45 research outputs found
Metabolismo e teatro, alchimia e religione. Appunti per una metaforologia del “Capitale” di Marx
No full textPremessa a Per d’Arco Silvio Avalle, «Le forme del canto». Interventi di Lino Leonardi, Pietro G. Beltrami, Maria Sofia Lannutti, Arnaldo Soldani
No full textThis collection of essays on medieval poetic metres, edited by Maria Sofia Lannutti following the arrangement conceived by its author, confirms the importance of d'Arco Silvio Avalle's metrical studies. Key issues are the relationship between metrical structure and music in the texts dating back to the origin of romance literatures, the multi-perspective complexity of the approach, and the exemplarity of the methodology used. © 2019 Societa Editrice il Mulino. All rights reserved
SeaClouds: An Open Reference Architecture for Multi-Cloud Governance
No full textA. Brogi, J. Carrasco, J. Cubo, F. D'Andria, E. Di Nitto, M. Guerriero, D. Pérez, E. Pimentel, J. Soldani. "SeaClouds: An Open Reference Architecture for Multi-Cloud Governance". In B. Tekinerdogan et al. (Eds.): ECSA 2016, LNCS 9839, pp. 334–338, 2016.We present the open reference architecture of the SeaClouds solution. It aims at enabling a seamless adaptive multi-cloud management of complex applications by supporting the distribution, monitoring and reconfiguration of app modules over heterogeneous cloud providers.Universidad de Málaga. Campus de Excelencia Internacional Andalucía Tech
Comparative analysis of senescent exorbital lacrimal glands in male and female albino rats
No full textIn our previous study we described a bilateral-macroscopic and structural dimorphism of young rat exorbital lacrimal gland (Loewenthal's gland), which was the probable cause of the bibliographic discrepancies in the entity and the onset of its sexual dimorphism. Relevant literature also reported sex-dependent alterations in gland structure during senescence. The present study aims to carry out a comparative analysis on age-dependent changes in glands of both sides from male and female rats, using histological, histochemical and transmission electron microscopy, to evaluate whether the gland bilateral-macroscopic and structural dimorphism might influence the kind of alterations which occur in senescence. Our findings indicate that the macroscopic and structural side-specific dimorphism is not so evident in comparison with young rats. The side-specific dimorphism is evident only in male rats, in which the roundish gland appears to be more Sudan-positive in comparison with the ellipsoidal gland. The gland bilateral-macroscopic and structural dimorphism, although more evident in comparison with young animals, does not seem to influence these kinds of alterations due to senescence, a time-window in which we still observed some sexual differences also in more aged rats
SYNTHESIS, PLATELET ANTI-AGGREGATING ACTIVITY AND ANTIINFLAMMATORY ACTIVITY OF A SERIES OF BETA-AMINOXYPROPIONIC ACIDS
No full textThis paper reports the platelet anti-aggregating activity induced by arachidonic acid (AA) and by adenosine-diphosphate (ADP), together with the anti-inflammatory activity evaluated by the carrageenan-induced rat paw edema method, of a series of beta-aminoxypropionic acids which were projected and synthesised as analogues of non-steroidal anti-inflammatory drugs with an arylacetic structure B, in which the aromatic group is substituted by a methyleneaminoxymethylic moiety. Some of the beta-aminoxypropionic acids were evaluated for their capacity to inhibit the cyclooxygenase enzyme by measuring the malondialdehyde (MDA) produced by incubation of sodium arachidonate with platelet-rich plasma (PRP)
SYNTHESIS, ANTIINFLAMMATORY ACTIVITY AND MOLECULAR-ORBITAL STUDIES OF A SERIES OF BENZYLIDENEAMINOXYPROPIONIC ACIDS SUBSTITUTED ON THE PHENYL RING
No full textAn examination of the antiinflammatory properties of certain β-aminoxypropionic acids A (AOPAs) previously synthesized as analogs of antiinflammatory drugs with an arylacetic structure B (ArAAs), indicated that the most active acid is the (E)-3(benzylideneaminoxy)-propionic acid (1), which was found to possess an activity comparable to that of Diclofenac (8). In an attempt to verify whether appropriate substitutions on the aromatic ring of 1 can modulate the antiinflammatory properties of this class of drugs, a series of benzylideneaminoxypropionic acids (BAOPAs) were synthesized, in which the phenyl group is substituted, in its 3 possible positions, by groups possessing different electronic, steric, and lipophilic characteristics. The antiinflammatory activity of the new compounds was determined by carrageenan-induced rat paw edema, using Diclofenac (8) as the reference drug. The pharmacological results revealed that among the BAOPAs examined, the most active are the m-chloro (7b) and p-ethoxy (7p) substituted compounds, which exhibit an antiinflammatory activity comparable to that of 1. Quantum mechanical calculations were also carried out in order to gain insight into the possible correlations between the pharmacological activity observed and the electronic and conformational effects induced by the presence of the various substituents
Enantiopure 3-(arylmethylidene)aminoxy-2-methylpropionic acids: synthesis and antiinflammatory properties
No full textSome optically active 3-(arylmethylidene)aminoxy- (3a-g, 4a-g) and fluorenylideneaminoxy-2-methylpropionic acids (5, 6), were prepared as analogues of the antiinflammatory arylpropionic acids of type B, in which the aromatic group is substituted by an MAOM moiety. Some of the new compounds. tested in vivo for their antiinflammatory properties by means of the carrageenan-induced paw edema method in rats, exhibited activity indices similar to that shown in the same test by ibuprofen. Compounds 3a.b and 4a,b, for which at least one of the two enantiomers had shown an inhibition value higher than 40% in the in vivo test, were assayed for their in vitro enzymatic inhibitory activity. showing percentage inhibition values between 40 and 50% at a concentration of 10 muM against COX-2: at the same concentration, they appeared to be devoid of any activity towards COX-1. Compounds 3a.b and 4a,b also proved to possess a similar toxicity. The lack of enantioselectivity shown by compounds 3-6 was tentatively explained in terms of a conformational freedom of the enantiomers which allows their quasi-superimposition
