48 research outputs found
MultiPLIER Fileset
No full textThis is the code and data from the MultiPLIER project v0.2.0 (https://github.com/greenelab/multi-plier/tree/v0.2.0). Please see the GitHub repository for more information, including code licensing information.Please see https://github.com/greenelab/rheum-plier-data for more information about individual datasets and citations and cite the original publications as appropriate.If you use any PLIER models, please be sure to cite:Mao W, Harmann B, Sealfon SC, Zaslavsky E, Chikina M. Pathway-Level Information ExtractoR (PLIER) for gene expression data. bioRxiv. 2017. DOI: 10.1101/116061If you use any recount2 data or models trained on these data, please be sure to cite:Collado-Torres L, Nellore A, Kammers K, Ellis SE, Taub MA, Hansen KD,
Jaffe AE, Langmead B and Leek JT (2017). "Reproducible RNA-seq analysis
using recount2." Nature Biotechnology. doi: 10.1038/nbt.3838All recount2 data is CC-BY, recount2 authors.</div
Big images of two-dimensional pseudorepresentations
No full textBellaïche has recently applied Pink-Lie theory to prove that, under mild conditions, the image of a continuous 2-dimensional pseudorepresentation of a profinite group on a local pro- domain contains a nontrivial congruence subgroup of for a certain subring of . We enlarge Bellaïche\u27s ring and give this new a conceptual interpretation in terms of conjugate self-twists of , symmetries that naturally constrain its image. As a corollary, this new is optimal among congruence subgroups contained in the image. We also interpret the new vis-a-vis the adjoint trace ring of , which we show is a more natural ring for these questions in general. Finally, we use our purely algebraic result to recover and extend a variety of arithmetic big-image results for Galois representations arising from elliptic, Hilbert, and Bianchi modular forms and -adic Hida or Coleman families of elliptic and Hilbert modular forms.71 pages. Improved optimality results. Most revisions are in the current sections 1, 3, 4, 5, 11, which have been reorganized. Main results are unchanged. To appear in Math. Ann. Comments very welcome
Author Correction: A deep learning system accurately classifies primary and metastatic cancers using passenger mutation patterns
No full textIn the published version of this paper, the members of the Pan-Cancer Analysis of Whole Genomes (PCAWG) Consortiumwere listed in the Supplementary Information; however, these members shouldhave been included in themainpaper.The originalArticle has been corrected to include the members and affiliations of the PCAWG Consortium in the main paper; the corrections have been made to the HTML version of the Article but not the PDF version. Additional corrections to affiliations and author names have been made to the PDF and HTML versions of the original Article for consistency of information between the PCAWG list and the main paper
The effects of footwear cushioning on walking performance in females with multiple sclerosis
No full text2018 Fall.Includes bibliographical references.Multiple sclerosis is a chronic and progressive neurodegenerative disease which incurs a multitude of walking impairments. Protective strategies targeted at maintaining postural stability during walking include increasing stance and double support time with reciprocal decreases in swing and single support time, however these adaptions inadvertently increase fall risk. The midsole construct of footwear has demonstrated the ability to mediate these deficits in running but has not been explored in a neurologic population with known fall risk. The purpose of this study was to investigate the effects of two different midsole conditions on the spatiotemporal parameters of gait in females with multiple sclerosis (MS). Gait testing was conducted while 18 females with MS performed two-minute walk tests in 1) a high-cushion and 2) a standard-cushion midsole shoe. Spatiotemporal gait parameters were assessed using wireless inertial sensors. Participants spent less time in double support and stance phase with concomitantly more time in single support and swing phase in the high-cushion midsole shoe as compared to the standard-cushion. The high-cushion shoe may decrease fall risk by improving gait parameters associated with increased risk of falls
Evaluating central mechanisms for age-related force control deficits of the legs
No full text2019 Fall.Includes bibliographical references.Advancing age is accompanied by several motor control impairments, including increased movement and force variability. Specifically, older adults display more variable and less accurate submaximal forces than young adults, which have been associated with fall risk in the aged population. These motor control changes take place in muscles in both the upper and lower limbs, and the mechanisms of these alterations are multifactorial, including sources in the peripheral and central nervous systems. Furthermore, inhibitory signaling in the motor cortex is related to force variability in small hand muscles, as well as to coordination of the legs during walking. It is unknown, however, whether inhibition is associated with force variability in the legs. Therefore, the purpose of this study was to assess the relationship between motor cortex inhibition and force variability in the quadriceps muscles of young and old adults. We measured quadriceps force variability and accuracy during a 2-minute force matching task and inhibition via the cortical silent period in 14 young and 15 old adults. Older adults produced more variable and less accurate forces than the young adults, though these differences were not significant. Additionally, older adults displayed less inhibition in their right cortical hemisphere than young adults, as well as interhemispheric inhibitory differences. Specifically, the left hemisphere displayed more inhibition than the right hemisphere in old adults. Furthermore, young adults with more inhibition generally produced more variable and less accurate forces than young adults with less inhibition, while older adults with more inhibition displayed less variable and more accurate forces. The between- and within-group differences in inhibition may point to age-related decline in right hemispheric function. Moreover, between-group differences in inhibition and force variability associations indicate a shift in the inhibitory control of movement, which is a similar finding to previous work on inhibition and lower limb coordination
Author Correction: Comprehensive analysis of chromothripsis in 2,658 human cancers using whole-genome sequencing
No full textauthor correctio
