1,721,039 research outputs found
Association Between History of Polymerase Chain Reaction-verified COVID-19 Infection and Outcomes of Subsequent ST-Elevation Myocardial Infarction
Get PDFWhile the acute phase of coronavirus disease 2019 (COVID-19) is associated with worsening cardiac outcomes, it is unclear whether it affects the outcome of patients with ST-segment elevation myocardial infarction (STEMI) after the acute phase. In addition, while many studies compared the course of STEMI during the COVID-19 pandemic with the years before the outbreak, we evaluated the course of STEMI during the pandemic according to whether or not patients had history of COVID-19. Patients diagnosed with STEMI during the ongoing COVID-19 pandemic were included in the study. The Ministry of Health database was analyzed retrospectively, and patients with (n = 191) and without (n = 127) a history of polymerase chain reaction (PCR) confirmed COVID-19 infection were divided into groups. Clinical and angiographic characteristics were assessed. The rates of in-hospital major adverse cardiac events (MACE) were higher in those who had a history of PCR-verified COVID-19 infection. Angiographic and procedural findings indicating successful reperfusion were better in patients without a history of COVID-19. A history of COVID-19 infection (odds ratio 1.40, 95% confidence interval 1.25–1.60, P < .01) independently predicted MACE. A history of COVID-19 infection is a predictor of worse outcomes following coronary intervention and in-hospital MACE among patients with STEMI
Assessment of subtle cardiac dysfunction induced by premature ventricular contraction using two-dimensional strain echocardiography and the effects of successful ablation
No full textIntroduction and objectives: We aimed to assess the effects of successful ablation on impaired left ventricular global longitudinal strain (LV-GLS) in patients with frequent premature ventricular contractions (PVCs). We also evaluated the potential risk factors of impaired LV-GLS. Methods: Thirty-six consecutive patients without any structural heart disease, who were treated with radiofrequency (RF) ablation due to frequent PVCs, were included in the study. All patients were evaluated with standard transthoracic and two-dimensional speckle tracking echocardiography. Results: Mean LV-GLS before ablation was 17.3 ± 3.7 and 20.5 ± 2.6 after ablation; the difference was statistically significant (p−16% and those ≤16%. Low PVC E flow/post-PVC E flow and PVC SV/post-PVC SV ratios were associated with impaired LV-GLS. Conclusion: In symptomatic patients with frequent PVCs and normal left ventricular ejection fraction, we observed significant improvement in LV-GLS value following successful RF ablation. Patients with impaired LV-GLS more often display non-ejecting PVCs and post-extrasystolic potentiation (PEP) compared to patients with normal LV-GLS. Resumo: Introdução e objetivos: O nosso objetivo foi avaliar os efeitos de ablação eficaz na deformação longitudinal global do ventrículo esquerdo (LV-GLS) em doentes com extrassístoles ventriculares (PVCs). Também avaliamos os potenciais fatores de risco de LVGLS anormal. Métodos: Trinta e seis doentes consecutivos sem doença cardíaca estrutural tratados com ablação por radiofrequência (RF) devido a PVCs frequentes foram incluídos no estudo. Todos os doentes foram avaliados com ecocardiografia transtorácica com speckle tracking bidimensional (2D-STE). Resultados: Os valores médios de LVGLS antes da ablação foram de 17,3 ± 3,7. Esse valor foi observado como 20,5 ± 2,6 após a ablação e a diferença foi estatisticamente significativa (p−16% e ≤16%. Baixo valor de PVC E flow/post-PVC E flow e PVC SV/post-PVC SV associaram-se com LV-GLS anormal. Conclusão: Em doentes sintomáticos com PVCs frequentes e fração de ejeção do ventrículo esquerdo (FEVE) normal, observamos melhoria significativa no valor LV-GLS após ablação por RF bem-sucedida. Doentes com LV-GLS anormal apresentam frequentemente nonejecting PVCs e potencialização pós-extrassistólica (PEP) em comparação com doentes com LV-GLS normal
Evaluation of the relationship between monocyte to high-density lipoprotein cholesterol ratio and thrombus burden in patients with deep vein thrombosis
No full textBu çalışmanın amacı, derin ven trombozlu hastalarda monosit sayısı ve yüksek yoğunluklu lipoprotein kolesterol düzeylerini ve oranlarını (monosit/yüksek yoğunluklu lipoprotein oranı) değerlendirmek ve tanı anında bu oranın uygulanıp uygulanamayacağını belirlemektir. derin ven trombozunda trombüs yerleşimi açısından trombüs yükünün bir göstergesidir.
2018 ve 2022 yılları arasında ayakta tedavi gören hastalar için bir veri tabanı sorgusu kullanarak, hastanın venöz Doppler ultrason ile doğrulanan derin ven trombozu tanısını retrospektif olarak analiz ettik. Dahil edilen 378 hastadan 356'sının tanı anında kan sayımı sonuçları mevcuttu. ve kontrol grubu olarak, poliklinik veri tabanı sorgulanarak, kan sayımı uygun olan, derin ven trombozu tanısı olmayan cinsiyet uyumlu hastalar alındı. Monosit/yüksek yoğunluklu lipoprotein oranı, monosit sayısının yüksek yoğunluklu lipoprotein-C'ye oranından hesaplanmıştır. Hastalar, Doppler ultrason bulguları ile kanıtlandığı gibi, trombüs düzeyine ve tutulan damar segmentlerinin sayısına göre kategorize edildi.
Serum monosit/yüksek dansiteli lipoprotein oranı hasta grubunda kontrol grubuna göre anlamlı olarak yüksekti (p<0.01). Proksimal derin ven trombozu olan hastalarda ortalama monosit/yüksek yoğunluklu lipoprotein oranı (19.6±5.1'e karşı 17.1±5.5; p<0.01), distal derin ven trombozu olan hastalardan daha yüksekti. Monosit/yüksek yoğunluklu lipoprotein oranı tutulan damar segmenti sayısı ile arttı (p<0.01).
Monosit/yüksek dansiteli lipoprotein oranı derin ven trombozlu hastalarda kontrol grubu ile karşılaştırıldığında anlamlı olarak yüksektir. Monosit/yüksek yoğunluklu lipoprotein oranı seviyeleri, trombüsün konumu ve derin venöz tromboz hastalarında yer alan ven segmentlerinin sayısı tarafından yansıtılan hastalık yükü ile korele idi.The aim of this study is to evaluate the monocyte count and high-density lipoprotein cholesterol levels and ratios (monocyte/high-density lipoprotein ratio) in patients with deep vein thrombosis and to determine whether this ratio can be applied at the time of diagnosis. In deep vein thrombosis, it is an indicator of thrombus load in terms of thrombus location.
Using a database query for outpatients between 2018 and 2022, we retrospectively analyzed the patient's diagnosis of deep vein thrombosis, which was confirmed by venous Doppler ultrasound. Of the 378 patients included, 356 had blood count results at the time of diagnosis. and as the control group, gender-matched patients without deep vein thrombosis diagnosis and with appropriate blood count were included by querying the outpatient clinic database. The monocyte/high-density lipoprotein ratio was calculated from the ratio of monocyte count to high-density lipoprotein-C. Patients were categorized according to the level of thrombus and the number of involved vessel segments, as evidenced by Doppler ultrasound findings.
Serum monocytes/high-density lipoprotein ratio was significantly higher in the patient group than in the control group (p<0.01). The mean monocyte/high-density lipoprotein ratio (19.6±5.1 vs. 17.1±5.5; p<0.01) was higher in patients with proximal deep vein thrombosis than in patients with distal deep vein thrombosis. Monocyte/high-density lipoprotein ratio increased with the number of involved vessel segments (p<0.01).
Monocyte/high-density lipoprotein ratio was significantly higher in patients with deep vein thrombosis compared to the control group. Monocyte/high-density lipoprotein ratio levels were correlated with disease burden as reflected by the location of the thrombus and the number of vein segments involved in deep venous thrombosis patients
Going Beyond Counting First Authors in Author Co-citation Analysis
Get PDFThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Variations on the Author
Get PDF“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Appropriate Similarity Measures for Author Cocitation Analysis
Get PDFWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
Prognostic factors of the patients admitted to the hospital at the subacut period of STEMI
Get PDFYÖK Tez No: 272444Amaç: Akut miyokard infarktüsü (AMİ), ciddi morbidite ve mortalite ile seyreden yaygın bir hastalıktır. Hastaların başvuru anındaki risk derecelendirilmesinin yapılması, uygulanacak medikal ve girişimsel tedavinin belirlenmesi açısından önemlidir. ST elevasyonlu miyokard infarktüsü (STEMI) tedavisinin en önemli aşaması hızlı damar reperfüzyonudur ve pek çok çalışmada reperfüzyon ne kadar erken sağlanırsa o kadar çok canlı miyokard dokusunun kurtarıldığı gösterilmiştir. Ancak subakut dönemde başvuran hastalarla ilgili halen süren iskemiye işaret eden klinik ve/veya elektrokardiyografik kanıt bulunmaması durumunda, perkutan koroner girişimin (PKG) semptomların başlamasının üzerinden 12 saatten daha uzun bir süre geçmiş hastalarda da yararlı olup olmadığı konusunda görüş birliği bulunmamaktadır. Bu çalışmada STEMI ile uyumlu semptomların başlamasından sonra subakut dönemde hastaneye başvuran hastalarda morbidite ve mortalite üzerine etkili olabilecek faktörlerin, girişimsel ve medikal tedavi seçenekleri ile ilgili önerilerin belirlenmesi hedeflenmiştir.Yöntem: Bu retrospektif çalışmaya subakut dönemde hastaneye başvurmuş 94 STEMI hastası (62 erkek, 32 bayan) dahil edilmiştir. Hastalar 29±27 ay süresince takip edilmiştir. Hastane içi dönemde ve takip süresince ölüm görülen ve hayatta kalan, takip döneminde major istenmeyen kardiyovasküler olay yaşayan ve yaşamayan hastaların klinik özellikleri ve laboratuvar değerleri birbirleri ile karşılaştırılmıştır.Bulgular: Ölen hastaların başvuru sırasındaki yaşı, Killip skoru, başvuru anında EKG'de ST elevasyon miktarı, kreatinin ve MPV değerleri yaşayanlardan anlamlı olarak daha yüksek iken ejeksiyon fraksiyonu ve hematokrit değerleri anlamlı olarak daha düşüktü. Ayrıca ölen hastalarda KKY öyküsü, hastane yatışında EKG'de atrial fibrilasyon ve geniş QRS varlığı anlamlı olarak daha fazlaydı. Hastane içi dönemde ölüm görülen hasta grubunda yaş, Killip skoru ve kreatinin değeri lojistik regresyon analizinde anlamlı mortalite belirteci olarak saptandı. Takip süresince PKG uygulanmış hasta grubunda ölüm ve major istenmeyen kardiyovasküler olay geçirme oranları daha düşük olarak tespit edildi.Sonuç: STEMI ile uyumlu semptomların başlamasından sonra subakut dönemde hastaneye başvuran hastalarda, başvuru anında morbidite ve mortalite üzerine etkili faktörlerin belirlenmesi, gerek hastane içi gerekse uzun dönem takip sonuçları ile ilgili öngörüde bulunmamıza ve hastalar için en uygun tedavi protokolünü belirlememize olanak sağlayabilir. Halen süren iskemiye işaret eden klinik ve/veya elektrokardiyografik kanıt bulunmayan hasta grubunda geç dönemde PKG uygulanması major kardiyovasküler istenmeyen olay yaşama ve ölüm görülme oranlarında azalma sağlayabilir.Background: Acute myokardial infarction (AMI) is a common disease that causes severe morbidity and mortality. Assesment of risk stratification at admission is important for deciding whether medical or interventional therapy is better. The most important step of the STEMI treatment is rapid reperfusion of arteries and it is shown in many studies that, sooner you get reperfusion more you get alive myocardial tissue. But it?s not clear whether percutaneus coronary intervention (PCI) is better for the patients who applied to hospital at subacute period and not have any clinic and/or electrocardiographic evidence for continued ischemia when more than 12 hours passed from onset of the symptoms. We aimed to determine the factors that may be responsible for morbidity and mortality at the time of admission and also interventional or medical treatment options in the patients who applied to hospital at subacute period after beginning of the STEMI concordant symptoms.Methods: 94 patients with subacute STEMI were included in this study. (62 male, 32 female) Their follow-up time is 29±27 months. The patients?, who died or lived and who had or not have major adverse cardiovascular events during in-hospital and out hospital follow up time, clinic and biochemical values were compared to each other.Results: Age, Killip score, ST elevation amount on admission ECG, creatinin and MPV values of the patients who died, were significantly higher than the patients who lived and their ejection fraction, hematocrit values were significantly lower. Also history of congestive cardiac failure, atrial fibrillation on ECG at admission and large QRS existance were significantly much more than the patients who survive. Killip score, age and creatinin were determined by logistics regression analysis to be significant mortality marker in the patients who died during in hospital follow up time. Major adverse cardiovascular events and death rate were found lower in the patients who underwent PCI during follow up time.Conclusions: Determination of the factors that may be responsible for morbidity and mortality at the time of admission in the patients who admitted to hospital at subacute period after beginning of the STEMI concordant symptoms, can help us to predict patients? in hospital and life time prognosis and to decide the most suitable therapy for the patients. Late percutaneus coronary intervention (PCI) may reduce major adverse cardiovascular events and death rate in the patients who not have any clinic and/or electrocardiographic evidence for continued ischemia
Dispelling the Myths Behind First-author Citation Counts
Get PDFWe conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued
use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation
counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more
sophisticated methods
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