İstanbul Atlas University Institutional Repository
Not a member yet
783 research outputs found
Sort by
The Sex-Dependent Ameliorative Effect of Intermittent Fasting on Urinary System Functions in Genetic Absence Epileptic Rats
No full textEpilepsy, a brain condition causing recurrent seizures, can disrupt various body functions, including urination. This study explored how alternate-day fasting (ADF), a type of intermittent fasting, a diet involving one day of eating and fasting, subsequently affects urinary system health in epileptic rats. Using a genetic rat model of epilepsy, we examined bladder and kidney function through tissue analysis, biochemical tests, and physiological assessments, focusing on differences between males and females. The results showed that epilepsy causes significant urinary system damage linked to inflammation and oxidative stress. However, ADF reduces this damage by lowering inflammation and restoring antioxidant balance. Male rats exhibited more oxidative damage, while female rats responded better to ADF, likely due to hormonal differences. These findings suggest ADF as a potential, cost-effective dietary approach to protect against urinary complications in epilepsy and similar conditions. Understanding these effects may lead to improved treatments for both genders and a better quality of life for people with chronic diseases
An innovative biosensing approach for Aflatoxin B1 detection via electrical impedance measurement
Full text linkAflatoxin B1 (AFB1) contamination poses a significant threat to food safety and public health, creating an urgent need for reliable and effective detection methods. This study presents a fast and sensitive biosensor for detecting AFB1 in complex food samples. Scanning Electron Microscopy (SEM) shows the current functionalization of tungsten wires with antibodies and multi-walled carbon nanotubes (MWCNTs). The surface morphological changes are easily visible as they give rise to a roughened, textured surface that provides a greater active area, since the surface used for hydrogen evolution. Results from Differential Scanning Calorimetry (DSC) show that the enthalpy changes associated with antibody AFB1 interactions are greater at higher AFB1 concentrations, indicative of higher affinities of binding interactions. Differential scanning calorimetry (DSC) thermograms display clear endothermic peaks corresponding to different levels of AFB1, providing information about the melting point as well as the stability and binding characteristics of the antibody complex. The biosensor achieves a broad detection range (0.1 ppb to 30 ppb), with charge transfer resistance decreasing from 1.5 ohm & sdot;cm2 to 0.5 ohm & sdot;cm2 as AFB1 concentration increases. Using Electrical Impedance Spectroscopy (EIS) and advanced nano- materials, this biosensor enables real-time monitoring of molecular interactions. By addressing the limitations of traditional detection methods, it offers a practical solution for enhancing food safety and preventing AFB1 contamination
The Effect of Nursing Interventions in Women With Gestational Hypertension: A Systematic Review and Meta-Analysis
Full text linkPregnancy-related hypertensive disorders are significant global causes of maternal morbidity and mortality. Quality nursing care is essential for pregnant women with hypertension to ensure a healthy pregnancy and delivery. This study aimed to systematically synthesize evidence on the effectiveness of nursing interventions for women with gestational hypertension. A systematic review and meta-analysis were conducted following PRISMA guidelines. Literature was searched across seven electronic databases from August 1 to September 27, 2023. Thirteen studies, encompassing 1458 women with gestational hypertension, were included. Quality assessment indicated that 10 randomized controlled trials were rated as good, one as fair, and all quasi-experimental studies as good quality. Various nursing interventions were analyzed, including training programs, home-based comprehensive nursing, case management, vascular symptom management, music therapy, and clinical nursing pathways. Meta-analysis results revealed that nursing interventions significantly reduced systolic and diastolic blood pressure, anxiety, depression, and hospital length of stay. These findings suggest that nursing interventions can effectively improve health outcomes for women with gestational hypertension, positively impacting at least one outcome in all included studies. PROSPERO Registration NumberCRD4202344482
The Importance of Resolvin D1, LXA4, and LTB4 in Patients with Acute Pancreatitis Due to Gallstones
Full text linkBackground and Objectives: Acute pancreatitis (AP) is an inflammatory disease where there is autodigestion of the pancreas by prematurely activated enzymes which may lead to a systemic inflammatory response. The aim of our study was to investigate the levels of circulating serum leukotriene B4 (LTB4), lipoxin A4 (LXA4), and resolvin D1 (RvD1) in pancreatitis due to gallstones in the etiologic investigation of AP. Materials and Methods: A total of 147 patients with AP (n: 49), AC (n: 49), and combined AP + AC (n: 49) will be included in the study. Healthy volunteers (n: 49) will be included as the control group. Results: RvD1 levels were significantly lower in patient groups compared to controls, while LXA4 levels were lower in patients with combined AP + AC (145.24 ng/L) compared to both controls (312.36 ng/L) and other patient groups. LTB4 levels were elevated in all patient groups compared to controls (335.56 ng/L vs. 65.56 ng/L) and were highest in combined AP + AC. Significant correlations were identified: RvD1 showed a negative correlation with LTB4 (r =-0.676; p < 0.001) and a positive correlation with LXA4 (r = 0.563, p < 0.001). ROC analysis demonstrated high diagnostic accuracy, with LXA4 and LTB4 achieving perfect differentiation (AUC: 1.0) between control and combined AP + AC cases. Conclusions: Our study showed that serum RvD1 and LXA4 levels have powerful anti-inflammatory properties in accordance with the literature. LTB4 may represent new, effective indicators to predict the severity of AP and the presence of necrosis in patients with AP. Despite its low sensitivity and specificity, RvD1 could be used as a complementary marker to the current scoring systems for the initial assessment of AP prognosis. These findings provide a new mechanistic understanding of how RvD1 attenuates inflammation to facilitate resolution, which could help develop novel therapeutic strategies for diseases caused by unresolved inflammation. It is easily obtainable and can provide additional prognostic information to clinicians
Awareness of Surgical and Medical Intensive Care Nurses' about Alcohol Withdrawal Syndrome and Care Practices
No full textAlcohol withdrawal syndrome is a significant global health concern affecting individuals with alcohol use disorder, particularly in hospital settings like intensive care units. Early diagnosis and management are crucial but often complicated by symptom overlap with other conditions. This study aims to evaluate the awareness and knowledge of surgical and medical intensive care unit nurses regarding AWS, focusing on risk factor identification, diagnosis, and care practices. A cross-sectional descriptive study was conducted from November 15 to December 01, 2021, involving 112 nurses from public and private hospitals. Data were collected via an online questionnaire developed from existing literature, which included demographic questions and a 20-item alcohol withdrawal syndrome awareness scale, where higher scores indicated better awareness. Statistical analysis utilized the Kolmogorov-Smirnov test for normality, Mann-Whitney Ufor two- group comparisons, and Kruskal-Wallis H for multiple-group comparisons. A multivariate generalized linear model assessed the influence of independent variables on alcohol withdrawal syndrome awareness. Nurses scored an average of 9.92 out of 20 on the alcohol withdrawal syndrome awareness scale, indicating moderate knowledge. Significant differences in awareness were noted based on professional experience, intensive care unit type, and prior training. Nurses with 5 or more years of experience and those with specific training in alcohol withdrawal syndrome care exhibited higher awareness levels (p < .05). The study reveals a gap in alcohol withdrawal syndrome awareness among intensive care unit nurses, particularly those with less experience and training. Enhanced educational programs and practical exposure are essential for improving early identification and management of alcohol withdrawal syndrome in critical care settings
Palyatif bakımdaki bakım vericilere verilen eğitimin bakıma hazır oluşluk ve bakım verme yükü üzerine etkisi / The effect of education given to caregivers in palliative care on readiness for care and caregiving burden
No full textBu randomize kontrollü çalışma palyatif bakım ünitesinde yatan informal bakım vericilerine verilen eğitimin bakım verici yükü ve bakıma hazır oluşluk düzeylerine etkisini değerlendirmek amacıyla gerçekleştirilmiştir. Araştırmaya Kasım 2024- Haziran 2025 tarihleri arasında İstanbul Bakırköy Dr. Sadi Konuk Eğitim ve Araştırma Hastanesi Palyatif Bakım biriminde yatan, dahil edilme, dışlanma kriterlerine uyan informal bakım vericileri alınmıştır. Randomizasyona göre öncelikle girişim grubundaki (n=35) bakım vericilere tanımlayıcı özellikler formu, Zarit Bakım Verme Yükü ve Bakıma Hazır Oluşluk Ölçekleri uygulandı. Daha sonra kitapçıkla birlikte eğitim verildi ve her hafta iletişim kurulmaya devam edildi. Bir ay sonunda aynı ölçekler yeniden uygulandı. Kontrol grubuna ise ölçekler uygulandıktan sonra 1 ay boyunca herhangi bir girişim uygulanmadı ve ay sonunda ölçekler yeniden uygulandı. Girişim ve kontrol grubundaki bakım vericilerin karşılaştırılmasında iki grup arasında anlamlı fark olmadığı anlaşıldı (p˃0.05) Bakım vermeye hazır oluşluk düzeylerinin girişim grubunda eğitim sonrasında arttığı ve aralarındaki farkın anlamlı olduğu bulundu. (p=0.000) Kontrol grubunda ise bakım vermeye hazır oluşluk düzeyinin 1 ay sonrasında arttığı ve aralarındaki farkın anlamlı olduğu bulundu. (p=0.015) Sonuç olarak her iki grubun 1 ay sonrasında bakıma hazır oluşluk düzeylerinin arttığı anlaşıldı (p˂0.05). Palyatif bakımda yatan hastaların informal bakım vericilerinde orta düzeyde bakım verici yükü olduğu anlaşılmıştır. Bakım vericilere verilen eğitim bakım verici yükünün azaltılmasına etkisi olmasa da az da olsa bakım verici yükünün azaltılmasına etkili olduğu belirlenmiştir. Anahtar kelimeler: İnformal bakım verici, Bakım verme yükü, Bakıma hazır oluşluk, Palyatif bakım, EğitimThis randomized controlled study was conducted to evaluate the effect of education given to informal caregivers of patients in a palliative care unit on caregiver burden and readiness for caregiving. The research was carried out between November 2024 and June 2025 with the caregivers of patients hospitalized in the Palliative Care Unit of Istanbul Bakırköy Dr. Sadi Konuk Training and Research Hospital. The study was conducted with informal caregivers who met the inclusion and exclusion criteria, divided into an intervention group (n=35) and a control group (n=35). Data were collected using a descriptive characteristics form, the Zarit Caregiver Burden Scale, and the Readiness for Caregiving Scale. After obtaining verbal and written informed consent, the caregivers assigned to the intervention group by randomization completed the forms. Then, an educational session was provided and an educational booklet was given to the caregiver. Weekly support was provided through communication with the caregivers for one month. At the end of the month, the scales were reapplied. In the control group, after the initial application of the scales, no intervention was applied for one month, and the scales were reapplied at the end of the month. When comparing the caregivers in the intervention and control groups, no statistically significant difference was found between the two groups in terms of caregiver burden (p˃0.05). However, it was found that the level of readiness for caregiving increased significantly in the intervention group after the education (p=0.000). In the control group, the readiness for caregiving level also increased after one month, and the difference was statistically significant (p=0.015). As a result, it was observed that the level of readiness for caregiving increased in both groups after one month. It was determined that caregivers of patients in palliative care experienced a moderate level of caregiver burden. Although the education provided to caregivers did not have a statistically significant effect on reducing caregiver burden, it was found to have a slight positive effect. Keywords: Informal care giver, Burden of caregiving, Readiness for care, Palliative care, Educatio
Immediate Autologous Fat Transfer into the Breast for Volume Restoration After Implant Removal
No full textBackground: Autologous fat transfer to the breast is utilized for various clinical indications, including breast augmentation, reconstruction, and correction of asymmetries and deformities. This study presents the outcomes of patients who underwent simultaneous volume restoration through fat transfer following breast implant removal. Patients and Methods: Thirty-eight patients received immediate fat transfer to the breast after their implants were removed. The participants were categorized into three groups based on the type of incision used for implant removal: inframammary fold, periareolar, and mastopexy incisions. The study aimed to compare patients' ages, satisfaction levels, complication rates, and follow-up durations among the different groups. Results: The mean age of the patients was 40.94 +/- 8.73 years (range 24-61 years), and the mean follow-up period was 24.60 +/- 17.10 months (range 3-60 months). The average volume of the implants was 318.8 cc (175-480 cc). Seventy-six breasts (38 patients bilaterally) underwent fat grafting, with a mean fat graft volume of 222.8 cc (SD 63.25; range 80-350 cc; median: 200 cc). Fourteen patients reported no complications. The periareolar incision group was excluded from statistical analysis due to a small sample size (n = 3). Patient satisfaction was notably higher in the mastopexy incision group than in those who underwent the inframammary fold incision (p = 0.037; p < 0.05). No significant differences in complication rates were observed between the groups. Conclusions: Autologous fat transfer represents a safe and effective method for achieving volume restoration following implant removal, with high patient satisfaction regarding breast shape and volume restoration
The Relationship between Violence Tendency and Premenstrual Symptoms among University Students: A Cross-Sectional Study in Turkey
Full text linkBackground:Literature discusses the relationship between young women's violent tendencies and biological, psychological, and social factors. Notably, hormonal fluctuations during the menstrual cycle are reflected in mood swings and aggression levels, which may increase the tendency of young women to resort to violence.Aim:This study aimed to evaluate the relationship between violent tendencies and premenstrual symptoms in university students.Methods:Data for this cross-sectional analytical study were collected from 1301 students via a Google survey between January and May 2020 using the Personal Information Form, Premenstrual Syndrome Scale (PMSS), and Violence Tendency Scale (VTS).Results:It was determined that 65.3% of students had PMS, and the students' VTS scores was high in 25.8% of them and low in 73.2 of them. There was significant correlation between the students' VTS scores in both subscales and total scores of PMSS (P < 0.05), PMSS' anxiety (beta = 0.171), irritability (beta = 0.348), and sleep changes (beta = 0.182) subscale scores positively affected VTS scores (P < 0.05).Conclusion:Most of the students in the study were found to suffer from PMS, and PMS symptoms, particularly anxiety, irritability, and sleep disturbances, were associated with higher VTS scores. These results suggest that specific symptoms of PMS may play an important role in determining students' VTS scores, and this may have implications for understanding PMS broader effects on student wellbeing and performance. Health professionals can provide education and health services aimed at reducing premenstrual symptoms, preventing violent tendencies, and providing resources and foundations for future studies by conducting more studies
Clinical Value of Circulating Angiopoietin-like Protein 8/Betatrophin Levels in Patients with Acute Pancreatitis
Full text linkBackground and Objectives: Acute pancreatitis (AP) is an inflammatory disorder of the pancreas, with severe cases linked to a higher mortality rate. The prognosis of AP is influenced by factors such as necrosis, secondary infections, and organ failure. Tissue damage in AP is driven by the activation of leukocytes and the release of inflammatory mediators. Angiopoietin-like protein 8 (ANGPTL8), also known as betatrophin, is a recently discovered protein that regulates lipid metabolism. This study aimed to investigate the relationship between ANGPTL8 levels and disease severity in AP patients, and to explore the potential of ANGPTL8 as a biomarker. Materials and Methods: This prospective study included 50 patients diagnosed with AP who were admitted to the Department of Internal Medicine at Dr. Cemil Ta & scedil;c & imath;o & gbreve;lu City Hospital between September 2021 and February 2022. Additionally, 39 healthy volunteers who underwent a check-up at the same hospital served as the control group. The Glasgow-Imrie (GI) score was used to assess the severity of pancreatitis. Results: ANGPTL8 levels were found to be significantly lower in the AP group compared to the control group, with a statistically significant correlation between ANGPTL8 levels and the severity of AP (p < 0.05). The cut-off level of ANGPTL8 based on the GI score was determined to be 70.9 ng/L. The GI score for ANGPTL8 was 0.749 (95% CI: 0.606-0.861) (p < 0.001). The overall cut-off value for ANGPTL8 was 179.2 ng/L, with an overall classification rate of 0.936 (95% CI: 0.864-0.977) (p < 0.001). Conclusions: This study demonstrates that ANGPTL8 levels vary between patients with and without AP, with lower levels observed in AP patients. Our research is the first to identify decreased ANGPTL8 levels as an independent predictor of AP severity. ANGPTL8 may play a crucial role in regulating inflammation or metabolic dysfunction in AP. However, further studies are needed to confirm these findings in larger populations and investigate ANGPTL8's mechanistic role in AP. Longitudinal studies could help determine whether ANGPTL8 levels act as a biomarker for disease progression or treatment response, potentially paving the way for targeted therapies to improve outcomes for AP patients
Histopathological features of chest wall masses: a systematic review
Full text linkChest wall masses can be caused by trauma, infections, inflammation, or cancer. These tumors can be benign or malignant and originate from different structures of the chest wall. This systematic review aimed to investigate the histopathological characteristics of chest wall masses. The study followed the PRISMA guidelines. PubMed, Scopus, and Web of Science databases were searched for case series that reported the histopathological features of chest wall masses, without any restrictions on the date. The risk of bias was assessed using the JBI critical appraisal tools. Nine studies were included in the final review. Studies included a total of 1,279 patients with chest wall masses, with diverse age ranges. Biopsy methods such as fine-needle aspiration biopsy (FNAB), cutting needle biopsy, and surgical resection biopsy were used to evaluate the pathology of the masses. The rate of malignancy in chest wall masses varied depending on the biopsy method used, ranging from 27.12% in needle biopsy to 47.16% in surgical resection biopsy. The overall rate of malignancy in chest wall tumors was 31.27%. About one-third of the chest wall masses are malignant, emphasizing the importance of accurate diagnosis and appropriate treatment selection. Choosing the proper biopsy method is crucial for achieving successful outcomes and reducing mortality rates. Further research with larger sample sizes and improved reporting is needed to enhance our understanding of chest wall tumor pathology and improve patient outcomes