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PENGARUH PEMBERIAN MESENCHYMAL STEM CELL WHARTON’S JELLY TERHADAP KADAR MATRIX METALLOPROTEINASE-1, A DISINTEGRIN-LIKE AND METALLOPROTEINASE WITH THROMBOSPONDIN MOTIF-4, INDUCIBLE NITRIC OXIDE SYNTHASE DAN INTERLEUKIN-4 PADA OSTEOARTRITIS
Full text linkABSTRAK
Pengaruh Pemberian Mesenchymal Stem Cell Wharton’s Jelly Terhadap Kadar Matrix Metalloproteinase-1, A Disintegrin-Like And Metalloproteinase With Thrombospondin Motif-4, Inducible Nitric Oxide Synthase Dan Interleukin-4 Pada Osteoartritis
Penelitian Eksperimental Pada Rattus Novergicus
Endrinaldi
Osteoarthritis (OA) secara umum dianggap sebagai penyakit sendi degeneratif yang disebabkan oleh perubahan biomekanik dan proses penuaan. Penelitian telah mengungkapkan peran proses inflamasi dalam patogenesis OA. Penelitian ini bertujuan untuk mempelajari pengaruh Mesenchymal Stem Cell Wharton’s Jelly terhadap bioactive marker osteoartritis.
Penelitian ini merupakan penelitian eksperimental dengan desain Posttest-Only Control Group Design. Sampel terdiri dari 18 ekor tikus OA sebagai kelompok kontrol dan 18 ekor tikus OA yang diterapi dengan MSC-WJ sebagai kelompok perlakuan. Induksi OA dilakukan dengan injeksi monosodium iodoacetate (MIA) ke intra-artikular lutut kanan. Pemberian MSC-WJ dilakukan pada minggu ke tiga setelah induksi MIA. Kadar MMP-1, ADAMTS-4, iNOS dan IL-4 serum tikus diukur dengan metoda ELISA. Uji statistik yang digunakan adalah uji t independen. Nilai p < 0,05 dikatakan bermakna secara statistik.
Dari hasil penelitian didapatkan bahwa kadar MMP-1 serum lebih tinggi pada kelompok yang diterapi MSC-WJ dibandingkan kelompok kontrol (3.96 ± 0.81 ng/ml versus 2.63 ± 0.55 ng/ml, p 0,05). Kadar iNOS serum lebih tinggi pada kelompok yang diterapi MSC-WJ dibandingkan kelompok kontrol (28,37 ± 4,23 ng/ml versus 26,21 ± 2,79 ng/ml, p > 0,05). Kadar IL-4 serum lebih tinggi pada kelompok yang diterapi MSC-WJ dibandingkan kelompok kontrol (47,95 ± 4,88 ng/L versus 43,90 ± 4,99 ng/L, p < 0,05).
Penelitian ini menyimpulkan bahwa terdapat perbedaan antara kadar MMP-1 dan IL-4 serum tikus OA lutut yang diterapi dengan MSC-WJ dan yang tidak diterapi. Tidak terdapat perbedaan antara kadar ADAMTS-4 dan iNOS serum tikus OA lutut yang diterapi dengan MSC-WJ dan yang tidak diterapi.
Kata Kunci : Osteoartritis, Masenchymal Stem Cell Wharton’s Jelly, MMP-1, ADAMTS-4, iNOS dan IL-
Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Variations on the Author
Full text link“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Appropriate Similarity Measures for Author Cocitation Analysis
Full text linkWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
Korelasi antara kadar gula darah puasa dengan stress oksidatif dan aktivitas katalase pada tikus model diabetes melitus tipe 1 yang diterapi dengan MSC-WJ
Full text linkObjective: This study was conducted to investigate the involvement of oxidative damage in type 1 diabetes mellitus rats treated with Mesenchymal Stem Cell Wharton's Jelly (MSC-WJ) and to explain the correlation between fasting blood sugar levels and MDA levels as an indicator of oxidative stress and catalase activity.
Methods: This research is experimental research with a Posttest-Only Control Group Design. It consisted of 3 groups, namely group 1 was healthy rats, group 2 was DM rats and group 3 was DM rats treated with MSC-WJ. This study conducted in vivo experiments on alloxan-induced diabetic rat models by testing fasting blood glucose (FBG), serum MDA levels, and catalase activity. Malondialdehyde (MDA) was measured by the Ohkawa method, and catalase activity (CAT) was measured by a modified Sinha method.
Results: The results showed the correlation analysis between fasting blood sugar levels and MDA levels (r = 0.697) and catalase activity (r = -0.850) in type 1 DM rats after being treated with Mesenchymal Stem Cell Wharton's Jelly.
Conclusion: This study shows a strong positive correlation between fasting blood sugar levels and oxidative stress and a very strong correlation between fasting blood sugar levels and catalase activity of type 1 DM rats treated with MSC-WJ
Dispelling the Myths Behind First-author Citation Counts
Full text linkWe conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued
use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation
counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more
sophisticated methods
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