559 research outputs found
Bazı önemli tıbbi bitkilerin antioksidan ve antikanser etkilerinin araştırılması
No full textTıbbi açıdan önemli bitkiler binlerce yıldır birçok hastalığın tedavisi amacıyla kullanılmaktadır. Buna ek olarak modern eczacılıkta birçok bitki bileşiği ilaç ham maddesi veya yeni ilaçların yapımında önemli bir yere sahiptir. Bu çalışmada tıbbi öneme sahip kudret narı (Momordica charantia), pepino (Solanum muricatum) ve altın çilek (Physalis peruviana) bitkilerinin meyvelerinden elde edilen özütlerin biyolojik etkinliklerinin ortaya konulması amaçlanmıştır. Bitkilerin meyve özütleri %80’lik etanolde hazırlandıktan sonra toplam polifenol içeriği Folin-Ciocaltute reaktifi kullanılarak spektrofotometrik olarak ölçüldü. Bitki örneklerinin serbest radikal giderme etkisi DPPH serbest radikali kullanılarak belirlendi. Özütlerin insan over ve meme kanseri hücre hatları (sıyasıyla A2780 ve MCF7) üzerine sitotoksik etkileri MTT yöntemi kullanılarak belirlendi. Bitki örneklerindeki toplam polifenolik düzeyin en düşük 138,14±12,15 ve en yüksek 415,71±36,89 µg/gr gallik asit düzeyinde olduğu belirlendi. Bütün özütlerin düşük seviyede antioksidan etki sergilediği saptandı. Son olarak over ve meme kanseri hücre serilerine uygulanan özütlerin güçlü sitotoksik etki gösterdiği belirlendi (p<0.05). Sonuçta her üç bitki örneğinin de antioksidan etkilerinden ziyade yüksek antikanser etkiye sahip olduğunu bizlere göstermektedir. Her üç örneğinde söz konusu kanser türleri üzerine etkilerini aydınlatmak için ileriki çalışmalara ihtiyaç vardır.For thousands of years, plants have been used for the treatment of many diseases. In addition, in modern pharmacy many plant compounds have an important place in the production of pharmaceutical raw materials or new medicines. The aim of this study was to determine the biological activity of extracts obtained from the fruits of the medical important bitter melon (Momordica charantia), pepino (Solanum muricatum) and goldenberry (Physalis peruviana). The total polyphenol content of the samples was measured spectrophotometrically using Folin-Ciocalteureactivity. The DPPH free radical scavenging effect of plant samples was determined and antioxidant capacities were determined. In addition, the cytotoxic effects of the samples on human over and breast cancer cell lines (A-2780 and MCF-7, respectively) were determined using MTT method. As a result of the study, it was determined that the highest total polyphenol content was in the case of potency and the lowest content was in the case of pepino. All three plant samples revealed the effect of free radical elimination of DPPH dependent predation. Finally, it was determined that all three plant samples showed high cytotoxic effect on both human over and breast cancer cell lines(p<0.05).Results show us that in all three plant samples it has a significantly higher anticancer effect than antioxidant effect. With the extensive studies to be carried out after that, the mechanism of the effect can be enlightened and contribute to new treatment approaches.Bu çalışma Bartın Üniversitesi Bilimsel Araştırma Projeleri Koordinasyon Birimi tarafından 2017-FENCY-003’nolu proje ile desteklenmiştir
Çok kıymetli ve sevgili hocam Prof. Dr. Zeyyat Hatiboğlu
No full textEren, Erol (Dogus Author)Bu satırlarda içimden ne geliyorsa ve ne gibi duygular içindeysem onları yazıyorum. Değerli hocamın sağlığında çıkarmaya çalıştığımız bu armağan kitabında yer almasını arzu ettiğim düşünce ve duygularım kendisiyle yüz yüze kaldığımızda dahi söylemediğim şeylerdir
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Author Correction: Bimetallic synergy in cobalt–palladium nanocatalysts for CO oxidation
No full textIn the version of this Article originally published, the author Baran Eren was mistakenly affiliated with the Harbin Institute of Technology, China; it has now been corrected to Materials Science Division, Lawrence Berkeley National Laboratory, Berkeley, CA, USA
Author's response: Ocular photodynamic therapy with verteporfin in pigmented and amelanotic choroidal melanoma
No full textÖrtüaltı domates yetiştiriciliğinde jeotermal enerji kaynaklarının kullanımının üretim maliyetlerine etkisinin karşılaştırmalı analizi
No full textBu araştırmada, Kütahya İli Simav İlçesinde örtü altı domates yetiştiriciliği yapan işletmelerdejeotermal enerji kullanımının üretim maliyetlerine etkisi belirlenmeye çalışılmıştır. Araştırmakapsamında, işletmeler soğuk seralar, jeotermal topraklı ve jeotermal topraksız seralar olmaküzere üç gruba ayrılarak incelenmiştir. Her grup için anket uygulanacak işletmelerinbelirlenmesinde tam sayım yöntemi kullanılmıştır. Elde edilen verilerin istatistiki analizinde Kikaretesti, Çoklu Doğrusal Regresyon Analizi, Mann Whitney U testi kullanılmıştır.İncelenen örtü altı işletmelerde domates üretiminde jeotermal topraklı ve topraksız seralardajeotermal enerjiyle seraların ısıtılması yoluyla kış aylarında da üretim yapılması nedeniyle yılda2 dönem üretim yapılmaktayken, soğuk seralarda kışın ısıtma sistemi bulunmaması nedeniyletek dönem üretim yapılmaktadır. Jeotermal topraklı ve topraksız seralarda yılda iki dönemüretim yapılması nedeniyle soğuk seralara kıyasla yıllık domates verim miktarında yaklaşık ikikat fark bulunmaktadır. Jeotermal topraklı seralarda domatesin yıllık ortalama verim miktarı21,16 kg/da ve jeotermal topraksız seralarda 22,26 kg/da iken, soğuk seralarda ortalama verimmiktarı 12,51 kg/da’dır. Jeotermal topraklı seralarda tek dönem domatesin ortalama verimmiktarı ise 15,90 kg/da ve jeotermal topraksız seralarda 15,81 kg/da’dır. Sera tipleri itibariyletek dönem üretim masrafları toplamı ise, soğuk seralarda 11.260,10 TL/da, jeotermal topraklıseralarda 13.098,47 TL/da ve jeotermal topraksız seralarda 19.144,50 TL/da’dır.İncelenen örtü altı işletmelerde sera tiplerine göre tek dönemlik ortalama domates üretimmaliyetini karşılaştırdığımızda jeotermal topraklı seralarda birim domates maliyetinin dahadüşük olduğu tespit edilmiştir. Buna göre soğuk seralarda ortalama domates maliyeti 0,89TL/kg iken, jeotermal topraklı seralarda 0,82 TL/kg ve jeotermal topraksız seralarda 1,20TL/kg’dır.AbstractIn this study, the province of Kütahya Simav in greenhouse tomato cultivation, production costsin effect the enterprises the use of geothermal energy is determined. Within the scope of theresearch, enterprises were evaluated in cold greenhouses, geothermal grounded and geothermalungrounded greenhouses in three groups. The survey foreach group to be applied to the operatorin the identification of full counting method was used. Statistical analysis of obtained data, theChi-square test, Multiple Linear Regression Analysis, Mann-Whitney u test were used.Examined green house enterprises production of tomatoes in geothermal grounded andungrounded greenhouse heating with geothermal energy in greenhouses through to year 2period in winter production is being made while performing, in cold greenhouses only periodbecause of the lack of heating system in winter. This difference between the greenhouse types intomato production the amount of the annual tomato yield due to the difference of about twotimes. The amount of the average annual yield of tomato in geothermal grounded greenhouses21.16 kg/da and geothermal ungrounded greenhouses 22.26 kg/da, whereas the amount of theaverage yield in the cold greenhouse 12.51 kg/da. The average yield of single period tomatoesin geothermal grounded greenhouses is 15,90 kg / da and 15,81 kg / da in geothermalungrounded greenhouses. The sum of single period production costs in terms of greenhousetypes is 11,260,10 TL / da in cold greenhouses, 13,098,47 TL / da in geothermal groundedgreenhouses and 19,144,50 TL / da in geothermal ungrounded greenhouses.When we compare the single-season average tomato production cost with the greenhouse typesin the underground plants examined, the unit cost of tomatoes was found to be lower in thegeothermal grounded greenhouses.This means that the average cost of tomatoes in cold green houses 0,89 TL/kg, while geothermalgrounded greenhouses 0,82 TL/kg and geothermal ungrounded greenhouses 1,20 TL/kg
Baudelaire, Ikbal ve Asya’da Insanin Yaratilisa ve Verili Olana Müdahalesi
No full textsame nation or the same author in terms of subject, motivation, and form. It is also possible that the studies in this discipline, whose exact boundaries cannot be mentioned, can address these three items together, or two or only one of them. This discipline, which emphasizes the similar and different sides of the texts, also emphasizes the causes of differences and similarities. This branch of science, which sees literature as a whole, aims to find all possible affinities of intercultural and intertextual relations and their reasons in works of different or the same period. In this context, the main criterion is that suitable motifs or thoughts can be handled in a common context in terms of comparability. In this study, Les Fleurs du Mal of Charles Baudelaire; The poem titled a Conversation Between God and Man by Muhammed Ikbal and the art poem of Arif Nihat Asya was primarily studied thematically. Different and common aspects of the texts were emphasized. The 'Pluralist Method' used in comparative literature science was taken as the basis.Karsilastirmali edebiyat bilimi, farkli uluslara ya da ayni ulus veya ayni yazara ait en az iki eserin konu, düsünce ve biçim açisindan incelenmesini esas alir. Kesin sinirlarindan söz edilemeyen bu bilim dalindaki çalismalarin bu üç maddeyi birlikte veya ikisini ya da tekini konu edinmesi de mümkündür. Metinlerin, ortak, benzer ve farkli yanlarini açik etmeyi hedefleyen bu disiplin özellikle metinlerdeki farklilik ve benzerliklerin nedenleri üzerinde durur. Farkli veya ayni zaman dilimindeki eserlerde, kültürlerarasi ve metinlerarasi iliskilerin olasi tüm yakinliklarini ve bunlarin nedenlerini açik etme de bu hedefler arasindadir. Bu baglamda temel kriter, mukayese edilebilirlik açisindan uygun motif ya da düsüncelerin ortak baglamda ele alinabilmesidir. Bu çalismada, Charles Baudelaire’in Sonsöz Tasarisi adli siiri, Muhammed Ikbal’in Allah ile Insan Arasinda bir Konusma baslikli siiri ile Arif Nihat Asya’nin Sanat baslikli siiri, öncelikle tematik açidan incelendi. Metinlerin ortak, benzer ve farkli yanlari üzerinde duruldu. Çalismada karsilastirmali edebiyat biliminde kullanilan yöntemlerden ‘Çogulcu Yöntem’ esas alindi
A secure and efficient inventory management system for disasters
No full textOver the last three decades, disasters worldwide claimed more than 3 million lives and adversely affected the lives of at least 1 billion people (Noji, 1997). Regarding the threats posed by these disasters, emergency disaster management has emerged as a vital tool to reduce the harm and alleviate the suffering these disasters can cause to their victims. A significant task of planners involved in emergency disaster management is planning for and satisfying the vital needs of the people located in emergency shelters such as the Superdome in New Orleans. This thesis proposes a novel and comprehensive framework for the development of a humanitarian emergency inventory management system based on the real-time tracking of emergency supplies and demands through the integration of emerging technologies such as Radio Frequency Identification Devices (RFID) for commodity tracking and logistics. The novelty of this thesis is that, for the first time in the emergency inventory management field, the proposed approach combines an offline planning strategy with online control techniques in a unified framework. Within this framework, the offline planning problem is solved by the stochastic humanitarian inventory management approach, whereas the online modeling strategies include the application of neural network-based functional approximation, simultaneous perturbation stochastic approximation (SPSA), and continuous time model predictive control (CMPC) techniques. Unlike previous studies, the flexibility of the proposed inventory management and control model allows the application of the developed mathematical model to extreme events making online real-time tracking possible. Realistic case studies built using information available from past disasters are used to examine the differences in inventory strategies for different types of disasters based on the impact area and duration of the extreme event. The proposed methodology is also capable of representing and understanding real-life cases where uncertainty and limitations on the inventory levels and flow of supplies can be modeled by introducing different levels of stochasticity and real-life constraints. The overall findings of this thesis have pointed out that the proposed integrated framework can be efficiently used for emergency inventory planning and inventory control during disaster relief operations without ignoring the real-world uncertainties, fluctuations, and constraints of disaster conditions.Ph. D.Includes bibliographical referencesIncludes vitaby Eren Erman Ozguve
The Middleast and Northern Tier Strategy
No full textBIOGRAPHICAL NOTE
He has his Ph.D. in Economics from the University of Luxembourg with special coursework in international economics from the London School of Economics; he has been a Senior Research Fellow at Princeton. As well as being a contributor ans author of two books, Dr. Eren has been founder and President of the Economic Research Foundation and the Social and Economic Studies Conference Board. HIs career has included being Director of Turkish Informantion Services in the US, Delegate to the Council of Europe, Negotiator of the Turkish-American Treaty of Commerce, and Turkish Director of NATO's Project for Economic Cooperation between Greece and Turkey.SPEAKER'S POSITION
Ambassador and Deputy Permanent Representative of Turkey to the UNSpeech Type: OCF
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