77 research outputs found
Manfred Max Neef y la revolución ambientalista para América Latina, 1932-2019 (in memoriam)
No full textWith the article, it is offered a tribute to the work of Manfred Max Neef, Chilean intellectual,
politician, ecologist and economist, Alternative Nobel Prize winner in Economics, a pioneer in ecological
criticism of both productivism and extractivism in Latin America. The methodology used in this work
is based on the review of the main books published by the author, such as Barefoot Economy (1982),
Development on a Human Scale (1986), The Lost Dimension (2007), and The Unmasked Economy
(2014). It is held as an assumption that Max Neef’s work fits into a Latin American theoretical body,
which breaks intellectually with macroeconomic models, be they developmentalist or neoliberal in
nature. The originality of his contribution is in the defense of the ecological foundations for human
development at a local scale.Con el artículo, se ofrece un homenaje a la obra de Manfred Max Neef, intelectual, político, eco-
logista y economista chileno, Premio Nobel Alternativo en Economía, pionero en la crítica ecológica,
tanto en el productivismo como en el extractivismo en América Latina. La metodología empleada
en este trabajo se funda en la revisión de los principales libros publicados por el autor, tales como
Economía descalza (1982), Desarrollo a escala humana (1986), La dimensión perdida (2007) y La
economía desenmascarada (2014). Se sostiene como supuesto que la obra de Max Neef se encuadra
en un cuerpo teórico latinoamericano, que rompe intelectualmente con los modelos macroeconómi-
cos, sean de corte desarrollista o de tipo neoliberal. La originalidad de su aporte se encuentra en la
defensa de los fundamentos ecológicos para el desarrollo humano a una escala local
Basic human needs in the situation of disabled people: from individual-environment relationship
No full textgráficas, ilustraciones, tablasLa presente propuesta se formula alrededor de la comprensión sobre las necesidades humanas fundamentales, abordando este tema desde una perspectiva relacional individuo-entorno, por eso, su objetivo principal fue comprender las maneras de realizar adecuada, oportuna y eficazmente las Necesidades Humanas Fundamentales (NHF) de personas en situación de discapacidad (PSD), esto a partir del reconocimiento de las relaciones que en la cotidianidad vive el individuo. La categoría “Necesidad” es un concepto polisémico, con un largo desarrollo conceptual desde diferentes perspectivas, por lo cual para este estudio se tomó como referente principal los postulados de Manfred Max-Neef y Col (1986), y los desarrollos posteriores que se encuentran en esta misma corriente teórica. Este autor rompe con muchos desarrollos que le antecedieron y postula nuevas formas de comprender las necesidades, desde una propuesta de concepción universal y social, que es fundamental para sustentar este trabajo investigativo. El propósito final de esta investigación, es proponer lineamientos que permitan aumentar las posibilidades de realización de las necesidades de las personas en situación de discapacidad, a partir del fortalecimiento de las relaciones sociales de los individuos, proponiendo un desarrollo basado en lo local, lo comunitario, lo “pequeño” (Mujica,N. Rincón,S. 2006), como eje fundamental donde se desenvuelve la vida de la gente y en definitiva, se concretan las posibilidades de desarrollo humano. Este estudio se realizó con la colaboración de seis informantes culturales de Bogotá D.C., desde un tipo de estudio cualitativo, con un nivel de profundidad analítico explicativo. Según la fuente de información será de tipo mixto, pues se tiene en cuenta, el análisis documental de la literatura encontrada a partir de los desarrollos de Max-Neef (1986) hasta hoy y las vivencias de las personas en situación de discapacidad, las técnicas utilizadas para la recolección de información, fueron narración de historia de vida, entrevista semiestructurada y taller de análisis individual de la matriz, propuesto por Max-Neef para interpretación de las formas de realizar las NHF. (texto tomado de la fuente)The proposed present is formulated around the understanding of the human fundamental
necessities, this topic will be approached from the individual's perspective with its
environment, for that reason its main objective is to understand the ways to satisfy and to carry
out appropriate, opportune and efficiently the human fundamental necessities of disability
people starting from the recognition of the relationship individual and environment
The category "Necessity" is a concept, with a conceptual long development from different
perspectives, reason why for this study we will recapture as initial referent some postulates of
Manfred Max-Neef and Cabbage (1986) and other later developments that are in this same
line. This author breaks up with many developments that preceded him/her and it postulates
new forms of understanding the necessities, from a proposal of universal and social
conception that is fundamental to sustain this investigative work.
The final purpose of this investigation to propose limits that allow to increase the possibilities
of realization of the necessities of people disability, starting from the invigoration of the social
relationships of the individuals, proposing a development based on the local thing, the
community thing, the "small" thing (Mujica, N. Corner, S. 2006), as fundamental axis where
people's life is unwrapped and in definitive, the possibilities of human development are
summed up.
This study is carried out D.C. with the collaboration of six people in disability situation of
Bogotá, from a type of qualitative study, with an analytic explanatory level of depth. According
to the source of information it will be of mixed type, because one will keep in mind, the
documental analysis of the opposing literature starting from the developments of Max-Neef
(1986) until today of people in disability situation, the techniques used for the gathering of
information, were narration of history of life, interviews to depth, interviews semiestructurada
and shop proposed for Max-Neef for interpretation of the womb proposal.MaestríaMagister en Discapacidad e Inclusión Socia
Modelling Capillary Effects in Heterogeneous Porous Media
No full textElectrical Engineering, Mathematics and Computer Scienc
Author response: The synaptic ribbon is critical for sound encoding at high rates and with temporal precision
No full textWe studied the role of the synaptic ribbon for sound encoding at the synapses between inner hair cells (IHCs) and spiral ganglion neurons (SGNs) in mice lacking RIBEYE (RBEKO/KO). Electron and immunofluorescence microscopy revealed a lack of synaptic ribbons and an assembly of several small active zones (AZs) at each synaptic contact. Spontaneous and sound-evoked firing rates of SGNs and their compound action potential were reduced, indicating impaired transmission at ribbonless IHC-SGN synapses. The temporal precision of sound encoding was impaired and the recovery of SGN-firing from adaptation indicated slowed synaptic vesicle (SV) replenishment. Activation of Ca2+-channels was shifted to more depolarized potentials and exocytosis was reduced for weak depolarizations. Presynaptic Ca2+-signals showed a broader spread, compatible with the altered Ca2+-channel clustering observed by super-resolution immunofluorescence microscopy. We postulate that RIBEYE disruption is partially compensated by multi-AZ organization. The remaining synaptic deficit indicates ribbon function in SV-replenishment and Ca2+-channel regulation
Management strenghening of development areas in student community: creation of the promoter group at san juan bosco college in giron *
No full textLa educación además de transmitir masiva y eficazmente un cúmulo de conocimientos teóricos y técnicos, implica un desarrollo personal en la medida que el individuo se prepara para la vida en sus diversos ámbitos. Basados en lo anterior, el presente trabajo utiliza como lineamiento teórico inicial la Teoría de las Necesidades Humanas propuesta por Maslow, quien las categoriza en cinco grandes grupos: Auto-superación, reconocimiento, sociales, seguridad y fisiológicas; a Max Neef quien hace una distinción entre necesidades, satisfactores y bienes económicos y como última referencia teórica se cita al autor Jerónimo de Moragas para describir algunos apartes del desarrollo humano vistos a través de las etapas del ser humano. Cada uno de los capítulos de este documento muestra la coherencia entre las etapas desarrolladas en el colegio San Juan Bosco de Girón, en las que se encuentran: conceptualización, contextualización, caracterización del colegio San Juan Bosco de Girón y del proceso desarrollado en dicha institución educativa. Concluyendo con una propuesta de intervención profesional denominada fortalecimiento de la gestión de las áreas de desarrollo de la comunidad estudiantil: creación del grupo gestor del colegio San Juan Bosco de Girón; y finalizando en la importancia de planear, coordinar, ejecutar y evaluar proyectos que propendan por el desarrollo integral de la comunidad bosquesina la cual fue sujeto de la intervención profesional de Trabajo Social.PregradoTrabajador SocialEducation, in addition to transmit massively and effectively a myriad of conceptual and technical knowledge, involves the personal development as an individual gets his/her preparation the several aspects of life. Based on it, this work uses as an initial and conceptual guideline the Theory of Human necessities proposed by Maslow, who ranks it in 5 major groups: auto-improvement, acknowledgment, social, security and physiological necessities; this work also takes into account the concept of Max Neef who makes a distinction between necessities, satisfyers and economical goods and as a last conceptual reference, the author Jerónimo de Moragas is quoted for describing some parts of human development seen through the phases of human being. Each chapter of this paper shows the coherence of the phases developed at San Juan Bosco in Giron, among them: Conceptualization, contextualization, characterization of San Juan Bosco College in Giron, and the process developed in such educational institution. We conclude with a proposal of professional intervention called strengthening of the management of the development areas in the student community: creation of the promoter group of San Juan Bosco College in Giron; finally, we stress on the importance of planning, coordinating, performing, evaluating the projects that promotes the integral development for the forrest community which was subjected to the professional intervention of social work
Immune consequences and therapeutic targeting of disrupted RNA splicing in cancer
No full textThesis (Ph.D.)--University of Washington, 2022Immunotherapies, such as checkpoint blockade, CAR-T cells, and vaccines, have proven to be a valuable tool to treat various types of cancer. This class of therapy capitalizes on the immune system’s natural ability to recognize foreign antigens and kill cancer cells. Typically, many of these therapies have focused on the changes to DNA, particularly point mutations, that mark cancer cells. However, RNA dysregulation is also a frequent characteristic of cancer, and these transcriptomic changes may provide a large repertoire of new targets that previously has not been well studied. In this thesis, I address the question of whether RNA splicing changes can be immunogenic by studying disrupted splicing arising from 1) pharmacologic manipulation and 2) recurrent driver mutations in splicing factors. I demonstrate that drugs targeting splicing machinery can elicit anti-tumor immune responses dependent on splicing-derived neoantigens, and that checkpoint blockade can be used in combination with these drugs to further improve immune response and tumor clearance. I further provide a framework for identifying splicing-derived neoepitopes and use this framework to identify potential immune targets in splicing factor-mutant cancers. I then use mass cytometry-based approaches with leukemic SF3B1-mutant patient samples to characterize the immune environment in SF3B1-mutant cancers and search for antigen-specific T cells that recognize and respond to splicing-derived neoantigens
Author response: Gender bias in scholarly peer review
No full textPeer review is the cornerstone of scholarly publishing and it is essential that peer reviewers are appointed on the basis of their expertise alone. However, it is difficult to check for any bias in the peer-review process because the identity of peer reviewers generally remains confidential. Here, using public information about the identities of 9000 editors and 43000 reviewers from the Frontiers series of journals, we show that women are underrepresented in the peer-review process, that editors of both genders operate with substantial same-gender preference (homophily), and that the mechanisms of this homophily are gender-dependent. We also show that homophily will persist even if numerical parity between genders is reached, highlighting the need for increased efforts to combat subtler forms of gender bias in scholarly publishing
Emma Blake: Social Networks and Regional Identity in Bronze Age Italy. Cambridge University Press, Cambridge, 2014. ISBN 978-11-070-6320-4
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