6,213 research outputs found
A common HLA-DPA1 variant is associated with hepatitis B virus infection but fails to distinguish active from inactive Caucasian carriers
No full textBackground and Aims: Chronic infection with the hepatitis B virus (HBV) is a major health issue worldwide. Recently, single nucleotide polymorphisms (SNPs) within the human leukocyte antigen (HLA)-DP locus were identified to be associated with HBV infection in Asian populations. Most significant associations were observed for the A alleles of HLA-DPA1 rs3077 and HLA-DPB1 rs9277535, which conferred a decreased risk for HBV infection. We assessed the implications of these variants for HBV infection in Caucasians.
Methods: Two HLA-DP gene variants (rs3077 and rs9277535) were analyzed for associations with persistent HBV infection and with different clinical outcomes, i.e., inactive HBsAg carrier status versus progressive chronic HBV (CHB) infection in Caucasian patients (n = 201) and HBsAg negative controls (n = 235).
Results: The HLA-DPA1 rs3077 C allele was significantly associated with HBV infection (odds ratio, OR = 5.1, 95% confidence interval, CI: 1.9–13.7; p = 0.00093). However, no significant association was seen for rs3077 with progressive CHB infection versus inactive HBsAg carrier status (OR = 2.7, 95% CI: 0.6–11.1; p = 0.31). In contrast, HLA-DPB1 rs9277535 was not associated with HBV infection in Caucasians (OR = 0.8, 95% CI: 0.4–1.9; p = 1).
Conclusions: A highly significant association of HLA-DPA1 rs3077 with HBV infection was observed in Caucasians. However, as a differentiation between different clinical courses of HBV infection was not possible, knowledge of the HLA-DPA1 genotype cannot be translated into personalized anti-HBV therapy approaches
Han Suyin (Chinese author) speaking at Dallas Brookes Hall.
No full textThis record was harvested from a previous catalogue system and will be withdrawn in 2025. Information in this record may be superseded or incomplete. Visit this record in UMA's new catalogue at: https://archives.library.unimelb.edu.au/nodes/view/276390Han Suyin (Chinese author) speaking at Dallas Brookes Hall.200056
Item: [1999.0081.00439] "Han Suyin (Chinese author) speaking at Dallas Brookes Hall.
Vortex lattice structure in a d-wave superconductor with orthorhombic distortion
No full textThe vortex lattice structure in an orthorhombic d-wave superconductor under a magnetic field parallel to the c axis is studied near the upper critical field using the phenomenological D-2h symmetric Ginzburg-Landau free-energy density. The equilibrium vortex lattices are commonly body-centered rectangular lattice with no rotation relative to the underlying crystal. At certain temperature which depends on the parameters describing the a-b anisotropy, the flux lattice undergoes a second-order phase transition with the direction of the elongation of the rectangular lattice rotated by 90 degrees (e.g., from the b-axis direction to the a-axis direction). The phase transition temperature is estimated within two microscopic models. [S0163-1829(99)05117-6].Physics, Condensed MatterSCI(E)2ARTICLE1711579-115865
Measurement of the Xi(-)(b) and Omega(-)(b) baryon lifetimes
No full textUsing a data sample of pp collisions corresponding to an integrated luminosity of 3 fb−1, the Ξ−b and Ω−b baryons are reconstructed in the Ξ−b → J/ψΞ− and Ω−b → J/ψΩ− decay modes and their lifetimes measured to be
τ(Ξ−b) = 1.55+0.10−0.09 (stat) ± 0.03 (syst) ps,
τ(Ω−b) = 1.54+0.26−0.21 (stat) ± 0.05 (syst) ps.
These are the most precise determinations to date. Both measurements are in good agreement with previous experimental results and with theoretical predictions
Asian-Pacific Consensus Statement on the Management of Chronic Hepatitis B: A 2008 Update
No full textLarge amounts of new data on the natural history and treatment of chronic hepatitis B virus (HBV) infection have become available since 2005. These include long-term follow- up studies in large community-based cohorts or asymptomatic subjects with chronic HBV infection, further studies on the role of HBV genotype/naturally occurring HBV mutations, treatment of drug resistance and new therapies. In addition, Pegylated interferon alpha 2a, entecavir and telbivudine have been approved globally. To update HBV management guidelines, relevant new data were reviewed and assessed by experts from the region, and the significance of the reported findings were discussed and debated. The earlier " Asian-Pacific consensus statement on the management of chronic hepatitis B" was revised accordingly. The key terms used in the statement were also defined. The new guidelines include general management, special indications for liver biopsy in patients with persistently normal alanine aminotransferase, time to start or stop drug therapy, choice of drug to initiate therapy, when and how to monitor the patients during and after stopping drug therapy. Recommendations on the therapy of patients in special circumstances, including women in childbearing age, patients with antiviral drug resistance, concurrent viral infection, hepatic decompensation, patients receiving immune- suppressive medications or chemotherapy and patients in the setting of liver transplantation, are also included
SCI citation analysis and impact factor prediction of JZUS-B in 2008
No full textWe analysis the SCI citation of Journal of Zhejiang University-SCIENCE B, predict its 2008 Impact Factor in the range of 0.737~0.915, and list the top-10 SCI cited articles
Randomized phase II study of GS-4774 as a therapeutic vaccine in virally suppressed patients with chronic hepatitis B
No full textGS-4774 is a heat-inactivated, yeast-based, T-cell vaccine designed to elicit hepatitis B virus (HBV)-specific T-cell responses. We evaluated the safety, tolerability and efficacy of GS-4774 in patients with chronic HBV infection
Corvèe under Han
No full textThe author distinguishes between the corvee systems of Ch'in and Han. In spite of the fact that the corvee system underwent a marked change in 167 B. C. in the reign of Emperor Wen of Former Han, the fact has been hitherto almost entirely overlooked. The author tries to reconstruct the Ch'in corvee system from various sources. In the sense that these two ancient empires were despotic in their constitution there was no essential difference between their system of government, but Han succeeded in melting feudalistic residues of the Chan-kuo period into her own system, while Ch'in failed in doing so due to the short period of her rule. Moreover, Ch'in failed in taking local differences into consideration in establishing her institutions. In the author's view the reign of Emperor Wen is significant in the sense that it represents renovation of the feudalistic taxation system and of the uniform and artificial system of local administration
Paragona nemorata Kononenko & Han, sp. n.
No full text<i>Paragona nemorata</i> Kononenko & Han, sp. n. <p>(Figs. 5, 6, 21, 22, 32)</p> <p> Kononenko 2005: 65 (<i>Paragona</i> sp.); Kononenko, Han 2007: 35, pl. 8, fig. 5; Pl. 182, fig. 1 (<i>Paragona</i> sp.).</p> <p> <b>Types.</b> Holotype: female, Korea, Gwangneung, Prov. Gyeonggi, 8.viii.2006 (H.L. Han), genitalia prep. KNA 788; Paratypes: 1 female, same locality, 6.vi.1999 (B.K. Byun), genitalia prep. KNA 786; 6 females same locality, 8.viii.2006 (H.L. Han), genitalia prep. KNA 787 (preserved in Korean National Arboretum, Gwangneung, Korea); 1 male, Forest Dam. Gwangneung, 37°45'14'' N, 127°09'E 13.viii 2005 (B.K. Byun), genitalia slide KNA 1049 HL; 1 female with same data, genitalia slide KNA 1050 HL (NEFU); 1 male, Russia, Primorye terr. Kedrovaya Pad Nature Reserve 12.vi. 1974 (V. Kononenko), genitalia prep. 554 VK IBSS. Holotype and 7 females paratypes preserved in Korean National Arboretum, Gwangneung, Korea; 1 male and 1 female paratype preserved in Northeast Forestry University, Harbin, China; 1 male paratype preserved in the Institute of Biology and Soil Science, Russia, Vladivostok.</p> <p> <b>Diagnosis.</b> <i>P. n e m o r a t a</i> is congeneric with <i>P. multisignata</i> and <i>P. cognata</i> and <i>P. cleorides.</i> Externally the new species is most similar to <i>P. cleorides</i>, but differs in smaller size, reduced shining scales on abdomen, narrower forewing, darker wing colour and details of wing pattern. In the male genitalia, it differs from its congeners in shape of valva with parallel costal and ventral margins, acute apex and ventral extension of costa and central position of clasper and harpe. The female genitalia have short anterior apophyses as in <i>P. multisignata</i>, sclerotized ductus bursae broader than in <i>P. multisignata</i>, but narrower than in <i>P. cognata</i>; corpus bursae with numerous small spine-like signa in bottom part of the corpus bursa unlike the related species, which have signa in mid part (<i>P. multisignata</i>) or in caudal part (<i>P. cognata</i>) of corpus bursae.</p> <p> <b>Description.</b> Adult (Figs. 5, 6). Head and thorax brown-grey; dorsal side of abdomen brown grey with pairs patch of silver-shining scales on each segment. Wings covered with thin elongated scales, cilia formed by long hair-like scales. Ground colour of wing dark brown-grey, darker in costal and basal areas, with suffusion of ash-grey scales; basal field darker than background, defined by diffused grey subbasal line; medial field brownish-grey with diffused rusty-reddish patch in center; orbicular not traceable; medial shadow somewhat darker background, diffused, darker in costal field; reniform blackish, as vertical streak; antemedial line pale ash-grey, wide, diffused; subterminal field grey-brownish, darker in costal area; subterminal line wide, pale yellowish-grey, diffused; terminal field brown-grey with suffusion of pale grey scales; cilia formed by long scales, yellowish-grey with dark grey. Hindwing pattern reflect those of forewing, basal area greyish, medial field ash-grey with rusty-brown patch; reniform thin, blackish; antemedial field brown-grey, subterminal line ash-grey, wide, diffused; terminal area brown-grey with ash-grey suffusion, cilia yellowishgrey with dark grey.</p> <p> <b>Male genitalia</b> (Figs. 21, 22). Uncus straight, apically somewhat extended and pointed; tegumen narrow, without lateral extensions; vinculum almost equal to tegumen; juxta vertically splitted; valva rather narrow, basally with parallel margins, apically somewhat extended; costa straight, apically pointed; digitus projected ventrally on apical third of valva, rather broad, sclerotized, pointed; harpe deposited in medial part of valva, short, broad at the base, pointed apically. Aedeagus straight, vesica bulbous, bearing two small cornuti.</p> <p> <b>Female genitalia</b> (Fig. 32). Papillae anales broad, quadrangular, apophyses anterior very short, 3 times shorter than posterior ones; antevaginal plates present, splitted; ductus bursae short, sclerotized; bursae copulatrix ovoid, in caudal part wrinkled, bearing small spine-like signum in proximal third; ductus seminalis falls into small extension in proximal part of bursae.</p> <p> <b>Distribution and biology.</b> (Fig. 41). Manchurian–continental. South of Russian Far East (south Primorye), South Korea. The species was collected in Primorye and South Korea in similar biotopes – old rich broad leaved mixed forest with <i>Pinus koraiensis</i> and <i>Abies nephrophila</i>.</p> <p> <b>Notes.</b> A single male was collected by the first author in 1974 in zone of mixed broad leaved – coniferous forest in the south of Primorye territory, Russian Far East. Twenty five years later a series was collected by the second author in similar habitat in Korean National Arboretum, Guangneung forest near Seoul, South Korea. The species was referred by Kononenko (2005) for the Primorye territory and male and female genitalia illustrated (Kononenko & Han 2007) as “ <i>Paragona</i> sp.”</p> <p> <b>Etymology.</b> The species name “ <i>nemorata</i> ” refers to nemoral Manchurian broadleaved – coniferous forest, the typical habitat of the new species.</p>Published as part of <i>Kononenko, Vladimir S., Han, Hui-Lin, Yu, Alexej & V, Ато, 2010, A review of the Eastern Palaearctic genera Paragona Staudinger, 1892 and Paragabara Hampson, 1926 with description of two new species and a new genus (Lepidoptera, Noctuidae: Aventiinae, Hypeninae), pp. 51-68 in Zootaxa 2679</i> on pages 55-56, DOI: <a href="http://zenodo.org/record/199269">10.5281/zenodo.199269</a>
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