2,546 research outputs found
Self-Assembly of Ternary Insulin-Polyethylenimine (PEI)-DNA Nanoparticles for Enhanced Gene Delivery and Expression in Alveolar Epithelial Cells
No full textEnhancing gene delivery and expression in alveolar epithelial cells could offer the opportunity for the treatment of acquired and inherited lung diseases. Here, we show that particle adsorption of human insulin (INS) is capable of increasing plasmid DNA (pDNA) delivery from polyethylenimine (PEI) nanoparticles specifically in alveolar epithelial cells. INS receptors were predominantly detected on alveolar but not on bronchial epithelial cells. INS was adsorbed on the surface of PEI gene vectors by spontaneous self-assembly resulting in ternary PEI−pDNA−INS nanoparticles. Surface adsorption was confirmed by particle size, surface charge, and fluorescence resonance energy transfer (FRET) measurements. INS adsorption significantly increased gene expression of PEI−pDNA nanoparticles up to 16-fold on alveolar epithelial cells but not on bronchial epithelial cells. This increased gene expression was INS receptor specific. Our results demonstrate that targeting INS receptor for gene delivery in alveolar epithelial cells represents a promising approach for enhanced gene delivery and expression
Evidence based leadership
No full textAuthor Markus PodduikinMasterarbeit Johannes Kepler Universität Linz 2024Arbeit gesperr
Improving the search for monitoring tools using recommender technology
No full textAuthor Markus Eisl BSc.Masterarbeit Universität Linz 2023Arbeit gesperr
Improving the search for monitoring tools using recommender technology
No full textAuthor Markus Eisl BSc.Masterarbeit Universität Linz 2023Arbeit gesperr
metal-organic framework 4H, 4H-octafluoroazobenezene perfluoroazobenzene
No full textauthor: Markus RödlKumulative Masterarbeit aus einem ArtikelMasterarbeit University of Innsbruck 2022Arbeit gesperr
metal-organic framework 4H, 4H-octafluoroazobenezene perfluoroazobenzene
No full textauthor: Markus RödlKumulative Masterarbeit aus einem ArtikelMasterarbeit University of Innsbruck 2022Arbeit gesperr
Strategi Pelayanan Lintas Budaya Berdasarkan Markus 4:1-34
No full textHarming & Katarina, Cross-cultural Service Strategy based on Mark 4: 1-34. The author conducted a study of the text of Mark 4: 1-34 using qualitative research literature study using the biblical hermeneutic principle. Based on the analysis of the text of Mark 4: 1-34 the authors find there are four cross-cultural service strategies namely by understanding local culture, using media. Harming & Katarina, Strategi Pelayanan Lintas budaya Berdasarkan Markus 4:1-34. Penulis melakukan penelitian terhadap teks Markus 4:1-34 dengan menggunakan penelitian kualitatif studi pustaka dengan menggunakan prinsip hermeneutik Alkitab. Berdasarkan analisis terhadap teks Markus 4:1-34 penulis menemukan ada empat strategi pelayanan lintas budaya yaitu dengan memahami budaya lokal, menggunakan media yang ada dalam budaya, memberdayakan potensi yang ada, dan menciptakan terobosan
Development of a Software Tool for Analyzing Experimental Data of a Recycling Machine
No full textAuthor DI Markus Kirchmayr, BScMasterarbeit Universität Linz 2022Arbeit nach Ablauf der Sperre auf den öffentlichen PCs in den Bibliotheken der JKU+Medizin abrufba
Machine-Learning-Based Photometric Stereo for Fracture Surface Reconstruction of Metal Samples
No full textAuthor Markus PrombergerMasterarbeit Johannes Kepler Universität Linz 2025Arbeit nach Ablauf der Sperre auf den öffentlichen PCs in den Bibliotheken der JKU+Medizin abrufba
Development of a Software Tool for Analyzing Experimental Data of a Recycling Machine
No full textAuthor DI Markus Kirchmayr, BScMasterarbeit Universität Linz 2022Arbeit nach Ablauf der Sperre auf den öffentlichen PCs in den Bibliotheken der JKU+Medizin abrufba
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