1016/j.bbi.2023.08.013 IV. Haroon, Humza, Ada Man-Choi Ho, Vinod K. Gupta, Surendra Dasari, Carl M. Sellgren, Simon Cervenka, Göran Engberg, Feride Eren, Sophie Erhardt, Jaeyun Sung, Doo-Sup Choi et al. 2024. ‘Cerebrospinal Fluid Proteomic Signatures Are Associated with Symptom Severity of First-Episode Psychosis’. Journal of Psychiatric Research. February, S0022395624000645. https://doi.org/10.1016/j.jpsychires.2024.02.002. https://doi.org/10.1016/j.jpsychires.2024.02.002 </p
STRUCTURE AND THEME IN HASAN ESKİL'S GİRİTLİ FERİDE
No full textHasan Eskil’in Giritli Feride romanı, 19. yüzyılın sonlarında Girit’teki Rumların Türklere yaptıkları baskıları ve bu baskılardan kaçarak Girit’ten Anadolu’ya göçmek zorunda kalan bir Türk kafilesinin hikâyesini Feride -ve kısmen Derviş Ali- etrafında anlatmaktadır. Feride’nin Anadolu’ya göçmesinin ardından, Ege beldelerindeki Yunan işgali ve sonrasındaki Millî Mücadele ve zaferle sonuçlanan Kurtuluş Savaşı da yine Feride etrafında ele alınmıştır. Hâkim bakış açısı ile vücut bulan romanda özetleme yöntemi kullanılarak tarihî gelişmeler geniş bir perspektiften ve panoramik arka plan olarak sunulmaya çalışılmıştır. Ayrıca Mevlevilik ve Mevlevihaneler de -daha çok bir fon olarak- roman boyunca bahsedilen konulardan biridir. Romanda özellikle romana adını da veren “Girit” meselesi ve Türklerin orada yaşadığı zorluklar ve zorunlu göç esnasında yaşadıkları sıkıntılar ve acılar ile Anadolu’ya ulaştıktan sonra yaşadıkları yabancılık duygusu ön plana çıkarılmıştır. Yunan işgali, Feride özelinde, yaşadığı vatansızlık korkusunun ve acısının bir devamı ve alınması gereken bir intikam gibi düşünülmüştür. Yine de Feride zafer kazanıldıktan sonra, savaş meydanında eline düşen çocuk yaştaki Yunan askerini öldürmemiş, ona ve diğer askerlere Türk-Yunan ayırmadan su vemiştir. Böylelikle yazar, başkişisi Feride merkezinde “intikam”dan kastın bir milletin tamamına duyulan bir kin duygusu değil, bir ödeşme ve kurtuluş yolu olduğunu göstermek istemiştir.Hasan Eskil's Giritli Feride tells the story of the oppression of the Greeks in Crete against Turks at the end of the 19th century and the story of a Turkish group who had to migrate from Crete to Anatolia, putting Feride, and partly Derviş Ali, at the center of the story. After Feride's migration to Anatolia, the Greek occupation in the Aegean regions, the National Struggle and the War of Independence, which resulted in victory, were also discussed putting Feride at the center. In the novel, the third person omniscient point of view and summarization method is used to present historical developments from a broader perspective and as a panoramic background. In addition, the Mevlevi (Mawlawi) and the Mevlevihane (Mawlawi-khana) were among the topics mentioned throughout the novel, mostly as a background. In the novel, the issue of "Crete" (which also gives its name to the novel) and the difficulties and suffering of the Turks, and the feeling of strangeness after reaching Anatolia, are highlighted. The Greek invasion was considered –especially from the perspective of Feride- as a continuation of the fear and pain of statelessness and as a revenge that should be taken. Nevertheless, Feride did not kill the young Greek soldier who fell into her hands on the battlefield after the victory, and gave water to him and the other soldiers without separating the Turks and Greeks. In this way, using Feride, the protagonist, as a reflector, the author wanted to show that, what "revenge" meant to him is evenness and salvation rather being a feeling of resentment towards a whole nation
Impact of medication burden on adherence with antihypertensive drugs
No full textAntihypertensive drug adherence is key in achieving blood pressure control and preventing cardiovascular complications. The objective of this study was to
understand how pill burden, age and comorbid conditions impact antihypertensive medication compliance. This retrospective study used
MarketScan claims to identify continuously enrolled adults with newly diagnosed hypertension, follow‐up 6‐month pre‐ and 12–month post‐index antihypertensive
prescription. Pill burden was defined as total number of prescriptions per month and/or doses per day. Medication possession ratio (MPR), defined as total number of index antihypertensive days’ supply divided by 365, was a proxy for compliance. MPR ≥ 0.80 was classified as high. Descriptive statistics were conducted for 27 variables including sociodemographic characteristics, comorbid conditions, health care resource utilization and costs. Logistic regression analysis was run (SAS, version 8.2, Cary, NC). Mean age was 53 years for 68,538 study subjects and 56% were female. Diabetes (18%) and other forms of heart disease (14%) were most prevalent. Most subjects were full‐time employees (64%), working in manufacturing/durable goods (36%) or transportation/communications/utilities (21%), and residing in the South (41%) or North Central (28%) United States. Preferred provider organizations
(41%) and comprehensive benefit plans (23%) provided coverage for most subjects. Approximately 25% of subjects received diuretics, 21% angiotensin‐converting
enzyme inhibitors, 20% beta‐blockers, 17% fixed‐dose combinations, 9% calciumchannel blockers, and 8% angiotensin receptor blockers (ARBs). Total index
antihypertensive copay was lowest for diuretics (98.12). Mean number of doses per day (excluding antihypertensive prescriptions) was 1.3 and number of prescriptions per month (excluding
antihypertensive prescriptions) was 1.85. Mean MPR was 0.70 and 57% of subjects were highly compliant with antihypertensive medications. Likelihood of
compliance decreased by 10% per additional dose per day, increased by 22.5% per additional prescription per month (excluding antihypertensive medications),
decreased by 10% per additional comorbid conditions, increased by 0.6% per additional year of age, by 1.1% per dollar increase in total copay and was 9% greater
for males (p < 0.0001). Increasing doses per day, comorbid conditions and being female had a negative impact on compliance with antihypertensive medications and may assist in targeting populations for quality improvement initiatives.Ph.D.Includes bibliographical referencesIncludes vitaby Feride H Frech-Tama
Structural analysis of a feature film screenplay: To the moon and back
No full textBaşarılı bir reklam yazarı olan Işıl'ın, uzun zamandır görüşmediği annesi İstanbul'a, Işıl'ın yanına gelir. Annesiyle çok iyi bir ilişkisi olmayan Işıl için tek destek, çocukluğundan beri onunla olan kuzeni Eren'dir. Ancak aynı dönemde Eren'in sevgilisiyle beraber Almanya'ya taşınacağını öğrenir. Anne mevzusunu unutan Işıl, Eren'in Türkiye'de kalması için uğraşmaya başlar. Diğer kahramanımız olan 8 yaşındaki Saadet'in ise babası evi terk eder. Saadet'in bu olaydan etkilenmemesi için, diğer aile büyüklerinin kararıyla kuzeni Eren, Saadet'le beraber kalmaya başlar. Çok geçmeden, Saadet annesiyle beraber Ankara'ya, anneannesinin yanına taşınacaklarını öğrenir. Taşınmak istemeyen Saadet, kuzeni Eren'le İstanbul'da kalmanın yollarını aramaya başlar. Böyle bir dönemde yolları kesişen Işıl ve Saadet, kuzenlerinin isimlerinin aynı olmasının dışında başka benzerliklerinin olduğunu keşfederler. Bu süreç içinde Saadet'in cesaretinden feyz alan Işıl, asıl problemleri yok saydığını fark edecek ve hayatını kökten etkileyen baba problemiyle yüz yüze gelecektir. Işıl'ın, sorunun kaynağına indiği nokta, her ikisinin de hayatını değiştirecek olan noktadır.Isil, who is a successful copywriter, lives in Istanbul and is visited by her mother, whom she hasn?t seen for a long time. Isil doesn?t have a great relationship with her mother and the only support in her life is her cousin, Eren, who has been in her life since their childhood. However, at that time, she learns that Eren is going to move to Germany with his boyfriend. She forgets about the situation with her mother and starts struggling for him to stay. Our other protagonist, Saadet, is eight years old, and her father abandons the family. Saadet?s cousin, also named Eren, starts staying with her as decided by the family members so that Saadet wouldn?t be traumatized. Soon, she learns that she and her mother are going to move to Ankara to live with her grandmother. Saadet doesn?t want to go, so with her cousin Eren, she starts searching for different ways to stay in Istanbul. Isil and Saadet, whose lives intersect during such a period, find out that they have other similarities apart from the fact that their cousins share the same name. Isil, inspired by Saadet?s courage, realizes that she has always ignored the main problems, and faces the father issue, which is a radical influence in her life. The point where she explores the essence of that problem is the point, which changes the lives of both
Integrative analysis multi-omics analysis of proteomics and metabolomics data of Karolinska Schizophrenia Project (KaSP)
No full textIntegrative analysis multi-omics analysis of proteomics and metabolomics data of Karolinska Schizophrenia Project (KaSP)
No full textFarklı Yağ Asitleriyle Sulu Kaplanmış Kalsiyum Karbonat Kullanılarak Polietilen/Kalsiyum Karbonat Kompozit Malzemelerin Üretilmesi ve Karakterizasyonu
No full textMuhammed El-Kefevî ve Hâşiye Ala Şerhi’l-İstiâre isimli eserinin tahkiki / حاشية الكفوي على استعارة العصام
No full textÖZETBu çalışma kültürü ihya etme, el yazması bir eseri karanlıktan aydınlığa çıkartma ve kütüphane raflarından okuyucunun hizmetine sunma amacı gütmektedir. Bu yüzden, Osmanlı âlimlerinden çok değerli bir âlimin bir kitabını tahkik etmeye karar verdik. Bu âlim, Akkirmanî olarak tanınan Muhammed b. Mustafa Hamid el-Kefevî el-Hanefî’dir. Bu âlimin, beyan ilmiyle ilgili Hâşiye Alâ Şerhi İsam alâ Risâleti’l-İstiâre li’s-Semerkandi eseri tahkik çalışmamızın konusunu oluşturmaktadır.İlgili eserin, üçü Süleymaniye Kütüphanesi, biri de Suudi Arabistan’daki Kral Suud Üniversitesinde olmak üzere dört nüshasını karşılaştırdım.Çalışma bir giriş ve beş bölümden oluşmaktadır:Giriş: Bu çalışmanın özet ve çevirisinden bahsedilmiş, daha sonra önsöz, sembol ve işaretleri ele alınmıştır.Metin sahibi Ebü’l-Kāsım b. Ebî Bekr el-Leysî es-Semerkandî ve şerhi yapan Ebû İshâk İsâmüddîn İbrâhîm b. Muhammed b. Arabşâh el-İsferâyîn tanıtılmıştır. bunun akabinde Hâşiye’nin sahibi el-Kefevî’nin hayatı detaylı bir şekilde ele alınmıştır.İkinci Bölüm: Eser tanıtılmıştır (adı, telif nedeni, nüshalar arasındaki farklar, içeriği, müellifin bilgileri işleme yöntemi, son olarak ta Haşiye’de Kefevî’nin yararlandığı kaynaklar).Üçüncü Bölüm: Tahkik esnasında izlenen yöntem açıklanmıştır. El yazması eserin dört nüshasından örnek ve resimler eklenmiştir.Dördüncü Bölüm: Bu bölümde Semerkandi’nin İstiâre ile ilgili metni yer almaktadır.Beşinci Bölüm: Bu bölümde Hâşiye’nin tahkiki, ayet ve hadislerin tahrici, eserde geçen şiirleri sahiplerine isnat etme, kapalı ve anlaşılması güç sözcükleri açıklama, ilgili eserde adı geçen kişilerin tanıtımı, mesel ve veciz sözlerin açıklanması, nüshaların karşılaştırılması yer almaktadır. El yazmanın kenarlarında geçen yorumları dipnotlara aldım. İsâmüddîn’ın sözlerini el-Kefevî’nin sözlerinden ayırdım. Bu bölümün sonunda da kaynaklar ve ndeksini zikrettim. İÇİNDEKİLERIÖZETIIIAbstractIVGİRİŞ- 1 -ÖZET(ARAPÇA)- 1 -ÖNSÖZ- 2 -KISALTMALAR DİZİNİ- 4 - Semerkandî ’nin ANLATIMI- 5 -Şerh Sahibi İsameddin el-İsferâyînî Anlatımı- 7 - KEFEVİ’nin Anlatımı- 10 -YETİŞTİĞİ YER- 10 -KIRIM’IN TARİHİ- 10 -AKKIRMAN ŞEHRİNİ TARİHİ- 11 -KIRIM ALİMLERİNDEN BAZILARI- 13 -İSMİ VE LAKABI- 15 -DOĞDUĞU VE AİT OLDUĞU YER- 15 -HAYATI VE GÖREVLERİ- 16 -Şahsiyeti- 17 -Düşüncesi VE MEZHEBİ- 17 -İLMİ ÇALIŞMALARI- 18 -ESERLERİ........................................................................................................................- 19 -EL YAZMA ESERLERİ- 19 -BASILMIŞ ESERLERİ- 22 -İKİNCİ BÖLÜM KİTABIN TANITIMI- 24 -KİTABIN İSMİ TELİF NEDENİ VE TARİHİ- 24 -Kitabın İçeriği- 25 -Kitabın Kaynakları- 26 -FAYDALANDIĞI KAYNAKLAR- 28 -KİTABIN BELAGAT İLMİNDEKİ YERİ- 34 -KİTABIN NÜSHALARI- 35 -ÜÇÜNCÜ BÖLÜM Tahkikin Yöntemi ve Metodolojisi- 38 -DÖRDÜNCÜ BÖLÜM SEMERKANDİ’NİN İSTİARE METNİ- 43 -TAHKİK’İN SONUÇ- 47 -BEŞİNCİ BÖLÜM- 47 -KEFEVİ ’NİN HAŞİYESİ- 47 -KEFEVİ’NİN ÖNSÖZÜ- 48 -İSAMUDDİN’İN ÖNSÖZÜNE KEFEVİ’NİN HAŞİYESİ - 50 -MECAZ TÜRÜNDE BİRİCİ IKID- 62 -Birinci Feride mecaz müfredin anlatımı ve mecaz Mürsel ve istia’reye ayrımı- 64 -İkinci Feride istia’renin asliyye ve tebaiyye ye ayrımı- 73 -Nisbeye göre fiilde istia’re - 79 -Istia’renin harflerde gerçekleşmesi- 85 -Üçüncü Feride istia’renin tahkikiyye ve tahyiyliyye ayrılmasI- 88 -Dördüncü Feride istia’renin Mutlaka Müreşşaha ve Mücerrede ye ayrılması - 89 -Beşinci Feride- 96 -Altıncı Feride: Mecaz Murekkeb- 99 - İkinci İkid:istia’re bil kinaye nin tahkiki- 111 -İkinci Feride: Sekaki mezhebinde istia’re Mekniye - 123 -Üçüncü Feride: El Hatip mezhebinde istia’re Mekniye - 128 -Isamuddin ve istia’re Mekniye- 131 -Dördüncü Feride - 132 -Birinci Feride Önceki alimlerin istia’re Tayiliyye ile ilgili Mezhepleri- 135 -İkinci Feride: Zamahşeri ve karine i Mekniye - 137 -Üçüncü Feride: Essekaki ve karine i Mekniye....................................................................-139-Dördüncü Feride: SEMERKANDİ ve Karine Mekniye ile ilgili seçimleri- 141 -Beşinci Feride; Terşhlerle alakalı- 143 -Kaynak ve referanslar- 146 -AbstractThis research falls under the scope of knowledge revival, which aims at bringing it out of the darkness and back into the light, and out of library shelves and back into the hands of the readers. For this reason, we chose to investigate a book of one of the leading scholars of the High Ottoman Empire that is Imam Muhammed Bin Mustafa Hamid, Al-Kafawyi, Al-Hanafi, known as Al-Akramany. For this research, we choose to investigate – and one's choice reflects their thinking – his Footnotes on Al-Essam's Explanation of the Manuscript of Samarqandiyyeh which falls under the Science of Rhetoric. Our investigation includes the following:- I compared and contrasted four copies of this work. Three of which were available in the Sulaymaniyyeh Library, and one in King Saud University, KSA.This research is divided into an introduction and seven chapters:Introduction: discusses the abstract of this research with its translation, introduces this work, and explains the terms and symbols used in it.Chapter 1: provides biographies of the author of the original book, Al-Samarqandiy, the author of its explanation, Al-Essam, and a detailed biography of Al-Kafawyi, author of the footnotes. Chapter 2: this division introduces the book: its name, reason of its composition, the difference between its copies, its content, its method of discussing information, and finally, the references which Al-Kafawyi used in writing the Footnotes. Chapter 3: introduces the research methods adopted in this investigation, and provides models and images of the manuscript in its four copies. Chapter 4: contains the text of Samarqandiyyeh In Metaphor.Chapter 5: Contains investigation of the Footnotes, and refers to the Quran verses and Hadiths as mentioned in their original scripts.s Moreover, this chapter refers to the authors of poetry lines mentioned, explains obscure vocabulary and terms, provides biographical information about some of the leading figures mentioned, explains proverbs and sayings of wisdom mentioned, compares and contrasts the four copies, and refers to the differences among them. In this chapter, the comments mentioned in the margins of the manuscripts are provided, and we clarified which are the words of Al-Kafawyi and which of Al-Essam. Finally, this chapter is followed by a list of references, and a list of conten
Breathable and Waterproof Fabric Structures Using Conventional Fabrics and Microporous Films
No full textThis work reports waterproof breathable layered fabrics consisting of simple fabric weave types (plain, twill) and microporous breathable films. The fabrics were pretreated and then treated with water repellent finishing chemicals. Afterwards, layered structures were generated by bringing the fabrics and the microporous breathable films together. According to the results of water repellency, water permeability and water vapor permeability tests conducted on the samples with/without microporous film layers, we were able to generate waterproof breathable layered fabrics
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