1,721,008 research outputs found
Glioblastoma cancer stem cells: Role of the microenvironment and therapeutic targeting
No full textIt has been recently suggested that many types of cancer, including glioblastoma (GBM), contain functionally subsets of cells with stem-like properties named "cancer stem cells" (CSCs). These are characterized by chemotherapy resistance and considered one of the key determinants driving tumor relapse. Many studies demonstrated that Glioma stem cells (GSCs) reside in particular tumor niches, that are necessary to support their behavior. A hypoxic microenvironment has been reported to play a crucial role in controlling GSC molecular and phenotypic profile and in promoting the recruitment of vascular and stromal cells in order to sustain tumor growth. Recent advances in the field allow researches to generate models able to recapitulate, at least in part, the extreme heterogeneity found within GBM tumors. These models try to account for the presence of GSCs and more differentiated cells, the influence of different microenvironments enclosed within the mass, heterotypic interactions between GBM and stromal cells and genetic aberrations. Understanding the mechanism of action of the microenvironmental signals and the interplay between different cell types within the tumor mass, open new questions on how GSCs modulate GBM aggressiveness and response to therapy. The definition of these tumor features will allow to setup innovative multimodal therapies able to target GBM cells at multiple levels. Here, we will discuss the major advances in the study of GSC role in GBM and the therapeutic implications resulting from them, thus reporting the latest strategies applied to counteract and overcome GBM intrinsic resistance to therapy for a better management of patient
Elena Rampazzo, Futurista al chiaro di luna. La poesia di Paolo Buzzi fra tradizione e avanguardia, Trieste, Edizioni Università di Trieste, 2020
Full text link«La poesia di Buzzi fu o non fu futurista?» È la domanda a cui prova a dare risposta Elena Rampazzo in Futurista al chiaro di luna. La poesia di Paolo Buzzi fra tradizione e avanguardia (Trieste, Edizioni Università di Trieste, 2020, 462 pp.), studio sulla produzione in versi del poeta milanese dagli esordi delle Rapsodie Leopardiane (1898) al provvisorio bilancio del Poema dei Quarantanni (1922), l’ultima raccolta pubblicata sotto l’egida marinettiana delle Edizioni Futuriste di «Poesia», che chiudeva di fatto la sua ultradecennale militanza all’interno del movimento. Lungo quest’arco della carriera poetica dello scrittore il saggio mette in luce i temi, le influenze e le ricerche formali, prendendo in esame l’intero repertorio testuale e ricostruendone la gestazione e la storia editoriale attraverso lo spoglio dei manoscritti e dei carteggi conservati presso la Biblioteca Comunale Centrale di Milano “Palazzo Sormani”. Il confronto puntuale con le fonti, la rigorosa mappatura dei riferimenti letterari, musicali e filosofici e l’inquadramento della sua attività di intellettuale nella cornice storica e culturale del tempo mirano a comprendere la complessa posizione di Buzzi all’interno del Futurismo e la sua controversa maniera di intendersi scrittore d’avanguardia
Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Eva Cattermole: il libro dei «Versi»
No full textBreve saggio di prefazione alla prima edizione moderna e commentata delle poesie (1883-1897) di Eva Cattermole, curata da Elena Rampazzo nell'ambito del programma di ricerca "Letteratura d'autrice dell'Otto/Nocevento: ragioni, forme, testi", prof.ssa Patrizia Zambon
Variations on the Author
Full text link“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Appropriate Similarity Measures for Author Cocitation Analysis
Full text linkWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
I «Colori» di Virgilio Giotti. Sei letture, a cura di Lorenzo Tommasini, Trieste, Centro Studi Scipio Slataper, 2021
No full textNato per iniziativa del Centro Studi Scipio Slataper di Trieste, il volume, frutto del lavoro congiunto di sei studiosi di diversa provenienza geografica e accademica – Stefano Carrai, Anna Modena, Lorenzo Tommasini, Elena Rampazzo, Paolo Senna e Luca Zorzenon –, offre una completa e particolareggiata lectura della produzione dialettale in versi del triestino Virgilio Giotti confluita nella raccolta Colori del 1957
The Three-Layer Concentric Model of Glioblastoma: Cancer Stem Cells, Microenvironmental Regulation, and Therapeutic Implications
Full text linkTumors arising in the central nervous system are thought to
originate from a sub-population of cells named cancer stem cells
(CSCs) or tumor initiating cells (TICs) that possess an immature
phenotype, combined with self-renewal and chemotherapy resistance
capacity. Moreover, in the last years, these cells have been
identified in particular brain tumor niches fundamental for
supporting their characteristics. In this paper, we report studies
from many authors demonstrating that hypoxia or the so called
“hypoxic niche” plays a crucial role in controlling CSC molecular
and phenotypic profile. We recently investigated the relationship
existing between Glioblastoma (GBM) stem cells and their niche,
defining the theory of three-concentric layers model for GBM mass.
According to this model, GBM stem cells reside preferentially
within the hypoxic core of the tumour mass, while more
differentiated cells are mainly localized along the peripheral and
vascularized part of the tumour. This GBM model provides
explanation of the effects mediated by the tumour microenvironment
on the phenotypic and molecular regulation of GBM stem cells,
describing their spatial distribution in the tumor bulk. Moreover,
we discuss the possible clinical implications of the creation of
this model for future GBM patient management and novel therapeutic
strategies development
Dispelling the Myths Behind First-author Citation Counts
Full text linkWe conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued
use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation
counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more
sophisticated methods
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