46 research outputs found
Promoting the communication skills of 3-4 year-old children in movement games
No full textKvalifikācijas darba autore ir Liena Timofejeva un darba tēma ir “3 – 4 gadus vecu bērnu saskarsmes prasmju sekmēšana kustību rotaļās”. Mērķis: teorētiski izanalizēt un praktiski pētīt 3 - 4 gadus vecu bērnu saskarsmes prasmju sekmēšanas iespējas kustību rotaļās. Darba ietvaros analizēta pedagoģiskā un psiholoģiskā teorētiskā literatūra, veikts pētījums Alūksnes pirmsskolas izglītības iestādē “X”, lai noskaidrotu kā kustību rotaļas ietekmē saskarsmes prasmju attīstību. Kvalifikācijas darbā izvirzītā hipotēze apstiprinājās, jo ar mērķtiecīgi organizētu mācību procesu un kustību rotaļām ir iespējams veicināt saskarsmes prasmju attīstību. Kvalifikācijas darbs sastāv no 48 lpp., 4 tabulām, 19 literatūras avotiem, 7 pielikumiem.The author of the qualification work is Liena Timofejeva and the topic of the work is "Promoting the communication skills of 3 – 4 year-old children in movement games". Aim: to theoretically analyse and practically investigate the possibilities of promoting communication skills of 3 - 4 year old children in movement play. The theoretical literature on pedagogy and psychology has been analysed and a study has been conducted in the preschool educational institution "X" in Aluksne to find out how movement games influence the development of communication skills. The hypothesis of the qualification work was confirmed, as it is possible to promote the development of communication skills through a purposefully organised learning process and movement games. The qualification work consists of 48 pages, 4 tables, 19 references, 7 annexes
Music listening to promote cooperation of 5-6-year-old children in preschool
No full textKvalifikācijas darba temats: Mūzikas klausīšanās 5 - 6 gadīgu bērnu sadarbības veicināšanai pirmsskolā. Darba autore: Liena Pētersone Pētījuma mērķis - teorētiski izzināt un praktiski pētīt 5 – 6 gadīgu bērnu sadarbības veicināšanas iespējas, izmantojot mūzikas klausīšanos. Kvalifikācijas darba apjoms ir 50 lappuses, 3 pielikumi, 10 tabulas, 18 attēli un darbā izmantoti 42 literatūras un citi avoti latviešu un angļu valodās. Kvalifikācijas darbā tiek pētīta 5 – 6 gadīgu bērnu sadarbības prasmju veicināšanas iespēju mūzikas klausīšanās laikā. Kvalifikācijas darbs sastāv no divām daļām: 1.Teorētiskā daļa, kurā pētītas un analizēta dažādu autoru viedokļi par 5 – 6 gadīgu bērnu raksturojumu, sadarbības prasmju veicināšanas iespējām pirmsskolā, kā arī mūzikas uztveri un mūzikas klausīšanas veidiem. 2.Empīriskajā daļā veikts pedagoģiskais novērojums, izstrādāti septiņi aktīvās mūzikas klausīšanās uzdevumi, izstrādāti vērtēšanas kritēriji, kā arī iegūti un analizēti anketaptaujas rezultāti. Atslēgas vārdi: sadarbības prasmes, 5 – 6 gadīgi bērni, mūzikas uztvere, mūzikas aktīvā klausīšanās, mūzikas pasīvā klausīšanās.Subject of qualification paper: Music listening to promote cooperation of 5-6-year-old children in preschool. Author: Liena Pētersone The aim of the study is to theoretically and practically explore the possibilities for promoting cooperation between 5-6-year-olds through listening to music. The qualification paper consists of 50 pages, has 3 attachments, 10 tables, 18 images and the work refers to 42 literature and other sources both in Latvian and English. The qualification paper explores the possibility of promoting cooperation skills of 5-6-year-olds during listening to music. The qualification work consists of two parts: 1. A theoretical part exploring and analysing the views of different authors on the characteristics of 5-6-year-olds, possibilities for promoting cooperation skills in pre-school, as well as the perception of music and ways of listening to music. 2. An empirical part includes educational observation that has been performed, seven developed active music listening tasks, developed evaluation criteria, as well as the obtained and analysed results of the questionnaire. Keywords: cooperation skills, 5-6-year-olds, music perception, active music listening , passive music listening
Promoting the acquisition of multi-digit activities for 4 th grade pupils in the field of mathematics
No full textBakalaura darba autore: Liena Blauberga. Bakalaura darba nosaukums: Darbību ar daudzciparu skaitļiem apguves veicināšanai 4. klases skolēniem matemātikas jomā. Darba mērķis: pētīt un praktiski pārbaudīt darbību ar daudzciparu skaitļiem apguvi 4. klases skolēniem matemātikas jomā. Darba sastāvs: Bakalaura darbs sastāv no divām daļām – teorētiskās daļas un empīriskās. Darba teorētiskajā daļā tiek apskatīti aspekti matemātikas jomas raksturojums pamatskolas pirmajā posmā, kā arī daudzciparu skaitļu darbības ar tiem būtība sākumskolā, ko piedāvā Latvijas un ārzemju izglītības sistēmas. Bakalaura darba apjoms: 45 lpp., darbā viena tabula, deviņpadsmit attēli, pieci pielikumi. Pirmajā daļā tiek analizēta zinātniskā literatūra, salīdzinātas vairākas autoru atziņas par matemātikas mācību procesu sākumskolas posmā. Tiek veikta teorētiskā analīze par daudzciparu skaitļu apguves veicināšanu 4.klases matemātikas jomā. Otrajā daļā tiek pētīta reālā situācija daudzciparu skaitļu apguves veicināšanu 4. klases skolēniem matemātikas jomā, apkopoti ieteikumi matemātikas prasmju apguves veicināšanai. Atslēgas vārdi: daudzciparu skaitļi, reizināšana, dalīšana, Montesori pieeja, Montesori pedagoģiskie līdzekļi 4. klases matemātikas jomā.The author of the Bachelor's work: Liena Blauberga The title of the Bachelor's work: promoting the acquisition of multi-digit activities for 4 th grade pupils in the field of mathematics. The objective of the work: to study and test practically the acquisition of multi-digit activities for 4 th grade pupils in the field of mathematics. The composition of the work: the Bachelor's work consists of two parts, theoretical and empirical. The theoretical part of the work discusses the aspects characterising the field of mathematics in the first stage of primary school, as well as the nature of multi-digit activity with them in the primary school offered by Latvian and foreign education systems. The amount of Bachelor's work: 45 pages., one chart, nineteen images, five attachments. The first part analyses scientific literature, compares a number of authors' insights on the mathematics learning process at the primary school stage. There is carried out the theoretical analysis of the promotion of multi-digit numerical learning in the field of mathematics in Grade 4. Keywords: multi-digit numbers, multiplication, division, Montessori approach, Montessori educational tools in the field of mathematics for 4th grade
Ergonomic risks and health promotion measures in pallet manufacturing
No full text„Ergonomiskie riski un veselības veicināšanas pasākumi palešu ražošanā”. Darba autore: Liena Valdmane-Girgensone, darba vadītāja: asoc. profesore, Dr.med. Ženija Roja. Darbs izklāstīts uz 102 lpp., ietver 47 attēlus, 7 tabulas, 8 pielikumu, 45 informatīvos avotus. Pētījums sastāv no 4 daļām. Pirmajā daļā analizēta literatūru par darba vides riskiem palešu ražošanā. Otrajā daļā aprakstītas pētījumā lietotās metodes, bet trešajā daļā veikta iegūto datu apkopošana un rezultātu analīze. Ceturtajā daļā izstrādāti veselības veicināšanas pasākumi. Iegūtie pētījuma rezultāti ļauj secināt, ka palešu ražošanā nodarbinātie pakļauti darbam piespiedu pozā; biežām, monotonām, atkārtotām roku kustībām; smagam darbam, kas izraisa sāpes mugurā un augšējās ekstremitātēs. Palešu ražošanas iekārtu un modernu tehnoloģiju ieviešana var izslēgt atsevišķus ergonomiskos riskus un samazināt to ietekmi, bet pieaug kustību biežums kā arī kognitīvās ergonomikas riski. Izstrādāti priekšlikumi. Izmantotās metodes: darba vietu ergonomiskā analīze, Slodzes galveno rādītāju metodes: SGR-A un SGR-C, Ātrās Ekspozīcijas Kontroles (ĀEK) metode un LEA aplikācija. Atslēgas vārdi: ergonomiskie riski, dažādas palešu ražošanas iekārtas, MSS slimības, veselības veicināšana.“Ergonomic Risks and Health Promotion Measures in Pallet Manufacturing”. Author: Liena Valdmane-Girgensone, Supervisor: associate professor, Dr. med. Ženija Roja. There are 102 pages in the master thesis, including 47 pictures, 7 tables, 8 annexes and 45 literature references. The study consists of 4 parts. The first part analyzes the literature on work environment risks in pallet production. The second part describes the methods used in the research, while the third part collects the obtained data and analyzes the results. In the fourth part, health promotion measures are developed. The obtained research results allow us to conclude that those employed in the production of pallets are exposed to work in a forced position; frequent, monotonous, repetitive hand movements; for hard work that causes pain in the back and upper limbs. The introduction of pallet production equipment and modern technologies can eliminate certain ergonomic risks and reduce their impact, but the frequency of movements as well as the risks of cognitive ergonomics are increasing. Proposals have been developed. Used methods: ergonomic analysis of workplaces, Key indicator methods: KIM-LHC and KIM-MHO, Quick Exposure Check (QEC) method and LEA application. Key words: ergonomic risks, various pallet production equipment, MSD diseases, health promotion
AS "Diana" store network "Mājai un Dārzam" analysis and development opportunities in Bauska .
No full textKvalifikācijas darba autors – Liena Dravniece. Kvalifikācijas darba tēma ir AS „Diāna” veikalu tīkla „Mājai un Dārzam” saimnieciskās darbības analīze un attīstības iespējas Bauskā. Kvalifikācijas darba mērķis ir pētīt AS „Diana” veikalu tīkla „Mājai un Dārzam” saimniecisko darbību un attīstības iespējas Bauskā. Kvalifikācijas darba pirmajā nodaļā tiek apskatīti mazumtirdzniecības veikalu būtība un tās specifiku veikalos. Kvalifikācijas darba otrajā nodaļā tiek apskatīti saimnieciskās darbības analīzes teorētiskie pamati. Pētīta saimnieciskās darbības analīzes būtība, saturs un uzdevumi, saimnieciskās darbības analīzes metodes, kas ir SVID, PEST analīze, konkurētspējas analīze un kas ir uzņēmuma rentabilitātes analīze. Kvalifikācijas darba trešajā nodaļā tiek veikta AS „Diana” veikalu tīkla „Mājai un Dārzam” saimnieciskās darbības analīze iekļaujot tajā uzņēmuma darbības raksturojumu un uzņēmuma SVID , PEST analīzi, uzņēmuma konkurētspējas analīze un uzņēmuma rentabilitātes analīze. Noteiktas AS „Diana” veikalu tīkla „Mājai un Dārzam” attīstības iespējas Bauskā. Kvalifikācijas darba noslēgumā izdarīti secinājumi par uzņēmuma saimniecisko darbību un izvirzīti priekšlikumi, kā uzņēmums varētu veiksmīgi turpināt savu attīstību. Kvalifikācijas darba izstrādes gaitā tika izmantota teorētiskā pētījumu metode, zinātniskās literatūras un avotu analīze, tirgus izpētes metodes, matemātisko aprēķinu un datu apstrādes metode. Atslēgas vārdi: Saimnieciskā darbība, analīze, pilnveidošana. Kvalifikācijas darba apjoms ir 43 lapaspuses, 7 tabulas un 6 attēli, izmantoti 17 literatūras avoti. Kvalifikācijas darbam ir viens pielikums.The author of the qualification work - Liena Dravniece. The theme of the qualification work is AS "Diana" store network "Mājai un Dārzam" analysis and development opportunities in Bauska The objective of the qualification work is to study the business activities and development opportunities of the „Diana” network of stores „Mājai un Dārzam” in Bauska. The first part of the qualification paper examines the essence of retail stores and their specifics in shops. The second chapter of the qualification paper examines the theoretical basis of the analysis of economic activity. The essence, content and tasks of the analysis of economic activity, economic analysis analysis methods, which are SWOT, PEST analysis and competitiveness analysis, are analyzed. What are the indicators of profitability analysis. In the third chapter of the qualification work, the analysis of the economic activity of AS „Diana” store network „Mājai un Dārzam” is carried out, including the analysis of the company's activities and the company's SWOT, PEST analysis, the analysis of the company's competitiveness and the company's profitability analysis. Defined development opportunities in "Bauska" for „Diana” shop network „Mājai un Dārzam” At the end of the qualification work, conclusions were drawn about the company's economic activities and put forward proposals as to how the company could successfully continue its development. During the development of the qualification paper, the theoretical research method, the analysis of scientific literature and sources, market research methods, mathematical calculations and data processing method were used. Key words: Economic activity, analysis, improvement. The volume of the qualification paper is 43 pages, 7 tables and 6 figures, 17 sources of literature have been used. Qualification work has one attachment
Paraplégies spastiques héréditaires : exploration clinique au Soudan, études des origines moléculaires des formes autosomiques récessives et identification de nouveaux gènes en cause
No full textHereditary spastic paraplegias (HSP), a heterogeneous group of spastic neurodegenerative disorders which impose diagnostic challenges. I explored the clinical varieties and genetic pathways of spastic neurodegeneration in a familial Sudanese cohort. We recruited 41 Sudanese families [337 individuals/106 HSP patients]. I have established a genomic DNA bank and when necessary, skin biopsies and fibroblasts were also obtained. A phenotype-based candidate gene approach was followed in 4 families. A targeted next generation sequencing (NGS) for 74 HSP-related genes was the main screening strategy in all-remaining 37 families. Whole exome sequencing (WES) was done in search for novel mutations in new genes in families with negative screening results. Occasionally, functional studies were conducted when feasible and relevant. I identified the genetic cause in 17/41 families. In 12 families, the mutated genes were known HSP genes. In 3 families, novel genes were identified mutated. 5 candidate genes segregated with disease in 2 other families with more experiments needed to conclude. Analysis of the NGS screening panel and of WES data imposed certain challenges as multiple genetic disorders were sometimes found running in parallel in the same/different branches of highly inbred families. We could expand the phenotypic heterogeneity of these disorders due to clinical differences observed between Sudanese patients and patients of other origins even when caused by mutations by the same gene/variant. This is the first genetic screening in a large set of HSP families in Sudan. It describes new causative genes, paving the way for further deciphering of the underlying mechanisms.Les paraplégies spastiques héréditaires (PSH) font partie d’un groupe plus large de pathologies neurodégénératives associant une spasticité. J’ai exploré la variabilité clinique et moléculaire de ces pathologies à l’aide d’une cohorte de familles soudanaises. Nous avons recruté 41 familles soudanaises [337 individus/106 atteints de PSH]. J’ai extrait l’ADN génomique et constitué une banque. Le criblage de gènes candidats a été réalisé dans 4 familles en fonction du phénotype des patients. La technologie de séquençage de nouvelle génération (SNG) appliquée à 74 gènes de PSH a ensuite été appliquée aux 37 cas restants. Enfin, le séquençage de l’exome a permis de rechercher les gènes en cause dans les cas négatifs. Dans certains cas, des études fonctionnelles ont été utilisées afin de valider l’effet biologique des mutations. J’ai pu identifier la cause génétique dans 17 familles. Dans 12 familles, la mutation concernait un gène de PSH connu. Dans 3 familles, un nouveau gène a été identifié. 5 gènes candidats restent à départager dans 2 familles. Il est à noter que parfois, de multiple mutations ou maladies génétiques ségrégaient dans nos familles, dans la même branche ou dans des branches séparées. La complexité de ces familles fortement consanguines a rendu l’analyse des données du SNG difficile. Une autre particularité a été l’hétérogénéité clinique associée à des mutations du même gène entre patients de la même famille ou en comparaison avec la littérature. Ce travail est la première étude à grande échelle de patients soudanais avec PSH et rapporte de nouveaux gènes en cause, prérequis pour mieux comprendre dans le futur les mécanismes sous-jacents
Identifier les gènes candidats prédisposant à la dégénérescence spinocérébelleuse héréditaire dans une cohorte de familles soudanaises
No full textLes dégénérescences spinocérébelleuses héréditaires forme un groupe de troubles monogéniques qui partagent des mécanismes pathogènes communs et comprennent les paraplégies spastiques, l'ataxie cérébelleuse et l'ataxie spinocérébelleuse. Elles peuvent être pures ou complexe associant une neuropathie axonale ou des troubles cognitifs. Plus de 200 gènes et locus hérités via tous les modes de transmission mendéliens sont connus. L'hérédité autosomique récessive prédomine dans les communautés consanguines; cependant, une transmission autosomique dominante, de novo, et liée au chromosome X est parfois retrouvée. Le Soudan est composé de populations génétiquement diverses, mais il possède un des taux les plus élevés de consanguinité. Nous avons utilisé une combinaison de séquençage de nouvelle génération, de génotypage, d’analyse bioinformatique, et d'expérimentation fonctionnelle pour étudier 87 patients de 38 familles Soudanaises présentant ces maladies. Nous avons obtenu un diagnostic génétique dans 71-92% de ces familles, y compris sept familles dans lesquelles se transmettent des variants dans de nouveaux gènes candidats et trois familles associée à de nouveaux phénotypes dans des gènes connus. Ces résultats montrent l’hétérogénéité génétique de ces maladies et viennent compléter un peu plus leur nosologie avec des conséquences en diagnostic génétique en pratique médicale.Hereditary spinocerebellar degenerations are group of monogenic disorders that share common pathogenic mechanisms and include spastic paraplegia, cerebellar ataxia, and spinocerebellar ataxia. They can be pure or complicated with axonal neuropathy or mental impairment. More than 200 genes and loci inherited through all modes of Mendelian inheritance are known. Autosomal recessive inheritance predominates in consanguineous communities; however, autosomal dominant, de novo, and X-linked inheritance can also occur. Sudan is inhabited by genetically diverse populations, yet it has high rates of consanguinity. We used next-generation sequencing, genotyping, bioinformatics analysis, and functional experimentation to study 87 patients from 38 Sudanese families segregating multiple forms of these diseases. We reached a genetic diagnosis in 71-92% of these families, including seven families harboring variants in seven novel candidate genes and three families with novel phenotypes associated to known genes. These results highlight the heterogeneity of these diseases and add novel findings to their nosology which should have consequences in genetic diagnosis in clinical practice
Diseño de un libro ilustrado sobre personalidades femeninas revolucionarias de Latinoamérica
No full textEste proyecto de titulación se centra en el diseño de un libro ilustrado como
herramienta de difusión sobre personalidades femeninas revolucionarias de
Latinoamérica. Está dirigido a estudiantes de la Universidad de Cuenca, con el objetivo
de generar conciencia e inspiración sobre el legado y la lucha de la mujer por la igualdad
de oportunidades dentro de cualquier disciplina.
Para su correcto desarrollo se planteó el uso de la metodología de proyectación
propuesta por el autor Bonsiepe, en la que se estructura el problema mediante la
recopilación de información para luego pasar por un proceso de jerarquización de
los datos, y finalizar con la definición de criterios propios del diseño que permiten el
desarrollo de un producto editorial final, validado por la audiencia definida.This degree project focuses on the design of an illustrated book as a dissemination
tool about revolutionary female personalities of Latin America. It is aimed at students
of the University of Cuenca, with the objective of generating awareness and inspiration
about the legacy and the struggle of women for equal opportunities in any discipline.
For its correct development, we proposed the use of the design methodology
proposed by the author Bonsiepe, in which the problem is structured through the
collection of information and then go through a process of hierarchization of data, and
end with the definition of design criteria that allow the development of a final editorial
product, validated by the defined audience.0000-0003-1351-5428Licenciado en Diseño GráficoCuenc
Insights into Clinical, Genetic, and Pathological Aspects of Hereditary Spastic Paraplegias: A Comprehensive Overview
No full textInternational audienceHereditary spastic paraplegias (HSP) are a heterogeneous group of motor neurodegenerative disorders that have the core clinical presentation of pyramidal syndrome which starts typically in the lower limbs. They can present as pure or complex forms with all classical modes of monogenic inheritance reported. To date, there are more than 100 loci/88 spastic paraplegia genes (SPG) involved in the pathogenesis of HSP. New patterns of inheritance are being increasingly identified in this era of huge advances in genetic and functional studies. A wide range of clinical symptoms and signs are now reported to complicate HSP with increasing overall complexity of the clinical presentations considered as HSP. This is especially true with the emergence of multiple HSP phenotypes that are situated in the borderline zone with other neurogenetic disorders. The genetic diagnostic approaches and the utilized techniques leave a diagnostic gap of 25% in the best studies. In this review, we summarize the known types of HSP with special focus on those in which spasticity is the principal clinical phenotype ("SPGn" designation). We discuss their modes of inheritance, clinical phenotypes, underlying genetics, and molecular pathways, providing some observations about therapeutic opportunities gained from animal models and functional studies. This review may pave the way for more analytic approaches that take into consideration the overall picture of HSP. It will shed light on subtle associations that can explain the occurrence of the disease and allow a better understanding of its observed variations. This should help in the identification of future biomarkers, predictors of disease onset and progression, and treatments for both better functional outcomes and quality of life
Clinical and Genetic Characteristics of Leukodystrophies in Africa
No full textABSTRACTRecent understanding of the genetic basis of neurological disorders in Africa has grown rapidly in the last two decades. Africa harbors the largest genetic repertoire in the world which gives unique opportunity to discover novel variant, genes, and molecular pathways associated with various neurological diseases. Despite that, large-scale genomic and exome studies are severely lacking especially for neglected diseases such as leukodystrophies. This review aims to shed light on the currently developed research in leukodystrophies in Africa. We reviewed all research articles related to “Leukodystrophy in Africa” published in Medline/PubMed and Google Scholar databases up to date. We found very few studies in leukodystrophy from Africa, especially from the Sub-Saharan regions. Metachromatic leukodystrophy was the most studied type of leukodystrophy. Published studies from North Africa (Tunisia, Morocco, and Egypt) were very limited in either sample size (case studies or single/few family studies) or molecular methods (targeted sequencing or polymerase chain reaction-restriction fragment length polymorphisms). More studies (GWAS or large family studies) with advanced techniques such as exome or whole genome sequencing are needed to unveil the genetic basis of leukodystrophy in Africa. Unmasking novel genes and molecular pathways of leukodystrophies invariably lead to better detection and treatment for both Africans and worldwide populations.</jats:p
