200,552 research outputs found
Positiones ... medicas ...
No full textpro summis in medicina honoribus & privilegiis legitime reportandis publico eruditorum examini ad diem ... Decembr. anno M. DC. LXXVII. ... sistit Iohannes Christophorus Erb, Pos. Polon.Datum auf Titelblatt hs. ergänzt: ad diem XXVI. Decembr.Enth. 28 ThesenEinblattdruckDiss. med. Basel, 167
Was führt sie zu mir ...? Die Bedeutung des narrativen Spontanberichtes in der Klassischen Homöopathie
No full textR Code and Data Supporting: Ecological forecasts reveal limitations of common model selection methods: predicting changes in beaver colony densities
No full textDetailed documentation in readme text file.This repository contains the R and JAGS code supporting results reported in: Johnson-Bice, S.M., J.M. Ferguson, J.D. Erb, T.D. Gable, S.K. Windels (2020). Ecological forecasts reveal limitations of common model selection methods: predicting changes in beaver colony densities. Ecological Applications [In Press].Minnesota Environment and Natural Resources Trust Fund, as recommended by the Legislative-Citizen Commission on Minnesota Resources (project M.L. 2016, Chp. 186, Sec. 2, Subd.03j)Minnesota Department of Natural ResourcesUniversity of Minnesota DuluthUniversity of Minnesota Twin CitiesJohnson-Bice, Sean M; Ferguson, Jake M; Erb, John D; Gable, Thomas D; Windels, Steve K. (2020). R Code and Data Supporting: Ecological forecasts reveal limitations of common model selection methods: predicting changes in beaver colony densities. Retrieved from the University Digital Conservancy, https://doi.org/10.13020/rwp5-6413
Uncertainty principles on compact Riemannian manifolds
No full textAbstractBased on a result of Rösler and Voit for ultraspherical polynomials, we derive an uncertainty principle for compact Riemannian manifolds M. The frequency variance of a function in L2(M) is therein defined by means of the radial part of the Laplace–Beltrami operator. The proof of the uncertainty rests upon Dunkl theory. In particular, a special differential-difference operator is constructed which plays the role of a generalized root of the radial Laplacian. Subsequently, we prove with a family of Gaussian-like functions that the deduced uncertainty is asymptotically sharp. Finally, we specify in more detail the uncertainty principles for well-known manifolds like the d-dimensional unit sphere and the real projective space
Graph Wedgelets: Adaptive Data Compression on Graphs based on Binary Wedge Partitioning Trees and Geometric Wavelets
No full textWe introduce graph wedgelets - a tool for data compression on graphs based on
the representation of signals by piecewise constant functions on adaptively
generated binary graph partitionings. The adaptivity of the partitionings, a
key ingredient to obtain sparse representations of a graph signal, is realized
in terms of recursive wedge splits adapted to the signal. For this, we transfer
adaptive partitioning and compression techniques known for 2D images to general
graph structures and develop discrete variants of continuous wedgelets and
binary space partitionings. We prove that continuous results on best m-term
approximation with geometric wavelets can be transferred to the discrete graph
setting and show that our wedgelet representation of graph signals can be
encoded and implemented in a simple way. Finally, we illustrate that this
graph-based method can be applied for the compression of images as well.Comment: 12 pages, 10 figure
Das frühkaiserzeitliche Militärlager in den Augster Unterstadt. Forschungen in Augst 12 Köln:Rheinland-Verlag GmbH ,1994
No full textItem does not contain fulltextE. Deschler-Erb Das frühkaiserzeitliche Militärlager in den Augster Unterstadt. Forschungen in Augst 12 Köln:Rheinland-Verlag GmbH ,199
(Erb)Baurecht im slowenischen, österreichischen und deutschen Recht
No full textDiplomsko delo sestavljajo trije sklopi – tri poglavja: stavbna pravica bo obravnavana najprej z vidika slovenskega, nato pa še z vidika avstrijskega in nemškega prava.
V prvem poglavju bo predstavljena stavbna pravica v domačem, slovenskem pravu, njena narava in funkcija, njen nastanek, pravice strank v razmerju in prenehanje ter posledice prenehanja stavbne pravice.
V enakem smislu bo obravnavana tudi stavbna pravica in njene posebnosti v avstrijskem pravu (v sklopu drugega poglavja).
V tretjem poglavju se bomo po enakem ključu seznanili še s stavbno pravico in njenimi posebnostmi v nemškem pravu .
V zaključku bodo povzete temeljne karakteristike in bistvene razlike med ureditvami stavbnih pravic v vseh treh pravnih sistemih.
Namen diplomskega dela je prikazati razlike med (sorodnimi) pravnimi sistemi in njihove posebnosti v zakonodaji glede stavbne pravice.Meine Diplomarbeit ist aus zwei Kapitteln zusammengesetzt: das (Erb-) Baurecht wird aus der slowenischen Sichtpunkt und dann aus der Sichtpunkt des österreichischen und deutschen Gesetzes vorgestellt.
Im ersten Kapittel wird das (Erb-) Baurecht im heimlichen, slowenischen Recht vorgestellt, seine Natur und Funktion, seine Entstehung, die Rechte der Parteien im Verhältnis und die Kündigung und Konsequenzen der Kündigung des (Erb-) Baurechtes.
In der gleichen Weise wird auch das Baurecht und seine Besonderheiten im österreichischen Recht bearbeitet (innerhalb des zweiten Kapittels).
Im dritten Kapittel wird in der gleichen Weise auch das Erbbaurecht und seine Besonderheiten im deutschen Recht vorgestellt.
Zum Schluss werden die grundliegende Eigenschaften und die wesentlichen Unterschiede zwischen der Regulierung der (Erb-) Baurechte in allen drei Rechtssystemen zusammengefasst.
Der Zweck der Diplomarbeit ist die Unterschiede zwischen den verwandten Rechtssystemen und ihre Besonderheiten in dem (Erb-) Baurecht vorzustellen
A Novel Fully Human Antitumor ImmunoRNase Targeting ErbB2-Positive Tumors
No full textA second generation anti-ErbB2 ImmunoRNase, called Erb-hcAb-RNase, was obtained by the fusion of Erb-hcAb, a human compact anti-ErbB2 antibody, with human pancreatic ribonuclease (HP-RNase or RNase 1).
We show herein that Erb-hcAb-RNase retains the enzymatic activity of human pancreatic RNase and specifically binds to ErbB2-positive cells with an affinity comparable to that of the parental Erb-hcAb. Moreover, this novel immunoRNase is endowed with an effective and selective antiproliferative action for ErbB2-positive tumor cells both in vitro and in vivo. Its antitumor activity is more potent than that of the parental Erb-hcAb as the novel immunoconjugate has acquired RNase-based cytotoxicity in addition to the inhibitory growth effects, antibody-dependent and complement-dependent cytotoxicity of the compact antibody.
Erb-hcAb-RNase could be a promising candidate for the immunotherapy of ErbB2-positive tumours as it combines the advantages of the first generation scFv-based immunoRNase with those of a fully functional antibod
Differential expression and MAL-dependent targeting of the L-MAG and S-MAG isoforms to myelin membranes
No full textMany degenerative diseases of the nervous system, including Multiple Sclerosis and peripheral neuropathies, are triggered by an impaired interaction between the axons and their surrounding myelin sheaths. The cause for this disturbed axon-myelin interaction, and the secondary neuronal damage that produces the clinical symptoms, lies in a primary defect of the myelin sheath. The myelin sheath itself is formed and maintained by oligodendrocytes and Schwann cells, the myelinating glial cells of the central and peripheral nervous system, respectively. The isoforms of the myelin-associated glycoprotein (MAG) are thought to be potential key elements of axon-myelin interaction, since these immunoglobulin-like cell signalling proteins are known to be localized in the periaxonal and paranodal myelin membranes. The MAG isoforms each display one of two possible intracellular C-termini as a result of alternative mRNA splicing. The C-terminus of the large isoform (L-MAG) has been shown to mediate downstream signals via the non-receptor tyrosine kinase Fyn, while the Cterminus of the short isoform (S-MAG) is thought to interact with the glial cytoskeleton. We have investigated the regulation and differential expression of L- and S-MAG in oligodendroglial cells and in transgenic mice by the use of genomic constructs that encode individually green fluorescent protein-tagged MAG isoforms. In the oligodendroglial cells LMAG was the dominant isoform prior to the stimulation of cells with cyclicAMP, whereas upon cyclicAMP stimulation, S-MAG was predominantly expressed in cells exhibiting advanced morphological differentiation. The investigation of our transgenic mice revealed that the two MAG isoforms are differentially expressed in distinct fibre tracts of the striatum and that S-MAG seems to be predominantly expressed in the long projecting fibres of the corpus callosum. Thus, the two MAG isoforms appear not only to be differentially expressed during development and in the adult, but they seem to mediate isoform-specific aspects of the axon-myelin interaction in distinct regions of the adult brain. A major question in the formation and maintenance of the myelin-axon interaction concerns the coordinated targeting of myelin signalling molecules and lipids to the different myelin compartments. Recent results suggest that glycolipid-enriched microdomains, socalled 'lipid-rafts', are involved in special sorting and trafficking mechanisms of membrane proteins and lipids. Furthermore, they are thought to serve as platforms for signal transduction processes. This makes them to interesting candidates for axon-myelin interactions, as well as for interactions between the apposed myelin membranes. The integral membrane protein 'Myelin and Lymphocyte Protein' (MAL) is suggested to be involved in lipid-raft-mediated protein targeting and signalling in myelinating cells. Our investigation of adult brain tissue of MAL-deficient mice showed that the incorporation of particular myelin components, such as MAG, into myelin membranes was significantly reduced. Thus, the targeting of L- and S-MAG to the myelin membranes appears to be dependent on the lipid-raft protein MAL. Furthermore, the MAL-deficient mice showed several ultra structural alterations comparable to those of the MAG-deficient mice and that reflect an impaired axon-myelin interaction. Our data supports the idea that-raft mediated trafficking of myelin constituents, such as MAG, to the different myelin compartments is a major task of adult oligodendrocytes in the context of maintaining the axonal contact of the myelin sheath. With the use of the isoform specific tagged MAG expressing mice, it will be possible for the first time, to investigate their differential function in axon-glia interaction as well as their dependence on MAL in vivo
Individual, contextual, and age-related acoustic variation in Simakobu (Simias concolor) loud calls.
No full textPrimate loud calls have the potential to encode information about the identity, arousal, age, or physical condition of the caller, even at long distances. In this study, we conducted an analysis of the acoustic features of the loud calls produced by a species of Asian colobine monkey (simakobu, Simias concolor). Adult male simakobu produce loud calls spontaneously and in response to loud sounds and other loud calls, which are audible more than 500 m. Individual differences in calling rates and durations exist, but it is unknown what these differences signal and which other acoustic features vary among individuals. We aimed to describe the structure and usage of calls and to examine acoustic features that vary within and among individuals. We determined the context of 318 loud calls and analyzed 170 loud calls recorded from 10 adult males at an undisturbed site, Pungut, Siberut Island, Indonesia. Most calls (53%) followed the loud call of another male, 31% were spontaneous, and the remaining 16% followed a loud environmental disturbance. The fundamental frequency (F0) decreased while inter-unit intervals (IUI) increased over the course of loud call bouts, possibly indicating caller fatigue. Discriminant function analysis indicated that calls were not well discriminated by context, but spontaneous calls had higher peak frequencies, suggesting a higher level of arousal. Individual calls were distinct and individuals were mainly discriminated by IUI, call duration, and F0. Loud calls of older males had shorter IUI and lower F0, while middle-aged males had the highest peak frequencies. Overall, we found that calls were individually distinct and may provide information about the age, stamina, and arousal of the calling male, and could thus be a way for males and females to assess competitors and mates from long distances
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